Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity

ABSTRACT

The invention relates to substituted tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid trans: protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery disease.

This is a continuation of application Ser. No. 09/716,728, filed Nov.21, 2000, now abandoned, which is a continuation of application Ser. No.09/404,638, filed Sep. 23, 1999, now abandoned.

FIELD OF THE INVENTION

This invention is in the field of treating cardiovascular disease, andspecifically relates to compounds, compositions and methods for treatingatherosclerosis and other coronary artery disease. More particularly,the invention relates to substituted tertiary-heteroalkylamine compoundsthat inhibit cholesteryl ester transfer protein (CETP), also known asplasma lipid transfer protein-I.

BACKGROUND OF THE INVENTION

Numerous studies have demonstrated that a low plasma concentration ofhigh density lipoprotein (HDL) cholesterol is a powerful risk factor forthe development of atherosclerosis (Barter and Rye, Atherosclerosis,121, 1-12 (1996)). HDL is one of the major classes of lipoproteins thatfunction in the transport of lipids through the blood. The major lipidsfound associated with HDL include cholesterol, cholesteryl ester,triglycerides, phospholipids and fatty acids. The other classes oflipoproteins found in the blood are low density lipoprotein (LDL) andvery low density lipoprotein (VLDL). Since low levels of HDL cholesterolincrease the risk of atherosclerosis, methods for elevating plasma HDLcholesterol would be therapeutically beneficial for the treatment ofatherosclerosis and other diseases associated with accumulation of lipidin the blood vessels. These diseases include, but are not limited to,coronary heart disease, peripheral vascular disease, and stroke.

Atherosclerosis underlies most coronary artery disease (CAD), a majorcause of morbidity and mortality in modem society. High LDL cholesterol(above 180 mg/dl) and low HDL cholesterol (below 35 mg/dl) have beenshown to be important contributors to the development ofatherosclerosis. Other diseases, such as peripheral vascular disease,stroke, and hypercholesterolaemia subject compounds is shown toeffectively modify plasma HDL/LDL ratios, and to check the progressand/or formation of these diseases:

CETP is a plasma protein that facilitates the movement of cholesterylesters and triglycerides between the various lipoproteins in the blood(Tall, J. Lipid Res., 34, 1255-74 (1993)). The movement of cholesterylester from HDL to LDL by CETP has the effect of lowering HDLcholesterol. It therefore follows that inhibition of CETP should lead toelevation of plasma HDL cholesterol and lowering of plasma LDLcholesterol, thereby providing a therapeutically beneficial plasma lipidprofile (McCarthy, Medicinal Res. Revs., 13, 139-59 (1993); Sitori,Pharmac. Ther., 67,443-47 (1995)). This exact phenomenon was firstdemonstrated by Swenson et al., (J. Biol. Chem., 264, 14318 (1989)) withthe use of a monoclonal antibody that specifically inhibited CETP. Inrabbits, the antibody caused an elevation of the plasma HDL cholesteroland a decrease in LDL cholesterol. Son et al. (Biochim. Biophys. Acta795, 743-480 (1984)), Morton et al. (J. Lipid Res. 35, 836-847 (1994))and Tollefson et al. (Am. J. Physiol., 255, (Endocrinol. Metab. 18,E894-E902 (1988))) describe proteins from human plasma that inhibitCETP. U.S. Pat. No. 5,519,001, issued to Kushwaha et al., describes a 36amino acid peptide derived from baboon apo C-1 that inhibits CETPactivity.

There have been several reports of non-peptidic compounds that act asCETP inhibitors. Barrett et al. (J. Am. Chem. Soc., 188, 7863-63 (1996))and Kuo et al. (J. Am. Chem. Soc., 117, 10629-34 (1995)) describecyclopropane-containing CETP inhibitors. Pietzonka et al. (Bioorg. Med.Chem. Lett, 6, 1951-54 (1996)) describe phosphonate-containing analogsof cholesteryl ester as CETP inhibitors. Coval et al. (Bioorg. Med.Chem. Lett., 5, 605-610 (1995)) describe Wiedendiol-A and -B, andrelated sesquiterpene compounds as CETP inhibitors. Lee et al. (J.Antibiotics, 49, 693-96 (1996)) describe CETP inhibitors derived from aninsect fungus. Busch et al. (Lipids, 25, 216-220, (1990)) describecholesteryl acetyl bromide as a CETP inhibitor. Morton and Zilversmit(J. Lipid Res., 35, 836-47 (1982)) describe that p-chloromercuriphenylsulfonate, p-hydroxymercuribenzoate and ethyl mercurithiosalicylateinhibit CETP. Connolly et al. (Biochem. Biophys. Res. Comm. 223, 42-47(1996)) describe other cysteine modification reagents as CETPinhibitors. Xia et al. describe 1,3,5-triazines as CETP inhibitors(Bioorg. Med. Chem. Lett., 6, 919-22 (1996)). Bisgaier et al. (Lipids,29, 811-8 (1994)) describe 4-phenyl-5-tridecyl-4H-1,2,4-triazole-thiolas a CETP inhibitor.

Some substituted heteroalkylamine compounds are known. In EuropeanPatent Application No. 796846, Schmidt et al. describe2-aryl-substituted pyridines as cholesterol ester transfer proteininhibitors useful as cardiovascular agents. One substitutent at C3 ofthe pyridine ring can be an hydroxyalkyl group. In European PatentApplication No. 801060, Dow and Wright describe heterocyclic derivativessubstituted with an aldehyde addition product of an alkylamine to afford1-hydroxy-1-amines. These are reported to be β3-adrenergic receptoragonists useful for treating diabetes and other disorders. In GreatBritain Patent Application No. 2305665, Fisher et al. disclose 3-agonistsecondary amino alcohol substituted pyridine derivatives useful fortreating several disorders including cholesterol levels andartherosclerotic diseases. In European Patent Application No 818448,Schmidt et al. describe tetrahydroquinoline derivatives as chlolesterolester transfer protein inhibitors. European Patent Application No.818197, Schmek et al. describe pyridines with fused heterocycles aschlolesterol ester transfer protein inhibitors. Brandes et al. in GermanPatent Application No. 19627430 describe bicyclic condensed pyridinederivatives as cholesterol ester transfer protein inhibitors.

DESCRIPTION OF THE INVENTION

The present invention relates to a class of compounds comprisingsubstituted tertiary-heteroalkylamines which are beneficial in thetherapeutic and prophylactic treatment of coronary artery disease asgiven in Formula I (also referred to herein as generic tertiaryomegaheteroalkylamine):

wherein m=0 to 5; n=1 to 6; m+n=1 to 6; and a terminal carbon atom ofthe CH_(n)(R₃) moiety is directly bonded by a covalent bond to thenitrogen when m=0;

wherein R₁ is selected independently from:

(a) hydrido, alkyl, aryl, aralkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, haloalkylsulfinylalkyl, haloalkylsulfonylalkyl,haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroaralkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, heteroaralkylsulfonylalkyl,heteroaralkylsulfinyl, heteroaralkylsulfonyl,heteroaralkylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁+R₂ represents a spacer group selected from a moiety having achain length of 2 to 7 atoms to form a C3 to C8 cycloalkyl, a C5 to C8cycloalkenyl, a C4 to C8 saturated heterocyclyl, or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboxylalkyl, hydroxy,hydroxyalkyl, and halo groups;

(c) or R₁+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 2 to 7 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁+R₁₉ represents a spacer group selected from a covalent bond ora moiety having a chain length of 2 to 7 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein R₂ is independently selected from:

(a) hydrido, hydroxy, hydroxyalkyl, amino, alkylamino, dialkylamino,alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,aralkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, alkylsulfinylalkyl, alkylsulfonylalkyl,haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl,arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl,cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl,cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl,heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl,aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide,carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₂+R₁ represents a spacer group selected from a moiety having achain length of 2 to 7 atoms to form a C3 to C8 cycloalkyl, a C5 to C8cycloalkenyl, a C4 to C8 saturated heterocyclyl, or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboxylalkyl, hydroxy,hydroxyalkyl, and halo groups;

(c) or R₂+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(d) or R₂+R₁₄ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₂+R₁₅ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₂ represents a spacer group selected from a covalent bond or amoiety having a chain length of 1 to 4 atoms connected to a point ofbonding on A or Q to form a C5 to C8 saturated heterocyclyl or a C5 toC8 partially saturated heterocyclyl ring substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein R₃ is selected from:

(a) hydrido, hydroxy, cyano, aryloxy, hydroxyalkyl, amino, alkylamino,dialkylamino, acyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio,alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroarylthio, aralkylthio, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aroyl, heteroaroyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl,arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl,aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl,cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,beteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl:

(b) or R₃+R₁ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₃+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(d) or R₃+R₁₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₃+R₁₅ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₃ represents a spacer group selected from a covalent bond or alinear moiety having a chain length of 1 to 6 atoms connected to a pointof bonding on A or Q to form a C5 to C10 saturated heterocyclyl or a C5to C10 partially saturated heterocyclyl ring substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(g) or R₃+R₁₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein X is selected from —H, —F, —O—, —S—, —S(O)—, —S(O)₂—,—S(O)₂(NH)—, —NH—, —N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-,—N(alkoxy)-, —N(aryloxy)-, —N(heteroaryloxy)-, —N(acyloxy)-,—N(aroyloxy)-, —N(cycloalkyl), —N(aralkoxy)-, and —N(aryl)-;

wherein R₁₆ is selected from:

(a) hydrido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,monocarboalkoxyalkyl, monocarboalkoxy, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, acyl, aroyl,heteroaroyl, heteroaryloxyalkyl, dialkoxyphosphonoalkyl or absent:

(b) or a spacer group selected from a covalent bond or a moiety having achain length of 1 to 5 atoms connected to A or Q to form a C5 to C10saturated heterocyclyl or a C5 to C10 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, hydroxyl, thiol, amino, alkylamino,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, carboxy, aryloxy,heteroaryloxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(c) or R₁₆+R₁₄ represents a spacer group selected from a covalent bondor a moiety having a chain length of 1 to 5 atoms connected to form a C5to C10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, hydroxyl, thiol, amino,alkylamino, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, carboxy,aryloxy, heteroaryloxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, andhalo groups;

wherein Y is a (—C(R₁₄)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₄)_(y)—)_(n)—W—(—CH(R₁₄)_(y)—)_(n) where n=1 to 2 and y=0 to 1and R₁₄ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylaminohydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₄+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₄+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₄ represents a spacer group selected from a moiety having achain length of 3 to 6 atoms connected to Q to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₄ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms connected to point of bonding on A to forma C5 to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(g) or R₁₄+R₁₄ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₄+R₁₄ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein W is selected from —O—, —S—, —S(O)—, —S(O)₂—, —S(O)₂(NH)—, —NH—,—N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-,—N(heteroaryloxy)-, —N(acyloxy)-, —N(aroyloxy)-, —N(cycloalkyl),—N(aralkoxy)-, and —N(aryl)-;

wherein Z is independently selected from a covalent bond,(—C(R₁₅)_(y)—)_(n) wherein n=1 to 4 and y=0 to 2,(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,—N—, —N(OH)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-, —N(aralkoxy),—N(cycloalkyl)-, —N(aryl)-, oxygen radical (—O—), —OCH₂—, or—OCH(R₁₅)_(y)— where y=0 to 1;

wherein, when Z is (—C(R₁₅)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,R₁₅ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroaryl sulfonylheteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a moiety having achain length of 3 to 6 atoms connected to Q to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms connected to point of bonding on A to forma C5 to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;(g) or R₁₅+R₁₅ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₅+R₁₅ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is N, R₁₅ is independently selected from:

(a) hydrido, hydroxyalkyl, aryloxy, aminoalkyl, alkylaminoalkyl,dialkylaminoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalcyl,acylamido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,aralkoxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, heteroaralkylthioalkyl, aralkylthioalkyl,heteroaralkylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl,arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl,aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl,cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to A to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms connected to Q to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is (—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1to 2 and y=0 to 2 or —OCH(R₁₅)_(y)— wherein y=0 to 1, R₁₅ isindependently selected from:

(a) aryloxy, carboxyl, acyl, aroyl, heteroaroyl, hydroxyalkyl,heteroaryloxyalkyl, acylamido, alkoxy, alkylthio, arylthio, alkyl,alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroaryloxyalkyl, aralkoxyalkyl, heteroaralkoxyalkyl,alkylsulfonylalkyl, alkylsulfinylalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to A to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms connected to Q to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is a covalent bond, —N(OH)—, —N(alkyl)-, —N(alkoxy)-,—N(aryloxy)-, —N(cycloalkyl)-, —N(aryl)-, —N(aralkoxy)-, oxygen radical(—O—), or —OCH₂—, an R₁₅ substituent is not attached to Z;

wherein R₁₉ is selected from:

(a) hydrido, hydroxyalkyl, acyl, sulfhydryl, acylamido, alkoxy,alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl,aryloxyalkyl, heteroarylthio, aralkylthio, aroyl, aralkanoyl,heteroaroyl, aralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl,aralkylthioalkyl, heteroaralkylthioalkyl, alkoxyalkyl,heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl,cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₉+R₁ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₉+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₉+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₉+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₉+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;(g) or R₁₉ represents a spacer group selected from a covalent bond or alinear moiety having a chain length of 2 to 5 atoms connected to a pointof bonding on A or Q to form a C5 to C8 saturated heterocyclyl or a C5to C8 partially saturated heterocyclyl ring substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein A and Q are independently selected from alkyl, alkenyl, alkynyl,aryl, hydroxyalkyl, saturated heterocyclyl, partially saturatedheterocyclyl, heteroaryl, aralkyl, cycloalkyl, cycloalkylalkyl,cycloalkenyl, cycloalkenylalkyl, cycloalkylalkenyl, aryloxyalkyl,alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl,haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxyalkyl,halocycloalkenyloxyalkyl, perhaloaryl, perhaloaralkyl,perhaloaryloxyalkyl, heteroaralkyl, heteroaryloxyalkyl, carboxyalkyl,carboalkoxyalkyl, carboxamidoalkyl, cyanoalkyl, dialkoxyphosphonoalkyl,N-arylcarboxamidoalkyl, or N-heteroarylcarboxamidoalkyl, provided one ofA and Q must be aryl, aryloxyalkyl, heteroaryl, perhaloaryloxyalkyl,aralkyl, or heteroaralkyl;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula II (also referred to herein asGeneric Tertiary OmegaHeteroalkylamineammonium salt):

wherein m=0 to 5; n=1 to 6; m+n=1 to 6; and a terminal carbon atom ofthe CH(R₃) moiety is directly connected by a covalent bond to thenitrogen when m=0;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, R₁₉, A, Q, X, Y, and Z aresubstitutents selected from those disclosed for the compounds of FormulaI:

or a pharmaceutically-acceptable salt thereof.

The compounds of this invention can be used to inhibit cholesteryl estertransfer protein (CETP) activity, thereby decreasing the concentrationsof low density lipoprotein (LDL) and raising the level of high densitylipoprotein (HDL), resulting in a therapeutically beneficial plasmalipid profile. The compounds also can be used to treat dyslipidemia(hypoalphalipoproteinemia), hyperlipoproteinaemia (chylomicronemia andhyperapobetalipoproteinemia), peripheral vascular disease,hypercholesterolaemia, atherosclerosis, coronary artery disease andother CETP-mediated disorders. The compounds can also be used inprophylactic treatment of subjects who are at risk of developing suchdisorders. The compounds can be used to lower the risk ofatherosclerosis. The compounds of Formula I and Formula II would be alsouseful in prevention of cerebral vascular accident (CVA) or stroke.

Besides being useful for human treatment, these compounds are alsouseful for veterinary treatment of companion animals, exotic animals andfarm animals, including mammals, rodents, and the like. More preferredanimals include horses, dogs, and cats.

In one embodiment, the compounds correspond to Formula I wherein m=0 andn=1. Compounds of Formula I wherein m=0 and n=1 have the CH(R₃) moietydirectly connected by a covalent bond to the nitrogen and correspond toFormula III (also referred to herein as generic tertiary2-heteroalkylamine):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, A, Q, X, Y, and Z are as definedabove for the compounds of Formula I;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula IV (also referred to herein asgeneric tertiary 2-heteroalkylammonium salt):

wherein m=0 and n=1 have the terminal carbon atom of the CH(R₃) moietydirectly connected by a covalent bond to the nitrogen;

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, A, Q, X, Y, and Z are as definedabove for the compounds of Formula II;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula I wherein m=0to 5; n=1 to 5; m+n=1 to 6, A=aryl or heteroaryl substitutedindependently at one or more meta and para positions with substituentsindependently selected from alkoxy, aralkoxy, heteroaralkoxy,haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy, heteroaryloxy, aryl,arylthio, heteroaryl, heteroarylthio, arylamino, heteroarylamino, aroyl,heteroaroyl, and haloheteroaryloxy groups; Q=aryl or heteroarylsubstituted independently at one or more meta and para positions withsubstituents independently selected from alkoxy, aralkoxy,heteroaralkoxy, haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy,heteroaryloxy, aryl, arylthio, heteroaryl, heteroarylthio, arylamino,heteroarylamino, aroyl, heteroaroyl, and haloheteroaryloxy groups; and aterminal carbon atom of the CH(R₃) moiety is directly connected by acovalent bond to the nitrogen when m=0. Compounds of Formula I whereinm=0 to 5; n=1 to 5; m+n=1 to 6, A=aryl or heteroaryl substitutedindependently at one or more meta and para positions with substituentsindependently selected from alkoxy, aralkoxy, heteroaralkoxy,haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy, heteroaryloxy, andhaloheteroaryloxy groups, and Q=aryl or heteroaryl substitutedindependently at one or more meta and para positions with substituentsindependently selected from alkoxy, aralkoxy, heteroaralkoxy,haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy, heteroaryloxy, andhaloheteroaryloxy groups have the CH(R₃) moiety directly connected by acovalent bond to the nitrogen when m=0 and correspond to Formula I-I(also referred to herein as generic aromatic tertiaryomegaheteroalkylamines):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined forthe compounds of Formula I;

wherein A and Q are independently selected from aryl or heteroaryl,provided that at least one of A or Q must be substituted at one or moremeta and para positions with substituents independently selected fromalkoxy, aralkoxy, heteroaralkoxy, haloalkoxy, haloalkenyloxy, aryloxy,haloaryloxy, heteroaryloxy, aryl, arylthio, heteroaryl, heteroarylthio,arylamino, heteroarylamino, aroyl, heteroaroyl, and haloheteroaryloxygroups, and provided that A and Q may additionally both be substitutedoptionally and independently at one or more meta and para positions withsubstituents independently selected from haloalkenyloxy, haloaryloxy,haloheteroaryloxy heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino,aralkylamino, arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl,arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl,haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy, haloalkylenedioxy,cycloalkyl, cycloalkenyl, lower cycloalkylalkyl, lowercycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydroxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, N-aryl-N-cycloalkylamino,N-cycloalkylamino, N-alkenylamino, N-cycloalkenylamino, cycloalkenyloxy,N-heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy groups;

wherein A and Q are not linked together by a covalent bond or a spacergroup to form a C5 to C10 partially saturated heterocyclyl ring or a C5to C6 heteroaryl substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula II-II (also referred to herein asgeneric aromatic tertiary omegaheteroalkylammonium salt):

wherein m=0 to 5; n=1 to 5; m+n=1 to 6;

wherein the CH(R₃) moiety is directly connected when m=0 by a covalentbond to the nitrogen;

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, R₁₉, A, Q, X, Y, and Z are as definedabove for the compounds of Formula I-I;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula I wherein m=0to 5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl substitutedindependently at one or more meta and para positions with substituentsindependently selected from alkoxy, aralkoxy, heteroaralkoxy,haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy, heteroaryloxy, aryl,arylthio, heteroaryl, heteroarylthio, arylamino, heteroarylamino, aroyl,heteroaroyl, and haloheteroaryloxy groups; Q=aryl or heteroarylsubstituted independently at one or more meta and para positions withsubstituents independently selected from alkoxy, aralkoxy,heteroaralkoxy, haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy,heteroaryloxy, aryl, arylthio, heteroaryl, heteroarylthio, arylamino,heteroarylamino, aroyl, heteroaroyl, and haloheteroaryloxy groups; and aterminal carbon atom of the CH(R₃) moiety is directly connected by acovalent bond to the nitrogen when m=0. Compounds of Formula I whereinm=0 to 5; n=1 to 5; m+n=1 to 6, A=aryl or heteroaryl substitutedindependently at one or more meta and para positions with substituentsindependently selected from alkoxy, aralkoxy, heteroaralkoxy,haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy, heteroaryloxy, andhaloheteroaryloxy groups, and Q=aryl or heteroaryl substitutedindependently at one or more meta and para positions with substituentsindependently selected from alkoxy, aralkoxy, heteroaralkoxy,haloalkoxy, haloalkenyloxy, aryloxy, haloaryloxy, heteroaryloxy, andhaloheteroaryloxy groups have the CH(R₃) moiety directly connected by acovalent bond to the nitrogen when m=0 and correspond to Formula I-IA(also referred to herein as generic aromatic tertiaryomegaheteroalkylamines):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined forthe compounds of Formula I;

wherein A and Q are independently selected from aryl or heteroaryl,provided that at least one of A or Q must be substituted at one or moremeta and para positions with substituents independently selected fromalkoxy, aralkoxy, heteroaralkoxy, haloalkoxy, haloalkenyloxy, aryloxy,haloaryloxy, heteroaryloxy, aryl, arylthio, heteroaryl, heteroarylthio,arylamino, heteroarylamino, aroyl, heteroaroyl, and haloheteroaryloxygroups, and provided that A and Q may additionally both be substitutedoptionally and independently at one or more meta and para positions withsubstituents independently selected from haloalkenyloxy, haloaryloxy,haloheteroaryloxy heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino,aralkylamino, arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl,arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl,haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy, haloalkylenedioxy,cycloalkyl, cycloalkenyl, lower cycloalkylalkyl, lowercycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydroxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, N-aryl-N-cycloalkylamino,N-cycloalkylamino, N-alkenylamino, N-cycloalkenylamino, cycloalkenyloxy,N-heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy groups;

wherein A and Q may optionally be linked together by a covalent bond ora spacer group to form a C5 to C10 partially saturated heterocyclyl ringor a C5 to C6 heteroaryl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, hydroxy, hydroxyalkyl, cyano,carboalkoxy, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula II-IIA (also referred to herein asgeneric aromatic tertiary omegaheteroalkylammonium salt):

wherein m=0 to 5; n=1 to 5; m+n=1 to 6;

wherein the CH(R₃) moiety is directly connected by a covalent bond tothe nitrogen when m=0;

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, R₁₉, A, Q, X, Y, and Z are as definedabove for the compounds of Formula I-I;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula I whereinm=0; n=1; A=alkyl, haloalkyl, alkylene, haloalkylene, cycloalkyl,halocycloalkyl, cycloalkenyl, halocycloalkenyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when Q=alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, A must be aryl, aralkyl, heterocyclyl, aryloxyalkyl,heteroaryloxyalkyl, heteroaralkyl, or heteroaryl; Q=alkyl, haloalkyl,alkylene, haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, aryl, aralkyl, heterocyclyl, aryloxyalkyl,heteroaryloxyalkyl, heteroaralkyl, or heteroaryl provided that, whenA=alkyl, haloalkyl, alkylene, haloalkylene, cycloalkyl, halocycloalkyl,cycloalkenyl, halocycloalkenyl, Q must be aryl, aralkyl, heterocyclyl,aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, or heteroaryl; and aterminal carbon atom of the CH(R₃) moiety is directly connected by acovalent bond to the nitrogen when m=0. Compounds of Formula I whereinm=0; n=1; A=alkyl, haloalkyl, alkylene, haloalkylene, cycloalkyl,halocycloalkyl, cycloalkenyl, halocycloalkenyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when Q=alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl. A must be aryl, aralkyl, heterocyclyl, aryloxyalkyl,heteroaryloxyalkyl, heteroaralkyl, or heteroaryl; Q=alkyl, haloalkyl,alkylene, haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, aryl, aralkyl, heterocyclyl, aryloxyalkyl,heteroaryloxyalkyl, heteroaralkyl, or heteroaryl provided that, whenA=alkyl, haloalkyl, alkylene, haloalkylene, cycloalkyl, halocycloalkyl,cycloalkenyl, halocycloalkenyl, Q must be aryl, aralkyl, heterocyclyl,aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, or heteroaryl; and aterminal carbon atom of the CH(R₃) moiety is directly connected by acovalent bond to the nitrogen when m=0 correspond to Formula III-III(also referred to herein as generic aromatic tertiary2-heteroalkylamines):

wherein R₁ is as defined for the compounds of Formula I or R₁ ishydrido;

wherein R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula I;

wherein A is independently selected from alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, aryloxyhydroxyalkyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when Q is alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, or aryloxyhydroxyalkyl, A must bearyl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl;

wherein Q is independently selected from alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, aryloxyhydroxyalkyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when A is alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, or aryloxyhydroxyalkyl, Q must bearyl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl;

wherein A and Q are not linked together by a covalent bond or a spacergroup to form a C5 to C10 partially saturated heterocyclyl ring or a C5to C6 heteroaryl substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, hydroxy, hydroxyalkyl, cyano,carboalkoxy, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula IV-IV (also referred to herein asgeneric aromatic tertiary 2-heteroalkylammonium salt):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, A, Q, X, Y, and Z are as defined forthe compounds of Formula III-III;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl:

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula I whereinm=0; n=1; A=alkyl, haloalkyl, alkylene, haloalkylene, cycloalkyl,halocycloalkyl, cycloalkenyl, halocycloalkenyl, hydroxyhaloalkyl,aryloxyhydroxyalkyl, aryl, aralkyl, heterocyclyl, aryloxyalkyl,heteroaryloxyalkyl, heteroaralkyl, or heteroaryl provided that, whenQ=alkyl, haloalkyl, alkylene, haloalkylene, cycloalkyl, halocycloalkyl,cycloalkenyl, halocycloalkenyl, hydroxyhaloalkyl, oraryloxyhydroxyalkyl, A must be aryl, aralkyl, heterocyclyl,aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, or heteroaryl; Q=alkyl,haloalkyl, alkylene, haloalkylene, cycloalkyl, halocycloalkyl,cycloalkenyl, halocycloalkenyl, hydroxyhaloalkyl, aryloxyhydroxyalkyl,aryl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl provided that, when A=alkyl, haloalkyl,alkylene, haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, or aryloxyhydroxyalkyl, Q must bearyl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl; and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogen whenm=0. Compounds of Formula I wherein m=0; n=1; A=alkyl, haloalkyl,alkylene, haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, aryloxyhydroxyalkyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when Q=alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, or aryloxyhydroxyalkyl. A must bearyl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl; Q=alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, aryloxyhydroxyalkyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when A=alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, or aryloxyhydroxyalkyl, Q must bearyl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl; and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogen when m=0correspond to Formula III-IIIA (also referred to herein as genericaromatic tertiary 2-heteroalkylamines):

wherein R₁ is as defined for the compounds of Formula I or R₁ ishydrido;

wherein R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula I;

wherein A is independently selected from alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, aryloxyhydroxyalkyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when Q is alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, or aryloxyhydroxyalkyl. A must bearyl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl;

wherein Q is independently selected from alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, aryloxyhydroxyalkyl, aryl, aralkyl,heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl, heteroaralkyl, orheteroaryl provided that, when A is alkyl, haloalkyl, alkylene,haloalkylene, cycloalkyl, halocycloalkyl, cycloalkenyl,halocycloalkenyl, hydroxyhaloalkyl, or aryloxyhydroxyalkyl, Q must bearyl, aralkyl, heterocyclyl, aryloxyalkyl, heteroaryloxyalkyl,heteroaralkyl, or heteroaryl;

wherein A and Q may optionally be linked together by a covalent bond ora spacer group to form a C5 to C10 partially saturated heterocyclyl ringor a C5 to C6 heteroaryl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, hydroxy, hydroxyalkyl, cyano,carboalkoxy, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula IV-IVA (also referred to herein asgeneric aromatic tertiary 2-heteroalkylammonium salt):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, A, Q, X, Y, and Z are as defined forthe compounds of Formula III-IIIA;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula I wherein m=0to 5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl; Q=aryl or heteroaryl;and a terminal carbon atom of the CH(R₃) moiety is directly connected bya covalent bond to the nitrogen when m=0. Compounds of Formula I whereinm=0 to 5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl; and Q=aryl orheteroaryl have the CH(R₃) moiety directly connected by a covalent bondto the nitrogen when m=0 and correspond to Formula V-H (also referred toherein as generic heteroaryl tertiary omegaheteroalkylamines):

wherein R₁ is haloalkyl, haloalkenyl, haloalkoxyalkyl, orhaloalkenyloxyalkyl;

wherein X is oxy;

wherein R₁₆ is selected from:

(a) hydrido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,monocarboalkoxyalkyl, monocarboalkoxy, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, acyl, aroyl,heteroaroyl, heteroaryloxyalkyl, dialkoxyphosphonoalkyl;

(b) or a spacer group selected from a covalent bond or a linear moietyhaving a chain length of 1 to 4 atoms linked to the point of bonding ofR₄, R₈, R₉, R₁₃, R₁₄, or R₁₅ to form a C5 to C10 saturated heterocyclylor a C5 to C10 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein one or more spacer groups selected from a covalent bond or alinear moiety having a chain length of 1 to 6 atoms is present betweenany two points of bonding of any two of R₄, R₅, R₆, R₇, R₈, R₉, R₁₀,R₁₁, R₁₂, R₁₃, R₁₄, R₁₅, R₁₆, or R₁₉;

wherein D₁, D₂, J₁, J₂ and K₁ are independently selected from C, N, O, Sand a covalent bond provided that:

-   -   (a) no more than one can be a covalent bond,    -   (b) only one of D₁, D₂, J₁, J₂ and K₁ can be O,    -   (c) only one of D₁, D₂, J₁, J₂ and K₁ can be S,    -   (d) only two of D₁, D₂, J₁, J₂ and K₁ can be O and S,    -   (e) when two of D₁, D₂, J₁, J₂ and K₁ are O or S, one of D₁, D₂,        J₁, J₂ and K₁ must be a covalent bond,    -   (f) only four of D₁, D₂, J₁, J₂ and K₁ can be N,    -   (g) one of D₁, D₂, J₁, J₂ and K₁ must be N, O, or S unless one        of D₃, D₄, J₃, J₄ and K₂ is N, O, or S;

wherein D₃, D₄, J₃, J₄ and K₂ are independently selected from C, N, O, Sand a covalent bond provided that:

-   -   (a) no more than one can be a covalent bond,    -   (b) only one of D₃, D₄, J₃, J₄ and K₂ can be O,    -   (c) only one of D₃, D₄, J₃, J₄ and K₂ can be S,    -   (d) only two of D₃, D₄, J₃, J₄ and K₂ can be O and S,    -   (e) when two of D₃, D₄, J₃, J₄ and K₂ are O or S, one of D₃, D₄,        J₃, J₄ and K₂ must be a covalent bond,    -   (f) only four of D₃, D₄, J₃, J₄ and K₂ can be N,    -   (g) one of D₃, D₄, J₃, J₄ and K₂ must be N, O, or S unless one        of D₁, D₂, J₁, J₂ and K₁ is N, O, or S;

wherein R₂ is independently selected from:

(a) hydrido, hydroxy, hydroxyalkyl, amino, alkylamino, dialkylamino,alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,aralkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, alkylsulfinylalkyl, alkylsulfonylalkyl,haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl,arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl,cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl,cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl,heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl,aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide,carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₂+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₂+R₁₄ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₂+R₁₅ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₂+R₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(f) or R₂+R₈ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(g) or R₂+R₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(h) or R₂+R₁₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

wherein R₃ is selected from:

(a) hydrido, hydroxy, cyano, aryloxy, hydroxyalkyl, amino, alkylamino,dialkylamino, acyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio,alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroarylthio, aralkylthio, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aroyl, heteroaroyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl,arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl,aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl,cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₃+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₃+R₁₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₃+R₁₅ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₃+R₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(f) or R₃+R₈ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(g) or R₃+R₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(h) or R₃+R₁₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(i) or R₃+R₁₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups,

wherein Y is a (—C(R₁₄)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₄)_(y)—)_(n)—W—(—CH(R₁₄)_(y)—)_(n) where n=1 to 2 and y=0 to 1and R₁₄ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₄+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₄+R₃ represents a spacer group selected from a covalent bond ora moiety having, a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₄ represents a spacer group selected from a moiety having achain length of 3 to 6 atoms connected to the point of bonding of R₉ orR₁₃ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(f) or R₁₄ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms connected to the point of bonding of R₄ orR₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(g) or R₁₄+R₁₄ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₄+R₁₄ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein W is selected from —O—, —S—, —S(O)—, —S(O)₂—, —S(O)₂(NH)—, —NH—,—N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-,—N(heteroaryloxy)-, —N(acyloxy)-, —N(aroyloxy)-, —N(cycloalkyl),—N(aralkoxy)-, and —N(aryl)-;

wherein Z is independently selected from a covalent bond,(—C(R₁₅)_(y)—)_(n) wherein n=1 to 4 and y=0 to 2,(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,—N—, —N(OH)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-, —N(aralkoxy),—N(cycloalkyl)-, —N(aryl)-, oxygen radical (—O—), —OCH₂—, or—OCH(R₁₅)_(y)— where y=0 to 1;

wherein, when Z is (—C(R₁₅)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,R₁₅ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a moiety having achain length of 3 to 6 atoms connected to the point of bonding of R₄ orR₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms connected to the point of bonding of R₉ orR₁₃ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(g) or R₁₅+R₁₅ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₅+R₁₅ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is N, R₁₅ is independently selected from:

(a) hydrido, hydroxyalkyl, aryloxy, aminoalkyl, alkylaminoalkyl,dialkylaminoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl,acylamido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,aralkoxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to the point of bondingof R₄ or R₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms connected to the point of bondingof R₉ or R₁₃ form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is (—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1to 2 and y=0 to 2 or —OCH(R₁₅)_(y)— wherein y=0 to 1, R₁₅ isindependently selected from:

(a) aryloxy, carboxyl, acyl, aroyl, heteroaroyl, hydroxyalkyl,heteroaryloxyalkyl, acylamido, alkoxy, alkylthio, arylthio, alkyl,alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroaryloxyalkyl, aralkoxyalkyl, heteroaralkoxyalkyl,alkylsulfonylalkyl, alkylsulfinylalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to the point of bondingof R₄ or R₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for ex ample, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms connected to the point of bondingof R₉ or R₁₃ to form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is a covalent bond, —N(OH)—, —N(alkyl)-, —N(alkoxy)-,—N(aryloxy)-, —N(cycloalkyl)-, —N(aryl)-, —N(aralkoxy)-, oxygen radical(—O—), or —OCH₂—, an R₁₅ substituent is not attached to Z;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂ and R₁₃ are independentlyselected from hydrido, heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, alkylamino, aralkylamino, alkylthio, alkylthioalkyl, arylamino,arylthio, alkylsulfinyl, alkylsulfonyl, arylsulfinyl, arylsulfonyl,heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,hydroxyhaloalkyl, halolakanoyl, heteroarylthio, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, alkanoyl,alkenoyl, aroyl, heteroaroyl, alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroarylamino, heteroarylalkylamino, heteroaryloxy,heteroarylalkyl, heteroaryloxyalkyl, arylalkenyl, heteroarylalkenyl,carboalkoxy, carboaryloxy, carboaralkoxy, cyano, and carbohaloalkoxy;

wherein R₄+R₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₅+R₆ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₆+R₇ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₇+R₈ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₉+R₁₀ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₀+R₁₁ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₁+R₁₂ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₂+R₁₃ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₄+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₈+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₉+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₁₃+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₉+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₃+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₄+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₉+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₉+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₁₃+R₂ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₁₃+R₃ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₉ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₁₃ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally, for example, with one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₉ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally, for example, with one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₁₃ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

provided that there are no more than three non-hydrido ring substituentsR₄, R₅, R₆, R₇, and R₈, that there are no more than three non-hydridoring substituents R₉, R₁₀, R₁₁, R₁₂, and R₁₃, and R₄, R₅, R₆, R₇, R₈,R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are each independently selected to maintainthe tetravalent nature of carbon, trivalent nature of nitrogen, thedivalent nature of sulfur, and the divalent nature of oxygen;

wherein R₁₉ is selected from:

(a) hydrido, hydroxyalkyl, acyl, sulfhydryl, acylamido, alkoxy,alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl,aryloxyalkyl, aralkanoyl, heteroarylthio, aralkylthio, aroyl,heteroaroyl, aralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl,aralkylthioalkyl, heteroaralkylthioalkyl, alkoxyalkyl,heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl,cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl,diaralkoxyphosphonoalkyl;

(b) or R₁₉+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₉+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₉+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₉+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(g) or R₁₉ represents a spacer group selected from a covalent bond or alinear moiety having a chain length of 2 to 5 atoms connected to thepoint of bonding of R₄, R₈, R₉, or R₁₃ to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VI-H (also referred to herein asgeneric heteroaryl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-H;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅ are as defined for thecompounds of Formula V-H;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula V-H whereinm=0 to 5; n=1 to 5; m+n=1 to 6; D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, andK₂ are each a carbon atom; and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogen whenm=0. Compounds of Formula V-H wherein m=0 to S, n=1 to 5, m+n=1 to 6,and D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, and K₂ are each a carbon atom,have the CH(R₃) moiety directly connected by a covalent bond to thenitrogen when m=0 and correspond to Formula V (also referred to hereinas generic phenyl tertiary omegaheteroalkylamines):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-H;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅ are as defined for thecompounds of Formula V-H;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VI (also referred to herein asgeneric phenyl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅ are as defined for thecompounds of Formula V;

wherein R₁₇ and G as defined for the compounds of Formula VI-H;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula V, whereinm=0, n=1, and a terminal carbon atom of the CH(R₃) moiety is directlyconnected by a covalent bond to the nitrogen when m=0. Compounds ofFormula V, wherein m=0, n=1, and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogencorrespond to Formula VII (also referred to herein as generic phenyltertiary 2-heteroalkylamines):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula V;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are as definedfor Formula V;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃ are as defined for the compounds of Formula V;

wherein R₁₉, R₁₉+_(R) ₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅, R₁₉+R₂, R₁₉+R₃,R₁₉+R₁₄, R₁₉+R₁₅ substitutents are absent;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VIII (also referred to herein asgeneric phenyl tertiary 2-heteroalkylammonium salt):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula VII;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are as definedfor Formula VII;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃ are as defined for the compounds of Formula VII;

wherein R₁₇ and G as defined for the compounds of Formula VI;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula V-H whereinm=0 to 5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl; Q=aryl orheteroaryl; wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁,R₁₁+R₁₂, R₁₂+R₁₃, R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅,R₉+R₁₄, R₁₃+R₁₄, R₄+R₂, R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂,R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉, R₈+R₁₃ spacers are absent; and a terminalcarbon atom of the CH(R₃) moiety is directly connected by a covalentbond to the nitrogen when m=0. Compounds of Formula V-H wherein m=0 to5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl; and Q=aryl or heteroaryl;wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃ spacers are absent; have the CH(R₃) moiety directly connected bya covalent bond to the nitrogen when m=0 and correspond to Formula V-HA(also referred to herein as generic heteroaryl tertiaryomegaheteroalkylamines):

wherein R₁ is haloalkyl, haloalkenyl, haloalkoxyalkyl, orhaloalkenyloxyalkyl;

wherein X is oxy;

wherein R₁₆ is selected from hydrido, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,monocarboalkoxyalkyl, monocarboalkoxy, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, acyl, aroyl,heteroaroyl, heteroaryloxyalkyl, or dialkoxyphosphonoalkyl;

wherein D₁, D₂, J₁, J₂ and K₁ are independently selected from C, N, O, Sand a covalent bond provided that:

-   -   (a) no more than one can be a covalent bond,    -   (b) only one of D₁, D₂, J₁, J₂ and K₁ can be O,    -   (c) only one of D₁, D₂, J₁, J₂ and K₁ can be S,    -   (d) only two of D₁, D₂, J₁, J₂ and K₁ can be O and S,    -   (e) when two of D₁, D₂, J₁, J₂ and K₁ are O or S, one of D₁, D₂,        J₁, J₂ and K₁ must be a covalent,    -   (f) only four of D₁, D₂, J₁, J₂ and K₁ can be N,    -   (g) one of D₁, D₂, J₁, J₂ and K₁ must be N, O, or S unless one        of D₃, D₄, J₃, J₄ and K₂ is N, O, or S;

wherein D₃, D₄, J₃, J₄ and K₂ are independently selected from C, N, O, Sand a covalent bond provided that:

-   -   (a) no more than one can be a covalent bond,    -   (b) only one of D₃, D₄, J₃, J₄ and K₂ can be O,    -   (c) only one of D₃, D₄, J₃, J₄ and K₂ can be S,    -   (d) only two of D₃, D₄, J₃, J₄ and K₂ can be O and S,    -   (e) when two of D₃, D₄, J₃, J₄ and K₂ are O or S, one of D₃, D₄,        J₃, J₄ and K₂ must be a covalent bond,    -   (f) only four of D₃, D₄, J₃, J₄ and K₂ can be N,    -   (g) one of D₃, D₄, J₃, J₄ and K₂ must be N, O, or S unless one        of D₁, D₂, J₁, J₂ and K₁ is N, O, or S;    -   wherein R₂ is independently selected from:

(a) hydrido, hydroxy, hydroxyalkyl, amino, alkylamino, dialkylamino,alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,aralkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, alkylsulfinylalkyl, alkylsulfonylalkyl,haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl,arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl,cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl,cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl,heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl,aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide,carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₂+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₂+R₁₄ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₂+R₁₅ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₃ is selected from:

(a) hydrido, hydroxy, cyano, aryloxy, hydroxyalkyl, amino, alkylamino,dialkylamino, acyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio,alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroarylthio, aralkylthio, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aroyl, heteroaroyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl,arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl,aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl,cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₃+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₃+R₁₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₃+R₁₅ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₃+R₁₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein Y is a (—C(R₁₄)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₄)_(y)—)_(n)—W—(—CH(R₁₄)_(y)—)_(n) where n=1 to 2 and y=0 to 1and R₁₄ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₄+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₄+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₄+R₁₄ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₄+R₁₄ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein W is selected from —O—, —S—, —S(O)—, —S(O)2—, —S(O)₂(NH)—, —NH—,—N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-,—N(heteroaryloxy)-, —N(acyloxy)-, —N(aroyloxy)-, —N(cycloalkyl),—N(aralkoxy)-, and —N(aryl)-;

wherein Z is independently selected from a covalent bond,(—C(R₁₅)_(y)—)_(n) wherein n=1 to 4 and y=0 to 2,(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,—N—, —N(OH)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-, —N(aralkoxy),—N(cycloalkyl)-, —N(aryl)-, oxygen radical (—O—), —OCH₂—, or—OCH(R₁₅)_(y)— where y=0 to 1;

wherein, when Z is (—C(R₁₅)_(y))_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,R₁₅ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂, represents a spacer group selected from a covalent bondor a moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅+R₁₅ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅+R₁₅ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is N, R₁₅ is independently selected from:

(a) hydrido, hydroxyalkyl, aryloxy, aminoalkyl, alkylaminoalkyl,dialkylaminoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl,acylamido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,aralkoxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is (—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1to 2 and y=0 to 2 or —OCH(R₁₅)_(y)— wherein y=0 to 1, R₁₅ isindependently selected from:

(a) aryloxy, carboxyl, acyl, aroyl, heteroaroyl, hydroxyalkyl,heteroaryloxyalkyl, acylamido, alkoxy, alkylthio, arylthio, alkyl,alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroaryloxyalkyl, aralkoxyalkyl, heteroaralkoxyalkyl,alkylsulfonylalkyl, alkylsulfinylalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is a covalent bond, —N(OH)—, —N(alkyl)-, —N(alkoxy)-,—N(aryloxy)-, —N(cycloalkyl)-, —N(aryl)-, —N(aralkoxy)-, oxygen radical(—O—), or —OCH₂—, an R₁₅ substituent is not attached to Z;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are independentlyselected from hydrido, heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, alkylamino, aralkylamino, alkylthio, alkylthioalkyl, arylamino,arylaminoalkyl, arylsulfonyl, arylsulfinyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, hydroxyhaloalkyl, haloalkanoyl,arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, alkanoyl,alkenoyl, aroyl, heteroaroyl, alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroarylamino, heteroarylalkyl amino, heteroaryloxy,heteroarylalkyl, heteroaryloxyalkyl, arylalkenyl, heteroarylalkenyl,carboalkoxy, carboaryloxy, carboaralkoxy, cyano, and carbohaloalkoxy;

provided that there are no more than three non-hydrido ring substituentsR₄, R₅, R₆, R₇, and R₈, that there are no more than three non-hydridoring substituents R₉, R₁₀, R₁₁, R₁₂, and R₁₃, and R₄, R₅, R₆, R₇, R₈,R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are each independently selected to maintainthe tetravalent nature of carbon, trivalent nature of nitrogen, thedivalent nature of sulfur, and the divalent nature of oxygen;

wherein R₁₉ is selected from:

(a) hydrido, carboxyl, hydroxyalkyl, acyl, sulfhydryl, acylamido,alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl,aryloxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylthio,aralkylthio, aroyl, aralkanoyl, heteroaroyl, aralkoxyalkyl,alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroarylalkyl, heteroarylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl,diaralkoxyphosphonoalkyl;

(b) or R₁₉+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₉+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₉+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₉+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VI-HA (also referred to herein asgeneric heteroaryl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-HA;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylkyl, heteroaryloxyalkyl, heteroarylthioalkyl,and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula V-HA whereinm=0 to 5; n=1 to 5; m+n=1 to 6; D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, andK₂ are each a carbon atom; and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogen whenm=0. Compounds of Formula V-HA wherein m=0 to 5, n=1 to 5, m+n=1 to 6,and D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, and K₂ are each a carbon atom,have the CH(R₃) moiety directly connected by a covalent bond to thenitrogen when m=0 and correspond to Formula VA (also referred to hereinas generic phenyl tertiary omegaheteroalkylamines):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-HA;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VIA (also referred to herein asgeneric phenyl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaVA;

wherein R₁₇ and G as defined for the compounds of Formula VI-HA;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula VA, whereinm=0, n=1, and a terminal carbon atom of the CH(R₃) moiety is directlyconnected by a covalent bond to the nitrogen when m=0. Compounds ofFormula VA, wherein m=0, n=1, and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogencorrespond to Formula VIIA (also referred to herein as generic phenyltertiary 2-heteroalkylamines):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula VA;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are as definedfor Formula VA;

wherein R₁₉, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄,R₁₉+R₁₅ substitutents are absent;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VIIIA (also referred to herein asgeneric phenyl tertiary 2-heteroalkylammonium salt):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula VIIA;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are as definedfor Formula VIIA;

wherein R₁₇ and G as defined for the compounds of Formula VIA;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula I wherein m=0to 5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl; Q=aryl or heteroaryl;and a terminal carbon atom of the CH(R₃) moiety is directly connected bya covalent bond to the nitrogen when m=0. Compounds of Formula I whereinm=0 to 5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl; and Q=aryl orheteroaryl have the CH(R₃) moiety directly connected by a covalent bondto the nitrogen when m=0 and correspond to Formula V-HX (also referredto herein as generic heteroaryl tertiary omegaheteroalkylamines):

wherein R₁ is haloalkyl, haloalkenyl, haloalkoxyalkyl, orhaloalkenyloxyalkyl;

wherein X is selected from H, F, —S—, —S(O)—, —S(O)₂—, —S(O)₂(NH)—,—NH—, —N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-, or —N(alkoxy)-;

wherein R₁₆ is selected from:

(a) hydrido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,monocarboalkoxyalkyl, monocarboalkoxy, dicarboalkoxyalkyl,mononocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, acyl, aroyl,heteroaroyl, heteroaryloxyalkyl, dialkoxyphosphonoalkyl;

(b) or a spacer group selected from a covalent bond or a linear moietyhaving a chain length of 1 to 4 atoms linked to the point of bonding ofR₄, R₈, R₉, R₁₃, R₁₄, or R₁₅ to form a C5 to C10 saturated heterocyclylor a C5 to C10 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or absent when X is H or F;

wherein one or more spacer groups selected from a covalent bond or alinear moiety having a chain length of 1 to 6 atoms is present betweenany two points of bonding of any two of R₄, R₅, R₆, R₇, R₈, R₉, R₁₀,R₁₁, R₁₂, R₁₃, R₁₄, R₁₅, R₁₆, or R₁₉;

wherein D₁, D₂, J₁, J₂ and K₁ are independently selected from C, N, O, Sand a covalent bond provided that:

-   -   (a) no more than one can be a covalent bond,    -   (b) only one of D₁, D₂, J₁, J₂ and K₁, can be O,    -   (c) only one of D₁, D₂, J₁, J₂ and K₁, can be S,    -   (d) only two of D₁, D₂, J₁, J₂ and K₁, can be O and S,    -   (e) when two of D₁, D₂, J₁, J₂ and K₁ are O or S, one of D₁, D₂,        J₁, J₂ and K₁, must be a covalent bond,    -   (f) only four of D₁, D₂, J₁, J₂ and K₁ can be N,    -   (g) one of D₁, D₂, J₁, J₂ and K₁ must be N, O, or S unless one        of D₃, D₄, J₃, J₄ and K₂ is N, O, or S;    -   wherein D₃, D₄, J₃, J₄ and K₂ are independently selected from C,        N, O, S and a covalent bond provided that:    -   (a) no more than one can be a covalent bond,    -   (b) only one of D₃, D₄, J₃, J₄ and K₂, can be O,    -   (c) only one of D₃, D₄, J₃, J₄ and K₂, can be S,    -   (d) only two of D₃, D₄, J₃, J₄ and K₂, can be O and S,    -   (e) when two of D₃, D₄, J₃, J₄ and K₂ are O or S, one of D₃, D₄,        J₃, J₄ and K₂, must be a covalent bond,    -   (f) only four of D₃, D₄, J₃, J₄ and K₂ can be N,    -   (g) one of D₃, D₄, J₃, J₄ and K₂ must be N, O, or S unless one        of D₁, D₂, J₁, J₂ and K₁ is N, O, or S;    -   wherein R₂ is independently selected from:

(a) hydrido, hydroxy, hydroxyalkyl, amino, alkylamino, dialkylamino,alkyl alkenyl, alkynyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,aralkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, alkylsulfinylalkyl, alkylsulfonylalkyl,haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl,arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl,cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl,cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl,heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl,aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide,carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₂+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₂+R₁₄ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₂+R₁₅ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₂+R₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(f) or R₂+R₈ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(g) or R₂+R₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(h) or R₂+R₁₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

wherein R₃ is selected from:

(a) hydrido, hydroxy, cyano, aryloxy, hydroxyalkyl, amino, alkylamino,dialkylamino, acyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio,alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroarylthio, aralkylthio, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aroyl, heteroaroyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl,arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl,aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl,cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₃+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₃+R₁₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₃+R₁₅ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₃+R₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(f) or R₃+R₈ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(g) or R₃+R₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(h) or R₃+R₁₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 6 atoms to form a C5 toC10 saturated heterocyclyl or a C5 to C10 partially saturatedheterocyclyl ring substituted independently and optionally with, forexample, one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl,alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halogroups;

(i) or R₃+R₁₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C8 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein Y is a (—C(R₁₄)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₄)_(y)—)_(n)—W—(—CH(R₁₄)_(y)—)_(n) where n=1 to 2 and y=0 to 1and R₁₄ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalcyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₄+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₄+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₄ represents a spacer group selected from a moiety having achain length of 3 to 6 atoms connected to the point of bonding of R₉ orR₁₃ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example; one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(f) or R₁₄ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms connected to the point of bonding of R₄ orR₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(g) or R₁₄+R₁₄ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₄+R₁₄ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein W is selected from —O—, —S—, —S(O)—, —S(O)₂—, —S(O)₂(NH)—, —NH—,—N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-,—N(heteroaryloxy)-, —N(acyloxy)-, —N(aroyloxy)-, —N(cycloalkyl),—N(aralkoxy)-, and —N(aryl)-;

wherein Z is independently selected from a covalent bond,(—C(R₁₅)_(y)—)_(n) wherein n=1 to 4 and y=0 to 2,(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,—N—, —N(OH)—, —N(alkyl)-, —N(alkoxy), —N(aryloxy)-, —N(aralkoxy),—N(cycloalkyl)-, —N(aryl)-, oxygen radical (—O—), —OCH₂—, or—OCH(R₁₅)_(y)— where y=0 to 1;

wherein, when Z is (—C(R₁₅)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,R₁₅ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a moiety having achain length of 3 to 6 atoms connected to the point of bonding of R₄ orR₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms connected to the point of bonding of R₉ orR₁₃ to form a C5 to C8 saturated heterocyclyl or a C5 to C8 partiallysaturated heterocyclyl substituted independently and optionally with,for example, one to three alkyl, haloalkyl, aryl, heteroaryl,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

(g) or R₁₅+R₁₅ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₅+R₁₅ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is N, R₁₅ is independently selected from:

(a) hydrido, hydroxyalkyl, aryloxy, aminoalkyl, alkylaminoalkyl,dialkylaminoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl,acylamido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,aralkoxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, akylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to the point of bondingof R₄ or R₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms connected to the point of bondingof R₉ or R₁₃ form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is (—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1to 2 and y=0 to 2 or —OCH(R₁₅)_(y)— wherein y=0 to 1, R₁₅ isindependently selected from:

(a) aryloxy, carboxyl, acyl, aroyl, heteroaroyl, hydroxyalkyl,heteroaryloxyalkyl, acylamido, alkoxy, alkylthio, arylthio, alkyl,alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroaryloxyalkyl, aralkoxyalkyl, heteroaralkoxyalkyl,alkylsulfonylalkyl, alkylsulfinylalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to the point of bondingof R₄ or R₈ to form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₅ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms connected to the point of bondingof R₉ or R₁₃ to form a C5 to C8 saturated heterocyclyl or a C5 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is a covalent bond, —N(OH)—, —N(alkyl)-, —N(alkoxy)-,—N(aryloxy)-, —N(cycloalkyl)-, —N(aryl)-, —N(aralkoxy)-, oxygen radical(—O—), or —OCH₂—, an R₁₅ substituent is not attached to Z;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are independentlyselected from hydrido, heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, alkylamino, aralkylamino, alkylthio, alkylthioalkyl, arylamino,arylalkylamino, arylsulfinyl, arylsulfonyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, hydroxyhaloalkyl, haloalkanoyl,arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, alkanoyl,alkenoyl, aroyl, heteroaroyl, alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroarylamino, heteroarylalkylamino, heteroaryloxy,heteroarylalkyl, heteroaryloxyalkyl, arylalkenyl, heteroarylalkenyl,carboalkoxy, carboaryloxy, carboaralkoxy, cyano, and carbohaloalkoxy;

wherein R₄+R₅ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₅+R₆ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₆+R₇ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₇+R₈ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₉+R₁₀ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₀+R₁₁ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₁+R₁₂ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₂+R₁₃ represents a spacer group selected from a linear moietyhaving a chain length of 3 to 6 atoms connected to form a C5 to C8cycloalkenyl, a C6 to C8 partially saturated heterocyclyl ring, a C5 toC6 heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₄+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₈+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₉+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₁₃+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₉+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₁₃+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 cycloalkenyl, a C6 to C8 partially saturated heterocyclyl, a C5 to C6heteroaryl, an aryl, an aryl-C5 to C6-cycloalkyl, or an aryl-C5 toC6-cycloalkoxy substituted independently and optionally, for example,with one to three alkyl, haloalkyl, aryl, heteroaryl, aryloxy,alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy, hydroxy,hydroxyalkyl, and halo groups;

wherein R₄+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₉+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₉+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 4 atoms to form a C5 to C8partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₁₃+R₂ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₁₃+R₃ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 1 to 4 atoms to form a C5 toC8 partially saturated heterocyclyl substituted independently andoptionally, for example, with one to three alkyl, haloalkyl, aryl,heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₉ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₄+R₁₃ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally, for example, with one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₉ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally, for example, with one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₈+R₁₃ represents a spacer group to form a C5 to C8 partiallysaturated heterocyclyl ring or a C5 to C6 heteroaryl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, aryloxy, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

provided that there are no more than three non-hydrido ring substituentsR₄, R₅, R₆, R₇, and R₈, that there are no more than three non-hydridoring substituents R₉, R₁₀, R₁₁, R₁₂, and R₁₃, and R₄, R₅, R₆, R₇, R₈,R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are each independently selected to maintainthe tetravalent nature of carbon, trivalent nature of nitrogen, thedivalent nature of sulfur, and the divalent nature of oxygen;

wherein R₁₉ is selected from:

(a) hydrido, carboxyl, hydroxyalkyl, acyl, sulfhydryl acylamido, alkoxy,alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl,aryloxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylthio,aralkylthio, aroyl, aralkanoyl, heteroaroyl, aralkoxyalkyl,alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroarylalkyl, heteroarylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl,diaralkoxyphosphonoalkyl;

(b) or R₁₉+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₉+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₉+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₉+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(g) or R₁₉ represents a spacer group selected from a covalent bond or alinear moiety having a chain length of 2 to 5 atoms connected to thepoint of bonding of R₄, R₈, R₉, or R₁₃ to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VI-HX (also referred to herein asgeneric heteroaryl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-HX;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅ are as defined for thecompounds of Formula V-HX;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula V-HX whereinm=0 to 5; n=1 to 5; m+n=1 to 6; D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, andK₂ are each a carbon atom; and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogen whenm=0. Compounds of Formula V-HX wherein m=0 to 5, n=1 to 5, m+n=1 to 6,and D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, and K₂ are each a carbon atom,have the CH(R₃) moiety directly connected by a covalent bond to thenitrogen when m=0 and correspond to Formula VX (also referred to hereinas generic phenyl tertiary omegaheteroalkylamines):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-HX;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+_(R)₁₃, R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄,R₄+R₂, R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃,R₈+R₉, R₈+R₁₃, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅ are as defined for thecompounds of Formula V-HX;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VIX (also referred to herein asgeneric phenyl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaVX;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅ are as defined for thecompounds of Formula VX;

wherein R₁₇ and G as defined for the compounds of Formula VI-HX;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula VX, whereinm=0, n=1, and a terminal carbon atom of the CH(R₃) moiety is directlyconnected by a covalent bond to the nitrogen when m=0. Compounds ofFormula VX, wherein m=0, n=1, and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogencorrespond to Formula VIIX (also referred to herein as generic phenyltertiary 2-heteroalkylamines):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula VX;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are as definedfor Formula VX;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,R₈+R₁₃ are as defined for the compounds of Formula VX;

wherein R₁₉, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄,R₁₉+R₁₅ substitutents are absent;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VIIIX (also referred to herein asgeneric phenyl tertiary 2-heteroalkylammonium salt):

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, X, Y, and Z are as defined for thecompounds of Formula VIIX:

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are as definedfor Formula VIIX;

wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄,R₄R+R₂, R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉,R₄+R₁₃, R₈+R₉, R₈+R₁₃ are as defined for the compounds of Formula VIIX;

wherein R₁₇ and G as defined for the compounds of Formula VIX;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula I wherein m=0to 5; n=1 to 5; m+n=1 to 6; A=aryl or heteroaryl; Q=aryl or heteroaryl;wherein R₄+R₅, R₅+R₆, R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃,R₄+R₁₄, R₈+R₁₄, R₄+R₁₅, R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂,R₄+R₃, R₈+R₂, R₈+R₃, R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉,and R₈+R₁₃ spacers are absent; and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogen whenm=0. Compounds of Formula I wherein m=0 to 5; n=1 to 5; m+n=1 to 6;A=aryl or heteroaryl; and Q=aryl or heteroaryl; wherein R₄+R₅, R₅+R₆,R₆+R₇, R₇+R₈, R₉+R₁₀, R₁₀+R₁₁, R₁₁+R₁₂, R₁₂+R₁₃, R₄+R₁₄, R₈+R₁₄, R₄+R₁₅,R₈+R₁₅, R₉+R₁₅, R₁₃+R₁₅, R₉+R₁₄, R₁₃+R₁₄, R₄+R₂R₄+R₃, R₈+R₂, R₈+R₃,R₉+R₂, R₉+R₃, R₁₃+R₂, R₁₃+R₃, R₄+R₉, R₄+R₁₃, R₈+R₉, and R₈+R₁₃ spacersare absent; have the CH(R₃) moiety directly connected by a covalent bondto the nitrogen when m=0 and correspond to Formula V-HAX (also referredto herein as generic heteroaryl tertiary omegaheteroalkylamines):

wherein R₁ is haloalkyl, haloalkenyl, haloalkoxyalkyl, orhaloalkenyloxyalkyl;

wherein X is selected from H, F, —S—, —S(O)—, —S(O)₂—, —S(O)₂(NH)—,—NH—, —N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-, or —N(alkoxy)-;

wherein R₁₆ is selected from:

(a) hydrido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,monocarboalkoxyalkyl, monocarboalkoxy, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, acyl, aroyl,heteroaroyl, heteroaryloxyalkyl, dialkoxyphosphonoalkyl;

(b) or absent when X is H or F;

wherein D₁, D₂, J₁, J₂ and K₁ are independently selected from C, N, O, Sand a covalent bond provided that:

-   -   (a) no more than one can be a covalent bond,    -   (b) only one of D₁, D₂, J₁, J₂ and K₁ can be O,    -   (c) only one of D, D₂, J₁, J₂ and K₁, can be S,    -   (d) only two of D₁, D₂, J₁, J₂ and K₁ can be O and S,    -   (e) when two of D₁, D₂, J₁, J₂ and K₁ are O or S, one of D₁, D₂,        J₁, J₂ and K₁ must be a covalent bond,    -   (f) only four of D₁, D₂, J₁, J₂ and K₁ can be N,    -   (g) one of D₁, D₂, J₁, J₂ and K₁ must be N, O, or S unless one        of D₃, D₄, J₃, J₄ and K₂ is N, O, or S;

wherein D₃, D₄, J₃, J₄ and K₂ are independently selected from C, N, O, Sand a covalent bond provided that:

-   -   (a) no more than one can be a covalent bond,    -   (b) only one of D₃, D₄, J₃, J₄ and K₂ can be O,    -   (c) only one of D₃, D₄, J₃, J₄ and K₂ can be S,    -   (d) only two of D₃, D₄, J₃, J₄ and K₂ can be O and S,    -   (e) when two of D₃, D₄, J₃, J₄ and K₂ are O or S, one of D₃, D₄,        J₃, J₄ and K₂ must be a covalent bond,    -   (f) only four of D₃, D₄, J₃, J₄ and K₂ can be N,    -   (g) one of D₃, D₄, J₃, J₄ and K₂ must be N, O, or S unless one        of D₁, D₂, J₁, J₂ and K₁ is N, O, or S;

wherein R₂ is independently selected from:

(a) hydrido, hydroxy, hydroxyalkyl, amino, alkylamino, dialkylamino,alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,aralkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, alkylsulfinylalkyl, alkylsulfonylalkyl,haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl,arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl,cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl,cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl,heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl,aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide,carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₂+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₂+R₁₄ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₂+R₁₅ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein R₃ is selected from:

(a) hydrido, hydroxy, cyano, aryloxy, hydroxyalkyl, amino, alkylamino,dialkylamino, acyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio,alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroarylthio, aralkylthio, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aroyl, heteroaroyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl,arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl,aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl,cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₃+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 6 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

(c) or R₃+R₁₄ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₃+R₁₅ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₃+R₁₉ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkenyl, a C4 to C8 saturated heterocyclyl,or a C5 to C8 partially saturated heterocyclyl substituted independentlyand optionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein Y is a (—C(R₁₄)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₄)_(y)—)_(n)—W—(—CH(R₁₄)_(y)—)_(n) where n=1 to 2 and y=0 to 1and R₁₄ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoakyl, diaralkoxyphosphonoalkyl;

(b) or R₁₄+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₄+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₄+R₁₄ represents a covalent bond, an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₄+R₁₄ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein W is selected from —O—, —S—, —S(O)—, —S(O)₂—, —S(O)₂(NH)—, —NH—,—N(OH)—, —N(NH₂)—, —N(NHCH₃)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-,—N(heteroaryloxy)-, —N(acyloxy)-, —N(aroyloxy)-, —N(cycloalkyl),—N(aralkoxy)-, and —N(aryl)-;

wherein Z is independently selected from a covalent bond,(—C(R₁₅)_(y)—)_(n) wherein n=1 to 4 and y=0 to 2,(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,—N—, —N(OH)—, —N(alkyl)-, —N(alkoxy)-, —N(aryloxy)-, —N(aralkoxy),—N(cycloalkyl)-, —N(aryl)-, oxygen radical (—O—), —OCH₂—, or—OCH(R₁₅)_(y)— where y=0 to 1;

wherein, when Z is (—C(R₁₅)_(y)—)_(n) where n=1 to 4 and y=0 to 2 or(—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1 to 2 and y=0 to 2,R₁₅ is independently selected from:

(a) hydrido, hydroxy, cyano, aryloxy, amino, alkylamino, dialkylamino,hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl,acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₄+R₁₅ represents a spacer group selected from a moiety having achain length of 2 to 5 atoms to form a C5 to C8 saturated heterocyclylor a C5 to C8 partially saturated heterocyclyl ring substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₅+R₁₅ represents a covalent bond an alkylene, a haloalkylene,alkylenedioxy, haloalkylenedioxy, or a spacer group selected from amoiety having a chain length of 2 to 5 atoms connected to form a C5 toC8 saturated cycloalkyl, a C5 to C8 partially saturated cycloalkyl, a C5to C8 saturated heterocyclyl or a C5 to C8 partially saturatedheterocyclyl substituted independently and optionally with, for example,one to three alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(h) or R₁₅+R₁₅ represents, when bonded to the same atom, an oxo, analkylene, a haloalkylene, alkylenedioxy, haloalkylenedioxy, or a spacergroup selected from a moiety having a chain length of 3 to 7 atomsconnected to form a C4 to C8 saturated cycloalkyl, a C4 to C8 partiallysaturated cycloalkyl, a C4 to C8 saturated heterocyclyl or a C4 to C8partially saturated heterocyclyl substituted independently andoptionally with, for example, one to three alkyl, haloalkyl, aryl,heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano, carboalkoxy,hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is N, R₁₅ is independently selected from:

(a) hydrido, hydroxyalkyl, aryloxy, aminoalkyl, alkylaminoalkyl,dialkylaminoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl,acylamido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl,aralkoxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl,heteroarylthioalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is (—CH(R₁₅)_(y)—)_(n)—W—(—CH(R₁₅)_(y)—)_(n) wherein n=1to 2 and y=0 to 2 or —OCH(R₁₅)_(y)— wherein y=0 to 1, R₁₅ isindependently selected from:

(a) aryloxy, carboxyl, acyl, aroyl, heteroaroyl, hydroxyalkyl,heteroaryloxyalkyl, acylamido, alkoxy, alkylthio, arylthio, alkyl,alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl,heteroaryloxyalkyl, aralkoxyalkyl, heteroaralkoxyalkyl,alkylsulfonylalkyl, alkylsulfinylalkyl, alkenyloxyalkyl, alkylthioalkyl,arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl,cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl,halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl,halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl,heteroarylalkyl, heteroarylthioalkyl, monocarboalkoxyalkyl,dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl,arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl,aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl;

(b) or R₁₅+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(c) or R₁₅+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C5 to C8saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₅+R₁₄ represents a spacer group selected from a linear moietyhaving a chain length of 2 to 5 atoms to form a C5 to C8 saturatedheterocyclyl or a C5 to C8 partially saturated heterocyclyl ringsubstituted independently and optionally with, for example, one to threealkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy,cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

wherein, when Z is a covalent bond, —N(OH)—, —N(alkyl)-, —N(alkoxy)-,—N(aryloxy)-, —N(cycloalkyl)-, —N(aryl)-, —N(aralkoxy)-, oxygen radical(—O—), or —OCH₂—, an R₁₅ substituent is not attached to Z;

wherein R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are independentlyselected from hydrido, heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, alkylamino, aralkylamino, alkylthio, alkylthioalkyl, arylamino,arylaminoalkyl, arylsulfonyl, arylsulfinyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, hydroxyhaloalkyl, haloalkanoyl,arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, alkanoyl,alkenoyl, aroyl, heteroaroyl, alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroarylamino, heteroarylalkylamino, heteroaryloxy,heteroarylalkyl, heteroaryloxyalkyl, arylalkenyl, heteroarylalkenyl,carboalkoxy, carboaryloxy, carboaralkoxy, cyano, and carbohaloalkoxy;

provided that there are no more than three non-hydrido ring substituentsR₄, R₅, R₆, R₇, and R₈, a that there are no more than three non-hydridoring substituents R₉, R₁₀, R₁₁, R₁₂, and R₁₃, and R₄, R₅, R₆, R₇, R₈,R₉, R₁₀, R₁₁, R₁₂, and R₁₃ are each independently selected to maintainthe tetravalent nature of carbon, trivalent nature of nitrogen, thedivalent nature of sulfur, and the divalent nature of oxygen;

wherein R₁₉ is selected from:

(a) hydrido, carboxyl, hydroxyalkyl, acyl, sulfhydryl, acylamido,alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl,aryloxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl,alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl,cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy,haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl,perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylthio,aralkylthio, aroyl, aralkanoyl, heteroaroyl, aralkoxyalkyl,alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl,heteroaralkylthioalkyl, heteroarylalkyl, heteroarylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl,haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl,arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl,heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl,heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl,diaralkoxyphosphonoalkyl;

(b) or R₁₉+R₂ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(d) or R₁₉+R₃ represents a spacer group selected from a covalent bond ora linear moiety having a chain length of 1 to 5 atoms to form a C3 to C8cycloalkyl, a C5 to C8 cycloalkylenyl, a C4 to C8 saturatedheterocyclyl, or a C5 to C8 partially saturated heterocyclyl substitutedindependently and optionally with, for example, one to three alkyl,haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy, haloalkoxy, cyano,carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(e) or R₁₉+R₁₄ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

(f) or R₁₉+R₁₅ represents a spacer group selected from a covalent bondor a linear moiety having a chain length of 2 to 5 atoms to form a C5 toC8 saturated heterocyclyl or a C5 to C8 partially saturated heterocyclylring substituted independently and optionally with, for example, one tothree alkyl, haloalkyl, aryl, heteroaryl, alkoxyalkyl, alkoxy,haloalkoxy, cyano, carboalkoxy, hydroxy, hydroxyalkyl, and halo groups;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VI-HAX (also referred to herein asgeneric heteroaryl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-HAX;

wherein R₁₇ is selected from alkyl, alkenyl, alkynyl, aralkyl,aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl,cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, heteroaryloxyalkyl,heteroarylthioalkyl, and heteroarylalkenyl;

wherein G is selected from chloro, bromo, iodo, fluoride,trifluoroacetate, perhaloalkylcarboxylates, arylcarboxylates, formate,monoalkylsulfates, arylsulfonates, diarylsulfonylimide anion,benzenesulfonate, tosylate, brosylate, alkylphosphates, arylphosphates,mixed alkyl aryl phosphates, perhaloalkylsulfonates, betylates,perchlorate, mesylate, and pharmaceutically acceptable salts asdisclosed herein;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula V-HAX whereinm=0 to 5; n=1 to 5; m+n=1 to 6; D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, andK₂ are each a carbon atom; and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogen whenm=0. Compounds of Formula V-HAX wherein m=0 to 5, n=1 to 5, m+n=1 to 6,and D₁, D₂, D₃, D₄, J₁, J₂, J₃, J₄, K₁, and K₂ are each a carbon atom,have the CH(R₃) moiety directly connected by a covalent bond to thenitrogen when m=0 and correspond to Formula VIAX (also referred toherein as generic phenyl tertiary omegaheteroalkylamines):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaV-HAX;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VIAX (also referred to herein asgeneric phenyl tertiary omegaheteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, R₁₉, X, Y, and Z are as defined for the compounds of FormulaVAX;

wherein R₁₇ and G as defined for the compounds of Formula VI-HAX;

or a pharmaceutically-acceptable salt thereof.

In another embodiment, the compounds correspond to Formula VAX, whereinm=0, n=1, and a terminal carbon atom of the CH(R₃) moiety is directlyconnected by a covalent bond to the nitrogen when m=0. Compounds ofFormula VAX, wherein m=0, n=1, and a terminal carbon atom of the CH(R₃)moiety is directly connected by a covalent bond to the nitrogencorrespond to Formula VIIAX (also referred to herein as generic phenyltertiary 2-heteroalkylamines):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, X, Y, and Z are as defined for the compounds of Formula VAX;

wherein R₁₉, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄, R₁₉+R₁₅, R₁₉+R₂, R₁₉+R₃, R₁₉+R₁₄,R₁₉+R₁₅ substitutents are absent;

or a pharmaceutically-acceptable salt thereof.

Alternatively, compounds of the present invention consist of quaternaryammonium salt compounds of Formula VIIIAX (also referred to herein asgeneric phenyl tertiary 2-heteroalkylammonium salt):

wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄,R₁₅, R₁₆, X, Y, and Z are as defined for the compounds of Formula VIIAX;

wherein R₁₇ and G as defined for the compounds of Formula VIAX;

or a pharmaceutically-acceptable salt thereof.

In yet another emodiment of the present invention, the novel compoundsare selected from the compounds set forth in Tables 4, 5, 7, 8, 9, 12,14, 15, 16, 17, and 18.

The use of generic terms in the description of the compounds are hereindefined for clarity. Where the term “alkyl” is used, either alone orwithin other terms such as “haloalkyl” and “alkylthio”, it embraceslinear or branched radicals having one to about 10 carbon atoms. Morepreferred alkyl radicals are “lower alkyl” radicals having one to aboutsix carbon atoms. Examples of such radicals include methyl, ethyl,n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl,and the like. The term “alkenyl” denotes linear or branched radicalshaving from 1 to about 10 carbon atoms and having one or more doublebonds. Examples of such radicals include ethenyl, pentenyl, butenyl,butadienyl, and decenyl. The term “alkynyl” denotes linear or branchedradicals having from 1 to about 10 carbon atoms having one or moretriple bonds. Examples of such radicals include propynyl, hexynyl,heptynyl, octynyl, and decynyl. The term “hydrido” denotes a singlehydrogen atom (H). This hydrido radical may be attached, for example, toan oxygen atom to form a “hydroxyl” radical, one hydrido radical may beattached to a carbon atom to form a “methine” radical

or two hydrido radicals may be attached to a carbon atom to form a“methylene” (—CH₂—) radical. The term “carbon” radical denotes a carbonatom without any covalent bonds and capable of forming four covalentbonds. The term “cyano” radical denotes a carbon radical having three offour covalent bonds shared by a nitrogen atom. The term “hydroxyalkyl”embraces radicals wherein any one or more of the alkyl carbon atoms issubstituted with a hydroxyl as defined above. Specifically embraced aremonohydroxyalkyl, dihydroxyalkyl and polyhydroxyalkyl radicals. The term“alkanoyl” embraces radicals wherein one or more of the terminal alkylcarbon atoms are substituted with one or more carbonyl radicals asdefined below. Specifically embraced are monocarbonylalkyl anddicarbonylalkyl radicals. Examples of monocarbonylalkyl radicals includeformyl, acetyl, and pentanoyl. Examples of dicarbonylalkyl radicalsinclude oxalyl, malonyl, and succinyl. The term “alkylene” radicaldenotes linear or branched radicals having from 1 to about 10 carbonatoms and having attachment points for two or more covalent bonds.Examples of such radicals are methylene, ethylene, methylethylene, andisopropylidene. The term “halo” means halogens such as fluorine,chlorine, bromine or iodine atoms. The term “haloalkyl” embracesradicals wherein any one or more of the alkyl carbon atoms issubstituted with halo as defined above. Specifically embraced aremonohaloalkyl, dihaloalkyl and polyhaloalkyl radicals. A monohaloalkylradical, for one example, may have either a bromo, chloro or a fluoroatom within the radical. Dihalo radicals may have two or more of thesame halo atoms or a combination of different halo radicals andpolyhaloalkyl radicals may have more than two of the same halo atoms ora combination of different halo radicals. More preferred haloalkylradicals are “lower haloalkyl” radicals having one to about six carbonatoms. Examples of such haloalkyl radicals include fluoromethyl,difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl,trichloromethyl, pentafluoroethyl, heptafluoropropyl,difluorochloromethyl, dichlorofluoromethyl, difluoroethyl,difluoropropyl, dichloroethyl and dichloropropyl. The term“hydroxyhaloalkyl” embraces radicals wherein any one or more of thehaloalkyl carbon atoms is substituted with hydroxy as defined above. Theterm “haloalkylene radical” denotes alkylene radicals wherein any one ormore of the alkylene carbon atoms is substituted with halo as definedabove. Dihalo alkylene radicals may have two or more of the same haloatoms or a combination of different halo radicals and polyhaloalkyleneradicals may have more than two of the same halo atoms or a combinationof different halo radicals. More preferred haloalkylene radicals are“lower haloalkylene” radicals having one to about six carbon atoms.Examples of “haloalkylene” radicals include difluoromethylene,tetrafluoroethylene, tetrachloroethylene, alkyl substitutedmonofluoromethylene, and aryl substituted trifluoromethylene. The term“haloalkenyl” denotes linear or branched radicals having from 1 to about10 carbon atoms and having one or more double bonds wherein any one ormore of the alkenyl carbon atoms is substituted with halo as definedabove. Dihaloalkenyl radicals may have two or more of the same haloatoms or a combination of different halo radicals and polyhaloalkenylradicals may have more than two of the same halo atoms or a combinationof different halo radicals. The terms “alkoxy” and “alkoxyalkyl” embracelinear or branched oxy-containing radicals each having alkyl portions ofone to about ten carbon atoms, such as methoxy radical. The term“alkoxyalkyl” also embraces alkyl radicals having one or more alkoxyradicals attached to the alkyl radical, that is, to form monoalkoxyalkyland dialkoxyalkyl radicals. More preferred alkoxy radicals are “loweralkoxy” radicals having one to six carbon atoms. Examples of suchradicals include methoxy, ethoxy, propoxy, butoxy and tert-butoxyalkyls. The “alkoxy” radicals may be further substituted with one ormore halo atoms, such as fluoro, chloro or bromo, to provide“haloalkoxy” radicals. Examples of such radicals include fluoromethoxy,chloromethoxy, trifluoromethoxy, difluoromethoxy, trifluoroethoxy,fluoroethoxy, tetrafluoroethoxy, pentafluoroethoxy, and fluoropropoxy.The term “haloalkoxyalkyl” also embraces alkyl radicals having one ormore haloalkoxy radicals attached to the alkyl radical, that is, to formmonohaloalkoxyalkyl and dihaloalkoxyalkyl radicals. The term“haloalkenyloxy” also embraces oxygen radicals having one or morehaloalkenyloxy radicals attached to the oxygen radical, that is, to formmonohaloalkenyloxy and dihaloalkenyloxy radicals. The term“haloalkenyloxyalkyl” also embraces alkyl radicals having one or morehaloalkenyloxy radicals attached to the alkyl radical, that is, to formmonohaloalkenyloxyalkyl and dihaloalkenyloxyalkyl radicals. The term“alkylenedioxy” radicals denotes alkylene radicals having at least twooxygens bonded to a single alkylene group. Examples of “alkylenedioxy”radicals include methylenedioxy, ethylenedioxy, alkylsubstitutedmethylenedioxy, and arylsubstituted methylenedioxy. The term“haloalkylenedioxy” radicals denotes haloalkylene radicals having atleast two oxy groups bonded to a single haloalkyl group. Examples of“haloalkylenedioxy” radicals include difluoromethylenedioxy,tetrafluoroethylenedioxy, tetrachluoroethylenedioxy, alkylsubstitutedmonofluoromethylenedioxy, and arylsubstituted monofluoromethylenedioxy.The term “aryl”, alone or in combination, means a carbocyclic aromaticsystem containing one, two or three rings wherein such rings may beattached together in a pendent manner or may be fused. The term “aryl”embraces aromatic radicals such as phenyl, naphthyl, tetrahydronaphthyl,indane and biphenyl. Said “aryl” group may have 1 to 3 substituents suchas heteroarylamino, N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino,haloalkylthio, alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy,cycloalkenyloxy, hydroxy, amino, thio, nitro, lower alkylamnino,alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio,alkylsulfinyl, alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl,amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl,monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkylmonoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl,heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl,alkynyl, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkenyl,lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl,hydroxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl,heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy. The term “perhaloaryl”embraces aromatic radicals such as phenyl, naphthyl, tetrahydronaphthyl,indane and biphenyl wherein the aryl radical is substituted with 3 ormore halo radicals as defined above. The term “heterocyclyl” embracessaturated, partially saturated and unsaturated heteroatom-containingring-shaped radicals, where the heteroatoms may be selected fromnitrogen, sulfur and oxygen. Examples of saturated heterocyclic radicalsinclude saturated 3 to 6-membered heteromonocylic group containing 1 to4 nitrogen atoms[e.g. pyrrolidinyl, imidazolidinyl, piperidino,piperazinyl, etc.]; saturated 3 to 6-membered heteromonocyclic groupcontaining 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms [e.g.morpholinyl, etc.]; saturated 3 to 6 membered heteromonocyclic groupcontaining 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms [e.g.,thiazolidinyl, etc.]. Examples of partially saturated heterocyclylradicals include dihydrothiophene, dihydropyran, dihydrofuran anddihydrothiazole. Examples of unsaturated heterocyclic radicals, alsotermed “heteroaryl” radicals, include unsaturated 5 to 6 memberedheteromonocyclyl group containing 1 to 4 nitrogen atoms, for example,pyrrolyl, pyrrolinyl, imidazolyl, pyrazolyl, 2-pyridyl, 3-pyridyl,4-pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazolyl [e.g.,4H-1,2,4-triazolyl, 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, etc.]tetrazolyl [e.g. 1H-tetrazolyl, 2H-tetrazolyl, etc.], etc.; unsaturatedcondensed heterocyclic group containing 1 to 5 nitrogen atoms, forexample, indolyl, isoindolyl, indolizinyl, benzimidazolyl, quinolyl,isoquinolyl, indazolyl, benzotriazolyl, tetrazolopyridazinyl [e.g.,tetrazolo [1,5-b]pyridazinyl, etc.], etc.; unsaturated 3 to 6-memberedheteromonocyclic group containing an oxygen atom, for example, pyranyl,2-furyl, 3-furyl, etc.; unsaturated 5 to 6-membered heteromonocyclicgroup containing a sulfur atom, for example, 2-thienyl, 3-thienyl, etc.;unsaturated 5- to 6-membered heteromonocyclic group containing 1 to 2oxygen atoms and 1 to 3 nitrogen atoms, for example, oxazolyl,isoxazolyl, oxadiazolyl [e.g., 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl,1,2,5-oxadiazolyl, etc.] etc.; unsaturated condensed heterocyclic groupcontaining 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms [e.g.benzoxazolyl, benzoxadiazolyl, etc.]; unsaturated 5 to 6-memberedheteromonocyclic group containing 1 to 2 sulfur atoms and 1 to 3nitrogen atoms, for example, thiazolyl, thiadiazolyl [e.g., 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,5-thiadiazolyl, etc.] etc.;unsaturated condensed heterocyclic group containing 1 to 2 sulfur atomsand 1 to 3 nitrogen atoms [e.g., benzothiazolyl, benzothiadiazolyl,etc.] and the like. The term also embraces radicals where heterocyclicradicals are fused with aryl radicals. Examples of such fused bicyclicradicals include benzofuran, benzothiophene, and the like. Said“heterocyclyl” group may have 1 to 3 substituents such asheteroarylamino, N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino,haloalkylthio, alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy,cycloalkenyloxy, hydroxy, amino, thio, nitro, lower alkylamino,alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio,alkylsulfinyl, alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl,aridosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl,monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkylmonoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl,heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl,alkynyl, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkenyl,lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl,hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl,heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy. Preferred heterocyclicradicals include five to ten membered fused or unfused radicals. Morepreferred examples of heteroaryl radicals include pyridyl, thienyl,thiazolyl, oxazolyl, furyl, and pyrazinyl. The term “sulfonyl”, whetherused alone or linked to other terms such as alkylsulfonyl, denotesrespectively divalent radicals —SO₂—. “Alkylsulfonyl”, embraces alkylradicals attached to a sulfonyl radical, where alkyl is defined asabove. “Alkylsulfonylalkyl”, embraces alkylsulfonyl radicals attached toan alkyl radical, where alkyl is defined as above. “Haloalkylsulfonyl”,embraces haloalkyl radicals attached to a sulfonyl radical, wherehaloalkyl is defined as above. “Haloalkylsulfonylalkyl”, embraceshaloalkylsulfonyl radicals attached to an alkyl radical, where alkyl isdefined as above. The term “sulfinyl”, whether used alone or linked toother terms such as alkylsulfinyl, denotes respectively divalentradicals —S(O)—. “Alkylsulfinyl”, embraces alkyl radicals attached to asulfinyl radical, where alkyl is defined as above. “Alkylsulfinylalkyl”,embraces alkylsulfinyl radicals attached to an alkyl radical, wherealkyl is defined as above. “Haloalkylsulfinyl”, embraces haloalkylradicals attached to a sulfinyl radical, where haloalkyl is defined asabove. “Haloalkylsulfinylalkyl”, embraces haloalkylsulfinyl radicalsattached to an alkyl radical, where alkyl is defined as above. The term“aralkyl” embraces aryl-substituted alkyl radicals. Preferable aralkylradicals are “lower aralkyl” radicals having aryl radicals attached toalkyl radicals having one to six carbon atoms. Examples of such radicalsinclude benzyl, diphenylmethyl, triphenylmethyl, phenylethyl anddiphenylethyl. The aryl in said aralkyl may have additional substituentssuch as heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino,aralkylamino, arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl,arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl,haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy, haloalkylenedioxy,cycloalkyl, cycloalkenyl, lower cycloalkylalkyl, lowercycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The terms benzyl and phenylmethyl are interchangeable.The term “heteroaralkyl” embraces heteroaryl-substituted alkyl radicalswherein the heteroaralkyl radical may be additionally substituted withthree or more substituents as defined above for aralkyl radicals. Theterm “perhaloarakyl” embraces aryl-substituted alkyl radicals whereinthe aralkyl radical is substituted with three or more halo radicals asdefined above. The term “Aralkylsulfinyl”, embraces aralkyl radicalsattached to a sulfinyl radical, where aralkyl is defined as above.“Aralkylsulfinylalkyl”, embraces aralkylsulfinyl radicals attached to analkyl radical, where alkyl is defined as above. The term“Aralkylsulfonyl”, embraces aralkyl radicals attached to a sulfonylradical, where aralkyl is defined as above. “Aralkylsulfonylalkyl”,embraces aralkylsulfonyl radicals attached to an alkyl radical, wherealkyl is defined as above. The term “cycloalkyl” embraces radicalshaving three to ten carbon atoms. More preferred cycloalkyl radicals are“lower cycloalkyl” radicals having three to seven carbon atoms. Examplesinclude radicals such as cyclopropyl, cyclobutyl, cyclopentyl,cyclohexyl and cycloheptyl. The term “cycloalkylalkyl” embracescycloalkyl-substituted alkyl radicals. Preferable cycloalkylalkylradicals are “lower cycloalkylalkyl” radicals having cycloalkyl radicalsattached to alkyl radicals having one to six carbon atoms. Examples ofsuch radicals include cyclohexylhexyl. The term “cycloalkenyl” embracesradicals having three to ten carbon atoms and one or more carbon-carbondouble bonds. Preferred cycloalkenyl radicals are “lower cycloalkenyl”radicals having three to seven carbon atoms. Examples include radicalssuch as cyclobutenyl, cyclopentenyl, cyclohexenyl and cycloheptenyl. Theterm “halocycloalkyl” embraces radicals wherein any one or more of thecycloalkyl carbon atoms is substituted with halo as defined above.Specifically embraced are monohalocycloalkyl, dihalocycloalkyl andpolyhalocycloalkyl radicals. A monohalocycloalkyl radical, for oneexample, may have either a bromo, chloro or a fluoro atom within theradical. Dihalo radicals may have two or more of the same halo atoms ora combination of different halo radicals and polyhalocycloalkyl radicalsmay have more than two of the same halo atoms or a combination ofdifferent halo radicals. More preferred halocycloalkyl radicals are“lower halocycloalkyl” radicals having three to about eight carbonatoms. Examples of such halocycloalkyl radicals includefluorocyclopropyl, difluorocyclobutyl, trifluorocyclopentyl,tetrafluorocyclohexyl, and dichlorocyclopropyl. The term“halocycloalkenyl” embraces radicals wherein any one or more of thecycloalkenyl carbon atoms is substituted with halo as defined above.Specifically embraced are monohalocycloalkenyl, dihalocycloalkenyl andpolyhalocycloalkenyl radicals. The term “halocycloalkoxy” also embracescycloalkoxy radicals having one or more halo radicals attached to thecycloalkoxy radical, that is, to form monohalocycloalkoxy,dihalocycloalkoxy, and polycycloalkoxy radicals. The term“Cycloalkylsulfinyl”, embraces cycloalkyl radicals attached to asulfinyl radical, where cycloalkyl is defined as above.“Cycloalkylsulfinylalkyl”, embraces cycloalkylsulfinyl radicals attachedto an alkyl radical, where alkyl is defined as above. The term“Cycloalkylsulfonyl”, embraces cycloalkyl radicals attached to asulfonyl radical, where cycloalkyl is defined as above.“Cycloalkylsulfonylalkyl”, embraces cycloalkylsulfonyl radicals attachedto an alkyl radical, where alkyl is defined as above. The term“alkylthio” embraces radicals containing a linear or branched alkylradical, of one to ten carbon atoms, attached to a divalent sulfur atom.More preferred alkylthio radicals are “lower alkylthio” radicals havingone to six carbon atoms. An example of “lower alkylthio” is methylthio(CH₃—S—). The term “alkylsulfinyl” embraces radicals containing a linearor branched alkyl radical, of one to ten carbon atoms, attached to adivalent —S(═O)— atom. The term “aminosulfonyl” denotes an amino radicalattached to a sulfonyl radical. The terms alkylamino denotes“monoalkylamino” and “dialkylamino” containing one or two alkylradicals, respectively, attached to an amino radical. The termsarylamino denotes “monoarylamino” and “diarylamino” containing one ortwo aryl radicals, respectively, attached to an amino radical. The term“Aralkylamino”, embraces aralkyl radicals attached to an amino radical,where aralkyl is defined as above. The term aralkylamino denotes“monoaralkylamino” and “diaralkylamino” containing one or two aralkylradicals, respectively, attached to an amino radical. The termaralkylamino further denotes “monoaralkyl monoalkylamino” containing onearalkyl radical and one alkyl radical attached to an amino radical. Theterm “arylsulfinyl” embraces radicals containing an aryl radical, asdefined above, attached to a divalent —S(═O)— atom. The term“arylsulfinylalkyl” denotes arylsulfinyl radicals attached to a linearor branched alkyl radical, of one to ten carbon atoms. The term“Arylsulfonyl”, embraces aryl radicals attached to a sulfonyl radical,where aryl is defined as above. “Arylsulfonylalkyl”, embracesarylsulfonyl radicals attached to an alkyl radical, where alkyl isdefined as above. The term “heleroarylsulfinyl” embraces radicalscontaining an heteroaryl radical, as defined above, attached to adivalent —S(═O)— atom. The term “heteroarylsulfinylalkyl” denotesheteroarylsulfinyl radicals attached to a linear or branched alkylradical, of one to ten carbon atoms. The term “Heteroarylsulfonyl”,embraces heteroaryl radicals attached to a sulfonyl radical, whereheteroaryl is defined as above. “Heteroarylsulfonylalkyl”, embracesheteroarylsulfonyl radicals attached to an alkyl radical, where alkyl isdefined as above. The term “aryloxy” embraces aryl radicals, as definedabove, attached to an oxygen atom. Examples of such radicals includephenoxy. The aryl in said aryloxy may be additionally substituted withheteroarylamino, N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino,haloalkylthio, alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy,cycloalkenyloxy, hydroxy, amino, thio, nitro, lower alkylamino,alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio,alkylsulfinyl, alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl,amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl,monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkylmonoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl,heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl,alkynyl, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkenyl,lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl,hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl,heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy. The term “aroyl” embracesaryl radicals, as defined above, attached to an carbonyl radical asdefined above. Examples of such radicals include benzoyl and toluoyl.The aroyl in said aroyl may be additionally substituted withheteroarylamino, N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino,haloalkylthio, alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy,cycloalkenyloxy, hydroxy, amino, thio, nitro, lower alkylamino,alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio,alkylsulfinyl, alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl,amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl,monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkylmonoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl,heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl,alkynyl, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkenyl,lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl,hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl,heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy. The term “aralkanoyl”embraces aralkyl radicals, as defined herein, attached to an carbonylradical as defined above. Examples of such radicals include, forexample, phenylacetyl. The aryl in said aralalkanoyl may be additionallysubstituted with heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino,aralkylamino, arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl,arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl,haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy, haloalkylenedioxy,cycloalkyl, cycloalkenyl, lower cycloalkylalkyl, lowercycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “aralkoxy” embraces oxy-containing aralkylradicals attached through an oxygen atom to other radicals. Morepreferred aralkoxy radicals are “lower aralkoxy” radicals having phenylradicals attached to lower alkoxy radical as described above. The arylin said aralkoxy radicals may be additionally substituted withheteroarylarrino, N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino,haloalkylthio, alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy,cycloalkenyloxy, hydroxy, amino, thio, nitro, lower alkylamino,alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio,alkylsulfinyl, alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl,amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl,monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkylmonoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl,heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl,alkynyl, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkenyl,lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl,hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl,heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy. The tern “aryloxyalkyl”embraces aryloxy radicals, as defined above, attached to an alkyl group.Examples of such radicals include phenoxymethyl. The aryl in saidaryloxyalkyl may be additionally substituted with heteroarylamino,N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino, haloalkylthio,alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy,hydroxy, amino, thio, nitro, lower alkylamino, alkylthio,alkylthioalkyl, arylamino, aralkylamino, arylthio, alkylsulfinyl,alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl,monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl,arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl,arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl,heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl,heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy,haloalkylenedioxy, cycloalkyl, cycloalkenyl, lower cycloalkylalkyl,lower cycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “haloaryloxyalkyl” embraces aryloxyalkylradicals, as defined above, wherein one to five halo radicals areattached to an aryloxy group. The term “heteroaryloxy” embracesheteroaryl radicals, as defined above, attached to an oxygen atom.Examples of such radicals include pyridyloxy and furyloxy. Theheteroaryl in said heteroaryloxy may be additionally substituted withheteroarylamino, N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino,haloalkylthio, alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy,cycloalkenyloxy, hydroxy, amino, thio, nitro, lower alkylamino,alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio,alkylsulfinyl, alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl,amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl,monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkylmonoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio,heteroarylsulfinyl, heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl,heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl,alkynyl, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkenyl,lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl,haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl,hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy,aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl,heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl,heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboalkoxy,carboaralkoxy, cyano, and carbohaloalkoxy. The term “heteroaroyl”embraces heteroaryl radicals, as defined above, attached to an carbonylradical as defined above. Examples of such radicals include furoyl andnicotinyl. The heteroaryl in said heteroaroyl may be additionallysubstituted with heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino,aralkylamino, arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosul fonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl,arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl,haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy, haloalkylenedioxy,cycloalkyl, cycloalkenyl, lower cycloalkylalkyl, lowercycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “heteroaralkanoyl” embraces heteroaralkylradicals, as defined herein, attached to an carbonyl radical as definedabove. Examples of such radicals include, for example, pyridylacetyl andfurylbutyryl. The heteroaryl in said heteroaralalkanoyl may beadditionally substituted with heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino,aralkylamino, arylthio, alkylsulfinyl, alkylsulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl,arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl,haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy, haloalkylenedioxy,cycloalkyl, cycloalkenyl, lower cycloalkylalkyl, lowercycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “heteroaralkoxy” embraces oxy-containingheteroaralkyl radicals attached through an oxygen atom to otherradicals. More preferred heteroaralkoxy radicals are “lowerheteroaralkoxy” radicals having heteroaryl radicals attached to loweralkoxy radical as described above. The heteroaryl in said heteroaralkoxyradicals may be additionally substituted with heteroarylamino.N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino, haloalkylthio,alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy,hydroxy, amino, thio, nitro, lower alkylamino, alkylthio,alkylthioalkyl, arylamino, aralkylamino, arylthio, alkylsulfinyl,alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl,monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl,arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl,arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl,heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl,heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy,haloalkylenedioxy, cycloalkyl, cycloalkenyl, lower cycloalkylalkyl,lower cycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “heteroaryloxyalkyl” embraces heteroaryloxyradicals, as defined above, attached to an alkyl group. Examples of suchradicals include pyridyloxymethyl. The heteroaryl in saidheteroaryloxyalkyl may be additionally substituted with heteroarylamino,N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino, haloalkylthio,alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy,hydroxy, amino, thio, nitro, lower alkylamino, alkylthio,alkylthioalkyl, arylamino, aralkylamino, arylthio, alkylsulfinyl,alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl,monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl,arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl,arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl,heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl,heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy,haloalkylenedioxy, cycloalkyl, cycloalkenyl, lower cycloalkylalkyl,lower cycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “haloheteroaryloxyalkyl” embracesheteroaryloxyalkyl radicals, as defined above, wherein one to four haloradicals are attached to an heteroaryloxy group. The term “arylthio”embraces aryl radicals, as defined above, attached to an sulfur atom.Examples of such radicals include phenylthio. The aryl in said arylthiomay be additionally substituted with heteroarylamino,N-aryl-N-alkylamino, N-heteroarylamino-N-alkylamino, haloalkylthio,alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy,hydroxy, amino, thio, nitro, lower alkylamino, alkylthio,alkylthioalkyl, arylamino, aralkylamino, arylthio, alkylsulfinyl,alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl,monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl,arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl,arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl,heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl,heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy,haloalkylenedioxy, cycloalkyl, cycloalkenyl, lower cycloalkylalkyl,lower cycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “arylthioalkyl” embraces arylthio radicals, asdefined above, attached to an alkyl group. Examples of such radicalsinclude phenylthiomethyl. The aryl in said arylthioalkyl may beadditionally substituted with heteroarylamino, N-aryl-N-alkylamino,N-heteroarylamino-N-alkylamino, haloalkylthio, alkanoyloxy, alkoxy,heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, hydroxy, amino, thio,nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino,aralkylamino, arylthio, alkylsulfinyl, alkyisulfonyl, alkylsulfonamido,alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkylamidosulfonyl, monoarylamidosulfonyl, arylsulfonamido,diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl,arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl,haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy, haloalkylenedioxy,cycloalkyl, cycloalkenyl, lower cycloalkylalkyl, lowercycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloaltkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “alkylthioalkyl” embraces alkylthio radicals,as defined above, attached to an alkyl group. Examples of such radicalsinclude methylthiomethyl. The term “alkoxyalkyl” embraces alkoxyradicals, as defined above, attached to an alkyl group. Examples of suchradicals include methoxymethyl. The term “carbonyl” denotes a carbonradical having two of the four covalent bonds shared with an oxygenatom. The term “carboxy” embraces a hydroxyl radical, as defined above,attached to one of two unshared bonds in a carbonyl group. The term“carboxamide” embraces amino, monoalkylamino, and dialkylamino radicals,attached to one of two unshared bonds in a carbonyl group. The term“carboxamidoalkyl” embraces carboxamide radicals, as defined above,attached to an alkyl group. The term “carboxyalkyl” embraces a carboxyradical, as defined above, attached to an alkyl group. The term“carboalkoxy” embraces alkoxy radicals, as defined above, attached toone of two unshared bonds in a carbonyl group. The term “carboaralkoxy”embraces aralkoxy radicals, as defined above, attached to one of twounshared bonds in a carbonyl group. The term “monocarboalkoxyalkyl”embraces one carboalkoxy radical, as defined above, attached to an alkylgroup. The term “dicarboalkoxyalkyl” embraces two carboalkoxy radicals,as defined above, attached to an alkylene group. The term“monocyanoalkyl” embraces one cyano radical, as defined above, attachedto an alkyl group. The term “dicyanoalkylene” embraces two cyanoradicals, as defined above, attached to an alkyl group. The term“carboalkoxycyanoalkyl” embraces one cyano radical, as defined above,attached to an alkylene group. The term “acyl”, alone or in combination,means a carbonyl or thionocarbonyl group bonded to a radical selectedfrom, for example, hydrido, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy,alkoxyalkyl, haloalkoxy, aryl, heterocyclyl, heteroaryl,alkylsulfinylalkyl, alkylsulfonylalkyl, aralkyl, cycloalkyl,cycloalkylalkyl, cycloalkenyl, alkylthio, arylthio, amino, alkylamino,dialkylamino, aralkoxy, arylthio, and alkylthioalkyl. Examples of “acyl”are formyl, acetyl, benzoyl, trifluoroacetyl, phthaloyl, malonyl,nicotinyl, and the like. The term “haloalkanoyl” embraces one or morehalo radicals, as defined herein, attached to an alkanoyl radical asdefined above. Examples of such radicals include, for example,chloroacetyl, trifluoroacetyl, bromopropanoyl, and heptafluorobutyryl.The alkanoyl in said haloalkanoyl may be additionally substituted withhydroxy, amino, thio, lower alkylamino, alkylthio, alkylthioalkyl,arylamino, aralkylamino, arylthio, alkylsulfinyl, alkylsulfonyl,alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl, monoalkylamidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl,arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl,arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl,heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl,heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy,haloalkylenedioxy, cycloalkyl, cycloalkenyl, lower cycloalkylalkyl,lower cycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy. The term “phosphono” embraces a pentavalent phosphorusattached with two covalent bonds to an oxygen radical. The term“dialkoxyphosphono” denotes two alkoxy radicals, as defined above,attached to a phosphono radical with two covalent bonds. The term“diaralkoxyphosphono” denotes two aralkoxy radicals, as defined above,attached to a phosphono radical with two covalent bonds. The term“dialkoxyphosphonoalkyl” denotes dialkoxyphosphono radicals, as definedabove, attached to an alkyl radical. The term “diaralkoxyphosphonoalkyl”denotes diaralkoxyphosphono radicals, as defined above, attached to analkyl radical.

The term “spacer” can include a covalent bond and a linear moiety havinga backbone of 1 to 7 continous atoms. The spacer may have 1 to 7 atomsof a univalent or multi-valent chain. Univalent chains may beconstituted by a radical selected from ═C(H)—, ═C(R₁₇)—, —O—, —S—,—S(O)—, —S(O)₂—, —NH—, —N(R₂₀)—, —N═, —CH(OH)—, ═C(OH)—, —CH(OR₁₇)—,═C(OR₁₇)—, and —C(O)—. Multi-valent chains may consist of a straightchain of 1 or 2 or 3 or 4 or 5 or 6 or 7 atoms or a straight chain of 1or 2 or 3 or 4 or 5 or 6 atoms with a side chain. The chain may beconstituted of one or more radicals selected from: lower alkylene, loweralkenyl, —O—, —O—CH₂—, —S—CH₂—, —CH₂CH₂—, ethenyl, —CH═CH(OH)—, —OCH₂O—,—O(CH₂)₂O—, —NHCH₂—, —OCH(R₁₇)O—, —O(CH₂CHR₁₇)O—, —O(CF₂O—, —O(CF₂)₂O—,—S—, —S(O)—, —S(O)₂—, —N(H)—, —N(H)O—, —N(R₁₇)O—, —N(R₁₇)—, —C(O)—,—C(O)NH—, —C(O)NR₁₇—, —N═, —OCH₂—, —SCH₂—, S(O)CH₂—, —CH2C(O)—,—CH(OH)—, ═C(OH)—, —CH(OR₁₇)—, ═C(OR₁₇)—, S(O)₂CH₂—, and —NR₁₇CH₂— andmany other radicals defined above or generally known or ascertained byone of skill-in-the art. Side chains may include substituents such asheteroarylamino, N-aryl-N-alkylamino. N-heteroarylamino-N-alkylamino,haloalkylthio, alkanoyloxy, alkoxy, heteroaralkoxy, cycloalkoxy,cycloalkenyloxy, hydroxy, amino, thio, lower alkylamino, alkylthio,alkylthioalkyl, arylamino, aralkylamino, arylthio, alkylsulfinyl,alkylsulfonyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl,monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl,arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl,arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl,heteroarylsulfonyl, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl,heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkylenedioxy,haloalkylenedioxy, cycloalkyl, cycloalkenyl, lower cycloalkylalkyl,lower cycloalkenylalkyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl,hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl,aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl,partially saturated heterocyclyl, heteroaryl, heteroaryloxy,heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl,heteroarylalkenyl, carboalkoxy, carboaralkoxy, cyano, andcarbohaloalkoxy.

The terms “cis” and “trans” denote a form of geometric isomerism inwhich two carbon atoms connected by a double bond will each have ahydrogen atom on the same side of the double bond (“cis”) or on oppositesides of the double bond (“trans”).

Some of the compounds described contain alkenyl groups, and are meant toinclude both cis and trans or “E” and “Z” geometric forms.

Some of the compounds described contain one or more stereocenters andare meant to include R, S, and mixtures of R and S forms for eachstereocenter present.

Some of the compounds described herein may contain one or more ketonicor aldehydic carbonyl groups or combinations thereof alone or as part ofa heterocyclic ring system. Such carbonyl groups may exist in part orprincipally in the “keto” form and in part or principally as one or more“enol” forms of each aldehyde and ketone group present. Compounds of thepresent invention having aldehydic or ketonic carbonyl groups are meantto include both “keto” and “enol” tautomeric forms.

The present invention comprises a pharmaceutical composition comprisinga therapeutically-effective amount of a compound of Formulas I, II, III,IV, I-I, II-II, I-IA, II-IIA, III-III, IV-IV, III-IIIA, IV-IVA, V, VI,VA, VIA, V-H, VI-H, VX, VIX, V-HX, VI-HX, V-HA, VI-HA, V-HAX, VI-HAX,VAX, VIAX, VII, Cyclo-VII, VIIA, VIIAX, VIIX, VII, VIIIA, VIIIX, andVIIIAX in association with at least one pharmaceutically-acceptablecarrier, adjuvant or diluent.

The present invention also comprises a treatment and prophylaxis ofcoronary artery disease and other CETP-mediated disorders in a subject,comprising administering to the subject having such disorder atherapeutically-effective amount of a compound of Formula I:

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, R₁₉, A, Q, X, Y, and Z are as definedabove for the compounds of Formula I;

or a pharmaceutically-acceptable salt thereof.

The present invention also comprises a treatment and prophylaxis ofcoronary artery disease and other CETP-mediated disorders in a subject,comprising administering to the subject having such disorder atherapeutically-effective amount of a compound of a quaternary ammoniumsalt of Formula II:

wherein R₁, R₂, R₃, R₁₄, R₁₅, R₁₆, R₁₉, A, Q, X, Y, and Z are as definedabove for the compounds of Formula I;

wherein R₁₇ and G are as defined above for the compounds of Formula II;

or a pharmaceutically-acceptable salt thereof.

As a further embodiment, compounds of Formulas I, II, III, IV, I-I,II-II, I-IA, II-IIA, III-III, IV-IV, III-IIIA, IV-IVA, V, VI, VA, VIA,V-H, VI-H, VX, VIX, V-HX, VI-HX, V-HA, VI-HA, V-HAX, VI-HAX, VAX, VIAX,VII, Cyclo-VII, VIIA, VIIAX, VIIX, VIII, VIIIA, VIIIX, and VIIIAX of thepresent invention or a pharmaceutically-acceptable salt thereof asdefined above comprise a treatment and prophylaxis of coronary arterydisease and other CETP-mediated disorders in a subject, comprisingadministering to the subject having such disorder atherapeutically-effective amount of compounds I, II, III, IV, I-I,II-II, I-IA, II-IIA, III-III, IV-IV, III-IIIA, IV-IVA, V, VI, VA, VIA,V-H, VI-H, VX, VIX, V-HX, VI-HX, V-HA, VI-HA, V-HAX, VI-HAX, VAX, VIAX,VII, Cyclo-VII, VIIA, VIIAX, VIIX, VIII, VIIIA, VIIIX, and VIIIAX of thepresent invention or a pharmaceutically-acceptable salt thereofCompounds of Formulas I, II, III, IV, I-I, II-II, I-IA, II-IIA, III-III,IV-IV, III-III-A, IV-IVA, V, VI, VA, VIA, V-H, VI-H, VX, VIX, V-HX,VI-HX, V-HA, VI-HA, V-HAX, VI-HAX, VAX, VIAX, VII, Cyclo-VII, VIIA,VIIAX, VIIX, VIII, VIIIA, VIIIX, and VIIIAX are capable of inhibitingactivity of cholesteryl ester transfer protein (CETP), and thus could beused in the manufacture of a medicament, a method for the prophylacticor therapeutic treatment of diseases mediated by CETP, such asperipheral vascular disease, hyperlipidaemia, hypercholesterolemia, andother diseases attributable to either high LDL and low HDL or acombination of both, or a procedure to study the mechanism of action ofthe cholesteryl ester transfer protein (CETP) to enable the design ofbetter inhibitors. The compounds of Formula I and Formula II would bealso useful in prevention of cerebral vascular accident (CVA) or stroke.

Also included in the family of compounds of Formula I, II, III, IV, I-I,II-II, I-IA, II-IIA, III-III, IV-IV, III-IIIA, IV-IVA, V, VI, VA, VIA,V-H, VI-H, VX, VIX, V-HX, VI-HX, V-HA, VI-HA, V-HAX, VI-HAX, VAX, VIAX,VII, Cyclo-VII, VIIA, VIIAX, VIIX, VIII, VIIIA, VIIIX, and VIIIAX arethe pharmaceutically-acceptable salts thereof. The term“pharmaceutically-acceptable salts” embraces salts commonly used to formalkali metal salts and to form addition salts of free acids or freebases. The nature of the salt is not critical, provided that it ispharmaceutically acceptable. Suitable pharmaceutically-acceptable acidaddition salts of compounds of Formula I and II may be prepared frominorganic acid or from an organic acid. Examples of such inorganic acidsare hydrochloric, hydrobromic, hydroiodic, nitric, carbonic, sulfuricand phosphoric acid. Appropriate organic acids may be selected fromaliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic,carboxylic and sulfonic classes of organic acids, examples of which areformic, acetic, propionic, succinic, glycolic, gluconic, lactic, malic,tartaric, citric, ascorbic, glucoronic, maleic, fumaric, pyruvic,aspartic, glutamic, benzoic, anthranilic, mesylic, salicylic,p-hydroxybenzoic, phenylacetic, mandelic, embonic (pamoic),methanesulfonic, ethylsulfonic, benzenesulfonic, sulfanilic, stearic,cyclohexylaminosulfonic, algenic, galacturonic acid. Suitablepharmaceutically-acceptable base addition salts of compounds of FormulaI and II include metallic salts made from aluminum, calcium, lithium,magnesium, potassium, sodium and zinc or organic salts made fromN,N′-dibenzylethyleneldiamine, choline, chloroprocaine, diethanolamine,ethylenediamine, meglumine (N-methylglucamine) and procain. All of thesesalts may be prepared by conventional means from the correspondingcompound of Formula I and II by reacting, for example, the appropriateacid or base with the compound of Formula I and II.

Also embraced within this invention is a class of pharmaceuticalcompositions comprising the active compounds of Formula I in associationwith one or more non-toxic, pharmaceutically-acceptable carriers and/ordiluents and/or adjuvants (collectively referred to herein as “carrier”materials) and, if desired, other active ingredients. The activecompounds of the present invention may be administered by any suitableroute, preferably in the form of a pharmaceutical composition adapted tosuch a route, and in a dose effective for the treatment intended. Theactive compounds and composition may, for example, be administeredorally, intravascularly, intraperitoneally, subcutaneously,intramuscularly or topically.

For oral administration, the pharmaceutical composition may be in theform of, for example, a tablet, capsule, suspension or liquid. Thepharmaceutical composition is preferably made in the form of a dosageunit containing a particular amount of the active ingredient. Examplesof such dosage units are tablets or capsules. The active ingredient mayalso be administered by injection as a composition wherein, for example,saline, dextrose or water may be used as a suitable carrier.

The amount of therapeutically active compounds which are administeredand the dosage regimen for treating a disease condition with thecompounds and/or compositions of this invention depends on a variety offactors, including the age, weight, sex and medical condition of thesubject, the severity of the disease, the route and frequency ofadministration, and the particular compound employed, and thus may varywidely.

The pharmaceutical compositions may contain active ingredients in therange of about 0.1 to 2000 mg, and preferably in the range of about 0.5to 500 mg. A daily dose of about 0.01 to 100 mg/kg body weight, andpreferably between about 0.5 and about 20 mg/kg body weight, may beappropriate. The daily dose can be administered in one to four doses perday.

The compounds may be formulated in topical ointment or cream, or as asuppository, containing the active ingredients in a total amount of, forexample, 0.075 to 30% w/w, preferably 0.2 to 20% w/w and most preferably0.4 to 15% w/w. When formulated in an ointment, the active ingredientsmay be employed with either paraffinic or a water-miscible ointmentbase. Alternatively, the active ingredients may be formulated in a creamwith an oil-in-water cream base. If desired, the aqueous phase of thecream base may include, for example at least 30% w/w of a polyhydricalcohol such as propylene glycol, butane-1,3-diol, mannitol, sorbitol,glycerol, polyethylene glycol and mixtures thereof. The topicalformulation may desirably include a compound which enhances absorptionor penetration of the active ingredient through the skin or otheraffected areas. Examples of such dermal penetration enhancers includedimethylsulfoxide and related analogs. The compounds of this inventioncan also be administered by a transdermal device. Preferably topicaladministration will be accomplished using a patch either of thereservoir and porous membrane type or of a solid matrix variety. Ineither case, the active agent is delivered continuously from thereservoir or microcapsules through a membrane into the active agentpermeable adhesive, which is in contact with the skin or mucosa of therecipient. If the active agent is absorbed through the skin, acontrolled and predetermined flow of the active agent is administered tothe recipient. In the case of microcapsules, the encapsulating agent mayalso function as the membrane.

The oily phase of the emulsions of this invention may be constitutedfrom known ingredients in a known manner. While the phase may comprisemerely an emulsifier, it may comprise a mixture of at least oneemulsifier with a fat or an oil or with both a fat and an oil.Preferably, a hydrophilic emulsifier is included together with alipophilic emulsifier which acts as a stabilizer. It is also preferredto include both an oil and a fat. Together, the emulsifier(s) with orwithout stabilizer(s) make-up the so-called emulsifying wax, and the waxtogether with the oil and fat make up the so-called emulsifying ointmentbase which forms the oily dispersed phase of the cream formulations.Emulsifiers and emulsion stabilizers suitable for use in the formulationof the present invention include Tween 60, Span 80, cetostearyl alcohol,myristyl alcohol, glyceryl monostearate, and sodium lauryl sulfate,among others.

The choice of suitable oils or fats for the formulation is based onachieving the desired cosmetic properties, since the solubility of theactive compound in most oils likely to be used in pharmaceuticalemulsion formulations is very low. Thus, the cream should preferably bea non-greasy, non-staining and washable product with suitableconsistency to avoid leakage from tubes or other containers. Straight orbranched chain, mono- or dibasic alkyl esters such as di-isoadipate,isocetyl stearate, propylene glycol diester of coconut fatty acids,isopropyl myristate, decyl oleate, isopropyl palmitate, butyl stearate,2-ethylhexyl palmitate or a blend of branched chain esters may be used.These may be used alone or in combination depending on the propertiesrequired. Alternatively, high melting point lipids such as white softparaffin and/or liquid paraffin or other mineral oils can be used.

Formulations suitable for topical administration to the eye also includeeye drops wherein the active ingredients are dissolved or suspended insuitable carrier, especially an aqueous solvent for the activeingredients. The antiinflarmatory active ingredients are preferablypresent in such formulations in a concentration of 0.5 to 20%,advantageously 0.5 to 10% and particularly about 15% w/w.

For therapeutic purposes, the active compounds of this combinationinvention are ordinarily combined with one or more adjuvants appropriateto the indicated route of administration. If administered per os, thecompounds may be admixed with lactose, sucrose, starch powder, celluloseesters of alkanoic acids, cellulose alkyl esters, talc, stearic acid,magnesium stearate, magnesium oxide, sodium and calcium salts ofphosphoric and sulfuric acids, gelatin, acacia gum, sodium alginate,polyvinylpyrrolidone, and/or polyvinyl alcohol, and then tableted orencapsulated for convenient administration. Such capsules or tablets maycontain a controlled-release formulation as may be provided in adispersion of active compound in hydroxypropylmethyl cellulose.Formulations for parenteral administration may be in the form of aqueousor non-aqueous isotonic sterile injection solutions or suspensions.These solutions and suspensions may be prepared from sterile powders orgranules having one or more of the carriers or diluents mentioned foruse in the formulations for oral administration. The compounds may bedissolved in water, polyethylene glycol, propylene glycol, ethanol, cornoil, cottonseed oil, peanut oil, sesame oil, benzyl alcohol, sodiumchloride, and/or various buffers. Other adjuvants and modes ofadministration are well and widely known in the pharmaceutical art.

All mentioned references are incorporated by reference as if herewritten.

Although this invention has been described with respect to specificembodiments, the details of these embodiments are not to be construed aslimitations.

General Synthetic Procedures

The compounds of the present invention can be synthesized, for example,according to the following procedures of Schemes 1 to 18, wherein thesubstituents are as defined for Formulas I, II, III, IV, I-I, II-II,I-IA, II-IIA. III-III, IV-IV, III-IIIA, IV-IVA, V, VI, VA, VIA, V-H,VI-H, VX, VIX, V-HX, VI-HX, V-HA, VI-HA, V-HAX, VI-HAX, VAX, VIAX, VII,Cyclo-VII, VIIA, VIIAX, VIIX, VIII, VIIIA, VIIIAX, and VIIIX aboveexcept where further noted.

Synthetic Schemes 1 and 2 shows the preparation of compounds of formulaXIII (“Generic Secondary Amines”) which are intermediates in thepreparation of the compounds of the present invention corresponding toFormula I (“Generic tertiary-OmegaHeteroalkylamine”), Formula I-I(“Generic Aromatic tertiary-OmegaHeteroalkylamine”), Formula III(“Generic tertiary-2-heteroalkylamine”), and Formula III-III andIII-IIIA (“Generic Aromatictertiary-2-heteroalkylamines”).

The “Generic Imine” corresponding to Formula XII can be prepared throughreductive amination techniques generally known in the art and thepreferred technique depending on the nature of “Generic Amine-1” ofFormula X by reacting it with the “Generic Carbonyl Compound” of FormulaXI. For example, when Z is a covalent bond, methylene, methinesubstituted with another subsitutent, or another substituent as definedin Formula I, the two reactants (X and XI) react by refluxing them in anaprotic solvent, such as hexane, toluene, cyclohexane, benzene, and thelike, using a Dean-Stark type trap to remove water. After about 2-8hours or until the removal of water is complete, the aprotic solvent isremoved in vacuo to yield the “Generic Imine” of Formula XII.Alternately, when Z is an oxygen, the “Generic Imine” is an oximederivative. Oxime type “Generic Imine” compounds are readily preparedfrom the corresponding O-substituted hydroxylamine and the appropriatealdehyde or ketone type “Generic Carbonyl Compound”. Suitable proceduresare described by Shriner, Fuson, and Curtin in The SystematicIndentification of Organic Compounds, 5th Edition, John Wiley & Sons andby Fieser and Fieser in Reagents for Organic Synthesis, Volume 1, JohnWiley & Sons, which are incorporated herein by reference. Alternately,when Z is a nitrogen, the “Generic Imine” is a hydrazone derivative.Hydrazone type “Generic Imine” compounds are readily prepared from thecorresponding hydrazine and the appropriate aldehyde or ketone type“Generic Carbonyl Compound”. Suitable procedures for forming thehydrazone imines are also described by Shriner, Fuson, and Curtin in TheSystematic Indentification of Organic Compounds, 5th Edition, John Wiley& Sons, and by Fieser and Fieser in Reagents for Organic Synthesis,Volume 1, John Wiley & Sons, which are incorporated herein by reference.

Scheme 1 shows the preparation of “Generic Imine” compounds in which theamine functionality is bonded to Z; Z is bonded to A; and Y is bonded toQ. One of skill in the art will recognize that A and Q as defined can bestructurally interchanged to prepare “Generic Imine” compounds withsimilar, identical or different structures.

The “Generic Secondary Amines” of Formula XIII can be prepared from thecorresponding “Generic Imine” of Formula XII in several ways.

For example, in one synthetic scheme (Reduction Method-1), which ispreferred when Z is a nitrogen, the “Generic Imine” hydrazone of FormulaXII is partially or completely dissolved in lower alkanols such asethanol or like solvent containing sufficient organic acid such asacetic acid or mineral acid such as HCl or sulfuric acid to neutralizethe hydrazone as described in WO Patent Application No. 9738973, SwissPatent CH 441366 and U.S. Pat. Nos. 3,359,316 and 3,334,017, which areincorporated herein by reference. The resulting mixture is thenhydrogenated at 0-100° C., more preferrably 20-50° C., and mostpreferrably between 20-30° C. and pressures of 10-200 psi hydrogen ormore preferrably between 50-70 psi hydrogen in the presence of a noblemetal catalyst such as PtO₂. The mixture is cooled, and a base such assodium carbonate or sodium hydroxide added until the solution is neutralto just alkaline (pH 6-8).

Isolation of the desired product can be accomplished, for example, byremoving the ethanol, adding water, and extracting the aqueous-organicmixture twice with a solvent, such as diethyl ether or methylenechloride, that is immiscible with water. The combined solvent extract iswashed with saturated brine, dried with a drying agent such as anhydrousmagnesium sulfate, and concentrated in vacuo to yield the “GenericSecondary Amines” hydrazine of Formula XIII. If needed the “GenericSecondary Amines” hydrazine can be further purified by crystallization,distillation at reduced pressure, or liquid chromatography.

In another synthetic scheme (Reduction Method-2), which is preferredwhen Z is a single bond or carbon based, the “Generic Imine” of FormulaXII is slurried in a lower alcohol such as ethanol, methanol or likesolvent at 0-10° C. and solid sodium borohydride is added in batchesover 5-10 minutes at 0-10° C. with stirring. The reaction mixture isstirred below 10° C. for 30-90 minutes and then is warmed gradually to15-30° C. After about 1-10 hours, the mixture is cooled and acid isadded until the aqueous layer was just acidic (pH 5-7).

Isolation of the desired product can be accomplished, for example, byextracting the aqueous layer twice with a solvent, such as diethyl etheror methylene chloride, that is immiscible with water. The combinedsolvent extract is washed with saturated brine, dried with a dryingagent such as anhydrous MgSO4, and concentrated in vacuo to yield the“Generic Secondary Amines” amine, aniline, or amine of Formula XIII. Ifneeded the “Generic Secondary Amines” amine, aniline, or aminederivative can be further purified by crystallization, distillation atreduced pressure, or liquid chromatography.

In yet another synthetic scheme (Reduction Method-3), which is preferredwhen Z is an oxygen, the “Generic Imine” oxime of Formula XII isslurried in a lower alcohol solvent such methanol or like solvent at0-10° C. and acidified to a pH less than 4. Solid sodiumcyanoborohydride is added in batches over 30-90 minutes at 0-20° C. withstirring and addition of a suitable organic or mineral acid to keep thepH at or below 4. The reaction mixture is stirred and warmed graduallyto about 20-25° C. After about 1-10 hours, the mixture is cooled andbase added until the mixture was just slightly alkaline.

Isolation of the desired product can be accomplished, for example, byremoving the methanol or other low boiling solvent in vacuo. The residueis slurried with water and aqueous-organic mixture is extracted twicewith a solvent, such as diethyl ether or methylene chloride, that isimmiscible with water. The combined solvent extract is washed withsaturated brine, dried with a drying agent such as anhydrous MgSO4, andconcentrated in vacuo to yield the “Generic Secondary Amines”hydoxylamine of Formula XIII. If needed the “Generic Secondary Amines”hydroxylamine can be further purified by crystallization, distillationat reduced pressure, or liquid chromatography.

The “Generic Secondary Amines” of Formula XIII can also be prepared,according to Scheme 1 by two alkylation procedures based on thenucleophilic substitution of bromides by amines. In one procedure,“Generic Amine-1” of Formula X is reacted with “Generic Bromide-1” ofFormula XXI. In another alkylation procedure, “Generic Amine-2” ofFormula XXII is reacted together with “Generic Bromide-2” of FormulaXXIII.

In one synthetic alkylation scheme (Alkylation Method-1), a “GenericAmine-1” of Formula X is reacted with a “Generic Bromide-2” of FormulaXXIII as described in Vogel's Textbook of Practical Organic Chemistry,Fifth Edition, 1989, pages 902 to 905 and references cited therein allof which are incorporated herein by reference. In this procedure, the“Generic Amine-1” is placed in a reaction vessel equipped with a refluxcondenser with the capability to either cool or heat the vessel asdictated by the reaction. A suitable “Generic Amine-1” will be selectedfrom primary amine and primary aromatic amine classes of compounds.Cooling may be needed and used should the reaction prove stronglyexothermic. Heating may be needed and used to drive the reaction tocompletion. A suitable solvent may also be used to dissolve the “GenericAmine-1”. Suitable solvents are hydrocarbons such as toluene, hexane,xylene, and cyclohexane, ethers, amides such as dimethylformamide,esters such as ethyl acetate, ketones such as acetone, and nitriles suchas acetonitrile or mixtures of two or more of these solvents. A suitablebase is also added to the reaction vessel. Suitable bases include cesiumcarbonate, calcium carbonate, sodium carbonate and sodium bicarbonate.The base will normally be added in at least a stoichmetric quantitycompared to the “Generic Amine-1” so as to neutralize liberated acid asit forms.

The “Generic Bromide-1” of Formula XXIII is then added to the reactionvessel in portions so as to minimize the rate of heat evolution andminimize the concentration of the “Generic Bromide-1”. The “GenericBromide-1” will be selected from primary and secondary organic alkyl andsubstituted alkyl halide compounds. The halide will preferrably be abromide although iodides and chlorides may also be generally used. Oneof skill in the art will also be able to readily select and utilizeorganic alkyl and substituted alkyl compounds containing readilydisplaceable primary and secondary groups such as tosylates, mesylates,triflates, and the like. Alternately, the halides can be generallyprepared from the corresponding alcohols by reaction with, for example,concentrated hydrohalic acids such as HBr or by reaction with phosphorustrihalides such as PBr₃ as described in Fieser and Fieser in Reagentsfor Organic Synthesis, Volume 1, John Wiley & Sons, which areincorporated herein by reference. The appropriate alcohols can beconverted to tosylates, mesylates, and triflates using proceduresdescribed below.

Addition of the “Generic Bromide-1” is carried out over a period of afew minutes to several hours at temperatures between 0 and 150° C.Preferrably, the addition will take 30-120 minutes at a temperature of 0to 50° C. The reaction can be stirred until completion. Completion canbe monitored, for example, spectroscopically using nuclear magneticresonance or chromatographically using thin layer, liquid, or gaschromatographic procedures. If the reaction does not proceed tocompletion, the reactants may be heated until completion is obtained andverified.

Isolation of the desired product can be accomplished, for example, whena water immiscible solvent was used for the reaction, by adding water tothe finished reaction. Additional base such as sodium carbonate can beadded to ensure the reaction is basic (pH of 9 to 11). The organic layercontaining the “Generic Secondary Amine” is washed with saturated brine,dried with a drying agent such as anhydrous MgSO4, and concentrated invacuo to yield the “Generic Secondary Amine” amine, aniline, or amine ofFormula XIII. If needed the “Generic Secondary Amine” amine, aniline, oramine derivative can be further purified by crystallization,distillation at reduced pressure, or liquid chromatography.

In a second synthetic alkylation scheme (Alkylation Method-2), a“Generic Amine-2” of Formula XXII is reacted with a “Generic Bromide-2”of Formula XXIII in a method employing pallladium catalyzedcarbon-nitrogen bond formation. Suitable procedures for this conversionare described in Wagaw and Buchwald, J. Org. Chem. (1996), 61,7240-7241, Wolfe, Wagaw and Buchwald, J. Am. Chem. Soc. (1996), 118,7215-7216, and Wolfe and Buchwald, Tetrahedron Letters (1997), 38(36),6359-6362 and references cited therein all of which are incorporatedherein by reference. The preferred “Generic Bromide-2” of Formula XXIIIare generally aryl bromides, aryl triflates, and heterocyclic bromides.

The “Generic Amine-1” and “Generic Amine-2” amines, hydroxylamines, andhydrazines, the “Generic Carbonyl Compound” aldehydes, ketones,hydrazones, and oximes, and “Generic Bromide-1” and “Generic Bromide-2”halides, tosylates, mesylates, triflates, and precursor alcoholsrequired to prepare the “Generic Secondary Amine” compounds areavailable from commercial sources and/or can be prepared by one skilledin the art from published procedures. Commercial sources include but arenot limited to Aldrich Chemical, TCI-America, Lancaster-Synthesis,Oakwood Products, Acros Organics, and Maybridge Chemical. Disclosedprocedures for “Generic Amine” amines, hydroxylamines, and hydrazinesinclude Sheradsky and Nov, J. Chem. Soc., Perkin Trans.1 (1980), (12),2781-6; Marcoux, Doyc, and Buchwald, J. Am. Chem. Soc. (1997), 119,1053-9; Stembach and Jamison, Tetrahedron Lett. (1981), 22(35), 3331-4;U.S. Pat. No. 5,306,718; EP No. 314435; WO No. 9001874; WO No. 9002113;JP No. 05320117; WO No. 9738973; Swiss Patent No. CH 441366; U.S. Pat.Nos. 3,359,316 and 3,334,017; and references cited therein which areincorporated herein by reference. Representative specific “GenericSecondary Amine” of Formula XIII compounds useful for the preparation ofcompounds of the present invention are listed in Tables 3, 6, 11 and 13.

Synthetic Scheme 2 shows the preparation of the class of compounds ofthe present invention corresponding to Formula I (“Generictertiary-OmegaHeteroalkylamine”). Formula I-I (“Generic Aromatictertiary-OmegaHeteroalkylamine”), Formula III (“Generictertiary-2-heteroalkylamine”), and Formula III-III and III-IIIA(“Generic Aromatictertiary-2-heteroalkylamine”).

Derivatives of “Generic tertiary-OmegaHeteroalkylamine” of Formula I andFormula I-I and I-IA (“Generic Aromatictertiary-OmegaHeteroalkylamines”) in which the hetero atom (—O—, —N═, or—S—) are attached to an alkyl group removed from the amine by two ormore carbons are readily prepared by anion chemistry using Method B ofScheme 2. The anion of “Generic Secondary Amine” amines, hydroxylamines,and hydrazines of Formula XIII are readily formed by dissolving thespecific amine, hydroxylamine, or hydrazine in an aprotic solvent, suchas tetrahydrofuran, toluene, ether, dimethylformamide, anddimethylformamide, under anhydrous conditions. The solution is cooled toa temperature between −78 and 0° C., preferrably between −78 and −60° C.and the anion formed by the addition of at least one equivalent of astrong, aprotic, non-nucleophillic base such as NaH or n-butyllithiumunder an inert atmosphere for each acidic group present. Maintaining thetemperature between −78 and 0° C., preferrably between −78 and −60° C.,with suitable cooling, an appropriate alkyl halide, alkylbenzenesulfonate such as a alkyl tosylate, alkyl mesylate, alkyltriflate or similar alkylating reagent of the general structure,

where M is a readily displaceable group such as chloride, bromide,iodide, tosylate, triflate, and mesylate. After allowing the reactionmixture to warm to room temperature, the reaction product is added towater, neutralized if necessary, and extracted with a water-immisciblesolvent such as diethyl ether or methylene chloride. The combinedaprotic solvent extract is washed with saturated brine, dried overdrying agent such as anhydrous MgSO4 and concentrated in vacuo to yieldcrude Formula I (“Generic tertiary-OmegaHeteroalkylamine”) and FormulaI-I and I-IA (“Generic Aromatic tertiary-OmegaHeteroalkylamine”). Thismaterial is purified, for example, by eluting through silica gel with5-40% of a medium polar solvent such as ethyl acetate in a non-polarsolvent such as hexanes to yield Formula I (“Generictertiary-OmegaHeteroalkylamine”) and Formula I-I and I-IA (“GenericAromatic tertiary-OmegaHeteroalkylamine”). Products are tested forpurity by HPLC. If necessary, the Formula I (“Generictertiary-OmegaHeteroalkylamine”) and Formula I-I and I-IA (“GenericAromatic tertiary-OmegaHeteroalkylamine”) compounds are purified byadditional chromatography or recrystallization. Products arestructurally confirmed by low and high resolution mass spectrometry andNMR. Examples of specific Formula I (“Generictertiary-OmegaHeteroalkylamine”) and Formula I-I and I-IA (“GenericAromatic tertiary-OmegaHeteroalkylamine”), compounds prepared aresummarized in Tables 15 and 16.

Sources of specific, representative, non-limiting example alcohol-glycolderivatives of the general structure:

used to prepare the “Generic tertiary-omega-Heteroalkylamine” compoundsof Tables 15 and 16 are given in Table 2. Reagents 2a and 3a in Table 2are prepared from the corresponding alcohols available from theindicated sources. The tosylates are readily obtained by reacting thecorresponding alcohol with tosyl chloride using procedures found inHouse's Modern Synthetic Reactions, Chapter 7, W. A. Benjamin. Inc.,Shriner, Fuson, and Curtin in The Systematic Indentification of OrganicCompounds, 5th Edition, John Wiley & Sons, and Fieser and Fieser inReagents for Organic Synthesis, Volume 1, John Wiley & Sons, which areincorporated herein by reference.

A preferred procedure for Formula III (“Generictertiary-2-heteroalkylamine”), and Formula III-III and III-IIIA(“Generic Aromatictertiary-2-heteroalkylamines”) compounds is Method Aof Scheme 2. Oxirane, thiiranes, and aziridine reagents useful in MethodA are exemplified, but not limited to those in Table 1. Formula III(“Generic tertiary-2-heteroalkylamine”), and Formula III-III and III-IIA(“Generic Aromatictertiary-2-heteroalkylamines”) compounds are preparedby using “Generic Secondary Amine” amines, hydroxylamines, andhydrazines of Formula XIII prepared above with oxiranes, thiiranes, oraziridines of the type listed in Table 1 and represented by the generalstructure:

In some cases as indicated by metachloroperbenzoic acid (MCPBA) in thesource table, some of the oxiranes are prepared by reaction ofepoxidation reagents such as MCPBA and similar type reagents readilyselectable by a person of skill-in-the-art with alkenes. Fieser andFieser in Reagents for Organic Synthesis, John Wiley & Sons provides,along with cited references, numerous suitable epoxidation reagents andreaction conditions, which are incorporated herein by reference.Oxiranes having a specific stereochemical arrangement of R₁, R₂ and R₃can be prepared chiral using procedures such as those published in 1995by Ramachandran, Gong, and Brown in the Journal of Organic Chemistry,Vol. 60, pages 41 to 46 along with cited references, which areincorporated herein by reference.

A mixture of a “Generic Secondary Amine” amine, hydroxylamine, orhydrazine of Formula XIII and an oxirane, thiirane, or aziridine ofFormula XX are stirred and heated to 60-90° C. for 5 to 48 hours in atightly capped or contained reaction vessel. A Lewis acid such asytterbium triflate in tetrahydrofuran may be added to speed up reactionand improve yield. When a Lewis acid is used, the reaction should becarried out under inert, anhydrous conditions using a blanket of drynitrogen or argon gas. After cooling to room temperature and testing thereaction mixture for complete reaction by thin layer chromatography orhigh pressure liquid chromatography (hplc), the reaction product isadded to water and extracted with a solvent immisible such as diethylether or methylene chloride. (Note: If the above analysis indicates thatreaction is incomplete, heating should be resumed until complete withthe optional addition of more of the oxirane, thiirane, or aziridine.)The combined aprotic solvent extract is washed with saturated brine,dried over drying agent such as anhydrous MgSO4 and concentrated invacuo to yield crude Formula III (“Generictertiary-2-heteroalkylamine”), and Formula III-III and III-IIIA(“Generic Aromatic tertiary-2-heteroalkylamines”) compounds. Thismaterial is purified by eluting through silica gel with 5-40% of amedium polar solvent such as ethyl acetate in a non-polar solvent suchas hexanes to yield the Formula III (“Generictertiary-2-heteroalkylamine”), and Formula III-III and III-IIIA(“Generic Aromatic tertiary-2-heteroalkylamines”) Products are testedfor purity by HPLC. If necessary, the Formula III (“Generictertiary-2-heteroalkylamine”), and Formula III-III and III-IIIA(“Generic Aromatic tertiary-2-heteroalkylamines”) compounds are purifiedby additional chromatography or recrystallization. Products arestructurally confirmed by low and high resolution mass spectrometry andNMR. Examples of specific Formula III (“Generictertiary-2-heteroalkylamine”), and Formula III-III and III-IIIA(“Generic Aromatic tertiary-2-heteroalkylamines”) compounds prepared aresummarized in Table 4, 5, 7, 8, 9, 12, and 14.

Synthetic Schemes 13, 14, 15, and 16 shows the preparation of a class ofcompounds of the present, invention corresponding to Formula I (“Generictertiary-OmegaHeteroalkylamine”), Formula I-I (“Generic Aromatictertiary-OmegaHeteroalkylamine”), Formula III (“Generictertiary-2-heteroalkylamine”), Formula III-III and III-IIIA (“GenericAromatic tertiary-2-heteroalkylamine”), Formula V-H, V-HA, V-HAX, andV-HX (“Generic Heteroaryl Tertiary Omegaheteroalkylamines), and FormulaVII, VIIA, VIIAX, and VIIX (“Generic Phenyl TertiaryOmegaheteroalkylamines).

Derivatives of Formula I (“Generic tertiary-OmegaHeteroalkylamine”),Formula I-I (“Generic Aromatic tertiary-OmegaHeteroalkylamine”), FormulaIII (“Generic tertiary-2-heteroalkylamine”), Formula III-III andIII-IIIA (“Generic Aromatic tertiary-2-heteroalkylamine”), Formula V-H,V-HA, V-HAX, and V-HX (“Generic Heteroaryl TertiaryOmegaheteroalkylamines), and Formula VII, VIIA, VIIAX, and VIIX(“Generic Phenyl Tertiary Omegaheteroalkylamines) in which a hydrogen orhalogen such as fluoride has replaced the hetero atom (—O—, —N═, or —S—)in an alkyl group removed from the amine by two or more carbons arereadily prepared by acylation chemistry using Schemes 13, 14, 15, and16.

In the first step, the “Generic Secondary Amine” amines, hydroxylamines,and hydrazines of Formula XIII are first dissolved in an aproticsolvent, such as tetrahydrofuran, toluene, ether, dimethylformamide, anddimethylformamide, under anhydrous conditions in the present of at leastone molecular equivalent of a tertiary amine such as triethylamine ortri-n-butylamine. The solution is cooled to a temperature between −78and 50° C., preferably between −30 and 10° C., and at least one molarequivalent of an acylating agent added in portions so as to maintain thetemperature between −78 and 50° C., preferably between −30 and 10° C.,with suitable cooling. A suitable acylating agent, for example, willhave the general structure,

where F is a readily displaceable group such as fluoride, chloride, orbromide, and R₁, R₂, R₃, and n are as defined previously herein. Afterallowing the reaction mixture to warm to room temperature, the reactionproduct is added to water, acidified if necessary, and extracted with awater-immiscible solvent such as diethyl ether or methylene chloride.The combined aprotic solvent extract is washed with saturated brine,dried over drying agent such as anhydrous MgSO4 and concentrated invacuo to yield a crude acylated intermediate amide (XXXXI). Thismaterial can be used as is in the next step or, if judged to be impure,purified, for example, by eluting through silica gel, for example, with5-90% of a medium polar solvent such as ethyl acetate in a non-polarsolvent such as hexanes to yield materials of Formula (XXXXI).

In the second step, a resulting amide of Formula (XXXXI) can then beconverted to a compound of Formula I (“Generictertiary-OmegaHeteroalkylamine”), Formula I-I (“Generic Aromatictertiary OmegaHeteroalkylamine”), Formula III (“Generictertiary-2-heteroalkylamine”), Formula III-III and III-IIIA (“GenericAromatic tertiary-2-heteroalkylamine”), Formula V-H, V-HA, V-HAX, andV-HX (“Generic Heteroaryl Tertiary Omegaheteroalkylamines), and FormulaVII, VIIIA, VIIAX, and VIIX (“Generic Phenyl TertiaryOmegaheteroalkylamines) by reduction under anhydrous aprotic conditionswith an inert atmosphere using borane-dimethylsulfide in a suitablesolvent, such as tetrahydrofuran, toluene, or diethyl ether, or lithiumaluminum hydride in a suitable solvent such as diethyl ether,tetrahydrofuran, glyme, or dioxane. The reaction is carried out at atemperature between −78 and 100° C., preferably between 25 and 100° C.,most preferably at reflux of the solvent, with at least one molarequivalent of the reducing agent. When the reduction is completed in oneto 24 hours, the reaction mixture is cooled and the excess reducingagent is destroyed by adding a minimal, sufficient amount of aqueousmineral acid. The resulting reaction mixture is added to water and thenadjusted to pH 8 to 10 with an alkali metal hydroxide such as sodiumhydroxide. The resulting mixture is then extracted multiple times with awater-immiscible solvent such as diethyl ether, toluene, or methylenechloride. The combined aprotic solvent extract is washed with saturatedbrine, dried over drying agent such as anhydrous MgSO₄ and concentratedin vacuo to yield crude Formula I (“Generictertiary-OmegaHeteroalkylamine”), Formula I-I (“Generic Aromatictertiary-OmegaHeteroalkylamine”), Formula III (“Generictertiary-2-heteroalkylamine”), Formula III-III and III-IIIA (“GenericAromatic tertiary-2-heteroalkylamine”), Formula V-H, V-HA, V-HAX, andV-HX (“Generic Heteroaryl Tertiary Omegaheteroalkylamines), and FormulaVII, VIIA, VIIAX, and VIIX (“Generic Phenyl TertiaryOmegaheteroalkylamines) compounds. This material is purified by elutingthrough silica gel with 5-40% of a medium polar solvent such as ethylacetate in a non-polar solvent such as hexanes to yield the desiredcompounds. Products are tested for purity by HPLC. If necessary, thecompounds are purified by additional chromatography orrecrystallization. Products are structurally confirmed by low and highresolution mass spectrometry and NMR.

Specific, representative, non-limiting example acylating derivatives ofthe general structure,

wherein F is a readily displaceable group such as fluoride, chloride, orbromide, and R₁, R₂, R₃, and n are as previously defined, are readilyavailable by reference to the scientific literature or commercialsources. Alternatively, the carboxylic acids corresponding to XXXX ,wherein F equals OH, are readily available by reference to thescientific literature or commercial sources and can be readily convertedwith a suitable reagent to XXXX, wherein F equals fluoride, chloride, orbromide. Suitable reagents are well-known in the art and include thionylchloride, phosphorus trichloride, 2,4,6-trifluorotriazene, and thionylbromide.

Formula I (“Generic tertiary-OmegaHeteroalkylamine”), Formula I-I andI-IA (“Generic Aromatic tertiary-OmegaHeteroalkylamines”). Formula III(“Generic tertiary-2-heteroalkylamine”), and Formula III-III andIII-IIIA (“Generic Aromatic tertiary-2-heteroalkylamines”) compounds canbe readily converted to a broad array and type of their correspondingquaternary ammonium salts II, II-II, II-IIA, IV, IV-IV, and IV-IVA,respectively. These quaternary ammonium salts are readily obtained usingSchemes 3 and 4.

II, II-II, II-IIA, IV, IV-IV, and IV-IVA are readily obtained byreacting the compound R₁₇-G with the Formula I (“Generictertiary-OmegaHeteroalkylamine”), Formula I-I and I-IA (“GenericAromatic tertiary-OmegaHeteroalkylamines”), Formula III (“Generictertiary-2-heteroalkylamine”), and Formula III-III and III-IIIA(“Generic Aromatictertiary-2-heteroalkylamines”) compounds. R₁₇-G asdefined above is typically a primary or secondary lower alkyl, higheralkyl, lower alkenyl, higher alkenyl, lower alkynyl, higher alkynyl,aralkyl, aryloxyalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl,cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkoxyalkyl,perhaloaralkyl, heteroarylalkyl, and heteroarylalkenyl halide orsulfonate ester. A wide variety and types of R₁₇-G are commerciallyavailable or can be prepared from readily available precursor alcoholsby well-established procedures known to those of skill-in-the-art.Suitable procedures for preparing II, II-II, II-IIA, IV, IV-IV, andIV-IVA can be found in in House's Modem Synthetic Reactions, Chapter 7,W. A. Benjamin, Inc., Shriner, Fuson, and Curtin in The SystematicIndentification of Organic Compounds, 5th Edition, John Wiley & Sons,and Fieser and Fieser in Reagents for Organic Synthesis, Volume 1, JohnWiley & Sons which are incorporated herein by reference.

Formula I (“Generic tertiary-OmegaHeteroalkylamine”), Formula I-I andI-IA (“Generic Aromatic tertiary-OmegaHeteroalkylamines”), Formula III(“Generic tertiary-2-heteroalkylamine”), and Formula III-III andIII-IIIA (“Generic Aromatictertiary-2-heteroalkylamines”) and othercompounds of this invention can be converted to the corresponding acylderivatives. The hydroxyl, thiol, and amino group X, wherein R₁₆ is ahydrogen or a hydrogen is present on the amino group, of compounds ofFormulas I, II, III, IV, I-I, II-II, I-IA, II-IIA, III-III, IV-IV,III-IIIA, IV-IVA, V, VI, VA, VIA, V-H, VI-H, VX, VIX, V-HX, VI-HX, V-HA,VI-HA, V-HAX, VI-HAX, VAX, VIAX, VII, VIIA, VIIAX, VIIX, VIII, VIIIA,VIIIX, and VIIAX can be readily acylated to their corresponding esters,thioesters, and amides. Acylation is readily effected using a suitableacylating reagent such as an aliphatic or aromatic acid anhydride oracid chloride. Such reactions are generally carried out using an aminecatalyst such as pyridine in an inert solvent. Suitable procedures forpreparing acylated derivatives can be found in House's Modem SyntheticReactions, W. A. Benjamin, Inc., Shriner, Fuson, and Curtin in TheSystematic Indentification of Organic Compounds, 5th Edition, John Wiley& Sons, and Fieser and Fieser in Reagents for Organic Synthesis, Volume1, John Wiley & Sons. Acylating agents of a wide variety that can beused are available from commerical sources or the references citedabove, which are incorporated herein by reference.

Certain Formula I (“Generic tertiary-OmegaHeteroalkylamine”), FormulaI-I and I-IA (“Generic Aromatic tertiary-OmegaHeteroalkylamines”),Formula III (“Generic tertiary-2-heteroalkylamine”), and Formula III-IIIand III-IIIA (“Generic Aromatictertiary-2-heteroalkylamines”) andcertain other compounds of this invention can be converted to thecorresponding cyclic derivatives represented by the general designation“Tricyclic tertiary-heteroalkylamines” exmplified by Formula Cyclo-VII(“Substituted Tricyclic Phenyl tertiary-2-Heteroalkylamines”). Thehydroxyl, thiol, or amino group X, wherein R₁₆ is a hydrogen or ahydrogen is present on the amino group, of compounds of Formulas I, II,III, IV, I-I, II-II, I-IA, II-IIA, III-III, IV-IV, III-IIIA, IV-IVA, V,VI, VA, VIA, V-H, VI-H, VX, VIX, V-HX, VI-HX, V-HA, VI-HA, V-HAX,VI-HAX, VAX, VIAX, VII, VIIA, VIIAX, VIIX, VIII, VIIIA, VIIIX, andVIIIAX can be cyclized to corresponding cyclic ethers, thioethers, andamines. Compounds suitable for cyclization will normally have at leastone leaving group within 5 to 10 continuous atoms of the hydroxyl,thiol, and amino group X wherein R₁₆ is a hydrogen or a hydrogen ispresent on the amino group. Most preferrably the leaving group will bewithin 5 to 7 atoms of the hydroxyl, thiol, and amino group X so as toform a 5 to 7 membered ring heteroatom containing ring. When the leavinggroup is part of an aromatic ring system, the leaving group will bepreferrably in an ortho position. Suitable leaving groups generallyinclude halides, sulfates, sulfonates, trisubsituted amino,disubstituted sulfonium, diazonium, and like, and, in the case ofaromatic systems, also includes nitro, alkoxy, aryloxy, heteroaryloxy,and alkylthio.

The cyclization reaction to form “Tricyclic tertiary-heteroalkylamines”can be accomplished by aromatic and aliphatic nucleophilic substitutionreactions such as those disclosed in March's Advanced Organic Chemistry,4th Edition, John Wiley & Sons, especially at pages 293-412 and 649-658and the references cited therein, which are incorporated herein byreference. Hydroxyl, thiol, and amino containing suitably substitutedcompounds can be converted, according to Schemes 17 and 18, to a cyclicanalog by heating a suitably substituted compound under anhydrousconditions in a suitable solvent, such as dimethylformamide (DMF),dimethylsulfoxide (DMSO), N-methylpyrrolidone, tetraglyme, orhexamethylphosphoramide (HMPA), in the presence of a suitable base suchas potassium carbonate, cesium carbonate, sodium hydroxide, potassiumtertiary-butoxide, or lithium diisopropylamide (LDA). Altemately, sodiumamide in anhydrous ammonia solvent can be used. Temperatures in therange of −20° C. to 200° C. can be used for lime periods of 30 minutesto more than 24 hours. The preferred temperature can be selected bystandard synthetic chemical technique balancing maximum yield, maximumpurity, cost, ease of isolation and operation, and time required.Isolation of the “Tricyclic tertiary-heteroalkylamines” can be effectedas described above for other tertiary-heteroalkylamines.

Schemes 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, and 18 givenbelow provide synthetic routes for other embodiments of the compounds ofthe present invention. Schemes 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,16, 17, and 18 can be readily used to prepare these compounds as well.

One skilled in the art may use these generic methods to prepare thefollowing specific examples, which have been properly characterized by¹H NMR and mass spectrometry. These compounds also may be formed invivo.

The following examples contain detailed descriptions of the methods ofpreparation of compound of Formula I. These detailed descriptions fallwithin the scope and are presented for illustrative purposes only andare not intended as a restriction on the scope of the invention. Allparts are by weight and temperatures are Degrees centigrade unlessotherwise indicated.

EXAMPLE 1

Preparation of Compound 1N

The 3-phenoxyaniline (2.78 g, 15 mmol) and3-tetrafluoroethoxy-benzaldehyde 3.332 g, 15 mmol) were refluxed incyclohexane (60 mL) using a Dean-Stark trap to remove water. After 4hours, the cyclohexane was removed in vacuo to yield imine (5.63 g). Theimine was slurried in methanol (60 mL) at 0° C. and solid NaBH₄ (1 g, 29mmole) was added in batches over 5 minutes at 0° C. with stirring. Thereaction mixture was stirred below 10° C. for 30 minutes and then warmedgradually to 20° C. After 4 hours, the mixture was cooled and 3%hydrochloric acid solution was added until the aqueous layer was justacidic. The aqueous solution was extracted twice with diethyl ether. Thecombined diethyl ether extract was washed with saturated brine (2 times)and water (1 time), dried over drying agent such as anhydrous MgSO₄ andconcentrated in vacuo to yield the amine 1N (4.15 g, 70.1% yieldoverall). MS parent ion: 391. NMR (CDCl₃) ppm: 6.97-7.35 (10H, m), 6.37(2H, m), 6.27 (1H, t, J=2.2 Hz), 5.90 (1H, tt, J=53.3, 2.9 Hz), 4.32 (2Hbs).

Preparation of Amino Alcohol 1-1N

The amine 1N (3.13 g, 8 mmol) prepared above and3,3,3-trifluoro-1,2-epoxypropane (1.26 g, 11.2 mmol) were stirred andheated to 90° C. for 24 hours in a tightly capped vessel. (A Lewis acidsuch as ytterbium triflate in tetrahydrofuran can be added to speed upreaction and improve yield provided that the reaction vessel in keptanhydrous by use of a blanket of dry nitrogen or argon gas.) Cool toroom temperature, and test for product by TLC. The reaction product, wasadded to water and extracted with diethyl ether. The diethyl etherextract was washed with saturated brine (2 times) and water (1 time),dried over drying agent such as anhydrous MgSO₄ and concentrated invacuo to yield crude amino alcohol 1-1N. This material was purified byeluting through silica gel with 5-6% ethyl acetate in hexanes to yieldamino alcohol 1-1N (2.85 g, 70.8%). Product was one peak by HPLC,reverse phase. MS parent ion: 503. NMR (CDCl₃) ppm: 7.30 (3H, m),7.06-7.20 (4H, m), 7.02 (1H, bs), 6.96 (2H, m), 6.48 (1H, dd, J=8.5, 2.0Hz), 6.41 (1H, dd, J=7.92, 1.9 Hz), 6.37 (1H, m), 5.89 (1H, tt, J=53.4,2.9 Hz), 4.64(2H ABq J=17.7, 2.8 Hz), 4.34 (1H, m), 3.87 (1H, dd,J=15.5, 2.9 Hz), 3.55 (1H, dd, J=15.5, 8,9 Hz), 2.41 (1H, bs).

Other substituted tertiary-2-heteroalkylamines including, substitutedtertiary-2-hydroxyalkylamines, substituted tertiary-2-aminoalkylamines,and substituted tertiary-2-sulfhydrylalkylamines, can be prepared by oneskilled in the art using similar methods. Examples of such compounds aresummarized in Tables 4, 5, 7, 8, 9, 12, 14, and 17.

Other substituted tertiary-omega-heteroalkylamines can be prepared byone skilled in the art using similar methods. Examples of such compoundsare summarized in Tables 15 and 16.

Other substituted tricyclictertiary-heteroalkylamines can be prepared byone skilled in the art using similar methods. Examples of such compoundsare summarized in Table 18.

BIOLOGICAL EVALUATION

Whole Serum CETP Activity Assay (Tritiated Colesterol Eter)

Blood was obtained from healthy volunteers recruited from the personnelof Monsanto Company, Saint Louis, Mo. Blood was either collected intubes containing EDTA (EDTA plasma pool) or without (spun to form theserum pool). The EDTA human plasma pool or human serum pool, previouslystored at −20° C., was thawed at room temperature, and centrifuged for 5minutes to remove any particulate matter. Tritiated HDL, radiolabeled inthe cholesteryl ester moiety ([¹³H]CE-HDL) as described by Morton andZilversmit (J. Biol. Chem., 256, 11992-95 (1981)), was added to theplasma or serum to a final concentration of (25 μg/ml cholesterol).Inhibitor compounds were added to the plasma or serum as follows: Equalvolumes of the plasma or serum containing the [³H]CE-HDL (396 μl) werepipetted into micro tubes (Titertube®, Bio-Rad Laboratories,Hercules,Calif.). Compounds, usually dissolved as 20-50 mM stock solutions inDMSO, were serially diluted in DMSO (or an alternative solvent in somecases, such as dimethylformamide or ethanol). Four μl of each of theserial dilutions of inhibitor compounds or DMSO alone were then added toeach of the plasma or serum tubes. The tubes were immediately mixed.Triplicate aliquots (110 μl) from each plasma or serum tube were thentransferred to wells of 96-well round-bottomed polystyrene microtiterplates (Corning, Corning, N.Y.). Plates were sealed with plastic filmand incubated at 37° C. for 4 hours. Test wells contained plasma orserum with dilutions of inhibitor compounds. Control wells containedplasma or serum with DMSO alone. Blank wells contained plasma or serumwith DMSO alone that were left in the micro tubes at 4° C. for the 4hour incubation and were added to the microtiter wells at the end of theincubation period. VLDL and LDL were precipitated by the addition of 10μl of precipitating reagent (1% (w/v) Dextran Sulfate (Dextralip50) 0.5Mmagnesium chloride, pH 7.4) to all wells. The wells were mixed on aplate mixer and then incubated at ambient temperature for 10 min. Theplates were then centrifuged at 1000×g for 30 mins at 10° C. Thesupernatants (50 μl) from each well were then transferred to Picoplate™96 plate wells (Packard, Meriden, Conn.) containing 250:1 Microscint™-40(Packard, Meriden, Conn.). The plates were heat-sealed (TopSeal™-P,Packard, Meriden, Conn.) according to the manufacturers directions andmixed for 30 min. Radioactivity was measured on a microplatescintillation counter (TopCount, Packard, Meriden, Conn.). IC₅₀'s weredetermined as the concentration of inhibitor compound inhibitingtransfer of [³H]CE from the supernatant [³H]CE-HDL to the precipitatedVLDL and LDL by 50% compared to the transfer obtained in the controlwells. The maximum percent transfer (in the control wells) wasdetermined using the following equation:${\%\quad{Transfer}} = \frac{\lbrack {{dpm}_{blank} - {dpm}_{control}} \rbrack \times 100}{{dpm}_{blank}}$The percent of control transfer determined in the wells containinginhibitor compounds was determined as follows:${\%\quad{Control}} = \frac{\lbrack {{dpm}_{blank} - {dpm}_{test}} \rbrack \times 100}{{dpm}_{blank} - {dpm}_{control}}$IC₅₀ values were then calculated from plots of % control versusconcentration of inhibitor compound. Examples of IC₅₀ values determinedby this method are specified in Table 10CETP Activity In Vitro

The ability of compounds to inhibit CETP were assessed using an in vitroassay that measured the rate of transfer of radiolabled cholesterylester ([3H]CE) from HDL donor particles to LDL acceptor particles.Details of the assay are provided by Glenn et al. (“Quantification ofCholesteryl Ester Transfer Protein (CETP): A) CETP Activity and B)Immunochemical Assay of CETP Protein,” Meth. Enzymol., Glenn and Melton(Meth. Enzymol., 263, 339-351 (1996)). CETP was obtained from theserum-free conditioned medium of CHO cells transfected with a cDNA forCETP (Wang, S, et al. J. Biol Chem. 267, 17487-17490 1992). To measureCETP activity, [³H]CE-labeled HDL, LDL, CETP and assay buffer (50 mMtris(hydroxymethyl)aminomethane, pH 7.4; 150 mM sodium chloride; 2 mMethylenediamine-tetraacetic acid; 1% bovine serum albumin) wereincubated in a volume of 200μ, for 2 hours at 37° C. in 96 well plates.LDL was differentially precipitated by the addition of 50 μl of 1% (w/v)dextran sulfate/0.5 M magnesium chloride, mixed by vortex, and incubatedat room temperature for 10 minutes. The solution (200 μl) wastransferred to a filter plate (Millipore). After filtration, theradioactivity present in the precipitated LDL was measured by liquidscintillation counting. Correction for non-specific transfer orprecipitation was made by including samples that did not contain CETP.The rate of [³H]CE transfer using this assay was linear with respect totime and CETP concentration, up to 25-30% of [³HCE transferred.

The potency of test compounds was determined by performing the abovedescribed assay in the presence of varying concentrations of the testcompounds and determining the concentration required for 50% inhibitionof transfer of [³H]CE from HDL to LDL. This value was defined as theIC₅₀. Examples of IC₅₀ values determined by this method are specified inTable 10

Inhibition of CETP Activity In Vivo.

Inhibition of CETP by a test compound can be determined by administeringthe compound to an animal by intravenous injection, determining the rateof transfer of tritium-labeled cholesteryl ester (³H]CE) from HDL toVLDL and LDL particles, and comparing the rate of transfer with the rateof transfer observed in control animals. Male golden Syrian hamsterswere maintained on a diet of chow containing 0.24% cholesterol for atleast two weeks prior to the study. Immediately before the experiment,animals were anesthetized with pentobarbital. Anesthesia was maintainedthroughout the experiment. In-dwelling catheters were inserted into thejugular vein and carotid artery. Test compound was dissolved as a 80 mMstock solution in vehicle (2% ethanol: 98% PEG 400, Sigma ChemicalCompany, St. Louis. Mo., USA). At the start of the experiment allanimals received 0.2 ml of a solution containing [³H]CE-HDL into thejugular vein. [³H]CE-HDL is a preparation of human HDL containingtritium-labeled cholesteryl ester, and was prepared according to themethod of Glenn et al. (Meth. Enzymol., 263, 339-351 (1996)). After 2minutes, animals received 0.1 ml of the test solution injected into thejugular vein. Control animals received 0.1 ml of the vehicle solutionwithout test compound. After 5 minutes, the first blood samples (0.5 ml)were taken from the carotid artery and collected in standard microtainertubes containing ethylenediame tetraacetic acid. Saline (0.5 ml) wasinjected to flush the catheter and replace blood volume. Subsequentblood samples were taken at two hours and four hours by the same method.Blood samples were mixed well and kept on ice until the completion ofthe experiment. Plasma was obtained by centrifugation of the bloodsamples at 4° C. The plasma (50 μl) was treated with 5 μl ofprecipitating reagent (dextran sulfate, 10 g/l; 0.5 M magnesiumchloride) to remove VLDL/LDL. After centrifugation, the resultingsupernatant (25 μl) containing the HDL was analyzed for radioactivityusing a liquid scintillation counter. The percentage [³H]CE transferredfrom HDL to LDL and VLDL (% transfer) was calculated based on the totalradioactivity in equivalent serum samples before precipitation.Typically, the amount of transfer from HDL to LDL and VLDL in controlanimals was 20 to 35% after 4 hours. The polyethylene glycol vehicle wasdetermined to have no effect on CETP activity in this model.

Table 10 shows the results of experiments utilizing compounds of thepresent invention.

TABLE 1 Structure and Source of Oxiranes, Thiaranes and AziridineReagents. (XX)

Reagent Number R₁ R₂ R₃ R₁₆ X Source of Reagent 1 CF₃ H H none O J. Org.Chem. (1995), 60(1), 41-46. 2 CCl₃ H H none O Chem. --Eur. J. (1997),3(4), 517-522. 3 CF₃ CH₃ H none O Chem. Ber. (1986), 119(7), 2233-48. 4CF₃CF₂ H H none O Metalloorg. Khim. (1989), 2(4), 889-92. 5 CF₃CF₂CF₂ HH none O Melalloorg. Khim. (1989), 2(4), 889-92. 6 CF₃OCF₂CF₂ H H none OMetalloorg. Khim. (1989), 2(4), 889-92. 7 CF₃CH₂ H H none O Metalloorg.Khim. (1989), 2(4), 889-92. 8 CF₃ CHF₂ H nonc O Zh. Org. Khim. (1976),12(7), 1377-9. 9 CF₃ H CF₃ none O J. Flourine Chem. (1979), 14(1),19-28. 10 CF₃ CF₃ H none O Can. J. Chem. (1977), 55(13), 2465-72 andcited references. 11 CF₃ C₆H₅ H none O Arch. Biochem. Biophys. (1980),204(1), 255-63. 12 CCl₃ C₆H₅ H none O SU 1212007 13 CCl₃ Cyclopropyl Hnone O SU 1212007 14 CCl₃ CH₃ H none O J. Chem. Res., Synop. (1994),(4), 150-1. 15 CCl₃ (CH₃)₂CH H none O J. Chem. Res., Synop. (1994), (4),150-1. 16 CHCl₂ H H none O US 3455996 and cited references. 17 CHCl₂ ClH none O Biochem. Pharmacol. (1981), 30(12), 1712-14 and citedreferences. 18 CF₃ H CH₃ none O 19 CF₃ CF₃ H H N Izv. Akad. Nauk SSSR,Ser. Khim. (1967), (3), 711 20 CF₃ H H H N JP 08092206 21 CF₃ H H BenzylN JP 08092206 22 CF₃ H H CH₃O N JP 08092206 23 CF₃ H H CH₃ N JP 0809220624 CF₃ H H Benzyloxy N JP 08092206 25 CF₃ H H none S Izv. Akad. NaukSSSR, Ser. Khim. (1989), (1), 116-22. 26 CF₃CF₂ H H none S Izv. Akad.Nauk SSSR, Ser. Khim. (1989), (1), 116-22. 27 CCl₃CH₂ H H none O Arch.Biochem. Biophys. (1980), 204(1), 255-63. 28 CBr₃CH₂ H H none O US3455996 and cited references. 29 CHBr₂CH₂ H H none O US 3455996 andcited references. 30 CBrCl₂ H H none O US 3455996 and cited references.31 CClF₂ H H none O US 3455996 and cited references. 32 CCl₂F H H none OUS 3455996 and cited references. 33 CCl₃CCl₂ H H none O US 3455996 andcited references. 34 CH₃ H H none O Aldrich Chemical 35 CH₃ CH₃ H none OAldrich Chemical 36 CH₃CH₂ H H none O Aldrich Chemical 37 CH₂═CH H Hnone O Aldrich Chemical 38 CH₃CH₂CH₂ H H none O Aldrich Chemical 39CH₂═CHCH₂CH₂ H H none O Aldrich Chemical 40 CH₃(CH₂)₄CH₂ H H none OAldrich Chemical 41 CH₂═CH(CH₂)₃CH₂ H H none O Aldrich Chemical 42 HOCH₂H H none O Aldrich Chemical 43 FCH₂ H H none O Aldrich Chemical 44(CH₃)₃COCH₂ H H none O Aldrich Chemical 45 R₁ + R₂ = (CH₂)₅ H none OHeterocycles (1977), 8, 397-401. 46 CF₃ R₂ + R₃ = (CH₂)₃ none O J.Flourine Chem. (1995), 70(2), 249-53 plus MCPBA 47 CF₃ R₂ + R₃ = (CH₂)₄none O Chem. Ber. (1985), 118(7), 3004-10 plus MCPBA 48 CHF₂ R₂ + R₃ =(CH₂)₄ none O Chem. Ber. (1985), 118(7), 3004-10 plus MCPBA 49 H R₂ + R₃= none O J. Org. Chem. (1996), 61(5), 1830-41. (CF₃)CH(CH₂)₃ 50 H R₂ +R₃ = none O J. Flourine Chem. (1995), 70(2), 249-53 plus MCPBA(CF₃)CH(CH₂)₂ 51 H R₂ + R₃ = none O J. Flourine Chem. (1995), 70(2),249-53 plus MCPBA CH₂(CF₃)CHCH₂ 52 R₁ + R₂ = (CH₂)₆ H none OHeterocycles (1977), 8, 397-401. 53 CH₃CH₂O₂C H H none O Acros Organics54 CH₃CH₂CH₂ H H none O Aldrich Chemical 55 CH₃OCH₂ H H none O TCIAmerica 56 CBrF₂CClFCH₂ H H none O Oakwood Products 57 HCF₂CF₂OCH₂ H Hnone O Aldrich Chemical 58 [(CH₃CH₂O)]₂POCH₂ H H none O Maybridge 59 HR₂ + R₃ = (CH₂)₂SO₂ none O Aldrich Chemical 60 Cl^(—(CH) ₃)₃N^(⊕CH) ₂ HH none O Aldrich Chemical 61 N-piperidinyl-CH₂ H H none O OakwoodProducts 62 N-phthalimido-CH₂ H H none O Aldrich Chemical 63 C₆H₅ H Hnone O Aldrich Chemical 64 C₆H₅ H CH₃ none O Aldrich Chemical 65 C₆F₅ HH none O Arch. Biochem. Biophys. (1980), 204(1), 255-63. 66 C₆F₅ CH₃ Hnone O Arch. Biochem. Biophys. (1980), 204(1), 255-63. 67 C₆F₅ CClH₂ Hnone O Arch. Biochem. Biophys. (1980), 204(1), 255-63. 68 2-CH₃C₆H₄ H Hnone O EP 611826 and references cited therein. 69 3-CH₃C₆H₄ H H none OTetrahedron Lett. (1995), 36(31), 5457-60. 70 4-CH₃C₆H₄ H H none O EP611826 and references cited therein. 71 2-BrC₆H₄ H H none O Z. Chem.(1981), 21(11), 406-07. 72 4-BrC₆H₄ H H none O Z. Chem. (1981), 21(11),406-07. 73 2-ClC₆H₄ H H none O EP 611826 and references cited therein.74 3-ClC₆H₄ H H none O Z. Chem. (1981), 21(11), 406-07. 75 4-ClC₆H₄ H Hnone O Heterocycles (1977), 8, 397-401. 76 2-CH₃OC₆H₄ H H none O EP611826 and references cited therein. 77 3-CH₃OC₆H₄ H H none O Z. Chem.(1981), 21(11), 406-07. 78 4-CH₃OC₆H₄ H H none O Heterocycles (1977), 8,397-401. 79 3-CF₃C₆H₄ H H none O Tetrahedron Lett. (1995), 36(31),5457-60. 80 C₆H₅CH₂ H H none O Aldrich Chemical 81 4F—C₆H₄ H H none O Z.Chem. (1981), 21(11), 406-07. 82 4F—C₆H₄ H 4F—C₆H₄ none O Maybridge 832-CH₃O-4-CH₃OC₆H₃ H H none O Z. Chem. (1981), 21(11), 406-07. 843,4-OCH₂O—C₆H₃ H H none O Z. Chem. (1981), 21(11), 406-07. 853-Cl-4-Cl—C₆H₃ H H none O EP 611826 and references cited therein. 863-Cl-5-Cl—C₆H₃ H H none O EP 611826 and references cited therein. 87C₆H₅OCH₂ H H none O Aldrich Chemical 88 4Cl—C₆H₄OCH₂ H H none O AldrichChemical 89 CH₃OC₆H₄OCH₂ H H none O Aldrich Chemical 90 C₆H₅ H CO₂C₂H₅none O Aldrich Chemical 91 2-Pyridyl H H none O EP 611826 and referencescited therein.

TABLE 2 Structure and Source of Alcohol and Glycol Reagents. (XXX)

Reagent Number R₁ n M m R₂ R₃ XR₁₆ Source of Reagent 1A CF₃ 1 Cl 1 H HCH₂OH Chem. Lett. (1987), (7), 1435-8. 2A CF₃ 1 OTs 2 H H OH Tosylationof alcohol from Justus Liebigs Ann. Chem. (1969), 720, 81-97. 3ACF₃CH₂CH₂ 1 OTs 1 H H OH Tosylation of alcohol from Z. Naturforsch., B:Chem. Sci. (1997), 52(3), 413-418 4A CF₃ 1 Cl 1 H H OH J. Fluorine Chem.(1982), 20(3), 301-6.

TABLE 3 Structure of “Secondary Phenyl Amine” Reagents. (XIIIA)

Reagent Number R₄ R₅ R₆ R₇ R₉ R₁₀ R₁₁ Y R₁₄ 1N H phenoxy H H H OCF₂CF₂HH CH H 2N H OCF₃ H H H OCF₂CF₂H H CH H 3N F H H F H OCF₂CF₂H H CH H 4N HF H H H OCF₂CF₂H H CH H 5N H phenoxy H H H OCF₃ H CH H 6N H OCF₃ H H HOCF₃ H CH H 7N H H phenyl H H OCF₃ H CH H 8N H phenyl H H H OCF₃ H CH H9N H H H H H OCF₃ H CH H 10N H Br H H H OCF₃ H CH H 11N H CF₃ F H H CF₃H CH H 12N H CH₃ H H H CF₃ H CH H 13N H CF₃ H H H CF₃ H CH H 14N H CH₃ HH H OCF₃ H CH H 15N H F F H H OCF₃ H CH H 16N H Br H H H CF₃ H CH H 17NH CF₃ F H H OCF₃ H CH H 18N H F H H H OCF₃ H CH H 19N H Cl H H H OCF₃ HCH H 20N H F H H H CF₃ H CH H 21N H F F H H CF₃ H CH H 22N H Cl H H HCF₃ H CH H 23N H F H H H phenoxy H CH H 24N H CF₃ Cl H H CH₃ H CH H 25NH CF₃ F H H CH₃ H CH H 26N H H H H H CF₃ H CH H 27N F F H H H CF₃ H CH H28N H H OCH₃ H H CF₃ H CH H 29N H F F H H CH₃ H CH H 30N H OCH₃ H H HCH₃ H CH H 31N H H CH₃ H H H H CH H 32N H Cl H H H H H CH H 33N H F H HH F H CH H 34N H H OCH₃ H H CH₃ H CH H 35N H H H H H H H CH H 36N H HCH₃ H H CH₃ H CH H 37N H H Cl H H H H CH H 38N H F H H H 3-CF₃-phenoxy HCH H 39N H F H H H 4-CH₃O-phenoxy H CH H 40N H F H H H 4-Cl-phenoxy H CHH 41N H F H H H H H CH H 42N H F H H H CH₃ H CH H 43N H F H F H CH₃ H CHH 44N F F H H H CH₃ H CH H 45N H Cl H H H CH₃ H CH H 46N H CH₃ H H H CH₃H CH H 47N CH₃ H H H H H H CH H 48N H H CH₃ H H CF₃ H CH H 49N CH₃ H H HH CF₃ H CH H 50N CH₃ H H H H CH₃ H CH H 51N H H CH₃ H H F H CH H 52N HCF₃ H H H F H CH H 53N H CF₃ H H H CH₃ H CH H 54N H OCH₃ H H H CF₃ H CHH 55N OCH₃ H H H H CH₃ H CH H 56N H H CH₃ H H CF₃ H CH H 57N H phenoxy HH H H OCF₃ CH H 58N H H H H H H OCF₃ CH H 59N H OCF₃ H H H H OCF₃ CH H60N H CF₃ F H H H CF₃ CH H 61N H H OCH₃ H H H CF₃ CH H 62N H CH₃ H H H HCF₃ CH H 63N H Cl H H H H CF₃ CH H 64N H CF₃ H H H H OCF₃ CH H 65N H F HH H H OCF₃ CH H 66N H F H F H H OCF₃ CH H 67N H Br H H H H OCF₃ CH H 68NH Cl H H H H OCF₃ CH H 69N H F F H H H OCF₃ CH H 70N H F H H H H phenylCH H 71N H CH₃ H H H H OCF₃ CH H 72N H F F H H H CF₃ CH H 73N H Cl H H HH CH₃ CH H 74N H OCH₃ H H H H CH₃ CH H 75N H F H H H H CH₃ CH H 76N F FH H H H OCF₃ CH H 77N OCH₃ H H H H H CF₃ CH H 78N H H OCH₃ H H H CH₃ CHH 79N H H CH₃ H H H CH₃ CH H 80N H CH₃ H H H H CH₃ CH H 81N CH₃ H H H HH CH₃ CH H 82N H F F H H H CH₃ CH H 83N H F H F H H CH₃ CH H 84N F F H HH H CH₃ CH H 85N F CF₃ H H H H CH₃ CH H 86N H H CH₃ H H H CF₃ CH H 87NCH₃ H H H H H CF₃ CH H 88N H CF₃ H H H H CH₃ CH H 89N OCH₃ H H H H H CH₃CH H 90N H H CF₃ H H H CH₃ CH H 91N CF₃ H H H H H CH₃ CH H 92N H CF₃ F HH H CH₃ CH H

TABLE 4 Structure of Substituted Phenyl tertiary-2-Heteroalkylamines (Zis covalent bond; Y is CH and R₁₄ is H).

Inhibitor Number Column 1 + Column 2 Reagent Reagent R₁ R₂ R₃ X R₄ R₅ R₆R₇ R₁₀ R₁₁ 1  1N CF₃ H H O H C₆H₅O H H OCF₂CF₂H H 1  2N CF₃ H H O H OCF₃H H OCF₂CF₂H H 1  3N CF₃ H H O F H H F OCF₂CF₂H H 1  4N CF₃ H H O H F HH OCF₂CF₂H H 1  5N CF₃ H H O H C₆H₅O H H OCF₃ H 1  6N CF₃ H H O H OCF₃ HH OCF₃ H 1  7N CF₃ H H O H H phenyl H OCF₃ H 1  8N CF₃ H H O H phenyl HH OCF₃ H 1  9N CF₃ H H O H H H H OCF₃ H 1 10N CF₃ H H O H Br H H OCF₃ H1 11N CF₃ H H O H CF₃ F H CF₃ H 1 12N CF₃ H H O H CH₃ H H CF₃ H 1 13NCF₃ H H O H CF₃ H H CF₃ H 1 14N CF₃ H H O H CH₃ H H OCF₃ H 1 15N CF₃ H HO H F F H OCF₃ H 1 16N CF₃ H H O H Br H H CF₃ H 1 17N CF₃ H H O H CF₃ FH OCF₃ H 1 18N CF₃ H H O H F H H OCF₃ H 1 19N CF₃ H H O H Cl H H OCF₃ H1 20N CF₃ H H O H F H H CF₃ H 1 21N CF₃ H H O H F F H CF₃ H 1 22N CF₃ HH O H Cl H H CF₃ H 1 23N CF₃ H H O H F H H phenoxy H 1 24N CF₃ H H O HCF₃ Cl H CH₃ H 1 25N CF₃ H H O H CF₃ F H CH₃ H 1 26N CF₃ H H O H H H HCF₃ H 1 27N CF₃ H H O F F H H CF₃ H 1 28N CF₃ H H O H H OCH₃ H CF₃ H 129N CF₃ H H O H F F H CH₃ H 1 30N CF₃ H H O H OCH₃ H H CH₃ H 1 31N CF₃ HH O H H CH₃ H H H 1 32N CF₃ H H O H Cl H H H H 1 33N CF₃ H H O H F H H FH 1 34N CF₃ H H O H H OCH₃ H CH₃ H 1 35N CF₃ H H O H H H H H H 1 36N CF₃H H O H H CH₃ H CH₃ H 1 37N CF₃ H H O H H Cl H H H 1 38N CF₃ H H O H F HH 3-CF₃-phenoxy H 1 39N CF₃ H H O H F H H 4-CH₃O-phenoxy H 1 40N CF₃ H HO H F H H 4-Cl-phenoxy H 1 41N CF₃ H H O H F H H H H 1 42N CF₃ H H O H FH H CH₃ H 1 43N CF₃ H H O H F H F CH₃ H 1 44N CF₃ H H O F F H H CH₃ H 145N CF₃ H H O H Cl H H CH₃ H 1 46N CF₃ H H O H CH₃ H H CH₃ H 1 47N CF₃ HH O CH₃ H H H H H 1 48N CF₃ H H O H H CH₃ H CF₃ H 1 49N CF₃ H H O CH₃ HH H CF₃ H 1 50N CF₃ H H O CH₃ H H H CH₃ H 1 51N CF₃ H H O H H CH₃ H F H1 52N CF₃ H H O H CF₃ H H F H 1 53N CF₃ H H O H CF₃ H H CH₃ H 1 54N CF₃H H O H OCH₃ H H CF₃ H 1 55N CF₃ H H O OCH₃ H H H CH₃ H 1 56N CF₃ H H OH H CH₃ H CF₃ H 1 57N CF₃ H H O H C₆H₅O H H H OCF₃ 1 58N CF₃ H H O H H HH H OCF₃ 1 59N CF₃ H H O H OCF₃ H H H OCF₃ 1 60N CF₃ H H O H CF₃ F H HCF₃ 1 61N CF₃ H H O H H OCH₃ H H CF₃ 1 62N CF₃ H H O H CH₃ H H H CF₃ 163N CF₃ H H O H Cl H H H CF₃ 1 64N CF₃ H H O H CF₃ H H H OCF₃ 1 65N CF₃H H O H F H H H OCF₃ 1 66N CF₃ H H O H F H F H OCF₃ 1 67N CF₃ H H O H BrH H H OCF₃ 1 68N CF₃ H H O H Cl H H H OCF₃ 1 69N CF₃ H H O H F F H HOCF₃ 1 70N CF₃ H H O H F H H H phenyl 1 71N CF₃ H H O H CH₃ H H H OCF₃ 172N CF₃ H H O H F F H H CF₃ 1 73N CF₃ H H O H Cl H H H CH₃ 1 74N CF₃ H HO H OCH₃ H H H CH₃ 1 75N CF₃ H H O H F H H H CH₃ 1 76N CF₃ H H O F F H HH OCF₃ 1 77N CF₃ H H O OCH₃ H H H H CF₃ 1 78N CF₃ H H O H H OCH₃ H H CH₃1 79N CF₃ H H O H H CH₃ H H CH₃ 1 80N CF₃ H H O H CH₃ H H H CH₃ 1 81NCF₃ H H O CH₃ H H H H CH₃ 1 82N CF₃ H H O H F F H H CH₃ 1 83N CF₃ H H OH F H F H CH₃ 1 84N CF₃ H H O F F H H H CH₃ 1 85N CF₃ H H O F CF₃ H H HCH₃ 1 86N CF₃ H H O H H CH₃ H H CF₃ 1 87N CF₃ H H O CH₃ H H H H CF₃ 188N CF₃ H H O H CF₃ H H H CH₃ 1 89N CF₃ H H O OCH₃ H H H H CH₃ 1 90N CF₃H H O H H CF₃ H H CH₃ 1 91N CF₃ H H O CF₃ H H H H CH₃ 1 92N CF₃ H H O HCF₃ F H H CH₃ 2  1N CCl₃ H H O H C₆H₅O H H OCF₂CF₂H H 2  2N CCl₃ H H O HOCF₃ H H OCF₂CF₂H H 2  3N CCl₃ H H O F H H F OCF₂CF₂H H 2  4N CCl₃ H H OH F H H OCF₂CF₂H H 2  5N CCl₃ H H O H C₆H₅O H H OCF₃ H 2  6N CCl₃ H H OH OCF₃ H H OCF₃ H 2  7N CCl₃ H H O H H phenyl H OCF₃ H 2  8N CCl₃ H H OH phenyl H H OCF₃ H 2  9N CCl₃ H H O H H H H OCF₃ H 2 10N CCl₃ H H O HBr H H OCF₃ H 2 11N CCl₃ H H O H CF₃ F H CF₃ H 2 12N CCl₃ H H O H CH₃ HH CF₃ H 2 13N CCl₃ H H O H CF₃ H H CF₃ H 2 14N CCl₃ H H O H CH₃ H H OCF₃H 2 15N CCl₃ H H O H F F H OCF₃ H 2 16N CCl₃ H H O H Br H H CF₃ H 2 17NCCl₃ H H O H CF₃ F H OCF₃ H 2 18N CCl₃ H H O H F H H OCF₃ H 2 19N CCl₃ HH O H Cl H H OCF₃ H 2 20N CCl₃ H H O H F H H CF₃ H 2 21N CCl₃ H H O H FF H CF₃ H 2 22N CCl₃ H H O H Cl H H CF₃ H 2 23N CCl₃ H H O H F H Hphenoxy H 2 24N CCl₃ H H O H CF₃ Cl H CH₃ H 2 25N CCl₃ H H O H CF₃ F HCH₃ H 2 26N CCl₃ H H O H H H H CF₃ H 2 27N CCl₃ H H O F F H H CF₃ H 228N CCl₃ H H O H H OCH₃ H CF₃ H 2 29N CCl₃ H H O H F F H CH₃ H 2 30NCCl₃ H H O H OCH₃ H H CH₃ H 2 31N CCl₃ H H O H H CH₃ H H H 2 32N CCl₃ HH O H Cl H H H H 2 33N CCl₃ H H O H F H H F H 2 34N CCl₃ H H O H H OCH₃H CH₃ H 2 35N CCl₃ H H O H H H H H H 2 36N CCl₃ H H O H H CH₃ H CH₃ H 237N CCl₃ H H O H H Cl H H H 2 38N CCl₃ H H O H F H H 3-CF₃-phenoxy H 239N CCl₃ H H O H F H H 4-CH₃O-phenoxy H 2 40N CCl₃ H H O H F H H4-Cl-phenoxy H 2 41N CCl₃ H H O H F H H H H 2 42N CCl₃ H H O H F H H CH₃H 2 43N CCl₃ H H O H F H F CH₃ H 2 44N CCl₃ H H O F F H H CH₃ H 2 45NCCl₃ H H O H Cl H H CH₃ H 2 46N CCl₃ H H O H CH₃ H H CH₃ H 2 47N CCl₃ HH O CH₃ H H H H H 2 48N CCl₃ H H O H H CH₃ H CF₃ H 2 49N CCl₃ H H O CH₃H H H CF₃ H 2 50N CCl₃ H H O CH₃ H H H CH₃ H 2 51N CCl₃ H H O H H CH₃ HF H 2 52N CCl₃ H H O H CF₃ H H F H 2 53N CCl₃ H H O H CF₃ H H CH₃ H 254N CCl₃ H H O H OCH₃ H H CF₃ H 2 55N CCl₃ H H O OCH₃ H H H CH₃ H 2 56NCCl₃ H H O H H CH₃ H CF₃ H 2 57N CCl₃ H H O H C₆H₅O H H H OCF₃ 2 58NCCl₃ H H O H H H H H OCF₃ 2 59N CCl₃ H H O H OCF₃ H H H OCF₃ 2 60N CCl₃H H O H CF₃ F H H CF₃ 2 61N CCl₃ H H O H H OCH₃ H H CF₃ 2 62N CCl₃ H H OH CH₃ H H H CF₃ 2 63N CCl₃ H H O H Cl H H H CF₃ 2 64N CCl₃ H H O H CF₃ HH H OCF₃ 2 65N CCl₃ H H O H F H H H OCF₃ 2 66N CCl₃ H H O H F H F H OCF₃2 67N CCl₃ H H O H Br H H H OCF₃ 2 68N CCl₃ H H O H Cl H H H OCF₃ 2 69NCCl₃ H H O H F F H H OCF₃ 2 70N CCl₃ H H O H F H H H phenyl 2 71N CCl₃ HH O H CH₃ H H H OCF₃ 2 72N CCl₃ H H O H F F H H CF₃ 2 73N CCl₃ H H O HCl H H H CH₃ 2 74N CCl₃ H H O H OCH₃ H H H CH₃ 2 75N CCl₃ H H O H F H HH CH₃ 2 76N CCl₃ H H O F F H H H OCF₃ 2 77N CCl₃ H H O OCH₃ H H H H CF₃2 78N CCl₃ H H O H H OCH₃ H H CH₃ 2 79N CCl₃ H H O H H CH₃ H H CH₃ 2 80NCCl₃ H H O H CH₃ H H H CH₃ 2 81N CCl₃ H H O CH₃ H H H H CH₃ 2 82N CCl₃ HH O H F F H H CH₃ 2 83N CCl₃ H H O H F H F H CH₃ 2 84N CCl₃ H H O F F HH H CH₃ 2 85N CCl₃ H H O F CF₃ H H H CH₃ 2 86N CCl₃ H H O H H CH₃ H HCF₃ 2 87N CCl₃ H H O CH₃ H H H H CF₃ 2 88N CCl₃ H H O H CF₃ H H H CH₃ 289N CCl₃ H H O OCH₃ H H H H CH₃ 2 90N CCl₃ H H O H H CF₃ H H CH₃ 2 91NCCl₃ H H O CF₃ H H H H CH₃ 2 92N CCl₃ H H O H CF₃ F H H CH₃ 3  1N CF₃CH₃ H O H C₆H₅O H H OCF₂CF₂H H 3  2N CF₃ CH₃ H O H OCF₃ H H OCF₂CF₂H H 3 3N CF₃ CH₃ H O F H H F OCF₂CF₂H H 3  4N CF₃ CH₃ H O H F H H OCF₂CF₂H H3  5N CF₃ CH₃ H O H C₆H₅O H H OCF₃ H 3  6N CF₃ CH₃ H O H OCF₃ H H OCF₃ H3  7N CF₃ CH₃ H O H H phenyl H OCF₃ H 3  8N CF₃ CH₃ H O H phenyl H HOCF₃ H 3  9N CF₃ CH₃ H O H H H H OCF₃ H 3 10N CF₃ CH₃ H O H Br H H OCF₃H 3 11N CF₃ CH₃ H O H CF₃ F H CF₃ H 3 12N CF₃ CH₃ H O H CH₃ H H CF₃ H 313N CF₃ CH₃ H O H CF₃ H H CF₃ H 3 14N CF₃ CH₃ H O H CH₃ H H OCF₃ H 3 15NCF₃ CH₃ H O H F F H OCF₃ H 3 16N CF₃ CH₃ H O H Br H H CF₃ H 3 17N CF₃CH₃ H O H CF₃ F H OCF₃ H 3 18N CF₃ CH₃ H O H F H H OCF₃ H 3 19N CF₃ CH₃H O H Cl H H OCF₃ H 3 20N CF₃ CH₃ H O H F H H CF₃ H 3 21N CF₃ CH₃ H O HF F H CF₃ H 3 22N CF₃ CH₃ H O H Cl H H CF₃ H 3 23N CF₃ CH₃ H O H F H Hphenoxy H 3 24N CF₃ CH₃ H O H CF₃ Cl H CH₃ H 3 25N CF₃ CH₃ H O H CF₃ F HCH₃ H 3 26N CF₃ CH₃ H O H H H H CF₃ H 3 27N CF₃ CH₃ H O F F H H CF₃ H 328N CF₃ CH₃ H O H H OCH₃ H CF₃ H 3 29N CF₃ CH₃ H O H F F H CH₃ H 3 30NCF₃ CH₃ H O H OCH₃ H H CH₃ H 3 31N CF₃ CH₃ H O H H CH₃ H H H 3 32N CF₃CH₃ H O H Cl H H H H 3 33N CF₃ CH₃ H O H F H H F H 3 34N CF₃ CH₃ H O H HOCH₃ H CH₃ H 3 35N CF₃ CH₃ H O H H H H H H 3 36N CF₃ CH₃ H O H H CH₃ HCH₃ H 3 37N CF₃ CH₃ H O H H Cl H H H 3 38N CF₃ CH₃ H O H F H H3-CF₃-phenoxy H 3 39N CF₃ CH₃ H O H F H H 4-CH₃O-phenoxy H 3 40N CF₃ CH₃H O H F H H 4-Cl-phenoxy H 3 41N CF₃ CH₃ H O H F H H H H 3 42N CF₃ CH₃ HO H F H H CH₃ H 3 43N CF₃ CH₃ H O H F H F CH₃ H 3 44N CF₃ CH₃ H O F F HH CH₃ H 3 45N CF₃ CH₃ H O H Cl H H CH₃ H 3 46N CF₃ CH₃ H O H CH₃ H H CH₃H 3 47N CF₃ CH₃ H O CH₃ H H H H H 3 48N CF₃ CH₃ H O H H CH₃ H CF₃ H 349N CF₃ CH₃ H O CH₃ H H H CF₃ H 3 50N CF₃ CH₃ H O CH₃ H H H CH₃ H 3 51NCF₃ CH₃ H O H H CH₃ H F H 3 52N CF₃ CH₃ H O H CF₃ H H F H 3 53N CF₃ CH₃H O H CF₃ H H CH₃ H 3 54N CF₃ CH₃ H O H OCH₃ H H CF₃ H 3 55N CF₃ CH₃ H OOCH₃ H H H CH₃ H 3 56N CF₃ CH₃ H O H H CH₃ H CF₃ H 3 57N CF₃ CH₃ H O HC₆H₅O H H H OCF₃ 3 58N CF₃ CH₃ H O H H H H H OCF₃ 3 59N CF₃ CH₃ H O HOCF₃ H H H OCF₃ 3 60N CF₃ CH₃ H O H CF₃ F H H CF₃ 3 61N CF₃ CH₃ H O H HOCH₃ H H CF₃ 3 62N CF₃ CH₃ H O H CH₃ H H H CF₃ 3 63N CF₃ CH₃ H O H Cl HH H CF₃ 3 64N CF₃ CH₃ H O H CF₃ H H H OCF₃ 3 65N CF₃ CH₃ H O H F H H HOCF₃ 3 66N CF₃ CH₃ H O H F H F H OCF₃ 3 67N CF₃ CH₃ H O H Br H H H OCF₃3 68N CF₃ CH₃ H O H Cl H H H OCF₃ 3 69N CF₃ CH₃ H O H F F H H OCF₃ 3 70NCF₃ CH₃ H O H F H H H phenyl 3 71N CF₃ CH₃ H O H CH₃ H H H OCF₃ 3 72NCF₃ CH₃ H O H F F H H CF₃ 3 73N CF₃ CH₃ H O H Cl H H H CH₃ 3 74N CF₃ CH₃H O H OCH₃ H H H CH₃ 3 75N CF₃ CH₃ H O H F H H H CH₃ 3 76N CF₃ CH₃ H O FF H H H OCF₃ 3 77N CF₃ CH₃ H O OCH₃ H H H H CF₃ 3 78N CF₃ CH₃ H O H HOCH₃ H H CH₃ 3 79N CF₃ CH₃ H O H H CH₃ H H CH₃ 3 80N CF₃ CH₃ H O H CH₃ HH H CH₃ 3 81N CF₃ CH₃ H O CH₃ H H H H CH₃ 3 82N CF₃ CH₃ H O H F F H HCH₃ 3 83N CF₃ CH₃ H O H F H F H CH₃ 3 84N CF₃ CH₃ H O F F H H H CH₃ 385N CF₃ CH₃ H O F CF₃ H H H CH₃ 3 86N CF₃ CH₃ H O H H CH₃ H H CF₃ 3 87NCF₃ CH₃ H O CH₃ H H H H CF₃ 3 88N CF₃ CH₃ H O H CF₃ H H H CH₃ 3 89N CF₃CH₃ H O OCH₃ H H H H CH₃ 3 90N CF₃ CH₃ H O H H CF₃ H H CH₃ 3 91N CF₃ CH₃H O CF₃ H H H H CH₃ 3 92N CF₃ CH₃ H O H CF₃ F H H CH₃ 4  1N CF₃CF₂ H H OH C₆H₅O H H OCF₂CF₂H H 4  2N CF₃CF₂ H H O H OCF₃ H H OCF₂CF₂H H 4  3NCF₃CF₂ H H O F H H F OCF₂CF₂H H 4  4N CF₃CF₂ H H O H F H H OCF₂CF₂H H 4 5N CF₃CF₂ H H O H C₆H₅O H H OCF₃ H 4  6N CF₃CF₂ H H O H OCF₃ H H OCF₃ H4  7N CF₃CF₂ H H O H H phenyl H OCF₃ H 4  8N CF₃CF₂ H H O H phenyl H HOCF₃ H 4  9N CF₃CF₂ H H O H H H H OCF₃ H 4 10N CF₃CF₂ H H O H Br H HOCF₃ H 4 11N CF₃CF₂ H H O H CF₃ F H CF₃ H 4 12N CF₃CF₂ H H O H CH₃ H HCF₃ H 4 13N CF₃CF₂ H H O H CF₃ H H CF₃ H 4 14N CF₃CF₂ H H O H CH₃ H HOCF₃ H 4 15N CF₃CF₂ H H O H F F H OCF₃ H 4 16N CF₃CF₂ H H O H Br H H CF₃H 4 17N CF₃CF₂ H H O H CF₃ F H OCF₃ H 4 18N CF₃CF₂ H H O H F H H OCF₃ H4 19N CF₃CF₂ H H O H Cl H H OCF₃ H 4 20N CF₃CF₂ H H O H F H H CF₃ H 421N CF₃CF₂ H H O H F F H CF₃ H 4 22N CF₃CF₂ H H O H Cl H H CF₃ H 4 23NCF₃CF₂ H H O H F H H phenoxy H 4 24N CF₃CF₂ H H O H CF₃ Cl H CH₃ H 4 25NCF₃CF₂ H H O H CF₃ F H CH₃ H 4 26N CF₃CF₂ H H O H H H H CF₃ H 4 27NCF₃CF₂ H H O F F H H CF₃ H 4 28N CF₃CF₂ H H O H H OCH₃ H CF₃ H 4 29NCF₃CF₂ H H O H F F H CH₃ H 4 30N CF₃CF₂ H H O H OCH₃ H H CH₃ H 4 31NCF₃CF₂ H H O H H CH₃ H H H 4 32N CF₃CF₂ H H O H Cl H H H H 4 33N CF₃CF₂H H O H F H H F H 4 34N CF₃CF₂ H H O H H OCH₃ H CH₃ H 4 35N CF₃CF₂ H H OH H H H H H 4 36N CF₃CF₂ H H O H H CH₃ H CH₃ H 4 37N CF₃CF₂ H H O H H ClH H H 4 38N CF₃CF₂ H H O H F H H 3-CF₃-phenoxy H 4 39N CF₃CF₂ H H O H FH H 4-CH₃O-phenoxy H 4 40N CF₃CF₂ H H O H F H H 4-Cl-phenoxy H 4 41NCF₃CF₂ H H O H F H H H H 4 42N CF₃CF₂ H H O H F H H CH₃ H 4 43N CF₃CF₂ HH O H F H F CH₃ H 4 44N CF₃CF₂ H H O F F H H CH₃ H 4 45N CF₃CF₂ H H O HCl H H CH₃ H 4 46N CF₃CF₂ H H O H CH₃ H H CH₃ H 4 47N CF₃CF₂ H H O CH₃ HH H H H 4 48N CF₃CF₂ H H O H H CH₃ H CF₃ H 4 49N CF₃CF₂ H H O CH₃ H H HCF₃ H 4 50N CF₃CF₂ H H O CH₃ H H H CH₃ H 4 51N CF₃CF₂ H H O H H CH₃ H FH 4 52N CF₃CF₂ H H O H CF₃ H H F H 4 53N CF₃CF₂ H H O H CF₃ H H CH₃ H 454N CF₃CF₂ H H O H OCH₃ H H CF₃ H 4 55N CF₃CF₂ H H O OCH₃ H H H CH₃ H 456N CF₃CF₂ H H O H H CH₃ H CF₃ H 4 57N CF₃CF₂ H H O H C₆H₅O H H H OCF₃ 458N CF₃CF₂ H H O H H H H H OCF₃ 4 59N CF₃CF₂ H H O H OCF₃ H H H OCF₃ 460N CF₃CF₂ H H O H CF₃ F H H CF₃ 4 61N CF₃CF₂ H H O H H OCH₃ H H CF₃ 462N CF₃CF₂ H H O H CH₃ H H H CF₃ 4 63N CF₃CF₂ H H O H Cl H H H CF₃ 4 64NCF₃CF₂ H H O H CF₃ H H H OCF₃ 4 65N CF₃CF₂ H H O H F H H H OCF₃ 4 66NCF₃CF₂ H H O H F H F H OCF₃ 4 67N CF₃CF₂ H H O H Br H H H OCF₃ 4 68NCF₃CF₂ H H O H Cl H H H OCF₃ 4 69N CF₃CF₂ H H O H F F H H OCF₃ 4 70NCF₃CF₂ H H O H F H H H phenyl 4 71N CF₃CF₂ H H O H CH₃ H H H OCF₃ 4 72NCF₃CF₂ H H O H F F H H CF₃ 4 73N CF₃CF₂ H H O H Cl H H H CH₃ 4 74NCF₃CF₂ H H O H OCH₃ H H H CH₃ 4 75N CF₃CF₂ H H O H F H H H CH₃ 4 76NCF₃CF₂ H H O F F H H H OCF₃ 4 77N CF₃CF₂ H H O OCH₃ H H H H CF₃ 4 78NCF₃CF₂ H H O H H OCH₃ H H CH₃ 4 79N CF₃CF₂ H H O H H CH₃ H H CH₃ 4 80NCF₃CF₂ H H O H CH₃ H H H CH₃ 4 81N CF₃CF₂ H H O CH₃ H H H H CH₃ 4 82NCF₃CF₂ H H O H F F H H CH₃ 4 83N CF₃CF₂ H H O H F H F H CH₃ 4 84N CF₃CF₂H H O F F H H H CH₃ 4 85N CF₃CF₂ H H O F CF₃ H H H CH₃ 4 86N CF₃CF₂ H HO H H CH₃ H H CF₃ 4 87N CF₃CF₂ H H O CH₃ H H H H CF₃ 4 88N CF₃CF₂ H H OH CF₃ H H H CH₃ 4 89N CF₃CF₂ H H O OCH₃ H H H H CH₃ 4 90N CF₃CF₂ H H O HH CF₃ H H CH₃ 4 91N CF₃CF₂ H H O CF₃ H H H H CH₃ 4 92N CF₃CF₂ H H O HCF₃ F H H CH₃ 5  1N CF₃CF₂CF₂ H H O H C₆H₅O H H OCF₂CF₂H H 5  2NCF₃CF₂CF₂ H H O H OCF₃ H H OCF₂CF₂H H 5  3N CF₃CF₂CF₂ H H O F H H FOCF₂CF₂H H 5  4N CF₃CF₂CF₂ H H O H F H H OCF₂CF₂H H 5  5N CF₃CF₂CF₂ H HO H C₆H₅O H H OCF₃ H 5  6N CF₃CF₂CF₂ H H O H OCF₃ H H OCF₃ H 5  7NCF₃CF₂CF₂ H H O H H phenyl H OCF₃ H 5  8N CF₃CF₂CF₂ H H O H phenyl H HOCF₃ H 5  9N CF₃CF₂CF₂ H H O H H H H OCF₃ H 5 10N CF₃CF₂CF₂ H H O H Br HH OCF₃ H 5 11N CF₃CF₂CF₂ H H O H CF₃ F H CF₃ H 5 12N CF₃CF₂CF₂ H H O HCH₃ H H CF₃ H 5 13N CF₃CF₂CF₂ H H O H CF₃ H H CF₃ H 5 14N CF₃CF₂CF₂ H HO H CH₃ H H OCF₃ H 5 15N CF₃CF₂CF₂ H H O H F F H OCF₃ H 5 16N CF₃CF₂CF₂H H O H Br H H CF₃ H 5 17N CF₃CF₂CF₂ H H O H CF₃ F H OCF₃ H 5 18NCF₃CF₂CF₂ H H O H F H H OCF₃ H 5 19N CF₃CF₂CF₂ H H O H Cl H H OCF₃ H 520N CF₃CF₂CF₂ H H O H F H H CF₃ H 5 21N CF₃CF₂CF₂ H H O H F F H CF₃ H 522N CF₃CF₂CF₂ H H O H Cl H H CF₃ H 5 23N CF₃CF₂CF₂ H H O H F H H phenoxyH 5 24N CF₃CF₂CF₂ H H O H CF₃ Cl H CH₃ H 5 25N CF₃CF₂CF₂ H H O H CF₃ F HCH₃ H 5 26N CF₃CF₂CF₂ H H O H H H H CF₃ H 5 27N CF₃CF₂CF₂ H H O F F H HCF₃ H 5 28N CF₃CF₂CF₂ H H O H H OCH₃ H CF₃ H 5 29N CF₃CF₂CF₂ H H O H F FH CH₃ H 5 30N CF₃CF₂CF₂ H H O H OCH₃ H H CH₃ H 5 31N CF₃CF₂CF₂ H H O H HCH₃ H H H 5 32N CF₃CF₂CF₂ H H O H Cl H H H H 5 33N CF₃CF₂CF₂ H H O H F HH F H 5 34N CF₃CF₂CF₂ H H O H H OCH₃ H CH₃ H 5 35N CF₃CF₂CF₂ H H O H H HH H H 5 36N CF₃CF₂CF₂ H H O H H CH₃ H CH₃ H 5 37N CF₃CF₂CF₂ H H O H H ClH H H 5 38N CF₃CF₂CF₂ H H O H F H H 3-CF₃-phenoxy H 5 39N CF₃CF₂CF₂ H HO H F H H 4-CH₃O-phenoxy H 5 40N CF₃CF₂CF₂ H H O H F H H 4-Cl-phenoxy H5 41N CF₃CF₂CF₂ H H O H F H H H H 5 42N CF₃CF₂CF₂ H H O H F H H CH₃ H 543N CF₃CF₂CF₂ H H O H F H F CH₃ H 5 44N CF₃CF₂CF₂ H H O F F H H CH₃ H 545N CF₃CF₂CF₂ H H O H Cl H H CH₃ H 5 46N CF₃CF₂CF₂ H H O H CH₃ H H CH₃ H5 47N CF₃CF₂CF₂ H H O CH₃ H H H H H 5 48N CF₃CF₂CF₂ H H O H H CH₃ H CF₃H 5 49N CF₃CF₂CF₂ H H O CH₃ H H H CF₃ H 5 50N CF₃CF₂CF₂ H H O CH₃ H H HCH₃ H 5 51N CF₃CF₂CF₂ H H O H H CH₃ H F H 5 52N CF₃CF₂CF₂ H H O H CF₃ HH F H 5 53N CF₃CF₂CF₂ H H O H CF₃ H H CH₃ H 5 54N CF₃CF₂CF₂ H H O H OCH₃H H CF₃ H 5 55N CF₃CF₂CF₂ H H O OCH₃ H H H CH₃ H 5 56N CF₃CF₂CF₂ H H O HH CH₃ H CF₃ H 5 57N CF₃CF₂CF₂ H H O H C₆H₅O H H H OCF₃ 5 58N CF₃CF₂CF₂ HH O H H H H H OCF₃ 5 59N CF₃CF₂CF₂ H H O H OCF₃ H H H OCF₃ 5 60NCF₃CF₂CF₂ H H O H CF₃ F H H CF₃ 5 61N CF₃CF₂CF₂ H H O H H OCH₃ H H CF₃ 562N CF₃CF₂CF₂ H H O H CH₃ H H H CF₃ 5 63N CF₃CF₂CF₂ H H O H Cl H H H CF₃5 64N CF₃CF₂CF₂ H H O H CF₃ H H H OCF₃ 5 65N CF₃CF₂CF₂ H H O H F H H HOCF₃ 5 66N CF₃CF₂CF₂ H H O H F H F H OCF₃ 5 67N CF₃CF₂CF₂ H H O H Br H HH OCF₃ 5 68N CF₃CF₂CF₂ H H O H Cl H H H OCF₃ 5 69N CF₃CF₂CF₂ H H O H F FH H OCF₃ 5 70N CF₃CF₂CF₂ H H O H F H H H phenyl 5 71N CF₃CF₂CF₂ H H O HCH₃ H H H OCF₃ 5 72N CF₃CF₂CF₂ H H O H F F H H CF₃ 5 73N CF₃CF₂CF₂ H H OH Cl H H H CH₃ 5 74N CF₃CF₂CF₂ H H O H OCH₃ H H H CH₃ 5 75N CF₃CF₂CF₂ HH O H F H H H CH₃ 5 76N CF₃CF₂CF₂ H H O F F H H H OCF₃ 5 77N CF₃CF₂CF₂ HH O OCH₃ H H H H CF₃ 5 78N CF₃CF₂CF₂ H H O H H OCH₃ H H CH₃ 5 79NCF₃CF₂CF₂ H H O H H CH₃ H H CH₃ 5 80N CF₃CF₂CF₂ H H O H CH₃ H H H CH₃ 581N CF₃CF₂CF₂ H H O CH₃ H H H H CH₃ 5 82N CF₃CF₂CF₂ H H O H F F H H CH₃5 83N CF₃CF₂CF₂ H H O H F H F H CH₃ 5 84N CF₃CF₂CF₂ H H O F F H H H CH₃5 85N CF₃CF₂CF₂ H H O F CF₃ H H H CH₃ 5 86N CF₃CF₂CF₂ H H O H H CH₃ H HCF₃ 5 87N CF₃CF₂CF₂ H H O CH₃ H H H H CF₃ 5 88N CF₃CF₂CF₂ H H O H CF₃ HH H CH₃ 5 89N CF₃CF₂CF₂ H H O OCH₃ H H H H CH₃ 5 90N CF₃CF₂CF₂ H H O H HCF₃ H H CH₃ 5 91N CF₃CF₂CF₂ H H O CF₃ H H H H CH₃ 5 92N CF₃CF₂CF₂ H H OH CF₃ F H H CH₃ 6  1N CF₃OCF₂CF₂ H H O H C₆H₅O H H OCF₂CF₂H H 6  2NCF₃OCF₂CF₂ H H O H OCF₃ H H OCF₂CF₂H H 6  3N CF₃OCF₂CF₂ H H O F H H FOCF₂CF₂H H 6  4N CF₃OCF₂CF₂ H H O H F H H OCF₂CF₂H H 6  5N CF₃OCF₂CF₂ HH O H C₆H₅O H H OCF₃ H 6  6N CF₃OCF₂CF₂ H H O H OCF₃ H H OCF₃ H 6  7NCF₃OCF₂CF₂ H H O H H phenyl H OCF₃ H 6  8N CF₃OCF₂CF₂ H H O H phenyl H HOCF₃ H 6  9N CF₃OCF₂CF₂ H H O H H H H OCF₃ H 6 10N CF₃OCF₂CF₂ H H O H BrH H OCF₃ H 6 11N CF₃OCF₂CF₂ H H O H CF₃ F H CF₃ H 6 12N CF₃OCF₂CF₂ H H OH CH₃ H H CF₃ H 6 13N CF₃OCF₂CF₂ H H O H CF₃ H H CF₃ H 6 14N CF₃OCF₂CF₂H H O H CH₃ H H OCF₃ H 6 15N CF₃OCF₂CF₂ H H O H F F H OCF₃ H 6 16NCF₃OCF₂CF₂ H H O H Br H H CF₃ H 6 17N CF₃OCF₂CF₂ H H O H CF₃ F H OCF₃ H6 18N CF₃OCF₂CF₂ H H O H F H H OCF₃ H 6 19N CF₃OCF₂CF₂ H H O H Cl H HOCF₃ H 6 20N CF₃OCF₂CF₂ H H O H F H H CF₃ H 6 21N CF₃OCF₂CF₂ H H O H F FH CF₃ H 6 22N CF₃OCF₂CF₂ H H O H Cl H H CF₃ H 6 23N CF₃OCF₂CF₂ H H O H FH H phenoxy H 6 24N CF₃OCF₂CF₂ H H O H CF₃ Cl H CH₃ H 6 25N CF₃OCF₂CF₂ HH O H CF₃ F H CH₃ H 6 26N CF₃OCF₂CF₂ H H O H H H H CF₃ H 6 27NCF₃OCF₂CF₂ H H O F F H H CF₃ H 6 28N CF₃OCF₂CF₂ H H O H H OCH₃ H CF₃ H 629N CF₃OCF₂CF₂ H H O H F F H CH₃ H 6 30N CF₃OCF₂CF₂ H H O H OCH₃ H H CH₃H 6 31N CF₃OCF₂CF₂ H H O H H CH₃ H H H 6 32N CF₃OCF₂CF₂ H H O H Cl H H HH 6 33N CF₃OCF₂CF₂ H H O H F H H F H 6 34N CF₃OCF₂CF₂ H H O H H OCH₃ HCH₃ H 6 35N CF₃OCF₂CF₂ H H O H H H H H H 6 36N CF₃OCF₂CF₂ H H O H H CH₃H CH₃ H 6 37N CF₃OCF₂CF₂ H H O H H Cl H H H 6 38N CF₃OCF₂CF₂ H H O H F HH 3-CF₃-phenoxy H 6 39N CF₃OCF₂CF₂ H H O H F H H 4-CH₃O-phenoxy H 6 40NCF₃OCF₂CF₂ H H O H F H H 4-Cl-phenoxy H 6 41N CF₃OCF₂CF₂ H H O H F H H HH 6 42N CF₃OCF₂CF₂ H H O H F H H CH₃ H 6 43N CF₃OCF₂CF₂ H H O H F H FCH₃ H 6 44N CF₃OCF₂CF₂ H H O F F H H CH₃ H 6 45N CF₃OCF₂CF₂ H H O H Cl HH CH₃ H 6 46N CF₃OCF₂CF₂ H H O H CH₃ H H CH₃ H 6 47N CF₃OCF₂CF₂ H H OCH₃ H H H H H 6 48N CF₃OCF₂CF₂ H H O H H CH₃ H CF₃ H 6 49N CF₃OCF₂CF₂ HH O CH₃ H H H CF₃ H 6 50N CF₃OCF₂CF₂ H H O CH₃ H H H CH₃ H 6 51NCF₃OCF₂CF₂ H H O H H CH₃ H F H 6 52N CF₃OCF₂CF₂ H H O H CF₃ H H F H 653N CF₃OCF₂CF₂ H H O H CF₃ H H CH₃ H 6 54N CF₃OCF₂CF₂ H H O H OCH₃ H HCF₃ H 6 55N CF₃OCF₂CF₂ H H O OCH₃ H H H CH₃ H 6 56N CF₃OCF₂CF₂ H H O H HCH₃ H CF₃ H 6 57N CF₃OCF₂CF₂ H H O H C₆H₅O H H H OCF₃ 6 58N CF₃OCF₂CF₂ HH O H H H H H OCF₃ 6 59N CF₃OCF₂CF₂ H H O H OCF₃ H H H OCF₃ 6 60NCF₃OCF₂CF₂ H H O H CF₃ F H H CF₃ 6 61N CF₃OCF₂CF₂ H H O H H OCH₃ H H CF₃6 62N CF₃OCF₂CF₂ H H O H CH₃ H H H CF₃ 6 63N CF₃OCF₂CF₂ H H O H Cl H H HCF₃ 6 64N CF₃OCF₂CF₂ H H O H CF₃ H H H OCF₃ 6 65N CF₃OCF₂CF₂ H H O H F HH H OCF₃ 6 66N CF₃OCF₂CF₂ H H O H F H F H OCF₃ 6 67N CF₃OCF₂CF₂ H H O HBr H H H OCF₃ 6 68N CF₃OCF₂CF₂ H H O H Cl H H H OCF₃ 6 69N CF₃OCF₂CF₂ HH O H F F H H OCF₃ 6 70N CF₃OCF₂CF₂ H H O H F H H H phenyl 6 71NCF₃OCF₂CF₂ H H O H CH₃ H H H OCF₃ 6 72N CF₃OCF₂CF₂ H H O H F F H H CF₃ 673N CF₃OCF₂CF₂ H H O H Cl H H H CH₃ 6 74N CF₃OCF₂CF₂ H H O H OCH₃ H H HCH₃ 6 75N CF₃OCF₂CF₂ H H O H F H H H CH₃ 6 76N CF₃OCF₂CF₂ H H O F F H HH OCF₃ 6 77N CF₃OCF₂CF₂ H H O OCH₃ H H H H CF₃ 6 78N CF₃OCF₂CF₂ H H O HH OCH₃ H H CH₃ 6 79N CF₃OCF₂CF₂ H H O H H CH₃ H H CH₃ 6 80N CF₃OCF₂CF₂ HH O H CH₃ H H H CH₃ 6 81N CF₃OCF₂CF₂ H H O CH₃ H H H H CH₃ 6 82NCF₃OCF₂CF₂ H H O H F F H H CH₃ 6 83N CF₃OCF₂CF₂ H H O H F H F H CH₃ 684N CF₃OCF₂CF₂ H H O F F H H H CH₃ 6 85N CF₃OCF₂CF₂ H H O F CF₃ H H HCH₃ 6 86N CF₃OCF₂CF₂ H H O H H CH₃ H H CF₃ 6 87N CF₃OCF₂CF₂ H H O CH₃ HH H H CF₃ 6 88N CF₃OCF₂CF₂ H H O H CF₃ H H H CH₃ 6 89N CF₃OCF₂CF₂ H H OOCH₃ H H H H CH₃ 6 90N CF₃OCF₂CF₂ H H O H H CF₃ H H CH₃ 6 91N CF₃OCF₂CF₂H H O CF₃ H H H H CH₃ 6 92N CF₃OCF₂CF₂ H H O H CF₃ F H H CH₃ 7  1NCF₃CH₂ H H O H C₆H₅O H H OCF₂CF₂H H 7  2N CF₃CH₂ H H O H OCF₃ H HOCF₂CF₂H H 7  3N CF₃CH₂ H H O F H H F OCF₂CF₂H H 7  4N CF₃CH₂ H H O H FH H OCF₂CF₂H H 7  5N CF₃CH₂ H H O H C₆H₅O H H OCF₃ H 7  6N CF₃CH₂ H H OH OCF₃ H H OCF₃ H 7  7N CF₃CH₂ H H O H H phenyl H OCF₃ H 7  8N CF₃CH₂ HH O H phenyl H H OCF₃ H 7  9N CF₃CH₂ H H O H H H H OCF₃ H 7 10N CF₃CH₂ HH O H Br H H OCF₃ H 7 11N CF₃CH₂ H H O H CF₃ F H CF₃ H 7 12N CF₃CH₂ H HO H CH₃ H H CF₃ H 7 13N CF₃CH₂ H H O H CF₃ H H CF₃ H 7 14N CF₃CH₂ H H OH CH₃ H H OCF₃ H 7 15N CF₃CH₂ H H O H F F H OCF₃ H 7 16N CF₃CH₂ H H O HBr H H CF₃ H 7 17N CF₃CH₂ H H O H CF₃ F H OCF₃ H 7 18N CF₃CH₂ H H O H FH H OCF₃ H 7 19N CF₃CH₂ H H O H Cl H H OCF₃ H 7 20N CF₃CH₂ H H O H F H HCF₃ H 7 21N CF₃CH₂ H H O H F F H CF₃ H 7 22N CF₃CH₂ H H O H Cl H H CF₃ H7 23N CF₃CH₂ H H O H F H H phenoxy H 7 24N CF₃CH₂ H H O H CF₃ Cl H CH₃ H7 25N CF₃CH₂ H H O H CF₃ F H CH₃ H 7 26N CF₃CH₂ H H O H H H H CF₃ H 727N CF₃CH₂ H H O F F H H CF₃ H 7 28N CF₃CH₂ H H O H H OCH₃ H CF₃ H 7 29NCF₃CH₂ H H O H F F H CH₃ H 7 30N CF₃CH₂ H H O H OCH₃ H H CH₃ H 7 31NCF₃CH₂ H H O H H CH₃ H H H 7 32N CF₃CH₂ H H O H Cl H H H H 7 33N CF₃CH₂H H O H F H H F H 7 34N CF₃CH₂ H H O H H OCH₃ H CH₃ H 7 35N CF₃CH₂ H H OH H H H H H 7 36N CF₃CH₂ H H O H H CH₃ H CH₃ H 7 37N CF₃CH₂ H H O H H ClH H H 7 38N CF₃CH₂ H H O H F H H 3-CF₃-phenoxy H 7 39N CF₃CH₂ H H O H FH H 4-CH₃O-phenoxy H 7 40N CF₃CH₂ H H O H F H H 4-Cl-phenoxy H 7 41NCF₃CH₂ H H O H F H H H H 7 42N CF₃CH₂ H H O H F H H CH₃ H 7 43N CF₃CH₂ HH O H F H F CH₃ H 7 44N CF₃CH₂ H H O F F H H CH₃ H 7 45N CF₃CH₂ H H O HCl H H CH₃ H 7 46N CF₃CH₂ H H O H CH₃ H H CH₃ H 7 47N CF₃CH₂ H H O CH₃ HH H H H 7 48N CF₃CH₂ H H O H H CH₃ H CF₃ H 7 49N CF₃CH₂ H H O CH₃ H H HCF₃ H 7 50N CF₃CH₂ H H O CH₃ H H H CH₃ H 7 51N CF₃CH₂ H H O H H CH₃ H FH 7 52N CF₃CH₂ H H O H CF₃ H H F H 7 53N CF₃CH₂ H H O H CF₃ H H CH₃ H 754N CF₃CH₂ H H O H OCH₃ H H CF₃ H 7 55N CF₃CH₂ H H O OCH₃ H H H CH₃ H 756N CF₃CH₂ H H O H H CH₃ H CF₃ H 7 57N CF₃CH₂ H H O H C₆H₅O H H H OCF₃ 758N CF₃CH₂ H H O H H H H H OCF₃ 7 59N CF₃CH₂ H H O H OCF₃ H H H OCF₃ 760N CF₃CH₂ H H O H CF₃ F H H CF₃ 7 61N CF₃CH₂ H H O H H OCH₃ H H CF₃ 762N CF₃CH₂ H H O H CH₃ H H H CF₃ 7 63N CF₃CH₂ H H O H Cl H H H CF₃ 7 64NCF₃CH₂ H H O H CF₃ H H H OCF₃ 7 65N CF₃CH₂ H H O H F H H H OCF₃ 7 66NCF₃CH₂ H H O H F H F H OCF₃ 7 67N CF₃CH₂ H H O H Br H H H OCF₃ 7 68NCF₃CH₂ H H O H Cl H H H OCF₃ 7 69N CF₃CH₂ H H O H F F H H OCF₃ 7 70NCF₃CH₂ H H O H F H H H phenyl 7 71N CF₃CH₂ H H O H CH₃ H H H OCF₃ 7 72NCF₃CH₂ H H O H F F H H CF₃ 7 73N CF₃CH₂ H H O H Cl H H H CH₃ 7 74NCF₃CH₂ H H O H OCH₃ H H H CH₃ 7 75N CF₃CH₂ H H O H F H H H CH₃ 7 76NCF₃CH₂ H H O F F H H H OCF₃ 7 77N CF₃CH₂ H H O OCH₃ H H H H CF₃ 7 78NCF₃CH₂ H H O H H OCH₃ H H CH₃ 7 79N CF₃CH₂ H H O H H CH₃ H H CH₃ 7 80NCF₃CH₂ H H O H CH₃ H H H CH₃ 7 81N CF₃CH₂ H H O CH₃ H H H H CH₃ 7 82NCF₃CH₂ H H O H F F H H CH₃ 7 83N CF₃CH₂ H H O H F H F H CH₃ 7 84N CF₃CH₂H H O F F H H H CH₃ 7 85N CF₃CH₂ H H O F CF₃ H H H CH₃ 7 86N CF₃CH₂ H HO H H CH₃ H H CF₃ 7 87N CF₃CH₂ H H O CH₃ H H H H CF₃ 7 88N CF₃CH₂ H H OH CF₃ H H H CH₃ 7 89N CF₃CH₂ H H O OCH₃ H H H H CH₃ 7 90N CF₃CH₂ H H O HH CF₃ H H CH₃ 7 91N CF₃CH₂ H H O CF₃ H H H H CH₃ 7 92N CF₃CH₂ H H O HCF₃ F H H CH₃ 8  1N CF₃ CHF₂ H O H C₆H₅O H H OCF₂CF₂H H 8  2N CF₃ CHF₂ HO H OCF₃ H H OCF₂CF₂H H 8  3N CF₃ CHF₂ H O F H H F OCF₂CF₂H H 8  4N CF₃CHF₂ H O H F H H OCF₂CF₂H H 8  5N CF₃ CHF₂ H O H C₆H₅O H H OCF₃ H 8  6NCF₃ CHF₂ H O H OCF₃ H H OCF₃ H 8  7N CF₃ CHF₂ H O H H phenyl H OCF₃ H 8 8N CF₃ CHF₂ H O H phenyl H H OCF₃ H 8  9N CF₃ CHF₂ H O H H H H OCF₃ H 810N CF₃ CHF₂ H O H Br H H OCF₃ H 8 11N CF₃ CHF₂ H O H CF₃ F H CF₃ H 812N CF₃ CHF₂ H O H CH₃ H H CF₃ H 8 13N CF₃ CHF₂ H O H CF₃ H H CF₃ H 814N CF₃ CHF₂ H O H CH₃ H H OCF₃ H 8 15N CF₃ CHF₂ H O H F F H OCF₃ H 816N CF₃ CHF₂ H O H Br H H C_(F) H 8 17N CF₃ CHF₂ H O H CF₃ F H OCF₃ H 818N CF₃ CHF₂ H O H F H H OCF₃ H 8 19N CF₃ CHF₂ H O H Cl H H OCF₃ H 8 20NCF₃ CHF₂ H O H F H H CF₃ H 8 21N CF₃ CHF₂ H O H F F H CF₃ H 8 22N CF₃CHF₂ H O H Cl H H CF₃ H 8 23N CF₃ CHF₂ H O H F H H phenoxy H 8 24N CF₃CHF₂ H O H CF₃ Cl H CH₃ H 8 25N CF₃ CHF₂ H O H CF₃ F H CH₃ H 8 26N CF₃CHF₂ H O H H H H CF₃ H 8 27N CF₃ CHF₂ H O F F H H CF₃ H 8 28N CF₃ CHF₂ HO H H OCH₃ H CF₃ H 8 29N CF₃ CHF₂ H O H F F H CH₃ H 8 30N CF₃ CHF₂ H O HOCH₃ H H CH₃ H 8 31N CF₃ CHF₂ H O H H CH₃ H H H 8 32N CF₃ CHF₂ H O H ClH H H H 8 33N CF₃ CHF₂ H O H F H H F H 8 34N CF₃ CHF₂ H O H H OCH₃ H CH₃H 8 35N CF₃ CHF₂ H O H H H H H H 8 36N CF₃ CHF₂ H O H H CH₃ H CH₃ H 837N CF₃ CHF₂ H O H H Cl H H H 8 38N CF₃ CHF₂ H O H F H H 3-CF₃-phenoxy H8 39N CF₃ CHF₂ H O H F H H 4-CH₃O-phenoxy H 8 40N CF₃ CHF₂ H O H F H H4-Cl-phenoxy H 8 41N CF₃ CHF₂ H O H F H H H H 8 42N CF₃ CHF₂ H O H F H HCH₃ H 8 43N CF₃ CHF₂ H O H F H F CH₃ H 8 44N CF₃ CHF₂ H O F F H H CH₃ H8 45N CF₃ CHF₂ H O H Cl H H CH₃ H 8 46N CF₃ CHF₂ H O H CH₃ H H CH₃ H 847N CF₃ CHF₂ H O CH₃ H H H H H 8 48N CF₃ CHF₂ H O H H CH₃ H CF₃ H 8 49NCF₃ CHF₂ H O CH₃ H H H CF₃ H 8 50N CF₃ CHF₂ H O CH₃ H H H CH₃ H 8 51NCF₃ CHF₂ H O H H CH₃ H F H 8 52N CF₃ CHF₂ H O H CF₃ H H F H 8 53N CF₃CHF₂ H O H CF₃ H H CH₃ H 8 54N CF₃ CHF₂ H O H OCH₃ H H CF₃ H 8 55N CF₃CHF₂ H O OCH₃ H H H CH₃ H 8 56N CF₃ CHF₂ H O H H CH₃ H CF₃ H 8 57N CF₃CHF₂ H O H C₆H₅O H H H OCF₃ 8 58N CF₃ CHF₂ H O H H H H H OCF₃ 8 59N CF₃CHF₂ H O H OCF₃ H H H OCF₃ 8 60N CF₃ CHF₂ H O H CF F H H CF₃ 8 61N CF₃CHF₂ H O H H OCH₃ H H CF₃ 8 62N CF₃ CHF₂ H O H CH₃ H H H CF₃ 8 63N CF₃CHF₂ H O H Cl H H H CF₃ 8 64N CF₃ CHF₂ H O H CF₃ H H H OCF₃ 8 65N CF₃CHF₂ H O H F H H H OCF₃ 8 66N CF₃ CHF₂ H O H F H F H OCF₃ 8 67N CF₃ CHF₂H O H Br H H H OCF₃ 8 68N CF₃ CHF₂ H O H Cl H H H OCF₃ 8 69N CF₃ CHF₂ HO H F F H H OCF₃ 8 70N CF₃ CHF₂ H O H F H H H phenyl 8 71N CF₃ CHF₂ H OH CH₃ H H H OCF₃ 8 72N CF₃ CHF₂ H O H F F H H CF₃ 8 73N CF₃ CHF₂ H O HCl H H H CH₃ 8 74N CF₃ CHF₂ H O H OCH₃ H H H CH₃ 8 75N CF₃ CHF₂ H O H FH H H CH₃ 8 76N CF₃ CHF₂ H O F F H H H OCF₃ 8 77N CF₃ CHF₂ H O OCH₃ H HH H CF₃ 8 78N CF₃ CHF₂ H O H H OCH₃ H H CH₃ 8 79N CF₃ CHF₂ H O H H CH₃ HH CH₃ 8 80N CF₃ CHF₂ H O H CH₃ H H H CH₃ 8 81N CF₃ CHF₂ H O CH₃ H H H HCH₃ 8 82N CF₃ CHF₂ H O H F F H H CH₃ 8 83N CF₃ CHF₂ H O H F H F H CH₃ 884N CF₃ CHF₂ H O F F H H H CH₃ 8 85N CF₃ CHF₂ H O F CF₃ H H H CH₃ 8 86NCF₃ CHF₂ H O H H CH₃ H H CF₃ 8 87N CF₃ CHF₂ H O CH₃ H H H H CF₃ 8 88NCF₃ CHF₂ H O H CF₃ H H H CH₃ 8 89N CF₃ CHF₂ H O OCH₃ H H H H CH₃ 8 90NCF₃ CHF₂ H O H H CF₃ H H CH₃ 8 91N CF₃ CHF₂ H O CF₃ H H H H CH₃ 8 92NCF₃ CHF₂ H O H CF₃ F H H CH₃ 9  1N CF₃ H CF₃ O H C₆H₅O H H OCF₂CF₂H H 9 2N CF₃ H CF₃ O H OCF₃ H H OCF₂CF₂H H 9  3N CF₃ H CF₃ O F H H F OCF₂CF₂HH 9  4N CF₃ H CF₃ O H F H H OCF₂CF₂H H 9  5N CF₃ H CF₃ O H C₆H₅O H HOCF₃ H 9  6N CF₃ H CF₃ O H OCF₃ H H OCF₃ H 9  7N CF₃ H CF₃ O H H phenylH OCF₃ H 9  8N CF₃ H CF₃ O H phenyl H H OCF₃ H 9  9N CF₃ H CF₃ O H H H HOCF₃ H 9 10N CF₃ H CF₃ O H Br H H OCF₃ H 9 11N CF₃ H CF₃ O H CF₃ F H CF₃H 9 12N CF₃ H CF₃ O H CH₃ H H CF₃ H 9 13N CF₃ H CF₃ O H CF₃ H H CF₃ H 914N CF₃ H CF₃ O H CH₃ H H OCF₃ H 9 15N CF₃ H CF₃ O H F F H OCF₃ H 9 16NCF₃ H CF₃ O H Br H H CF₃ H 9 17N CF₃ H CF₃ O H CF₃ F H OCF₃ H 9 18N CF₃H CF₃ O H F H H OCF₃ H 9 19N CF₃ H CF₃ O H Cl H H OCF₃ H 9 20N CF₃ H CF₃O H F H H CF₃ H 9 21N CF₃ H CF₃ O H F F H CF₃ H 9 22N CF₃ H CF₃ O H Cl HH CF₃ H 9 23N CF₃ H CF₃ O H F H H phenoxy H 9 24N CF₃ H CF₃ O H CF₃ Cl HCH₃ H 9 25N CF₃ H CF₃ O H CF₃ F H CH₃ H 9 26N CF₃ H CF₃ O H H H H CF₃ H9 27N CF₃ H CF₃ O F F H H CF₃ H 9 28N CF₃ H CF₃ O H H OCH₃ H CF₃ H 9 29NCF₃ H CF₃ O H F F H CH₃ H 9 30N CF₃ H CF₃ O H OCH₃ H H CH₃ H 9 31N CF₃ HCF₃ O H H CH₃ H H H 9 32N CF₃ H CF₃ O H Cl H H H H 9 33N CF₃ H CF₃ O H FH H F H 9 34N CF₃ H CF₃ O H H OCH₃ H CH₃ H 9 35N CF₃ H CF₃ O H H H H H H9 36N CF₃ H CF₃ O H H CH₃ H CH₃ H 9 37N CF₃ H CF₃ O H H Cl H H H 9 38NCF₃ H CF₃ O H F H H 3-CF₃-phenoxy H 9 39N CF₃ H CF₃ O H F H H4-CH₃O-phenoxy H 9 40N CF₃ H CF₃ O H F H H 4-Cl-phenoxy H 9 41N CF₃ HCF₃ O H F H H H H 9 42N CF₃ H CF₃ O H F H H CH₃ H 9 43N CF₃ H CF₃ O H FH F CH₃ H 9 44N CF₃ H CF₃ O F F H H CH₃ H 9 45N CF₃ H CF₃ O H Cl H H CH₃H 9 46N CF₃ H CF₃ O H CH₃ H H CH₃ H 9 47N CF₃ H CF₃ O CH₃ H H H H H 948N CF₃ H CF₃ O H H CH₃ H CF₃ H 9 49N CF₃ H CF₃ O CH₃ H H H CF₃ H 9 50NCF₃ H CF₃ O CH₃ H H H CH₃ H 9 51N CF₃ H CF₃ O H H CH₃ H F H 9 52N CF₃ HCF₃ O H CF₃ H H F H 9 53N CF₃ H CF₃ O H CF₃ H H CH₃ H 9 54N CF₃ H CF₃ OH OCH₃ H H CF₃ H 9 55N CF₃ H CF₃ O OCH₃ H H H CH₃ H 9 56N CF₃ H CF₃ O HH CH₃ H CF₃ H 9 57N CF₃ H CF₃ O H C₆H₅O H H H OCF₃ 9 58N CF₃ H CF₃ O H HH H H OCF₃ 9 59N CF₃ H CF₃ O H OCF₃ H H H OCF₃ 9 60N CF₃ H CF₃ O H CF₃ FH H CF₃ 9 61N CF₃ H CF₃ O H H OCH₃ H H CF₃ 9 62N CF₃ H CF₃ O H CH₃ H H HCF₃ 9 63N CF₃ H CF₃ O H Cl H H H CF₃ 9 64N CF₃ H CF₃ O H CF₃ H H H OCF₃9 65N CF₃ H CF₃ O H F H H H OCF₃ 9 66N CF₃ H CF₃ O H F H F H OCF₃ 9 67NCF₃ H CF₃ O H Br H H H OCF₃ 9 68N CF₃ H CF₃ O H Cl H H H OCF₃ 9 69N CF₃H CF₃ O H F F H H OCF₃ 9 70N CF₃ H CF₃ O H F H H H phenyl 9 71N CF₃ HCF₃ O H CH₃ H H H OCF₃ 9 72N CF₃ H CF₃ O H F F H H CF₃ 9 73N CF₃ H CF₃ OH Cl H H H CH₃ 9 74N CF₃ H CF₃ O H OCH₃ H H H CH₃ 9 75N CF₃ H CF₃ O H FH H H CH₃ 9 76N CF₃ H CF₃ O F F H H H OCF₃ 9 77N CF₃ H CF₃ O OCH₃ H H HH CF₃ 9 78N CF₃ H CF₃ O H H OCH₃ H H CH₃ 9 79N CF₃ H CF₃ O H H CH₃ H HCH₃ 9 80N CF₃ H CF₃ O H CH₃ H H H CH₃ 9 81N CF₃ H CF₃ O CH₃ H H H H CH₃9 82N CF₃ H CF₃ O H F F H H CH₃ 9 83N CF₃ H CF₃ O H F H F H CH₃ 9 84NCF₃ H CF₃ O F F H H H CH₃ 9 85N CF₃ H CF₃ O F CF₃ H H H CH₃ 9 86N CF₃ HCF₃ O H H CH₃ H H CF₃ 9 87N CF₃ H CF₃ O CH₃ H H H H CF₃ 9 88N CF₃ H CF₃O H CF₃ H H H CH₃ 9 89N CF₃ H CF₃ O OCH₃ H H H H CH₃ 9 90N CF₃ H CF₃ O HH CF₃ H H CH₃ 9 91N CF₃ H CF₃ O CF₃ H H H H CH₃ 9 92N CF₃ H CF₃ O H CF₃F H H CH₃ 10  1N CF₃ CF₃ H O H C₆H₅O H H OCF₂CF₂H H 10  2N CF₃ CF₃ H O HOCF₃ H H OCF₂CF₂H H 10  3N CF₃ CF₃ H O F H H F OCF₂CF₂H H 10  4N CF₃ CF₃H O H F H H OCF₂CF₂H H 10  5N CF₃ CF₃ H O H C₆H₅O H H OCF₃ H 10  6N CF₃CF₃ H O H OCF₃ H H OCF₃ H 10  7N CF₃ CF₃ H O H H phenyl H OCF₃ H 10  8NCF₃ CF₃ H O H phenyl H H OCF₃ H 10  9N CF₃ CF₃ H O H H H H OCF₃ H 10 10NCF₃ CF₃ H O H Br H H OCF₃ H 10 11N CF₃ CF₃ H O H CF₃ F H CF₃ H 10 12NCF₃ CF₃ H O H CH₃ H H CF₃ H 10 13N CF₃ CF₃ H O H CF₃ H H CF₃ H 10 14NCF₃ CF₃ H O H CH₃ H H OCF₃ H 10 15N CF₃ CF₃ H O H F F H OCF₃ H 10 16NCF₃ CF₃ H O H Br H H CF₃ H 10 17N CF₃ CF₃ H O H CF₃ F H OCF₃ H 10 18NCF₃ CF₃ H O H F H H OCF₃ H 10 19N CF₃ CF₃ H O H Cl H H OCF₃ H 10 20N CF₃CF₃ H O H F H H CF₃ H 10 21N CF₃ CF₃ H O H F F H CF₃ H 10 22N CF₃ CF₃ HO H Cl H H CF₃ H 10 23N CF₃ CF₃ H O H F H H phenoxy H 10 24N CF₃ CF₃ H OH CF₃ Cl H CH₃ H 10 25N CF₃ CF₃ H O H CF₃ F H CH₃ H 10 26N CF₃ CF₃ H O HH H H CF₃ H 10 27N CF₃ CF₃ H O F F H H CF₃ H 10 28N CF₃ CF₃ H O H H OCH₃H CF₃ H 10 29N CF₃ CF₃ H O H F F H CH₃ H 10 30N CF₃ CF₃ H O H OCH₃ H HCH₃ H 10 31N CF₃ CF₃ H O H H CH₃ H H H 10 32N CF₃ CF₃ H O H Cl H H H H10 33N CF₃ CF₃ H O H F H H F H 10 34N CF₃ CF₃ H O H H OCH₃ H CH₃ H 1035N CF₃ CF₃ H O H H H H H H 10 36N CF₃ CF₃ H O H H CH₃ H CH₃ H 10 37NCF₃ CF₃ H O H H Cl H H H 10 38N CF₃ CF₃ H O H F H H 3-CF₃-phenoxy H 1039N CF₃ CF₃ H O H F H H 4-CH₃O-phenoxy H 10 40N CF₃ CF₃ H O H F H H4-Cl-phenoxy H 10 41N CF₃ CF₃ H O H F H H H H 10 42N CF₃ CF₃ H O H F H HCH₃ H 10 43N CF₃ CF₃ H O H F H F CH₃ H 10 44N CF₃ CF₃ H O F F H H CH₃ H10 45N CF₃ CF₃ H O H Cl H H CH₃ H 10 46N CF₃ CF₃ H O H CH₃ H H CH₃ H 1047N CF₃ CF₃ H O CH₃ H H H H H 10 48N CF₃ CF₃ H O H H CH₃ H CF₃ H 10 49NCF₃ CF₃ H O CH₃ H H H CF₃ H 10 50N CF₃ CF₃ H O CH₃ H H H CH₃ H 10 51NCF₃ CF₃ H O H H CH₃ H F H 10 52N CF₃ CF₃ H O H CF₃ H H F H 10 53N CF₃CF₃ H O H CF₃ H H CH₃ H 10 54N CF₃ CF₃ H O H OCH₃ H H CF₃ H 10 55N CF₃CF₃ H O OCH₃ H H H CH₃ H 10 56N CF₃ CF₃ H O H H CH₃ H CF₃ H 10 57N CF₃CF₃ H O H C₆H₅O H H H OCF₃ 10 58N CF₃ CF₃ H O H H H H H OCF₃ 10 59N CF₃CF₃ H O H OCF₃ H H H OCF₃ 10 60N CF₃ CF₃ H O H CF₃ F H H CF₃ 10 61N CF₃CF₃ H O H H OCH₃ H H CF₃ 10 62N CF₃ CF₃ H O H CH₃ H H H CF₃ 10 63N CF₃CF₃ H O H Cl H H H CF₃ 10 64N CF₃ CF₃ H O H CF₃ H H H OCF₃ 10 65N CF₃CF₃ H O H F H H H OCF₃ 10 66N CF₃ CF₃ H O H F H F H OCF₃ 10 67N CF₃ CF₃H O H Br H H H OCF₃ 10 68N CF₃ CF₃ H O H Cl H H H OCF₃ 10 69N CF₃ CF₃ HO H F F H H OCF₃ 10 70N CF₃ CF₃ H O H F H H H phenyl 10 71N CF₃ CF₃ H OH CH₃ H H H OCF₃ 10 72N CF₃ CF₃ H O H F F H H CF₃ 10 73N CF₃ CF₃ H O HCl H H H CH₃ 10 74N CF₃ CF₃ H O H OCH₃ H H H CH₃ 10 75N CF₃ CF₃ H O H FH H H CH₃ 10 76N CF₃ CF₃ H O F F H H H OCF₃ 10 77N CF₃ CF₃ H O OCH₃ H HH H CF₃ 10 78N CF₃ CF₃ H O H H OCH₃ H H CH₃ 10 79N CF₃ CF₃ H O H H CH₃ HH CH₃ 10 80N CF₃ CF₃ H O H CH₃ H H H CH₃ 10 81N CF₃ CF₃ H O CH₃ H H H HCH₃ 10 82N CF₃ CF₃ H O H F F H H CH₃ 10 83N CF₃ CF₃ H O H F H F H CH₃ 1084N CF₃ CF₃ H O F F H H H CH₃ 10 85N CF₃ CF₃ H O F CF₃ H H H CH₃ 10 86NCF₃ CF₃ H O H H CH₃ H H CF₃ 10 87N CF₃ CF₃ H O CH₃ H H H H CF₃ 10 88NCF₃ CF₃ H O H CF₃ H H H CH₃ 10 89N CF₃ CF₃ H O OCH₃ H H H H CH₃ 10 90NCF₃ CF₃ H O H H CF₃ H H CH₃ 10 91N CF₃ CF₃ H O CF₃ H H H H CH₃ 10 92NCF₃ CF₃ H O H CF₃ F H H CH₃ 11  1N CF₃ C₆H₅ H O H C₆H₅O H H OCF₂CF₂H H11  2N CF₃ C₆H₅ H O H OCF₃ H H OCF₂CF₂H H 11  3N CF₃ C₆H₅ H O F H H FOCF₂CF₂H H 11  4N CF₃ C₆H₅ H O H F H H OCF₂CF₂H H 11  5N CF₃ C₆H₅ H O HC₆H₅O H H OCF₃ H 11  6N CF₃ C₆H₅ H O H OCF₃ H H OCF₃ H 11  7N CF₃ C₆H₅ HO H H phenyl H OCF₃ H 11  8N CF₃ C₆H₅ H O H phenyl H H OCF₃ H 11  9N CF₃C₆H₅ H O H H H H OCF₃ H 11 10N CF₃ C₆H₅ H O H Br H H OCF₃ H 11 11N CF₃C₆H₅ H O H CF₃ F H CF₃ H 11 12N CF₃ C₆H₅ H O H CH₃ H H CF₃ H 11 13N CF₃C₆H₅ H O H CF₃ H H CF₃ H 11 14N CF₃ C₆H₅ H O H CH₃ H H OCF₃ H 11 15N CF₃C₆H₅ H O H F F H OCF₃ H 11 16N CF₃ C₆H₅ H O H Br H H CF₃ H 11 17N CF₃C₆H₅ H O H CF₃ F H OCF₃ H 11 18N CF₃ C₆H₅ H O H F H H OCF₃ H 11 19N CF₃C₆H₅ H O H Cl H H OCF₃ H 11 20N CF₃ C₆H₅ H O H F H H CF₃ H 11 21N CF₃C₆H₅ H O H F F H CF₃ H 11 22N CF₃ C₆H₅ H O H Cl H H CF₃ H 11 23N CF₃C₆H₅ H O H F H H phenoxy H 11 24N CF₃ C₆H₅ H O H CF₃ Cl H CH₃ H 11 25NCF₃ C₆H₅ H O H CF₃ F H CH₃ H 11 26N CF₃ C₆H₅ H O H H H H CF₃ H 11 27NCF₃ C₆H₅ H O F F H H CF₃ H 11 28N CF₃ C₆H₅ H O H H OCH₃ H CF₃ H 11 29NCF₃ C₆H₅ H O H F F H CH₃ H 11 30N CF₃ C₆H₅ H O H OCH₃ H H CH₃ H 11 31NCF₃ C₆H₅ H O H H CH₃ H H H 11 32N CF₃ C₆H₅ H O H Cl H H H H 11 33N CF₃C₆H₅ H O H F H H F H 11 34N CF₃ C₆H₅ H O H H OCH₃ H CH₃ H 11 35N CF₃C₆H₅ H O H H H H H H 11 36N CF₃ C₆H₅ H O H H CH₃ H CH₃ H 11 37N CF₃ C₆H₅H O H H Cl H H H 11 38N CF₃ C₆H₅ H O H F H H 3-CF₃-phenoxy H 11 39N CF₃C₆H₅ H O H F H H 4-CH₃O-phenoxy H 11 40N CF₃ C₆H₅ H O H F H H4-Cl-phenoxy H 11 41N CF₃ C₆H₅ H O H F H H H H 11 42N CF₃ C₆H₅ H O H F HH CH₃ H 11 43N CF₃ C₆H₅ H O H F H F CH₃ H 11 44N CF₃ C₆H₅ H O F F H HCH₃ H 11 45N CF₃ C₆H₅ H O H Cl H H CH₃ H 11 46N CF₃ C₆H₅ H O H CH₃ H HCH₃ H 11 47N CF₃ C₆H₅ H O CH₃ H H H H H 11 48N CF₃ C₆H₅ H O H H CH₃ HCF₃ H 11 49N CF₃ C₆H₅ H O CH₃ H H H CF₃ H 11 50N CF₃ C₆H₅ H O CH₃ H H HCH₃ H 11 51N CF₃ C₆H₅ H O H H CH₃ H F H 11 52N CF₃ C₆H₅ H O H CF₃ H H FH 11 53N CF₃ C₆H₅ H O H CF₃ H H CH₃ H 11 54N CF₃ C₆H₅ H O H OCH₃ H H CF₃H 11 55N CF₃ C₆H₅ H O OCH₃ H H H CH₃ H 11 56N CF₃ C₆H₅ H O H H CH₃ H CF₃H 11 57N CF₃ C₆H₅ H O H C₆H₅O H H H OCF₃ 11 58N CF₃ C₆H₅ H O H H H H HOCF₃ 11 59N CF₃ C₆H₅ H O H OCF₃ H H H OCF₃ 11 60N CF₃ C₆H₅ H O H CF₃ F HH CF₃ 11 61N CF₃ C₆H₅ H O H H OCH₃ H H CF₃ 11 62N CF₃ C₆H₅ H O H CH₃ H HH CF₃ 11 63N CF₃ C₆H₅ H O H Cl H H H CF₃ 11 64N CF₃ C₆H₅ H O H CF₃ H H HOCF₃ 11 65N CF₃ C₆H₅ H O H F H H H OCF₃ 11 66N CF₃ C₆H₅ H O H F H F HOCF₃ 11 67N CF₃ C₆H₅ H O H Br H H H OCF₃ 11 68N CF₃ C₆H₅ H O H Cl H H HOCF₃ 11 69N CF₃ C₆H₅ H O H F F H H OCF₃ 11 70N CF₃ C₆H₅ H O H F H H Hphenyl 11 71N CF₃ C₆H₅ H O H CH₃ H H H OCF₃ 11 72N CF₃ C₆H₅ H O H F F HH CF₃ 11 73N CF₃ C₆H₅ H O H Cl H H H CH₃ 11 74N CF₃ C₆H₅ H O H OCH₃ H HH CH₃ 11 75N CF₃ C₆H₅ H O H F H H H CH₃ 11 76N CF₃ C₆H₅ H O F F H H HOCF₃ 11 77N CF₃ C₆H₅ H O OCH₃ H H H H CF₃ 11 78N CF₃ C₆H₅ H O H H OCH₃ HH CH₃ 11 79N CF₃ C₆H₅ H O H H CH₃ H H CH₃ 11 80N CF₃ C₆H₅ H O H CH₃ H HH CH₃ 11 81N CF₃ C₆H₅ H O CH₃ H H H H CH₃ 11 82N CF₃ C₆H₅ H O H F F H HCH₃ 11 83N CF₃ C₆H₅ H O H F H F H CH₃ 11 84N CF₃ C₆H₅ H O F F H H H CH₃11 85N CF₃ C₆H₅ H O F CF₃ H H H CH₃ 11 86N CF₃ C₆H₅ H O H H CH₃ H H CF₃11 87N CF₃ C₆H₅ H O CH₃ H H H H CF₃ 11 88N CF₃ C₆H₅ H O H CF₃ H H H CH₃11 89N CF₃ C₆H₅ H O OCH₃ H H H H CH₃ 11 90N CF₃ C₆H₅ H O H H CF₃ H H CH₃11 91N CF₃ C₆H₅ H O CF₃ H H H H CH₃ 11 92N CF₃ C₆H₅ H O H CF₃ F H H CH₃12  1N CCl₃ C₆H₅ H O H C₆H₅O H H OCF₂CF₂H H 12  2N CCl₃ C₆H₅ H O H OCF₃H H OCF₂CF₂H H 12  3N CCl₃ C₆H₅ H O F H H F OCF₂CF₂H H 12  4N CCl₃ C₆H₅H O H F H H OCF₂CF₂H H 12  5N CCl₃ C₆H₅ H O H C₆H₅O H H OCF₃ H 12  6NCCl₃ C₆H₅ H O H OCF₃ H H OCF₃ H 12  7N CCl₃ C₆H₅ H O H H phenyl H OCF₃ H12  8N CCl₃ C₆H₅ H O H phenyl H H OCF₃ H 12  9N CCl₃ C₆H₅ H O H H H HOCF₃ H 12 10N CCl₃ C₆H₅ H O H Br H H OCF₃ H 12 11N CCl₃ C₆H₅ H O H CF₃ FH CF₃ H 12 12N CCl₃ C₆H₅ H O H CH₃ H H CF₃ H 12 13N CCl₃ C₆H₅ H O H CF₃H H CF₃ H 12 14N CCl₃ C₆H₅ H O H CH₃ H H OCF₃ H 12 15N CCl₃ C₆H₅ H O H FF H OCF₃ H 12 16N CCl₃ C₆H₅ H O H Br H H CF₃ H 12 17N CCl₃ C₆H₅ H O HCF₃ F H OCF₃ H 12 18N CCl₃ C₆H₅ H O H F H H OCF₃ H 12 19N CCl₃ C₆H₅ H OH Cl H H OCF₃ H 12 20N CCl₃ C₆H₅ H O H F H H CF₃ H 12 21N CCl₃ C₆H₅ H OH F F H CF₃ H 12 22N CCl₃ C₆H₅ H O H Cl H H CF₃ H 12 23N CCl₃ C₆H₅ H O HF H H phenoxy H 12 24N CCl₃ C₆H₅ H O H CF₃ Cl H CH₃ H 12 25N CCl₃ C₆H₅ HO H CF₃ F H CH₃ H 12 26N CCl₃ C₆H₅ H O H H H H CF₃ H 12 27N CCl₃ C₆H₅ HO F F H H CF₃ H 12 28N CCl₃ C₆H₅ H O H H OCH₃ H CF₃ H 12 29N CCl₃ C₆H₅ HO H F F H CH₃ H 12 30N CCl₃ C₆H₅ H O H OCH₃ H H CH₃ H 12 31N CCl₃ C₆H₅ HO H H CH₃ H H H 12 32N CCl₃ C₆H₅ H O H Cl H H H H 12 33N CCl₃ C₆H₅ H O HF H H F H 12 34N CCl₃ C₆H₅ H O H H OCH₃ H CH₃ H 12 35N CCl₃ C₆H₅ H O H HH H H H 12 36N CCl₃ C₆H₅ H O H H CH₃ H CH₃ H 12 37N CCl₃ C₆H₅ H O H H ClH H H 12 38N CCl₃ C₆H₅ H O H F H H 3-CF₃-phenoxy H 12 39N CCl₃ C₆H₅ H OH F H H 4-CH₃O-phenoxy H 12 40N CCl₃ C₆H₅ H O H F H H 4-Cl-phenoxy H 1241N CCl₃ C₆H₅ H O H F H H H H 12 42N CCl₃ C₆H₅ H O H F H H CH₃ H 12 43NCCl₃ C₆H₅ H O H F H F CH₃ H 12 44N CCl₃ C₆H₅ H O F F H H CH₃ H 12 45NCCl₃ C₆H₅ H O H Cl H H CH₃ H 12 46N CCl₃ C₆H₅ H O H CH₃ H H CH₃ H 12 47NCCl₃ C₆H₅ H O CH₃ H H H H H 12 48N CCl₃ C₆H₅ H O H H CH₃ H CF₃ H 12 49NCCl₃ C₆H₅ H O CH₃ H H H CF₃ H 12 50N CCl₃ C₆H₅ H O CH₃ H H H CH₃ H 1251N CCl₃ C₆H₅ H O H H CH₃ H F H 12 52N CCl₃ C₆H₅ H O H CF₃ H H F H 1253N CCl₃ C₆H₅ H O H CF₃ H H CH₃ H 12 54N CCl₃ C₆H₅ H O H OCH₃ H H CF₃ H12 55N CCl₃ C₆H₅ H O OCH₃ H H H CH₃ H 12 56N CCl₃ C₆H₅ H O H H CH₃ H CF₃H 12 57N CCl₃ C₆H₅ H O H C₆H₅O H H H OCF₃ 12 58N CCl₃ C₆H₅ H O H H H H HOCF₃ 12 59N CCl₃ C₆H₅ H O H OCF₃ H H H OCF₃ 12 60N CCl₃ C₆H₅ H O H CF₃ FH H CF₃ 12 61N CCl₃ C₆H₅ H O H H OCH₃ H H CF₃ 12 62N CCl₃ C₆H₅ H O H CH₃H H H CF₃ 12 63N CCl₃ C₆H₅ H O H Cl H H H CF₃ 12 64N CCl₃ C₆H₅ H O H CF₃H H H OCF₃ 12 65N CCl₃ C₆H₅ H O H F H H H OCF₃ 12 66N CCl₃ C₆H₅ H O H FH F H OCF₃ 12 67N CCl₃ C₆H₅ H O H Br H H H OCF₃ 12 68N CCl₃ C₆H₅ H O HCl H H H OCF₃ 12 69N CCl₃ C₆H₅ H O H F F H H OCF₃ 12 70N CCl₃ C₆H₅ H O HF H H H phenyl 12 71N CCl₃ C₆H₅ H O H CH₃ H H H OCF₃ 12 72N CCl₃ C₆H₅ HO H F F H H CF₃ 12 73N CCl₃ C₆H₅ H O H Cl H H H CH₃ 12 74N CCl₃ C₆H₅ H OH OCH₃ H H H CH₃ 12 75N CCl₃ C₆H₅ H O H F H H H CH₃ 12 76N CCl₃ C₆H₅ H OF F H H H OCF₃ 12 77N CCl₃ C₆H₅ H O OCH₃ H H H H CF₃ 12 78N CCl₃ C₆H₅ HO H H OCH₃ H H CH₃ 12 79N CCl₃ C₆H₅ H O H H CH₃ H H CH₃ 12 80N CCl₃ C₆H₅H O H CH₃ H H H CH₃ 12 81N CCl₃ C₆H₅ H O CH₃ H H H H CH₃ 12 82N CCl₃C₆H₅ H O H F F H H CH₃ 12 83N CCl₃ C₆H₅ H O H F H F H CH₃ 12 84N CCl₃C₆H₅ H O F F H H H CH₃ 12 85N CCl₃ C₆H₅ H O F CF₃ H H H CH₃ 12 86N CCl₃C₆H₅ H O H H CH₃ H H CF₃ 12 87N CCl₃ C₆H₅ H O CH₃ H H H H CF₃ 12 88NCCl₃ C₆H₅ H O H CF₃ H H H CH₃ 12 89N CCl₃ C₆H₅ H O OCH₃ H H H H CH₃ 1290N CCl₃ C₆H₅ H O H H CF₃ H H CH₃ 12 91N CCl₃ C₆H₅ H O CF₃ H H H H CH₃12 92N CCl₃ C₆H₅ H O H CF₃ F H H CH₃

TABLE 5 Structure of Substituted Phenyl tertiary-2-Heteroalkylamines (Zis covalent bond; Y is CH and R₁₄ is H).

Inhibitor Number Column 1 + Column 2 Reagent Reagent R₁ R₂ R₃ R₁₆ X R₄R₅ R₆ R₇ R₁₀ R₁₁ 13  1N CCl₃ cyclo-propyl H H O H C₆H₅O H H OCF₂CF₂H H13  2N CCl₃ cyclo-propyl H H O H OCF₃ H H OCF₂CF₂H H 13  3N CCl₃cyclo-propyl H H O F H H F OCF₂CF₂H H 13  4N CCl₃ cyclo-propyl H H O H FH H OCF₂CF₂H H 13  5N CCl₃ cyclo-propyl H H O H C₆H₅O H H OCF₃ H 13  6NCCl₃ cyclo-propyl H H O H OCF₃ H H OCF₃ H 13  7N CCl₃ cyclo-propyl H H OH H C₆H₅ H OCF₃ H 13  8N CCl₃ cyclo-propyl H H O H C₆H₅ H H OCF₃ H 13 9N CCl₃ cyclo-propyl H H O H H H H OCF₃ H 13 10N CCl₃ cyclo-propyl H HO H Br H H OCF₃ H 13 11N CCl₃ cyclo-propyl H H O H CF₃ F H CF₃ H 13 12NCCl₃ cyclo-propyl H H O H CH₃ H H CF₃ H 13 13N CCl₃ cyclo-propyl H H O HCF₃ H H CF₃ H 13 14N CCl₃ cyclo-propyl H H O H CH₃ H H OCF₃ H 13 15NCCl₃ cyclo-propyl H H O H F F H OCF₃ H 13 16N CCl₃ cyclo-propyl H H O HBr H H CF₃ H 13 17N CCl₃ cyclo-propyl H H O H CF₃ F H OCF₃ H 13 18N CCl₃cyclo-propyl H H O H F H H OCF₃ H 13 19N CCl₃ cyclo-propyl H H O H Cl HH OCF₃ H 13 20N CCl₃ cyclo-propyl H H O H F H H CF₃ H 13 21N CCl₃cyclo-propyl H H O H F F H CF₃ H 13 22N CCl₃ cyclo-propyl H H O H Cl H HCF₃ H 13 23N CCl₃ cyclo-propyl H H O H F H H phenoxy H 13 24N CCl₃cyclo-propyl H H O H CF₃ Cl H CH₃ H 13 25N CCl₃ cyclo-propyl H H O H CF₃F H CH₃ H 13 26N CCl₃ cyclo-propyl H H O H H H H CF₃ H 13 27N CCl₃cyclo-propyl H H O F F H H CF₃ H 13 28N CCl₃ cyclo-propyl H H O H H OCH₃H CF₃ H 13 29N CCl₃ cyclo-propyl H H O H F F H CH₃ H 13 30N CCl₃cyclo-propyl H H O H OCH₃ H H CH₃ H 13 31N CCl₃ cyclo-propyl H H O H HCH₃ H H H 13 32N CCl₃ cyclo-propyl H H O H Cl H H H H 13 33N CCl₃cyclo-propyl H H O H F H H F H 13 34N CCl₃ cyclo-propyl H H O H H OCH₃ HCH₃ H 13 35N CCl₃ cyclo-propyl H H O H H H H H H 13 36N CCl₃cyclo-propyl H H O H H CH₃ H CH₃ H 13 37N CCl₃ cyclo-propyl H H O H H C1H H H 13 38N CCl₃ cyclo-propyl H H O H F H H 3-CF₃-phenoxy H 13 39N CCl₃cyclo-propyl H H O H F H H 4-CH₃O-phenoxy H 13 40N CCl₃ cyclo-propyl H HO H F H H 4-Cl-phenoxy H 13 41N CCl₃ cyclo-propyl H H O H F H H H H 1342N CCl₃ cyclo-propyl H H O H F H H CH₃ H 13 43N CCl₃ cyclo-propyl H H OH F H F CH₃ H 13 44N CCl₃ cyclo-propyl H H O F F H H CH₃ H 13 45N CCl₃cyclo-propyl H H O H Cl H H CH₃ H 13 46N CCl₃ cyclo-propyl H H O H CH₃ HH CH₃ H 13 47N CCl₃ cyclo-propyl H H O CH₃ H H H H H 13 48N CCl₃cyclo-propyl H H O H H CH₃ H CF₃ H 13 49N CCl₃ cyclo-propyl H H O CH₃ HH H CF₃ H 13 50N CCl₃ cyclo-propyl H H O CH₃ H H H CH₃ H 13 51N CCl₃cyclo-propyl H H O H H CH₃ H F H 13 52N CCl₃ cyclo-propyl H H O H CF₃ HH F H 13 53N CCl₃ cyclo-propyl H H O H CF₃ H H CH₃ H 13 54N CCl₃cyclo-propyl H H O H OCH₃ H H CF₃ H 13 55N CCl₃ cyclo-propyl H H O OCH₃H H H CH₃ H 13 56N CCl₃ cyclo-propyl H H O H H CH₃ H CF₃ H 13 57N CCl₃cyclo-propyl H H O H C₆H₅O H H H OCF₃ 13 58N CCl₃ cyclo-propyl H H O H HH H H OCF₃ 13 59N CCl₃ cyclo-propyl H H O H OCF₃ H H H OCF₃ 13 60N CCl₃cyclo-propyl H H O H CF₃ F H H CF₃ 13 61N CCl₃ cyclo-propyl H H O H HOCH₃ H H CF₃ 13 62N CCl₃ cyclo-propyl H H O H CH₃ H H H CF₃ 13 63N CCl₃cyclo-propyl H H O H Cl H H H CF₃ 13 64N CCl₃ cyclo-propyl H H O H CF₃ HH H OCF₃ 13 65N CCl₃ cyclo-propyl H H O H F H H H OCF₃ 13 66N CCl₃cyclo-propyl H H O H F H F H OCF₃ 13 67N CCl₃ cyclo-propyl H H O H Br HH H OCF₃ 13 68N CCl₃ cyclo-propyl H H O H Cl H H H OCF₃ 13 69N CCl₃cyclo-propyl H H O H F F H H OCF₃ 13 70N CCl₃ cyclo-propyl H H O H F H HH C₆H₅ 13 71N CCl₃ cyclo-propyl H H O H CH₃ H H H OCF₃ 13 72N CCl₃cyclo-propyl H H O H F F H H CF₃ 13 73N CCl₃ cyclo-propyl H H O H Cl H HH CH₃ 13 74N CCl₃ cyclo-propyl H H O H OCH₃ H H H CH₃ 13 75N CCl₃cyclo-propyl H H O H F H H H CH₃ 13 76N CCl₃ cyclo-propyl H H O F F H HH OCF₃ 13 77N CCl₃ cyclo-propyl H H O OCH₃ H H H H CF₃ 13 78N CCl₃cyclo-propyl H H O H H OCH₃ H H CH₃ 13 79N CCl₃ cyclo-propyl H H O H HCH₃ H H CH₃ 13 80N CCl₃ cyclo-propyl H H O H CH₃ H H H CH₃ 13 81N CCl₃cyclo-propyl H H O CH₃ H H H H CH₃ 13 82N CCl₃ cyclo-propyl H H O H F FH H CH₃ 13 83N CCl₃ cyclo-propyl H H O H F H F H CH₃ 13 84N CCl₃cyclo-propyl H H O F F H H H CH₃ 13 85N CCl₃ cyclo-propyl H H O F CF₃ HH H CH₃ 13 86N CCl₃ cyclo-propyl H H O H H CH₃ H H CF₃ 13 87N CCl₃cyclo-propyl H H O CH₃ H H H H CF₃ 13 88N CCl₃ cyclo-propyl H H O H CF₃H H H CH₃ 13 89N CCl₃ cyclo-propyl H H O OCH₃ H H H H CH₃ 13 90N CCl₃cyclo-propyl H H O H H CF₃ H H CH₃ 13 91N CCl₃ cyclo-propyl H H O CF₃ HH H H CH₃ 13 92N CCl₃ cyclo-propyl H H O H CF₃ F H H CH₃ 14  1N CCl₃ CH₃H H O H C₆H₅O H H OCF₂CF₂H H 14  2N CCl₃ CH₃ H H O H OCF₃ H H OCF₂CF₂H H14  3N CCl₃ CH₃ H H O F H H F OCF₂CF₂H H 14  4N CCl₃ CH₃ H H O H F H HOCF₂CF₂H H 14  5N CCl₃ CH₃ H H O H C₆H₅O H H OCF₃ H 14  6N CCl₃ CH₃ H HO H OCF₃ H H OCF₃ H 14  7N CCl₃ CH₃ H H O H H phenyl H OCF₃ H 14  8NCCl₃ CH₃ H H O H phenyl H H OCF₃ H 14  9N CCl₃ CH₃ H H O H H H H OCF₃ H14 10N CCl₃ CH₃ H H O H Br H H OCF₃ H 14 11N CCl₃ CH₃ H H O H CF₃ F HCF₃ H 14 12N CCl₃ CH₃ H H O H CH₃ H H CF₃ H 14 13N CCl₃ CH₃ H H O H CF₃H H CF₃ H 14 14N CCl₃ CH₃ H H O H CH₃ H H OCF₃ H 14 15N CCl₃ CH₃ H H O HF F H OCF₃ H 14 16N CCl₃ CH₃ H H O H Br H H CF₃ H 14 17N CCl₃ CH₃ H H OH CF₃ F H OCF₃ H 14 18N CCl₃ CH₃ H H O H F H H OCF₃ H 14 19N CCl₃ CH₃ HH O H Cl H H OCF₃ H 14 20N CCl₃ CH₃ H H O H F H H CF₃ H 14 21N CCl₃ CH₃H H O H F F H CF₃ H 14 22N CCl₃ CH₃ H H O H Cl H H CF₃ H 14 23N CCl₃ CH₃H H O H F H H phenoxy H 14 24N CCl₃ CH₃ H H O H CF₃ Cl H CH₃ H 14 25NCCl₃ CH₃ H H O H CF₃ F H CH₃ H 14 26N CCl₃ CH₃ H H O H H H H CF₃ H 1427N CCl₃ CH₃ H H O F F H H CF₃ H 14 28N CCl₃ CH₃ H H O H H OCH₃ H CF₃ H14 29N CCl₃ CH₃ H H O H F F H CH₃ H 14 30N CCl₃ CH₃ H H O H OCH₃ H H CH₃H 14 31N CCl₃ CH₃ H H O H H CH₃ H H H 14 32N CCl₃ CH₃ H H O H Cl H H H H14 33N CCl₃ CH₃ H H O H F H H F H 14 34N CCl₃ CH₃ H H O H H OCH₃ H CH₃ H14 35N CCl₃ CH₃ H H O H H H H H H 14 36N CCl₃ CH₃ H H O H H CH₃ H CH₃ H14 37N CCl₃ CH₃ H H O H H Cl H H H 14 38N CCl₃ CH₃ H H O H F H H3-CF₃-phenoxy H 14 39N CCl₃ CH₃ H H O H F H H 4-CH₃O-phenoxy H 14 40NCCl₃ CH₃ H H O H F H H 4-Cl-phenoxy H 14 41N CCl₃ CH₃ H H O H F H H H H14 42N CCl₃ CH₃ H H O H F H H CH₃ H 14 43N CCl₃ CH₃ H H O H F H F CH₃ H14 44N CCl₃ CH₃ H H O F F H H CH₃ H 14 45N CCl₃ CH₃ H H O H Cl H H CH₃ H14 46N CCl₃ CH₃ H H O H CH₃ H H CH₃ H 14 47N CCl₃ CH₃ H H O CH₃ H H H HH 14 48N CCl₃ CH₃ H H O H H CH₃ H CF₃ H 14 49N CCl₃ CH₃ H H O CH₃ H H HCF₃ H 14 50N CCl₃ CH₃ H H O CH₃ H H H CH₃ H 14 51N CCl₃ CH₃ H H O H HCH₃ H F H 14 52N CCl₃ CH₃ H H O H CF₃ H H F H 14 53N CCl₃ CH₃ H H O HCF₃ H H CH₃ H 14 54N CCl₃ CH₃ H H O H OCH₃ H H CF₃ H 14 55N CCl₃ CH₃ H HO OCH₃ H H H CH₃ H 14 56N CCl₃ CH₃ H H O H H CH₃ H CF₃ H 14 57N CCl₃ CH₃H H O H C₆H₅O H H H OCF₃ 14 58N CCl₃ CH₃ H H O H H H H H OCF₃ 14 59NCCl₃ CH₃ H H O H OCF₃ H H H OCF₃ 14 60N CCl₃ CH₃ H H O H CF₃ F H H CF₃14 61N CCl₃ CH₃ H H O H H OCH₃ H H CF₃ 14 62N CCl₃ CH₃ H H O H CH₃ H H HCF₃ 14 63N CCl₃ CH₃ H H O H Cl H H H CF₃ 14 64N CCl₃ CH₃ H H O H CF₃ H HH OCF₃ 14 65N CCl₃ CH₃ H H O H F H H H OCF₃ 14 66N CCl₃ CH₃ H H O H F HF H OCF₃ 14 67N CCl₃ CH₃ H H O H Br H H H OCF₃ 14 68N CCl₃ CH₃ H H O HCl H H H OCF₃ 14 69N CCl₃ CH₃ H H O H F F H H OCF₃ 14 70N CCl₃ CH₃ H H OH F H H H C₆H₅ 14 71N CCl₃ CH₃ H H O H CH₃ H H H OCF₃ 14 72N CCl₃ CH₃ HH O H F F H H CF₃ 14 73N CCl₃ CH₃ H H O H Cl H H H CH₃ 14 74N CCl₃ CH₃ HH O H OCH₃ H H H CH₃ 14 75N CCl₃ CH₃ H H O H F H H H CH₃ 14 76N CCl₃ CH₃H H O F F H H H OCF₃ 14 77N CCl₃ CH₃ H H O OCH₃ H H H H CF₃ 14 78N CCl₃CH₃ H H O H H OCH₃ H H CH₃ 14 79N CCl₃ CH₃ H H O H H CH₃ H H CH₃ 14 80NCCl₃ CH₃ H H O H CH₃ H H H CH₃ 14 81N CCl₃ CH₃ H H O CH₃ H H H H CH₃ 1482N CCl₃ CH₃ H H O H F F H H CH₃ 14 83N CCl₃ CH₃ H H O H F H F H CH₃ 1484N CCl₃ CH₃ H H O F F H H H CH₃ 14 85N CCl₃ CH₃ H H O F CF₃ H H H CH₃14 86N CCl₃ CH₃ H H O H H CH₃ H H CF₃ 14 87N CCl₃ CH₃ H H O CH₃ H H H HCF₃ 14 88N CCl₃ CH₃ H H O H CF₃ H H H CH₃ 14 89N CCl₃ CH₃ H H O OCH₃ H HH H CH₃ 14 90N CCl₃ CH₃ H H O H H CF₃ H H CH₃ 14 91N CCl₃ CH₃ H H O CF₃H H H H CH₃ 14 92N CCl₃ CH₃ H H O H CF₃ F H H CH₃ 15  1N CCl₃ (CH₃)₂CH HH O H C₆H₅O H H OCF₂CF₂H H 15  2N CCl₃ (CH₃)₂CH H H O H OCF₃ H HOCF₂CF₂H H 15  3N CCl₃ (CH₃)₂CH H H O F H H F OCF₂CF₂H H 15  4N CCl₃(CH₃)₂CH H H O H F H H OCF₂CF₂H H 15  5N CCl₃ (CH₃)₂CH H H O H C₆H₅O H HOCF₃ H 15  6N CCl₃ (CH₃)₂CH H H O H OCF₃ H H OCF₃ H 15  7N CCl₃ (CH₃)₂CHH H O H H phenyl H OCF₃ H 15  8N CCl₃ (CH₃)₂CH H H O H phenyl H H OCF₃ H15  9N CCl₃ (CH₃)₂CH H H O H H H H OCF₃ H 15 10N CCl₃ (CH₃)₂CH H H O HBr H H OCF₃ H 15 11N CCl₃ (CH₃)₂CH H H O H CF₃ F H CF₃ H 15 12N CCl₃(CH₃)₂CH H H O H CH₃ H H CF₃ H 15 13N CCl₃ (CH₃)₂CH H H O H CF₃ H H CF₃H 15 14N CCl₃ (CH₃)₂CH H H O H CH₃ H H OCF₃ H 15 15N CCl₃ (CH₃)₂CH H H OH F F H OCF₃ H 15 16N CCl₃ (CH₃)₂CH H H O H Br H H CF₃ H 15 17N CCl₃(CH₃)₂CH H H O H CF₃ F H OCF₃ H 15 18N CCl₃ (CH₃)₂CH H H O H F H H OCF₃H 15 19N CCl₃ (CH₃)₂CH H H O H Cl H H OCF₃ H 15 20N CCl₃ (CH₃)₂CH H H OH F H H CF₃ H 15 21N CCl₃ (CH₃)₂CH H H O H F F H CF₃ H 15 22N CCl₃(CH₃)₂CH H H O H Cl H H CF₃ H 15 23N CCl₃ (CH₃)₂CH H H O H F H H phenoxyH 15 24N CCl₃ (CH₃)₂CH H H O H CF₃ Cl H CH₃ H 15 25N CCl₃ (CH₃)₂CH H H OH CF₃ F H CH₃ H 15 26N CCl₃ (CH₃)₂CH H H O H H H H CF₃ H 15 27N CCl₃(CH₃)₂CH H H O F F H H CF₃ H 15 28N CCl₃ (CH₃)₂CH H H O H H OCH₃ H CF₃ H15 29N CCl₃ (CH₃)₂CH H H O H F F H CH₃ H 15 30N CCl₃ (CH₃)₂CH H H O HOCH₃ H H CH₃ H 15 31N CCl₃ (CH₃)₂CH H H O H H CH₃ H H H 15 32N CCl₃(CH₃)₂CH H H O H Cl H H H H 15 33N CCl₃ (CH₃)₂CH H H O H F H H F H 1534N CCl₃ (CH₃)₂CH H H O H H OCH₃ H CH₃ H 15 35N CCl₃ (CH₃)₂CH H H O H HH H H H 15 36N CCl₃ (CH₃)₂CH H H O H H CH₃ H CH₃ H 15 37N CCl₃ (CH₃)₂CHH H O H H Cl H H H 15 38N CCl₃ (CH₃)₂CH H H O H F H H 3-CF₃-phenoxy H 1539N CCl₃ (CH₃)₂CH H H O H F H H 4-CH₃O-phenoxy H 15 40N CCl₃ (CH₃)₂CH HH O H F H H 4-Cl-phenoxy H 15 41N CCl₃ (CH₃)₂CH H H O H F H H H H 15 42NCCl₃ (CH₃)₂CH H H O H F H H CH₃ H 15 43N CCl₃ (CH₃)₂CH H H O H F H F CH₃H 15 44N CCl₃ (CH₃)₂CH H H O F F H H CH₃ H 15 45N CCl₃ (CH₃)₂CH H H O HCl H H CH₃ H 15 46N CCl₃ (CH₃)₂CH H H O H CH₃ H H CH₃ H 15 47N CCl₃(CH₃)₂CH H H O CH₃ H H H H H 15 48N CCl₃ (CH₃)₂CH H H O H H CH₃ H CF₃ H15 49N CCl₃ (CH₃)₂CH H H O CH₃ H H H CF₃ H 15 50N CCl₃ (CH₃)₂CH H H OCH₃ H H H CH₃ H 15 51N CCl₃ (CH₃)₂CH H H O H H CH₃ H F H 15 52N CCl₃(CH₃)₂CH H H O H CF₃ H H F H 15 53N CCl₃ (CH₃)₂CH H H O H CF₃ H H CH₃ H15 54N CCl₃ (CH₃)₂CH H H O H OCH₃ H H CF₃ H 15 55N CCl₃ (CH₃)₂CH H H OOCH₃ H H H CH₃ H 15 56N CCl₃ (CH₃)₂CH H H O H H CH₃ H CF₃ H 15 57N CCl₃(CH₃)₂CH H H O H C₆H₅O H H H OCF₃ 15 58N CCl₃ (CH₃)₂CH H H O H H H H HOCF₃ 15 59N CCl₃ (CH₃)₂CH H H O H OCF₃ H H H OCF₃ 15 60N CCl₃ (CH₃)₂CH HH O H CF₃ F H H CF₃ 15 61N CCl₃ (CH₃)₂CH H H O H H OCH₃ H H CF₃ 15 62NCCl₃ (CH₃)₂CH H H O H CH₃ H H H CF₃ 15 63N CCl₃ (CH₃)₂CH H H O H Cl H HH CF₃ 15 64N CCl₃ (CH₃)₂CH H H O H CF₃ H H H OCF₃ 15 65N CCl₃ (CH₃)₂CH HH O H F H H H OCF₃ 15 66N CCl₃ (CH₃)₂CH H H O H F H F H OCF₃ 15 67N CCl₃(CH₃)₂CH H H O H Br H H H OCF₃ 15 68N CCl₃ (CH₃)₂CH H H O H Cl H H HOCF₃ 15 69N CCl₃ (CH₃)₂CH H H O H F F H H OCF₃ 15 70N CCl₃ (CH₃)₂CH H HO H F H H H C₆H₅ 15 71N CCl₃ (CH₃)₂CH H H O H CH₃ H H H OCF₃ 15 72N CCl₃(CH₃)₂CH H H O H F F H H CF₃ 15 73N CCl₃ (CH₃)₂CH H H O H Cl H H H CH₃15 74N CCl₃ (CH₃)₂CH H H O H OCH₃ H H H CH₃ 15 75N CCl₃ (CH₃)₂CH H H O HF H H H CH₃ 15 76N CCl₃ (CH₃)₂CH H H O F F H H H OCF₃ 15 77N CCl₃(CH₃)₂CH H H O OCH₃ H H H H CF₃ 15 78N CCl₃ (CH₃)₂CH H H O H H OCH₃ H HCH₃ 15 79N CCl₃ (CH₃)₂CH H H O H H CH₃ H H CH₃ 15 80N CCl₃ (CH₃)₂CH H HO H CH₃ H H H CH₃ 15 81N CCl₃ (CH₃)₂CH H H O CH₃ H H H H CH₃ 15 82N CCl₃(CH₃)₂CH H H O H F F H H CH₃ 15 83N CCl₃ (CH₃)₂CH H H O H F H F H CH₃ 1584N CCl₃ (CH₃)₂CH H H O F F H H H CH₃ 15 85N CCl₃ (CH₃)₂CH H H O F CF₃ HH H CH₃ 15 86N CCl₃ (CH₃)₂CH H H O H H CH₃ H H CF₃ 15 87N CCl₃ (CH₃)₂CHH H O CH₃ H H H H CF₃ 15 88N CCl₃ (CH₃)₂CH H H O H CF₃ H H H CH₃ 15 89NCCl₃ (CH₃)₂CH H H O OCH₃ H H H H CH₃ 15 90N CCl₃ (CH₃)₂CH H H O H H CF₃H H CH₃ 15 91N CCl₃ (CH₃)₂CH H H O CF₃ H H H H CH₃ 15 92N CCl₃ (CH₃)₂CHH H O H CF₃ F H H CH₃ 16  1N CHCl₂ H H H O H C₆H₅O H H OCF₂CF₂H H 16  2NCHCl₂ H H H O H OCF₃ H H OCF₂CF₂H H 16  3N CHCl₂ H H H O F H H FOCF₂CF₂H H 16  4N CHCl₂ H H H O H F H H OCF₂CF₂H H 16  5N CHCl₂ H H H OH C₆H₅O H H OCF₃ H 16  6N CHCl₂ H H H O H OCF₃ H H OCF₃ H 16  7N CHCl₂ HH H O H H phenyl H OCF₃ H 16  8N CHCl₂ H H H O H phenyl H H OCF₃ H 16 9N CHCl₂ H H H O H H H H OCF₃ H 16 10N CHCl₂ H H H O H Br H H OCF₃ H 1611N CHCl₂ H H H O H CF₃ F H CF₃ H 16 12N CHCl₂ H H H O H CH₃ H H CF₃ H16 13N CHCl₂ H H H O H CF₃ H H CF₃ H 16 14N CHCl₂ H H H O H CH₃ H H OCF₃H 16 15N CHCl₂ H H H O H F F H OCF₃ H 16 16N CHCl₂ H H H O H Br H H CF₃H 16 17N CHCl₂ H H H O H CF₃ F H OCF₃ H 16 18N CHCl₂ H H H O H F H HOCF₃ H 16 19N CHCl₂ H H H O H Cl H H OCF₃ H 16 20N CHCl₂ H H H O H F H HCF₃ H 16 21N CHCl₂ H H H O H F F H CF₃ H 16 22N CHCl₂ H H H O H Cl H HCF₃ H 16 23N CHCl₂ H H H O H F H H phenoxy H 16 24N CHCl₂ H H H O H CF₃Cl H CH₃ H 16 25N CHCl₂ H H H O H CF₃ F H CH₃ H 16 26N CHCl₂ H H H O H HH H CF₃ H 16 27N CHCl₂ H H H O F F H H CF₃ H 16 28N CHCl₂ H H H O H HOCH₃ H CF₃ H 16 29N CHCl₂ H H H O H F F H CH₃ H 16 30N CHCl₂ H H H O HOCH₃ H H CH₃ H 16 31N CHCl₂ H H H O H H CH₃ H H H 16 32N CHCl₂ H H H O HCl H H H H 16 33N CHCl₂ H H H O H F H H F H 16 34N CHCl₂ H H H O H HOCH₃ H CH₃ H 16 35N CHCl₂ H H H O H H H H H H 16 36N CHCl₂ H H H O H HCH₃ H CH₃ H 16 37N CHCl₂ H H H O H H Cl H H H 16 38N CHCl₂ H H H O H F HH 3-CF₃-phenoxy H 16 39N CHCl₂ H H H O H F H H 4-CH₃O-phenoxy H 16 40NCHCl₂ H H H O H F H H 4-Cl-phenoxy H 16 41N CHCl₂ H H H O H F H H H H 1642N CHCl₂ H H H O H F H H CH₃ H 16 43N CHCl₂ H H H O H F H F CH₃ H 1644N CHCl₂ H H H O F F H H CH₃ H 16 45N CHCl₂ H H H O H Cl H H CH₃ H 1646N CHCl₂ H H H O H CH₃ H H CH₃ H 16 47N CHCl₂ H H H O CH₃ H H H H H 1648N CHCl₂ H H H O H H CH₃ H CF₃ H 16 49N CHCl₂ H H H O CH₃ H H H CF₃ H16 50N CHCl₂ H H H O CH₃ H H H CH₃ H 16 51N CHCl₂ H H H O H H CH₃ H F H16 52N CHCl₂ H H H O H CF₃ H H F H 16 53N CHCl₂ H H H O H CF₃ H H CH₃ H16 54N CHCl₂ H H H O H OCH₃ H H CF₃ H 16 55N CHCl₂ H H H O OCH₃ H H HCH₃ H 16 56N CHCl₂ H H H O H H CH₃ H CF₃ H 16 57N CHCl₂ H H H O H C₆H₅OH H H OCF₃ 16 58N CHCl₂ H H H O H H H H H OCF₃ 16 59N CHCl₂ H H H O HOCF₃ H H H OCF₃ 16 60N CHCl₂ H H H O H CF₃ F H H CF₃ 16 61N CHCl₂ H H HO H H OCH₃ H H CF₃ 16 62N CHCl₂ H H H O H CH₃ H H H CF₃ 16 63N CHCl₂ H HH O H Cl H H H CF₃ 16 64N CHCl₂ H H H O H CF₃ H H H OCF₃ 16 65N CHCl₂ HH H O H F H H H OCF₃ 16 66N CHCl₂ H H H O H F H F H OCF₃ 16 67N CHCl₂ HH H O H Br H H H OCF₃ 16 68N CHCl₂ H H H O H Cl H H H OCF₃ 16 69N CHCl₂H H H O H F F H H OCF₃ 16 70N CHCl₂ H H H O H F H H H C₆H₅ 16 71N CHCl₂H H H O H CH₃ H H H OCF₃ 16 72N CHCl₂ H H H O H F F H H CF₃ 16 73N CHCl₂H H H O H Cl H H H CH₃ 16 74N CHCl₂ H H H O H OCH₃ H H H CH₃ 16 75NCHCl₂ H H H O H F H H H CH₃ 16 76N CHCl₂ H H H O F F H H H OCF₃ 16 77NCHCl₂ H H H O OCH₃ H H H H CF₃ 16 78N CHCl₂ H H H O H H OCH₃ H H CH₃ 1679N CHCl₂ H H H O H H CH₃ H H CH₃ 16 80N CHCl₂ H H H O H CH₃ H H H CH₃16 81N CHCl₂ H H H O CH₃ H H H H CH₃ 16 82N CHCl₂ H H H O H F F H H CH₃16 83N CHCl₂ H H H O H F H F H CH₃ 16 84N CHCl₂ H H H O F F H H H CH₃ 1685N CHCl₂ H H H O F CF₃ H H H CH₃ 16 86N CHCl₂ H H H O H H CH₃ H H CF₃16 87N CHCl₂ H H H O CH₃ H H H H CF₃ 16 88N CHCl₂ H H H O H CF₃ H H HCH₃ 16 89N CHCl₂ H H H O OCH₃ H H H H CH₃ 16 90N CHCl₂ H H H O H H CF₃ HH CH₃ 16 91N CHCl₂ H H H O CF₃ H H H H CH₃ 16 92N CHCl₂ H H H O H CF₃ FH H CH₃ 18  1N CF₃ H CH₃ H O H C₆H₅O H H OCF₂CF₂H H 18  2N CF₃ H CH₃ H OH OCF₃ H H OCF₂CF₂H H 18  3N CF₃ H CH₃ H O F H H F OCF₂CF₂H H 18  4N CF₃H CH₃ H O H F H H OCF₂CF₂H H 18  5N CF₃ H CH₃ H O H C₆H₅O H H OCF₃ H 18 6N CF₃ H CH₃ H O H OCF₃ H H OCF₃ H 18  7N CF₃ H CH₃ H O H H phenyl HOCF₃ H 18  8N CF₃ H CH₃ H O H phenyl H H OCF₃ H 18  9N CF₃ H CH₃ H O H HH H OCF₃ H 18 10N CF₃ H CH₃ H O H Br H H OCF₃ H 18 11N CF₃ H CH₃ H O HCF₃ F H CF₃ H 18 12N CF₃ H CH₃ H O H CH₃ H H CF₃ H 18 13N CF₃ H CH₃ H OH CF₃ H H CF₃ H 18 14N CF₃ H CH₃ H O H CH₃ H H OCF₃ H 18 15N CF₃ H CH₃ HO H F F H OCF₃ H 18 16N CF₃ H CH₃ H O H Br H H CF₃ H 18 17N CF₃ H CH₃ HO H CF₃ F H OCF₃ H 18 18N CF₃ H CH₃ H O H F H H OCF₃ H 18 19N CF₃ H CH₃H O H Cl H H OCF₃ H 18 20N CF₃ H CH₃ H O H F H H CF₃ H 18 21N CF₃ H CH₃H O H F F H CF₃ H 18 22N CF₃ H CH₃ H O H Cl H H CF₃ H 18 23N CF₃ H CH₃ HO H F H H phenoxy H 18 24N CF₃ H CH₃ H O H CF₃ Cl H CH₃ H 18 25N CF₃ HCH₃ H O H CF₃ F H CH₃ H 18 26N CF₃ H CH₃ H O H H H H CF₃ H 18 27N CF₃ HCH₃ H O F F H H CF₃ H 18 28N CF₃ H CH₃ H O H H OCH₃ H CF₃ H 18 29N CF₃ HCH₃ H O H F F H CH₃ H 18 30N CF₃ H CH₃ H O H OCH₃ H H CH₃ H 18 31N CF₃ HCH₃ H O H H CH₃ H H H 18 32N CF₃ H CH₃ H O H Cl H H H H 18 33N CF₃ H CH₃H O H F H H F H 18 34N CF₃ H CH₃ H O H H OCH₃ H CH₃ H 18 35N CF₃ H CH₃ HO H H H H H H 18 36N CF₃ H CH₃ H O H H CH₃ H CH₃ H 18 37N CF₃ H CH₃ H OH H Cl H H H 18 38N CF₃ H CH₃ H O H F H H 3-CF₃-phenoxy H 18 39N CF₃ HCH₃ H O H F H H 4-CH₃O-phenoxy H 18 40N CF₃ H CH₃ H O H F H H4-Cl-phenoxy H 18 41N CF₃ H CH₃ H O H F H H H H 18 42N CF₃ H CH₃ H O H FH H CH₃ H 18 43N CF₃ H CH₃ H O H F H F CH₃ H 18 44N CF₃ H CH₃ H O F F HH CH₃ H 18 45N CF₃ H CH₃ H O H Cl H H CH₃ H 18 46N CF₃ H CH₃ H O H CH₃ HH CH₃ H 18 47N CF₃ H CH₃ H O CH₃ H H H H H 18 48N CF₃ H CH₃ H O H H CH₃H CF₃ H 18 49N CF₃ H CH₃ H O CH₃ H H H CF₃ H 18 50N CF₃ H CH₃ H O CH₃ HH H CH₃ H 18 51N CF₃ H CH₃ H O H H CH₃ H F H 18 52N CF₃ H CH₃ H O H CF₃H H F H 18 53N CF₃ H CH₃ H O H CF₃ H H CH₃ H 18 54N CF₃ H CH₃ H O H OCH₃H H CF₃ H 18 55N CF₃ H CH₃ H O OCH₃ H H H CH₃ H 18 56N CF₃ H CH₃ H O H HCH₃ H CF₃ H 18 57N CF₃ H CH₃ H O H C₆H₅O H H H OCF₃ 18 58N CF₃ H CH₃ H OH H H H H OCF₃ 18 59N CF₃ H CH₃ H O H OCF₃ H H H OCF₃ 18 60N CF₃ H CH₃ HO H CF₃ F H H CF₃ 18 61N CF₃ H CH₃ H O H H OCH₃ H H CF₃ 18 62N CF₃ H CH₃H O H CH₃ H H H CF₃ 18 63N CF₃ H CH₃ H O H Cl H H H CF₃ 18 64N CF₃ H CH₃H O H CF₃ H H H OCF₃ 18 65N CF₃ H CH₃ H O H F H H H OCF₃ 18 66N CF₃ HCH₃ H O H F H F H OCF₃ 18 67N CF₃ H CH₃ H O H Br H H H OCF₃ 18 68N CF₃ HCH₃ H O H Cl H H H OCF₃ 18 69N CF₃ H CH₃ H O H F F H H OCF₃ 18 70N CF₃ HCH₃ H O H F H H H C₆H₅ 18 71N CF₃ H CH₃ H O H CH₃ H H H OCF₃ 18 72N CF₃H CH₃ H O H F F H H CF₃ 18 73N CF₃ H CH₃ H O H Cl H H H CH₃ 18 74N CF₃ HCH₃ H O H OCH₃ H H H CH₃ 18 75N CF₃ H CH₃ H O H F H H H CH₃ 18 76N CF₃ HCH₃ H O F F H H H OCF₃ 18 77N CF₃ H CH₃ H O OCH₃ H H H H CF₃ 18 78N CF₃H CH₃ H O H H OCH₃ H H CH₃ 18 79N CF₃ H CH₃ H O H H CH₃ H H CH₃ 18 80NCF₃ H CH₃ H O H CH₃ H H H CH₃ 18 81N CF₃ H CH₃ H O CH₃ H H H H CH₃ 1882N CF₃ H CH₃ H O H F F H H CH₃ 18 83N CF₃ H CH₃ H O H F H F H CH₃ 1884N CF₃ H CH₃ H O F F H H H CH₃ 18 85N CF₃ H CH₃ H O F CF₃ H H H CH₃ 1886N CF₃ H CH₃ H O H H CH₃ H H CF₃ 18 87N CF₃ H CH₃ H O CH₃ H H H H CF₃18 88N CF₃ H CH₃ H O H CF₃ H H H CH₃ 18 89N CF₃ H CH₃ H O OCH₃ H H H HCH₃ 18 90N CF₃ H CH₃ H O H H CF₃ H H CH₃ 18 91N CF₃ H CH₃ H O CF₃ H H HH CH₃ 18 92N CF₃ H CH₃ H O H CF₃ F H H CH₃ 19  1N CF₃ CF₃ H H N H C₆H₅OH H OCF₂CF₂H H 19  2N CF₃ CF₃ H H N H OCF₃ H H OCF₂CF₂H H 19  3N CF₃ CF₃H H N F H H F OCF₂CF₂H H 19  4N CF₃ CF₃ H H N H F H H OCF₂CF₂H H 19  5NCF₃ CF₃ H H N H C₆H₅O H H OCF₃ H 19  6N CF₃ CF₃ H H N H OCF₃ H H OCF₃ H19  7N CF₃ CF₃ H H N H H phenyl H OCF₃ H 19  8N CF₃ CF₃ H H N H phenyl HH OCF₃ H 19  9N CF₃ CF₃ H H N H H H H OCF₃ H 19 10N CF₃ CF₃ H H N H Br HH OCF₃ H 19 11N CF₃ CF₃ H H N H CF₃ F H CF₃ H 19 12N CF₃ CF₃ H H N H CH₃H H CF₃ H 19 13N CF₃ CF₃ H H N H CF₃ H H CF₃ H 19 14N CF₃ CF₃ H H N HCH₃ H H OCF₃ H 19 15N CF₃ CF₃ H H N H F F H OCF₃ H 19 16N CF₃ CF₃ H H NH Br H H CF₃ H 19 17N CF₃ CF₃ H H N H CF₃ F H OCF₃ H 19 18N CF₃ CF₃ H HN H F H H OCF₃ H 19 19N CF₃ CF₃ H H N H Cl H H OCF₃ H 19 20N CF₃ CF₃ H HN H F H H CF₃ H 19 21N CF₃ CF₃ H H N H F F H CF₃ H 19 22N CF₃ CF₃ H H NH Cl H H CF₃ H 19 23N CF₃ CF₃ H H N H F H H phenoxy H 19 24N CF₃ CF₃ H HN H CF₃ Cl H CH₃ H 19 25N CF₃ CF₃ H H N H CF₃ F H CH₃ H 19 26N CF₃ CF₃ HH N H H H H CF₃ H 19 27N CF₃ CF₃ H H N F F H H CF₃ H 19 28N CF₃ CF₃ H HN H H OCH₃ H CF₃ H 19 29N CF₃ CF₃ H H N H F F H CH₃ H 19 30N CF₃ CF₃ H HN H OCH₃ H H CH₃ H 19 31N CF₃ CF₃ H H N H H CH₃ H H H 19 32N CF₃ CF₃ H HN H Cl H H H H 19 33N CF₃ CF₃ H H N H F H H F H 19 34N CF₃ CF₃ H H N H HOCH₃ H CH₃ H 19 35N CF₃ CF₃ H H N H H H H H H 19 36N CF₃ CF₃ H H N H HCH₃ H CH₃ H 19 37N CF₃ CF₃ H H N H H Cl H H H 19 38N CF₃ CF₃ H H N H F HH 3-CF₃-phenoxy H 19 39N CF₃ CF₃ H H N H F H H 4-CH₃O-phenoxy H 19 40NCF₃ CF₃ H H N H F H H 4-Cl-phenoxy H 19 41N CF₃ CF₃ H H N H F H H H H 1942N CF₃ CF₃ H H N H F H H CH₃ H 19 43N CF₃ CF₃ H H N H F H F CH₃ H 1944N CF₃ CF₃ H H N F F H H CH₃ H 19 45N CF₃ CF₃ H H N H Cl H H CH₃ H 1946N CF₃ CF₃ H H N H CH₃ H H CH₃ H 19 47N CF₃ CF₃ H H N CH₃ H H H H H 1948N CF₃ CF₃ H H N H H CH₃ H CF₃ H 19 49N CF₃ CF₃ H H N CH₃ H H H CF₃ H19 50N CF₃ CF₃ H H N CH₃ H H H CH₃ H 19 51N CF₃ CF₃ H H N H H CH₃ H F H19 52N CF₃ CF₃ H H N H CF₃ H H F H 19 53N CF₃ CF₃ H H N H CF₃ H H CH₃ H19 54N CF₃ CF₃ H H N H OCH₃ H H CF₃ H 19 55N CF₃ CF₃ H H N OCH₃ H H HCH₃ H 19 56N CF₃ CF₃ H H N H H CH₃ H CF₃ H 19 57N CF₃ CF₃ H H N H C₆H₅OH H H OCF₃ 19 58N CF₃ CF₃ H H N H H H H H OCF₃ 19 59N CF₃ CF₃ H H N HOCF₃ H H H OCF₃ 19 60N CF₃ CF₃ H H N H CF₃ F H H CF₃ 19 61N CF₃ CF₃ H HN H H OCH₃ H H CF₃ 19 62N CF₃ CF₃ H H N H CH₃ H H H CF₃ 19 63N CF₃ CF₃ HH N H Cl H H H CF₃ 19 64N CF₃ CF₃ H H N H CF₃ H H H OCF₃ 19 65N CF₃ CF₃H H N H F H H H OCF₃ 19 66N CF₃ CF₃ H H N H F H F H OCF₃ 19 67N CF₃ CF₃H H N H Br H H H OCF₃ 19 68N CF₃ CF₃ H H N H Cl H H H OCF₃ 19 69N CF₃CF₃ H H N H F F H H OCF₃ 19 70N CF₃ CF₃ H H N H F H H H C₆H₅ 19 71N CF₃CF₃ H H N H CH₃ H H H OCF₃ 19 72N CF₃ CF₃ H H N H F F H H CF₃ 19 73N CF₃CF₃ H H N H Cl H H H CH₃ 19 74N CF₃ CF₃ H H N H OCH₃ H H H CH₃ 19 75NCF₃ CF₃ H H N H F H H H CH₃ 19 76N CF₃ CF₃ H H N F F H H H OCF₃ 19 77NCF₃ CF₃ H H N OCH₃ H H H H CF₃ 19 78N CF₃ CF₃ H H N H H OCH₃ H H CH₃ 1979N CF₃ CF₃ H H N H H CH₃ H H CH₃ 19 80N CF₃ CF₃ H H N H CH₃ H H H CH₃19 81N CF₃ CF₃ H H N CH₃ H H H H CH₃ 19 82N CF₃ CF₃ H H N H F F H H CH₃19 83N CF₃ CF₃ H H N H F H F H CH₃ 19 84N CF₃ CF₃ H H N F F H H H CH₃ 1985N CF₃ CF₃ H H N F CF₃ H H H CH₃ 19 86N CF₃ CF₃ H H N H H CH₃ H H CF₃19 87N CF₃ CF₃ H H N CH₃ H H H H CF₃ 19 88N CF₃ CF₃ H H N H CF₃ H H HCH₃ 19 89N CF₃ CF₃ H H N OCH₃ H H H H CH₃ 19 90N CF₃ CF₃ H H N H H CF₃ HH CH₃ 19 91N CF₃ CF₃ H H N CF₃ H H H H CH₃ 19 92N CF₃ CF₃ H H N H CF₃ FH H CH₃ 20  1N CF₃ H H H N H C₆H₅O H H OCF₂CF₂H H 20  2N CF₃ H H H N HOCF₃ H H OCF₂CF₂H H 20  3N CF₃ H H H N F H H F OCF₂CF₂H H 20  4N CF₃ H HH N H F H H OCF₂CF₂H H 20  5N CF₃ H H H N H C₆H₅O H H OCF₃ H 20  6N CF₃H H H N H OCF₃ H H OCF₃ H 20  7N CF₃ H H H N H H phenyl H OCF₃ H 20  8NCF₃ H H H N H phenyl H H OCF₃ H 20  9N CF₃ H H H N H H H H OCF₃ H 20 10NCF₃ H H H N H Br H H OCF₃ H 20 11N CF₃ H H H N H CF₃ F H CF₃ H 20 12NCF₃ H H H N H CH₃ H H CF₃ H 20 13N CF₃ H H H N H CF₃ H H CF₃ H 20 14NCF₃ H H H N H CH₃ H H OCF₃ H 20 15N CF₃ H H H N H F F H OCF₃ H 20 16NCF₃ H H H N H Br H H CF₃ H 20 17N CF₃ H H H N H CF₃ F H OCF₃ H 20 18NCF₃ H H H N H F H H OCF₃ H 20 19N CF₃ H H H N H Cl H H OCF₃ H 20 20N CF₃H H H N H F H H CF₃ H 20 21N CF₃ H H H N H F F H CF₃ H 20 22N CF₃ H H HN H Cl H H CF₃ H 20 23N CF₃ H H H N H F H H phenoxy H 20 24N CF₃ H H H NH CF₃ Cl H CH₃ H 20 25N CF₃ H H H N H CF₃ F H CH₃ H 20 26N CF₃ H H H N HH H H CF₃ H 20 27N CF₃ H H H N F F H H CF₃ H 20 28N CF₃ H H H N H H OCH₃H CF₃ H 20 29N CF₃ H H H N H F F H CH₃ H 20 30N CF₃ H H H N H OCH₃ H HCH₃ H 20 31N CF₃ H H H N H H CH₃ H H H 20 32N CF₃ H H H N H Cl H H H H20 33N CF₃ H H H N H F H H F H 20 34N CF₃ H H H N H H OCH₃ H CH₃ H 2035N CF₃ H H H N H H H H H H 20 36N CF₃ H H H N H H CH₃ H CH₃ H 20 37NCF₃ H H H N H H Cl H H H 20 38N CF₃ H H H N H F H H 3-CF₃-phenoxy H 2039N CF₃ H H H N H F H H 4-CH₃O-phenoxy H 20 40N CF₃ H H H N H F H H4-Cl-phenoxy H 20 41N CF₃ H H H N H F H H H H 20 42N CF₃ H H H N H F H HCH₃ H 20 43N CF₃ H H H N H F H F CH₃ H 20 44N CF₃ H H H N F F H H CH₃ H20 45N CF₃ H H H N H Cl H H CH₃ H 20 46N CF₃ H H H N H CH₃ H H CH₃ H 2047N CF₃ H H H N CH₃ H H H H H 20 48N CF₃ H H H N H H CH₃ H CF₃ H 20 49NCF₃ H H H N CH₃ H H H CF₃ H 20 50N CF₃ H H H N CH₃ H H H CH₃ H 20 51NCF₃ H H H N H H CH₃ H F H 20 52N CF₃ H H H N H CF₃ H H F H 20 53N CF₃ HH H N H CF₃ H H CH₃ H 20 54N CF₃ H H H N H OCH₃ H H CF₃ H 20 55N CF₃ H HH N OCH₃ H H H CH₃ H 20 56N CF₃ H H H N H H CH₃ H CF₃ H 20 57N CF₃ H H HN H C₆H₅O H H H OCF₃ 20 58N CF₃ H H H N H H H H H OCF₃ 20 59N CF₃ H H HN H OCF₃ H H H OCF₃ 20 60N CF₃ H H H N H CF₃ F H H CF₃ 20 61N CF₃ H H HN H H OCH₃ H H CF₃ 20 62N CF₃ H H H N H CH₃ H H H CF₃ 20 63N CF₃ H H H NH Cl H H H CF₃ 20 64N CF₃ H H H N H CF₃ H H H OCF₃ 20 65N CF₃ H H H N HF H H H OCF₃ 20 66N CF₃ H H H N H F H F H OCF₃ 20 67N CF₃ H H H N H Br HH H OCF₃ 20 68N CF₃ H H H N H Cl H H H OCF₃ 20 69N CF₃ H H H N H F F H HOCF₃ 20 70N CF₃ H H H N H F H H H C₆H₅ 20 71N CF₃ H H H N H CH₃ H H HOCF₃ 20 72N CF₃ H H H N H F F H H CF₃ 20 73N CF₃ H H H N H Cl H H H CH₃20 74N CF₃ H H H N H OCH₃ H H H CH₃ 20 75N CF₃ H H H N H F H H H CH₃ 2076N CF₃ H H H N F F H H H OCF₃ 20 77N CF₃ H H H N OCH₃ H H H H CF₃ 2078N CF₃ H H H N H H OCH₃ H H CH₃ 20 79N CF₃ H H H N H H CH₃ H H CH₃ 2080N CF₃ H H H N H CH₃ H H H CH₃ 20 81N CF₃ H H H N CH₃ H H H H CH₃ 2082N CF₃ H H H N H F F H H CH₃ 20 83N CF₃ H H H N H F H F H CH₃ 20 84NCF₃ H H H N F F H H H CH₃ 20 85N CF₃ H H H N F CF₃ H H H CH₃ 20 86N CF₃H H H N H H CH₃ H H CF₃ 20 87N CF₃ H H H N CH₃ H H H H CF₃ 20 88N CF₃ HH H N H CF₃ H H H CH₃ 20 89N CF₃ H H H N OCH₃ H H H H CH₃ 20 90N CF₃ H HH N H H CF₃ H H CH₃ 20 91N CF₃ H H H N CF₃ H H H H CH₃ 20 92N CF₃ H H HN H CF₃ F H H CH₃ 23  1N CF₃ H H CH₃ N H C₆H₅O H H OCF₂CF₂H H 23  2N CF₃H H CH₃ N H OCF₃ H H OCF₂CF₂H H 23  3N CF₃ H H CH₃ N F H H F OCF₂CF₂H H23  4N CF₃ H H CH₃ N H F H H OCF₂CF₂H H 23  5N CF₃ H H CH₃ N H C₆H₅O H HOCF₃ H 23  6N CF₃ H H CH₃ N H OCF₃ H H OCF₃ H 23  7N CF₃ H H CH₃ N H Hphenyl H OCF₃ H 23  8N CF₃ H H CH₃ N H phenyl H H OCF₃ H 23  9N CF₃ H HCH₃ N H H H H OCF₃ H 23 10N CF₃ H H CH₃ N H Br H H OCF₃ H 23 11N CF₃ H HCH₃ N H CF₃ F H CF₃ H 23 12N CF₃ H H CH₃ N H CH₃ H H CF₃ H 23 13N CF₃ HH CH₃ N H CF₃ H H CF₃ H 23 14N CF₃ H H CH₃ N H CH₃ H H OCF₃ H 23 15N CF₃H H CH₃ N H F F H OCF₃ H 23 16N CF₃ H H CH₃ N H Br H H CF₃ H 23 17N CF₃H H CH₃ N H CF₃ F H OCF₃ H 23 18N CF₃ H H CH₃ N H F H H OCF₃ H 23 19NCF₃ H H CH₃ N H Cl H H OCF₃ H 23 20N CF₃ H H CH₃ N H F H H CF₃ H 23 21NCF₃ H H CH₃ N H F F H CF₃ H 23 22N CF₃ H H CH₃ N H Cl H H CF₃ H 23 23NCF₃ H H CH₃ N H F H H phenoxy H 23 24N CF₃ H H CH₃ N H CF₃ Cl H CH₃ H 2325N CF₃ H H CH₃ N H CF₃ F H CH₃ H 23 26N CF₃ H H CH₃ N H H H H CF₃ H 2327N CF₃ H H CH₃ N F F H H CF₃ H 23 28N CF₃ H H CH₃ N H H OCH₃ H CF₃ H 2329N CF₃ H H CH₃ N H F F H CH₃ H 23 30N CF₃ H H CH₃ N H OCH₃ H H CH₃ H 2331N CF₃ H H CH₃ N H H CH₃ H H H 23 32N CF₃ H H CH₃ N H Cl H H H H 23 33NCF₃ H H CH₃ N H F H H F H 23 34N CF₃ H H CH₃ N H H OCH₃ H CH₃ H 23 35NCF₃ H H CH₃ N H H H H H H 23 36N CF₃ H H CH₃ N H H CH₃ H CH₃ H 23 37NCF₃ H H CH₃ N H H Cl H H H 23 38N CF₃ H H CH₃ N H F H H 3-CF₃-phenoxy H23 39N CF₃ H H CH₃ N H F H H 4-CH₃O-phenoxy H 23 40N CF₃ H H CH₃ N H F HH 4-Cl-phenoxy H 23 41N CF₃ H H CH₃ N H F H H H H 23 42N CF₃ H H CH₃ N HF H H CH₃ H 23 43N CF₃ H H CH₃ N H F H F CH₃ H 23 44N CF₃ H H CH₃ N F FH H CH₃ H 23 45N CF₃ H H CH₃ N H Cl H H CH₃ H 23 46N CF₃ H H CH₃ N H CH₃H H CH₃ H 23 47N CF₃ H H CH₃ N CH₃ H H H H H 23 48N CF₃ H H CH₃ N H HCH₃ H CF₃ H 23 49N CF₃ H H CH₃ N CH₃ H H H CF₃ H 23 50N CF₃ H H CH₃ NCH₃ H H H CH₃ H 23 51N CF₃ H H CH₃ N H H CH₃ H F H 23 52N CF₃ H H CH₃ NH CF₃ H H F H 23 53N CF₃ H H CH₃ N H CF₃ H H CH₃ H 23 54N CF₃ H H CH₃ NH OCH₃ H H CF₃ H 23 55N CF₃ H H CH₃ N OCH₃ H H H CH₃ H 23 56N CF₃ H HCH₃ N H H CH₃ H CF₃ H 23 57N CF₃ H H CH₃ N H C₆H₅O H H H OCF₃ 23 58N CF₃H H CH₃ N H H H H H OCF₃ 23 59N CF₃ H H CH₃ N H OCF₃ H H H OCF₃ 23 60NCF₃ H H CH₃ N H CF₃ F H H CF₃ 23 61N CF₃ H H CH₃ N H H OCH₃ H H CF₃ 2362N CF₃ H H CH₃ N H CH₃ H H H CF₃ 23 63N CF₃ H H CH₃ N H Cl H H H CF₃ 2364N CF₃ H H CH₃ N H CF₃ H H H OCF₃ 23 65N CF₃ H H CH₃ N H F H H H OCF₃23 66N CF₃ H H CH₃ N H F H F H OCF₃ 23 67N CF₃ H H CH₃ N H Br H H H OCF₃23 68N CF₃ H H CH₃ N H Cl H H H OCF₃ 23 69N CF₃ H H CH₃ N H F F H H OCF₃23 70N CF₃ H H CH₃ N H F H H H C₆H₅ 23 71N CF₃ H H CH₃ N H CH₃ H H HOCF₃ 23 72N CF₃ H H CH₃ N H F F H H CF₃ 23 73N CF₃ H H CH₃ N H Cl H H HCH₃ 23 74N CF₃ H H CH₃ N H OCH₃ H H H CH₃ 23 75N CF₃ H H CH₃ N H F H H HCH₃ 23 76N CF₃ H H CH₃ N F F H H H OCF₃ 23 77N CF₃ H H CH₃ N OCH₃ H H HH CF₃ 23 78N CF₃ H H CH₃ N H H OCH₃ H H CH₃ 23 79N CF₃ H H CH₃ N H H CH₃H H CH₃ 23 80N CF₃ H H CH₃ N H CH₃ H H H CH₃ 23 81N CF₃ H H CH₃ N CH₃ HH H H CH₃ 23 82N CF₃ H H CH₃ N H F F H H CH₃ 23 83N CF₃ H H CH₃ N H F HF H CH₃ 23 84N CF₃ H H CH₃ N F F H H H CH₃ 23 85N CF₃ H H CH₃ N F CF₃ HH H CH₃ 23 86N CF₃ H H CH₃ N H H CH₃ H H CF₃ 23 87N CF₃ H H CH₃ N CH₃ HH H H CF₃ 23 88N CF₃ H H CH₃ N H CF₃ H H H CH₃ 23 89N CF₃ H H CH₃ N OCH₃H H H H CH₃ 23 90N CF₃ H H CH₃ N H H CF₃ H H CH₃ 23 91N CF₃ H H CH₃ NCF₃ H H H H CH₃ 23 92N CF₃ H H CH₃ N H CF₃ F H H CH₃ 25  1N CF₃ H H H SH C₆H₅O H H OCF₂CF₂H H 25  2N CF₃ H H H S H OCF₃ H H OCF₂CF₂H H 25  3NCF₃ H H H S F H H F OCF₂CF₂H H 25  4N CF₃ H H H S H F H H OCF₂CF₂H H 25 5N CF₃ H H H S H C₆H₅O H H OCF₃ H 25  6N CF₃ H H H S H OCF₃ H H OCF₃ H25  7N CF₃ H H H S H H phenyl H OCF₃ H 25  8N CF₃ H H H S H phenyl H HOCF₃ H 25  9N CF₃ H H H S H H H H OCF₃ H 25 10N CF₃ H H H S H Br H HOCF₃ H 25 11N CF₃ H H H S H CF₃ F H CF₃ H 25 12N CF₃ H H H S H CH₃ H HCF₃ H 25 13N CF₃ H H H S H CF₃ H H CF₃ H 25 14N CF₃ H H H S H CH₃ H HOCF₃ H 25 15N CF₃ H H H S H F F H OCF₃ H 25 16N CF₃ H H H S H Br H H CF₃H 25 17N CF₃ H H H S H CF₃ F H OCF₃ H 25 18N CF₃ H H H S H F H H OCF₃ H25 19N CF₃ H H H S H Cl H H OCF₃ H 25 20N CF₃ H H H S H F H H CF₃ H 2521N CF₃ H H H S H F F H CF₃ H 25 22N CF₃ H H H S H Cl H H CF₃ H 25 23NCF₃ H H H S H F H H phenoxy H 25 24N CF₃ H H H S H CF₃ Cl H CH₃ H 25 25NCF₃ H H H S H CF₃ F H CH₃ H 25 26N CF₃ H H H S H H H H CF₃ H 25 27N CF₃H H H S F F H H CF₃ H 25 28N CF₃ H H H S H H OCH₃ H CF₃ H 25 29N CF₃ H HH S H F F H CH₃ H 25 30N CF₃ H H H S H OCH₃ H H CH₃ H 25 31N CF₃ H H H SH H CH₃ H H H 25 32N CF₃ H H H S H Cl H H H H 25 33N CF₃ H H H S H F H HF H 25 34N CF₃ H H H S H H OCH₃ H CH₃ H 25 35N CF₃ H H H S H H H H H H25 36N CF₃ H H H S H H CH₃ H CH₃ H 25 37N CF₃ H H H S H H Cl H H H 2538N CF₃ H H H S H F H H 3-CF₃-phenoxy H 25 39N CF₃ H H H S H F H H4-CH₃O-phenoxy H 25 40N CF₃ H H H S H F H H 4-Cl-phenoxy H 25 41N CF₃ HH H S H F H H H H 25 42N CF₃ H H H S H F H H CH₃ H 25 43N CF₃ H H H S HF H F CH₃ H 25 44N CF₃ H H H S F F H H CH₃ H 25 45N CF₃ H H H S H Cl H HCH₃ H 25 46N CF₃ H H H S H CH₃ H H CH₃ H 25 47N CF₃ H H H S CH₃ H H H HH 25 48N CF₃ H H H S H H CH₃ H CF₃ H 25 49N CF₃ H H H S CH₃ H H H CF₃ H25 50N CF₃ H H H S CH₃ H H H CH₃ H 25 51N CF₃ H H H S H H CH₃ H F H 2552N CF₃ H H H S H CF₃ H H F H 25 53N CF₃ H H H S H CF₃ H H CH₃ H 25 54NCF₃ H H H S H OCH₃ H H CF₃ H 25 55N CF₃ H H H S OCH₃ H H H CH₃ H 25 56NCF₃ H H H S H H CH₃ H CF₃ H 25 57N CF₃ H H H S H C₆H₅O H H H OCF₃ 25 58NCF₃ H H H S H H H H H OCF₃ 25 59N CF₃ H H H S H OCF₃ H H H OCF₃ 25 60NCF₃ H H H S H CF₃ F H H CF₃ 25 61N CF₃ H H H S H H OCH₃ H H CF₃ 25 62NCF₃ H H H S H CH₃ H H H CF₃ 25 63N CF₃ H H H S H Cl H H H CF₃ 25 64N CF₃H H H S H CF₃ H H H OCF₃ 25 65N CF₃ H H H S H F H H H OCF₃ 25 66N CF₃ HH H S H F H F H OCF₃ 25 67N CF₃ H H H S H Br H H H OCF₃ 25 68N CF₃ H H HS H Cl H H H OCF₃ 25 69N CF₃ H H H S H F F H H OCF₃ 25 70N CF₃ H H H S HF H H H C₆H₅ 25 71N CF₃ H H H S H CH₃ H H H OCF₃ 25 72N CF₃ H H H S H FF H H CF₃ 25 73N CF₃ H H H S H Cl H H H CH₃ 25 74N CF₃ H H H S H OCH₃ HH H CH₃ 25 75N CF₃ H H H S H F H H H CH₃ 25 76N CF₃ H H H S F F H H HOCF₃ 25 77N CF₃ H H H S OCH₃ H H H H CF₃ 25 78N CF₃ H H H S H H OCH₃ H HCH₃ 25 79N CF₃ H H H S H H CH₃ H H CH₃ 25 80N CF₃ H H H S H CH₃ H H HCH₃ 25 81N CF₃ H H H S CH₃ H H H H CH₃ 25 82N CF₃ H H H S H F F H H CH₃25 83N CF₃ H H H S H F H F H CH₃ 25 84N CF₃ H H H S F F H H H CH₃ 25 85NCF₃ H H H S F CF₃ H H H CH₃ 25 86N CF₃ H H H S H H CH₃ H H CF₃ 25 87NCF₃ H H H S CH₃ H H H H CF₃ 25 88N CF₃ H H H S H CF₃ H H H CH₃ 25 89NCF₃ H H H S OCH₃ H H H H CH₃ 25 90N CF₃ H H H S H H CF₃ H H CH₃ 25 91NCF₃ H H H S CF₃ H H H H CH₃ 25 92N CF₃ H H H S H CF₃ F H H CH₃ 26  1NCF₃CF₂ H H H S H C₆H₅O H H OCF₂CF₂H H 26  2N CF₃CF₂ H H H S H OCF₃ H HOCF₂CF₂H H 26  3N CF₃CF₂ H H H S F H H F OCF₂CF₂H H 26  4N CF₃CF₂ H H HS H F H H OCF₂CF₂H H 26  5N CF₃CF₂ H H H S H C₆H₅O H H OCF₃ H 26  6NCF₃CF₂ H H H S H OCF₃ H H OCF₃ H 26  7N CF₃CF₂ H H H S H H phenyl H OCF₃H 26  8N CF₃CF₂ H H H S H phenyl H H OCF₃ H 26  9N CF₃CF₂ H H H S H H HH OCF₃ H 26 10N CF₃CF₂ H H H S H Br H H OCF₃ H 26 11N CF₃CF₂ H H H S HCF₃ F H CF₃ H 26 12N CF₃CF₂ H H H S H CH₃ H H CF₃ H 26 13N CF₃CF₂ H H HS H CF₃ H H CF₃ H 26 14N CF₃CF₂ H H H S H CH₃ H H OCF₃ H 26 15N CF₃CF₂ HH H S H F F H OCF₃ H 26 16N CF₃CF₂ H H H S H Br H H CF₃ H 26 17N CF₃CF₂H H H S H CF₃ F H OCF₃ H 26 18N CF₃CF₂ H H H S H F H H OCF₃ H 26 19NCF₃CF₂ H H H S H Cl H H OCF₃ H 26 20N CF₃CF₂ H H H S H F H H CF₃ H 2621N CF₃CF₂ H H H S H F F H CF₃ H 26 22N CF₃CF₂ H H H S H Cl H H CF₃ H 2623N CF₃CF₂ H H H S H F H H phenoxy H 26 24N CF₃CF₂ H H H S H CF₃ Cl HCH₃ H 26 25N CF₃CF₂ H H H S H CF₃ F H CH₃ H 26 26N CF₃CF₂ H H H S H H HH CF₃ H 26 27N CF₃CF₂ H H H S F F H H CF₃ H 26 28N CF₃CF₂ H H H S H HOCH₃ H CF₃ H 26 29N CF₃CF₂ H H H S H F F H CH₃ H 26 30N CF₃CF₂ H H H S HOCH₃ H H CH₃ H 26 31N CF₃CF₂ H H H S H H CH₃ H H H 26 32N CF₃CF₂ H H H SH Cl H H H H 26 33N CF₃CF₂ H H H S H F H H F H 26 34N CF₃CF₂ H H H S H HOCH₃ H CH₃ H 26 35N CF₃CF₂ H H H S H H H H H H 26 36N CF₃CF₂ H H H S H HCH₃ H CH₃ H 26 37N CF₃CF₂ H H H S H H Cl H H H 26 38N CF₃CF₂ H H H S H FH H 3-CF₃-phenoxy H 26 39N CF₃CF₂ H H H S H F H H 4-CH₃O-phenoxy H 2640N CF₃CF₂ H H H S H F H H 4-Cl-phenoxy H 26 41N CF₃CF₂ H H H S H F H HH H 26 42N CF₃CF₂ H H H S H F H H CH₃ H 26 43N CF₃CF₂ H H H S H F H FCH₃ H 26 44N CF₃CF₂ H H H S F F H H CH₃ H 26 45N CF₃CF₂ H H H S H Cl H HCH₃ H 26 46N CF₃CF₂ H H H S H CH₃ H H CH₃ H 26 47N CF₃CF₂ H H H S CH₃ HH H H H 26 48N CF₃CF₂ H H H S H H CH₃ H CF₃ H 26 49N CF₃CF₂ H H H S CH₃H H H CF₃ H 26 50N CF₃CF₂ H H H S CH₃ H H H CH₃ H 26 51N CF₃CF₂ H H H SH H CH₃ H F H 26 52N CF₃CF₂ H H H S H CF₃ H H F H 26 53N CF₃CF₂ H H H SH CF₃ H H CH₃ H 26 54N CF₃CF₂ H H H S H OCH₃ H H CF₃ H 26 55N CF₃CF₂ H HH S OCH₃ H H H CH₃ H 26 56N CF₃CF₂ H H H S H H CH₃ H CF₃ H 26 57N CF₃CF₂H H H S H C₆H₅O H H H OCF₃ 26 58N CF₃CF₂ H H H S H H H H H OCF₃ 26 59NCF₃CF₂ H H H S H OCF₃ H H H OCF₃ 26 60N CF₃CF₂ H H H S H CF₃ F H H CF₃26 61N CF₃CF₂ H H H S H H OCH₃ H H CF₃ 26 62N CF₃CF₂ H H H S H CH₃ H H HCF₃ 26 63N CF₃CF₂ H H H S H Cl H H H CF₃ 26 64N CF₃CF₂ H H H S H CF₃ H HH OCF₃ 26 65N CF₃CF₂ H H H S H F H H H OCF₃ 26 66N CF₃CF₂ H H H S H F HF H OCF₃ 26 67N CF₃CF₂ H H H S H Br H H H OCF₃ 26 68N CF₃CF₂ H H H S HCl H H H OCF₃ 26 69N CF₃CF₂ H H H S H F F H H OCF₃ 26 70N CF₃CF₂ H H H SH F H H H C₆H₅ 26 71N CF₃CF₂ H H H S H CH₃ H H H OCF₃ 26 72N CF₃CF₂ H HH S H F F H H CF₃ 26 73N CF₃CF₂ H H H S H Cl H H H CH₃ 26 74N CF₃CF₂ H HH S H OCH₃ H H H CH₃ 26 75N CF₃CF₂ H H H S H F H H H CH₃ 26 76N CF₃CF₂ HH H S F F H H H OCF₃ 26 77N CF₃CF₂ H H H S OCH₃ H H H H CF₃ 26 78NCF₃CF₂ H H H S H H OCH₃ H H CH₃ 26 79N CF₃CF₂ H H H S H H CH₃ H H CH₃ 2680N CF₃CF₂ H H H S H CH₃ H H H CH₃ 26 81N CF₃CF₂ H H H S CH₃ H H H H CH₃26 82N CF₃CF₂ H H H S H F F H H CH₃ 26 83N CF₃CF₂ H H H S H F H F H CH₃26 84N CF₃CF₂ H H H S F F H H H CH₃ 26 85N CF₃CF₂ H H H S F CF₃ H H HCH₃ 26 86N CF₃CF₂ H H H S H H CH₃ H H CF₃ 26 87N CF₃CF₂ H H H S CH₃ H HH H CF₃ 26 88N CF₃CF₂ H H H S H CF₃ H H H CH₃ 26 89N CF₃CF₂ H H H S OCH₃H H H H CH₃ 26 90N CF₃CF₂ H H H S H H CF₃ H H CH₃ 26 91N CF₃CF₂ H H H SCF₃ H H H H CH₃ 26 92N CF₃CF₂ H H H S H CF₃ F H H CH₃ 27  1N CCl₃CH₂ H HH O H C₆H₅O H H OCF₂CF₂H H 27  2N CCl₃CH₂ H H H O H OCF₃ H H OCF₂CF₂H H27  3N CCl₃CH₂ H H H O F H H F OCF₂CF₂H H 27  4N CCl₃CH₂ H H H O H F H HOCF₂CF₂H H 27  5N CCl₃CH₂ H H H O H C₆H₅O H H OCF₃ H 27  6N CCl₃CH₂ H HH O H OCF₃ H H OCF₃ H 27  7N CCl₃CH₂ H H H O H H phenyl H OCF₃ H 27  8NCCl₃CH₂ H H H O H phenyl H H OCF₃ H 27  9N CCl₃CH₂ H H H O H H H H OCF₃H 27 10N CCl₃CH₂ H H H O H Br H H OCF₃ H 27 11N CCl₃CH₂ H H H O H CF₃ FH CF₃ H 27 12N CCl₃CH₂ H H H O H CH₃ H H CF₃ H 27 13N CCl₃CH₂ H H H O HCF₃ H H CF₃ H 27 14N CCl₃CH₂ H H H O H CH₃ H H OCF₃ H 27 15N CCl₃CH₂ H HH O H F F H OCF₃ H 27 16N CCl₃CH₂ H H H O H Br H H CF₃ H 27 17N CCl₃CH₂H H H O H CF₃ F H OCF₃ H 27 18N CCl₃CH₂ H H H O H F H H OCF₃ H 27 19NCCl₃CH₂ H H H O H Cl H H OCF₃ H 27 20N CCl₃CH₂ H H H O H F H H CF₃ H 2721N CCl₃CH₂ H H H O H F F H CF₃ H 27 22N CCl₃CH₂ H H H O H Cl H H CF₃ H27 23N CCl₃CH₂ H H H O H F H H phenoxy H 27 24N CCl₃CH₂ H H H O H CF₃ ClH CH₃ H 27 25N CCl₃CH₂ H H H O H CF₃ F H CH₃ H 27 26N CCl₃CH₂ H H H O HH H H CF₃ H 27 27N CCl₃CH₂ H H H O F F H H CF₃ H 27 28N CCl₃CH₂ H H H OH H OCH₃ H CF₃ H 27 29N CCl₃CH₂ H H H O H F F H CH₃ H 27 30N CCl₃CH₂ H HH O H OCH₃ H H CH₃ H 27 31N CCl₃CH₂ H H H O H H CH₃ H H H 27 32N CCl₃CH₂H H H O H Cl H H H H 27 33N CCl₃CH₂ H H H O H F H H F H 27 34N CCl₃CH₂ HH H O H H OCH₃ H CH₃ H 27 35N CCl₃CH₂ H H H O H H H H H H 27 36N CCl₃CH₂H H H O H H CH₃ H CH₃ H 27 37N CCl₃CH₂ H H H O H H Cl H H H 27 38NCCl₃CH₂ H H H O H F H H 3-CF₃-phenoxy H 27 39N CCl₃CH₂ H H H O H F H H4-CH₃O-phenoxy H 27 40N CCl₃CH₂ H H H O H F H H 4-Cl-phenoxy H 27 41NCCl₃CH₂ H H H O H F H H H H 27 42N CCl₃CH₂ H H H O H F H H CH₃ H 27 43NCCl₃CH₂ H H H O H F H F CH₃ H 27 44N CCl₃CH₂ H H H O F F H H CH₃ H 2745N CCl₃CH₂ H H H O H Cl H H CH₃ H 27 46N CCl₃CH₂ H H H O H CH₃ H H CH₃H 27 47N CCl₃CH₂ H H H O CH₃ H H H H H 27 48N CCl₃CH₂ H H H O H H CH₃ HCF₃ H 27 49N CCl₃CH₂ H H H O CH₃ H H H CF₃ H 27 50N CCl₃CH₂ H H H O CH₃H H H CH₃ H 27 51N CCl₃CH₂ H H H O H H CH₃ H F H 27 52N CCl₃CH₂ H H H OH CF₃ H H F H 27 53N CCl₃CH₂ H H H O H CF₃ H H CH₃ H 27 54N CCl₃CH₂ H HH O H OCH₃ H H CF₃ H 27 55N CCl₃CH₂ H H H O OCH₃ H H H CH₃ H 27 56NCCl₃CH₂ H H H O H H CH₃ H CF₃ H 27 57N CCl₃CH₂ H H H O H C₆H₅O H H HOCF₃ 27 58N CCl₃CH₂ H H H O H H H H H OCF₃ 27 59N CCl₃CH₂ H H H O H OCF₃H H H OCF₃ 27 60N CCl₃CH₂ H H H O H CF₃ F H H CF₃ 27 61N CCl₃CH₂ H H H OH H OCH₃ H H CF₃ 27 62N CCl₃CH₂ H H H O H CH₃ H H H CF₃ 27 63N CCl₃CH₂ HH H O H Cl H H H CF₃ 27 64N CCl₃CH₂ H H H O H CF₃ H H H OCF₃ 27 65NCCl₃CH₂ H H H O H F H H H OCF₃ 27 66N CCl₃CH₂ H H H O H F H F H OCF₃ 2767N CCl₃CH₂ H H H O H Br H H H OCF₃ 27 68N CCl₃CH₂ H H H O H Cl H H HOCF₃ 27 69N CCl₃CH₂ H H H O H F F H H OCF₃ 27 70N CCl₃CH₂ H H H O H F HH H C₆H₅ 27 71N CCl₃CH₂ H H H O H CH₃ H H H OCF₃ 27 72N CCl₃CH₂ H H H OH F F H H CF₃ 27 73N CCl₃CH₂ H H H O H Cl H H H CH₃ 27 74N CCl₃CH₂ H H HO H OCH₃ H H H CH₃ 27 75N CCl₃CH₂ H H H O H F H H H CH₃ 27 76N CCl₃CH₂ HH H O F F H H H OCF₃ 27 77N CCl₃CH₂ H H H O OCH₃ H H H H CF₃ 27 78NCCl₃CH₂ H H H O H H OCH₃ H H CH₃ 27 79N CCl₃CH₂ H H H O H H CH₃ H H CH₃27 80N CCl₃CH₂ H H H O H CH₃ H H H CH₃ 27 81N CCl₃CH₂ H H H O CH₃ H H HH CH₃ 27 82N CCl₃CH₂ H H H O H F F H H CH₃ 27 83N CCl₃CH₂ H H H O H F HF H CH₃ 27 84N CCl₃CH₂ H H H O F F H H H CH₃ 27 85N CCl₃CH₂ H H H O FCF₃ H H H CH₃ 27 86N CCl₃CH₂ H H H O H H CH₃ H H CF₃ 27 87N CCl₃CH₂ H HH O CH₃ H H H H CF₃ 27 88N CCl₃CH₂ H H H O H CF₃ H H H CH₃ 27 89NCCl₃CH₂ H H H O OCH₃ H H H H CH₃ 27 90N CCl₃CH₂ H H H O H H CF₃ H H CH₃27 91N CCl₃CH₂ H H H O CF₃ H H H H CH₃ 27 92N CCl₃CH₂ H H H O H CF₃ F HH CH₃ 28  1N CBr₃CH₂ H H H O H C₆H₅O H H OCF₂CF₂H H 28  2N CBr₃CH₂ H H HO H OCF₃ H H OCF₂CF₂H H 28  3N CBr₃CH₂ H H H O F H H F OCF₂CF₂H H 28  4NCBr₃CH₂ H H H O H F H H OCF₂CF₂H H 28  5N CBr₃CH₂ H H H O H C₆H₅O H HOCF₃ H 28  6N CBr₃CH₂ H H H O H OCF₃ H H OCF₃ H 28  7N CBr₃CH₂ H H H O HH phenyl H OCF₃ H 28  8N CBr₃CH₂ H H H O H phenyl H H OCF₃ H 28  9NCBr₃CH₂ H H H O H H H H OCF₃ H 28 10N CBr₃CH₂ H H H O H Br H H OCF₃ H 2811N CBr₃CH₂ H H H O H CF₃ F H CF₃ H 28 12N CBr₃CH₂ H H H O H CH₃ H H CF₃H 28 13N CBr₃CH₂ H H H O H CF₃ H H CF₃ H 28 14N CBr₃CH₂ H H H O H CH₃ HH OCF₃ H 28 15N CBr₃CH₂ H H H O H F F H OCF₃ H 28 16N CBr₃CH₂ H H H O HBr H H CF₃ H 28 17N CBr₃CH₂ H H H O H CF₃ F H OCF₃ H 28 18N CBr₃CH₂ H HH O H F H H OCF₃ H 28 19N CBr₃CH₂ H H H O H Cl H H OCF₃ H 28 20N CBr₃CH₂H H H O H F H H CF₃ H 28 21N CBr₃CH₂ H H H O H F F H CF₃ H 28 22NCBr₃CH₂ H H H O H Cl H H CF₃ H 28 23N CBr₃CH₂ H H H O H F H H phenoxy H28 24N CBr₃CH₂ H H H O H CF₃ Cl H CH₃ H 28 25N CBr₃CH₂ H H H O H CF₃ F HCH₃ H 28 26N CBr₃CH₂ H H H O H H H H CF₃ H 28 27N CBr₃CH₂ H H H O F F HH CF₃ H 28 28N CBr₃CH₂ H H H O H H OCH₃ H CF₃ H 28 29N CBr₃CH₂ H H H O HF F H CH₃ H 28 30N CBr₃CH₂ H H H O H OCH₃ H H CH₃ H 28 31N CBr₃CH₂ H H HO H H CH₃ H H H 28 32N CBr₃CH₂ H H H O H Cl H H H H 28 33N CBr₃CH₂ H H HO H F H H F H 28 34N CBr₃CH₂ H H H O H H OCH₃ H CH₃ H 28 35N CBr₃CH₂ H HH O H H H H H H 28 36N CBr₃CH₂ H H H O H H CH₃ H CH₃ H 28 37N CBr₃CH₂ HH H O H H Cl H H H 28 38N CBr₃CH₂ H H H O H F H H 3-CF₃-phenoxy H 28 39NCBr₃CH₂ H H H O H F H H 4-CH₃O-phenoxy H 28 40N CBr₃CH₂ H H H O H F H H4-Cl-phenoxy H 28 41N CBr₃CH₂ H H H O H F H H H H 28 42N CBr₃CH₂ H H H OH F H H CH₃ H 28 43N CBr₃CH₂ H H H O H F H F CH₃ H 28 44N CBr₃CH₂ H H HO F F H H CH₃ H 28 45N CBr₃CH₂ H H H O H Cl H H CH₃ H 28 46N CBr₃CH₂ H HH O H CH₃ H H CH₃ H 28 47N CBr₃CH₂ H H H O CH₃ H H H H H 28 48N CBr₃CH₂H H H O H H CH₃ H CF₃ H 28 49N CBr₃CH₂ H H H O CH₃ H H H CF₃ H 28 50NCBr₃CH₂ H H H O CH₃ H H H CH₃ H 28 51N CBr₃CH₂ H H H O H H CH₃ H F H 2852N CBr₃CH₂ H H H O H CF₃ H H F H 28 53N CBr₃CH₂ H H H O H CF₃ H H CH₃ H28 54N CBr₃CH₂ H H H O H OCH₃ H H CF₃ H 28 55N CBr₃CH₂ H H H O OCH₃ H HH CH₃ H 28 56N CBr₃CH₂ H H H O H H CH₃ H CF₃ H 28 57N CBr₃CH₂ H H H O HC₆H₅O H H H OCF₃ 28 58N CBr₃CH₂ H H H O H H H H H OCF₃ 28 59N CBr₃CH₂ HH H O H OCF₃ H H H OCF₃ 28 60N CBr₃CH₂ H H H O H CF₃ F H H CF₃ 28 61NCBr₃CH₂ H H H O H H OCH₃ H H CF₃ 28 62N CBr₃CH₂ H H H O H CH₃ H H H CF₃28 63N CBr₃CH₂ H H H O H Cl H H H CF₃ 28 64N CBr₃CH₂ H H H O H CF₃ H H HOCF₃ 28 65N CBr₃CH₂ H H H O H F H H H OCF₃ 28 66N CBr₃CH₂ H H H O H F HF H OCF₃ 28 67N CBr₃CH₂ H H H O H Br H H H OCF₃ 28 68N CBr₃CH₂ H H H O HCl H H H OCF₃ 28 69N CBr₃CH₂ H H H O H F F H H OCF₃ 28 70N CBr₃CH₂ H H HO H F H H H C₆H₅ 28 71N CBr₃CH₂ H H H O H CH₃ H H H OCF₃ 28 72N CBr₃CH₂H H H O H F F H H CF₃ 28 73N CBr₃CH₂ H H H O H Cl H H H CH₃ 28 74NCBr₃CH₂ H H H O H OCH₃ H H H CH₃ 28 75N CBr₃CH₂ H H H O H F H H H CH₃ 2876N CBr₃CH₂ H H H O F F H H H OCF₃ 28 77N CBr₃CH₂ H H H O OCH₃ H H H HCF₃ 28 78N CBr₃CH₂ H H H O H H OCH₃ H H CH₃ 28 79N CBr₃CH₂ H H H O H HCH₃ H H CH₃ 28 80N CBr₃CH₂ H H H O H CH₃ H H H CH₃ 28 81N CBr₃CH₂ H H HO CH₃ H H H H CH₃ 28 82N CBr₃CH₂ H H H O H F F H H CH₃ 28 83N CBr₃CH₂ HH H O H F H F H CH₃ 28 84N CBr₃CH₂ H H H O F F H H H CH₃ 28 85N CBr₃CH₂H H H O F CF₃ H H H CH₃ 28 86N CBr₃CH₂ H H H O H H CH₃ H H CF₃ 28 87NCBr₃CH₂ H H H O CH₃ H H H H CF₃ 28 88N CBr₃CH₂ H H H O H CF₃ H H H CH₃28 89N CBr₃CH₂ H H H O OCH₃ H H H H CH₃ 28 90N CBr₃CH₂ H H H O H H CF₃ HH CH₃ 28 91N CBr₃CH₂ H H H O CF₃ H H H H CH₃ 28 92N CBr₃CH₂ H H H O HCF₃ F H H CH₃ 41  1N CH₃(CH₂)₄CH₂ H H H O H C₆H₅O H H OCF₂CF₂H H 41  2NCH₃(CH₂)₄CH₂ H H H O H OCF₃ H H OCF₂CF₂H H 41  3N CH₃(CH₂)₄CH₂ H H H O FH H F OCF₂CF₂H H 41  4N CH₃(CH₂)₄CH₂ H H H O H F H H OCF₂CF₂H H 41  5NCH₃(CH₂)₄CH₂ H H H O H C₆H₅O H H OCF₃ H 41  6N CH₃(CH₂)₄CH₂ H H H O HOCF₃ H H OCF₃ H 41  7N CH₃(CH₂)₄CH₂ H H H O H H phenyl H OCF₃ H 41  8NCH₃(CH₂)₄CH₂ H H H O H phenyl H H OCF₃ H 41  9N CH₃(CH₂)₄CH₂ H H H O H HH H OCF₃ H 41 10N CH₃(CH₂)₄CH₂ H H H O H Br H H OCF₃ H 41 11NCH₃(CH₂)₄CH₂ H H H O H CF₃ F H CF₃ H 41 12N CH₃(CH₂)₄CH₂ H H H O H CH₃ HH CF₃ H 41 13N CH₃(CH₂)₄CH₂ H H H O H CF₃ H H CF₃ H 41 14N CH₃(CH₂)₄CH₂H H H O H CH₃ H H OCF₃ H 41 15N CH₃(CH₂)₄CH₂ H H H O H F F H OCF₃ H 4116N CH₃(CH₂)₄CH₂ H H H O H Br H H CF₃ H 41 17N CH₃(CH₂)₄CH₂ H H H O HCF₃ F H OCF₃ H 41 18N CH₃(CH₂)₄CH₂ H H H O H F H H OCF₃ H 41 19NCH₃(CH₂)₄CH₂ H H H O H Cl H H OCF₃ H 41 20N CH₃(CH₂)₄CH₂ H H H O H F H HCF₃ H 41 21N CH₃(CH₂)₄CH₂ H H H O H F F H CF₃ H 41 22N CH₃(CH₂)₄CH₂ H HH O H Cl H H CF₃ H 41 23N CH₃(CH₂)₄CH₂ H H H O H F H H phenoxy H 41 24NCH₃(CH₂)₄CH₂ H H H O H CF₃ Cl H CH₃ H 41 25N CH₃(CH₂)₄CH₂ H H H O H CF₃F H CH₃ H 41 26N CH₃(CH₂)₄CH₂ H H H O H H H H CF₃ H 41 27N CH₃(CH₂)₄CH₂H H H O F F H H CF₃ H 41 28N CH₃(CH₂)₄CH₂ H H H O H H OCH₃ H CF₃ H 4129N CH₃(CH₂)₄CH₂ H H H O H F F H CH₃ H 41 30N CH₃(CH₂)₄CH₂ H H H O HOCH₃ H H CH₃ H 41 31N CH₃(CH₂)₄CH₂ H H H O H H CH₃ H H H 41 32NCH₃(CH₂)₄CH₂ H H H O H Cl H H H H 41 33N CH₃(CH₂)₄CH₂ H H H O H F H H FH 41 34N CH₃(CH₂)₄CH₂ H H H O H H OCH₃ H CH₃ H 41 35N CH₃(CH₂)₄CH₂ H H HO H H H H H H 41 36N CH₃(CH₂)₄CH₂ H H H O H H CH₃ H CH₃ H 41 37NCH₃(CH₂)₄CH₂ H H H O H H Cl H H H 41 38N CH₃(CH₂)₄CH₂ H H H O H F H H3-CF₃-phenoxy H 41 39N CH₃(CH₂)₄CH₂ H H H O H F H H 4-CH₃O-phenoxy H 4140N CH₃(CH₂)₄CH₂ H H H O H F H H 4-Cl-phenoxy H 41 41N CH₃(CH₂)₄CH₂ H HH O H F H H H H 41 42N CH₃(CH₂)₄CH₂ H H H O H F H H CH₃ H 41 43NCH₃(CH₂)₄CH₂ H H H O H F H F CH₃ H 41 44N CH₃(CH₂)₄CH₂ H H H O F F H HCH₃ H 41 45N CH₃(CH₂)₄CH₂ H H H O H Cl H H CH₃ H 41 46N CH₃(CH₂)₄CH₂ H HH O H CH₃ H H CH₃ H 41 47N CH₃(CH₂)₄CH₂ H H H O CH₃ H H H H H 41 48NCH₃(CH₂)₄CH₂ H H H O H H CH₃ H CF₃ H 41 49N CH₃(CH₂)₄CH₂ H H H O CH₃ H HH CF₃ H 41 50N CH₃(CH₂)₄CH₂ H H H O CH₃ H H H CH₃ H 41 51N CH₃(CH₂)₄CH₂H H H O H H CH₃ H F H 41 52N CH₃(CH₂)₄CH₂ H H H O H CF₃ H H F H 41 53NCH₃(CH₂)₄CH₂ H H H O H CF₃ H H CH₃ H 41 54N CH₃(CH₂)₄CH₂ H H H O H OCH₃H H CF₃ H 41 55N CH₃(CH₂)₄CH₂ H H H O OCH₃ H H H CH₃ H 41 56NCH₃(CH₂)₄CH₂ H H H O H H CH₃ H CF₃ H 41 57N CH₃(CH₂)₄CH₂ H H H O H C₆H₅OH H H OCF₃ 41 58N CH₃(CH₂)₄CH₂ H H H O H H H H H OCF₃ 41 59NCH₃(CH₂)₄CH₂ H H H O H OCF₃ H H H OCF₃ 41 60N CH₃(CH₂)₄CH₂ H H H O H CF₃F H H CF₃ 41 61N CH₃(CH₂)₄CH₂ H H H O H H OCH₃ H H CF₃ 41 62NCH₃(CH₂)₄CH₂ H H H O H CH₃ H H H CF₃ 41 63N CH₃(CH₂)₄CH₂ H H H O H Cl HH H CF₃ 41 64N CH₃(CH₂)₄CH₂ H H H O H CF₃ H H H OCF₃ 41 65N CH₃(CH₂)₄CH₂H H H O H F H H H OCF₃ 41 66N CH₃(CH₂)₄CH₂ H H H O H F H F H OCF₃ 41 67NCH₃(CH₂)₄CH₂ H H H O H Br H H H OCF₃ 41 68N CH₃(CH₂)₄CH₂ H H H O H Cl HH H OCF₃ 41 69N CH₃(CH₂)₄CH₂ H H H O H F F H H OCF₃ 41 70N CH₃(CH₂)₄CH₂H H H O H F H H H C₆H₅ 41 71N CH₃(CH₂)₄CH₂ H H H O H CH₃ H H H OCF₃ 4172N CH₃(CH₂)₄CH₂ H H H O H F F H H CF₃ 41 73N CH₃(CH₂)₄CH₂ H H H O H ClH H H CH₃ 41 74N CH₃(CH₂)₄CH₂ H H H O H OCH₃ H H H CH₃ 41 75NCH₃(CH₂)₄CH₂ H H H O H F H H H CH₃ 41 76N CH₃(CH₂)₄CH₂ H H H O F F H H HOCF₃ 41 77N CH₃(CH₂)₄CH₂ H H H O OCH₃ H H H H CF₃ 41 78N CH₃(CH₂)₄CH₂ HH H O H H OCH₃ H H CH₃ 41 79N CH₃(CH₂)₄CH₂ H H H O H H CH₃ H H CH₃ 4180N CH₃(CH₂)₄CH₂ H H H O H CH₃ H H H CH₃ 41 81N CH₃(CH₂)₄CH₂ H H H O CH₃H H H H CH₃ 41 82N CH₃(CH₂)₄CH₂ H H H O H F F H H CH₃ 41 83NCH₃(CH₂)₄CH₂ H H H O H F H F H CH₃ 41 84N CH₃(CH₂)₄CH₂ H H H O F F H H HCH₃ 41 85N CH₃(CH₂)₄CH₂ H H H O F CF₃ H H H CH₃ 41 86N CH₃(CH₂)₄CH₂ H HH O H H CH₃ H H CF₃ 41 87N CH₃(CH₂)₄CH₂ H H H O CH₃ H H H H CF₃ 41 88NCH₃(CH₂)₄CH₂ H H H O H CF₃ H H H CH₃ 41 89N CH₃(CH₂)₄CH₂ H H H O OCH₃ HH H H CH₃ 41 90N CH₃(CH₂)₄CH₂ H H H O H H CF₃ H H CH₃ 41 91NCH₃(CH₂)₄CH₂ H H H O CF₃ H H H H CH₃ 41 92N CH₃(CH₂)₄CH₂ H H H O H CF₃ FH H CH₃

TABLE 6 Structure of “Secondary Phenyl Amine” Reagents (Z is covalentbond; there is no R₁₅ substituent, R₄ and R₁₃ equal H). (XIII-A)

Spacer Reagent Bond Number R₅ R₆ R₇ R₈ Y R₁₄ R₉ R₁₀ R₁₁ R₁₂ SpacerPoints 93N Br H H CH H H H OCF₃ —O— R₈ + R₉ 94N OCF₃ H H CH H H H OCF₃ —R₈ + R₉ 95N Br H H C H OCF₃ H H ═CH— R₈ + R₁₄ 96N OH OH H H CH H H C₆H₅OH H none none 97N C₆H₅O H H H CH H H OH OH H none none 98N 3-pyridyl H HH CH H H CF₃ H H none none 99N SO₂N(CH₃)₂ H H H CH H H OCF₃ H H nonenone 100N SO₂CH₃ H H H CH H H OCF₃ H H none none 101N C₆H₅O H H H CH H HC₆H₅O H H none none 102N CF₃O H H H CH H H C₆H₅O H H none none 103N C₆H₅H H H CH H H C₆H₅O H H none none 104N H C₆H₅ H H CH H H C₆H₅O H H nonenonc 105N C₆H₅O H H H CH H H 4-Cl—C₆H₄O H H none none 106N CF₃O H H H CHH H 4-Cl—C₆H₄O H H none none 107N C₆H₅O H H H CH H H 3,4-Cl—C₆H₃O H Hnone none 108N CF₃O H H H CH H H 3,4-Cl—C₆H₃O H H none none 109N CF₃O HH H CH H H 3,5-Cl—C₆H₃O H H none none 110N CF₃O H H H CH H H3-CH₃O—C₆H₄O H H none none 111N CF₃O H H H CH H H H 3-CH₃O—C₆H₄O H nonenone 112N CF₃O H H H CH H H 3-CF₃—C₆H₄O H H none none 113N CF₃O H H H CHH H C₆H₅—CH₂O H H none none 114N CF₃O H H H CH H H C₆H₅—CH₂O CH₃O H nonenone 115N CF₃O H H H CH H H C₆H₅—CH₂O C₆H₅—CH₂O H none none 116N CF₃O HH H CH H H ethoxy H H none none 117N CF₃O H H H CH H H CH₃CO₂ H H nonenone 118N CF₃O H H H CH H H HOCH₂—CH₂O H H none none 119N CF₃O H H H CHH H

H H none none 120N CF₃O H H H CH H H R₁₀ + R₁₁ = OCH₂O H none none 121NCF₃O H H H CH H H R₁₀ + R₁₁ =OCH₂CH₂O H none none 122N CF₃O H H H CH H HCH₃O CH₃O H none none 123N CF₃O H H H CH H H ethoxy CH₃O H none none124N CF₃O H H H CH H H ethoxy ethoxy H none none 125N CF₃O H H H CH H HCH₃CO₂ CH₃CO₂ H none none 126N CF₃O H H H CH H H CH₃O CH₃CO₂ H none none127N CF₃O H H H CH H H n-butoxy H H none none 128N CF₃O H H H CH H HCH₃O H H none none 129N CF₃O H H H CH H H H CH₃O H none none 130N CH₃O HH H CH H H CH₃O H H none none 131N CH₃O H H H CH H H H CF₃O H none none132N CF₃O H H H CH H H H ethoxy H none none 133N CF₃O H H H CH H H Hn-propoxy H none none 134N C₆H₅—CH₂O H H H CH H H CF₃O H H none none135N C₆H₅—CH₂O H H H CH H H C₆H₅O H H none none 136N ethoxy H H H CH H HCF₃O H H none none 137N R₅ + R₆ = OCH₂O H H CH H H CF₃O H H none none138N R₅ + R₆ = OCH₂O H H CH H H C₆H₅O H H none none 139N R₅ + R₆ =OCH₂CH₂O H H CH H H CF₃O H H none none 140N CH₃O CH₃O H H CH H H CF₃O HH none none 141N R₅ + R₆ = OCH₂CH₂CH₂O H H CH H H CF₃O H H none none142N cyclopentoxy CH₃O H H CH H H CF₃O H H none none 143N H C₆H₅O H H CHH H CF₃O H H none none 144N CH₃O CH₃O CH₃O H CH H H CF₃O H H none none145N H CF₃O H H CH H H CF₃O H H none none 146N H C₆H₅—CH₂ H H CH H HCF₃O H H none none 147N C₆H₅O H H H CH H H R₁₀ + R₁₁ = OCH₂CH₂O H nonenone 148N H CF₃O H H CH H H CF₃ H H none none 149N C₆H₅O H H H CH H HCF₃ H H none none 150N C₆H₅ H H H CH H H CF₃ H H none none 151N H C₆H₅ HH CH H H CF₃ H H none none 152N CN H H H CH H H CF₃ H H none none 153N HOCF₃ H H CH H H CF₃ H H none none 154N OCF₃ H H H CH H H H CF₃ H nonenone 155N C₆H₅O H H H CH H H H CF₃ H none none 156N C₆H₅ H H H CH H H HCF₃ H none none 157N H C₆H₅ H H CH H H H CF₃ H none none 158N CN H H HCH H H H CF₃ H none none 159N OCF₃ H H H CH H H H CF₃ H none none 160NCF₃ H H H CH H H H C₆H₅ H none none 161N CF₃ H H H CH H H 3-CF₃—C₆H₅O HH none none 162N CF₃ H H H CH H H C₆H₅O H H none none 163N CF₃ H H H CHH H CF₃O H H none none 164N H CF₃ H H CH H H H C₆H₅ H none none 165N HCF₃ H H CH H H 3-CF₃-C₆H₅O H H none none 166N H CF₃ H H CH H H CF₃O H Hnone none 167N H CF₃ H H CH H H C₆H₅O H H none none 168N CF₃ H CF₃ H CHH H CF₃O H H none none 169N CF₃ H CF₃ H CH H H C₆H₅O H H none none 170NCF₃O H H H CH H H CF₃ H CF₃ none none 171N C₆H₅O H H H CH H H CF₃ H CF₃none none 172N H C₆H₅O H H CH H H C₆H₅O H H none none 173N H CF₃O H H CHH H CF₃O H H none none 174N H CF₃O H H CH H H H C₆H₅O H none none 175NC₆H₅O H H H CH H H H C₆H₅O H none none 176N H C₆H₅O H H CH H H H OCF₃ Hnone none 177N H C₆H₅O H H CH H H H C₆H₅O H none none 178N C₆H₅O H H HCH H H H CN H none none 179N C₆H₅O H H H CH H H CN H H none none 180NC₆H₅O H H H CH H H NO₂ H H none none 181N C₆H₅O H H H CH H H H NO₂ Hnone none 182N C₆H₅O H H H CH H H H SO₂CH₃ H none none 183N C₆H₅O H H HCH H H H 2-NO₂4- H none none Cl—C₆H₃O 184N C₆H₅O H H H CH H H 4-Cl—C₆H₄OH H none none 185N C₆H₅O H H H CH H H 3,4-Cl—C₆H₃O H H none none 186NC₆H₅O H H H CH H H 3-CF₃-C₆H₃O H H none none 187N C₆H₅O H H H CH H H3,5-Cl—C₆H₃O H H none none 188N C₆H₅O H H H CH H H H CH₃O H none none189N C₆H₅O H H H CH H H H CO₂CH₃ H none none 190N C₆H₅O H H H CH H H3-CH₃OC₆H₅O H H none none 191N C₆H₅O H H H CH H H 4-CH₃OC₆H₅O H H nonenone 193N C₆H₅O H H H CH H H CO₂CH₃ H H none none 194N CN H H H CH H HOCF₃ H H none none 195N NO₂ H H H CH H H OCF₃ H H none none 196N H CN HH CH H H OCF₃ H H none none 197N H NO₂ H H CH H H OCF₃ H H none none198N SO₂CH₃ H H H CH H H OCF₃ H H none none 199N H SO₂CH₃ H H CH H HOCF₃ H H none none 200N H 4-F— H H CH H H OCF₃ H H none none C₆H₅SO₂201N SO₂N(CH₃)₂ H H H CH H H OCF₃ H H none none 202N H SO₂N(CH₃)₂ H H CHH H OCF₃ H H none none 203N H CONH₂ H H CH H H OCF₃ H H none none 204N HCONH— H H CH H H OCF₃ H H none none C₆H₅ 205N H CO₂CH₃ H H CH H H OCF₃ HH none none 206N H CO₂C₄H₉ H H CH H H OCF₃ H H none none 207N H4-Cl—C₆H₅ H H CH H H C₆H₅O H H none none 208N H 4-CF₃O— H H CH H H CF₃OH H none none C₆H₅ 209N 4-F—C₆H₄O H H H CH H H CF₃O H H none none 210NC₆F₅O H H H CH H H CF₃O H H none none 211N H 4-F—C₆H₅ H H CH H H CF₃O HH none none 212N H 4-CN—C₆H₅ H H CH H H CF₃O H H none none 213N H4-C₆H₅— H H CH H H CF₃O H H none none C₆H₅ 214N C₆H₅O H H H CH CH₃ HCF₃O H H none none 215N C₆H₅O H H H CH CH₃ H NO₂ H H none none 216NC₆H₅O H H H CH CH₃ H H CN H none none 217N C₆H₅O H H H CH 3-CF₃C₆H₅ HCF₃ H H none none 218N C₆H₅O H H H CH C₆H₅ H H C₆H₅ H none none 219NC₆H₅O H H H CH C₆H₅ H CF₃ H H none none 220N C₆H₅O H H H CH CH₃ H F H Hnone none 221N C₆H₅O H H H CH CF₃ H H H H none none 222N bond to —O— ofR₆ aryl group

H H CH H H CF₃O H H none none 223N to CH₂ of R₆ aryl group

H H CH H H CF₃O H H none none 224N C₆H₅O H H H CH H H OCF₂CF₂H H H nonenone 225N 4-Cl—C₆H₅O H H H CH H H OCF₂CF₂H H H none none 226N 4-F—C₆H₅OH H H CH H H OCF₂CF₂H H H none none 227N 3,4-Cl— H H H CH H H OCF₂CF₂H HH none none C₆H₅O 228N H C₆H₅ H H CH H H OCF₂CF₂H H H none none 229N H4-Cl—C₆H₅ H H CH H H OCF₂CF₂H H H none none 230N H 4-F—C₆H₅ H H CH H HOCF₂CF₂H H H none none 231N H 4-Br—C₆H₅ H H CH H H OCF₂CF₂H H H nonenone 232N 4-Br—C₆H₅O H H H CH H H OCF₂CF₂H H H none none 233N C₆H₅O H HH CH H H OCF₂CF₃ H H none none 234N 4-Cl—C₆H₅O H H H CH H H OCF₂CF₃ H Hnone none 235N 4-F—C₆H₅O H H H CH H H OCF₂CF₃ H H none none 236N 3,4-Cl—H H H CH H H OCF₂CF₃ H H none none C₆H₅O 237N H C₆H₅ H H CH H H OCF₂CF₃H H none none 238N H 4-Cl—C₆H₅ H H CH H H OCF₂CF₃ H H none none 239N H4-F-C₆H₅ H H CH H H OCF₂CF₃ H H none none 240N H 4-Br—C₆H₅ H H CH H HOCF₂CF₃ H H none none 241N 4-Br—C₆H₅O H H H CH H H OCF₂CF₃ H H none none242N C₆H₅O H H H CH H H OCCl₂CCl₂H H H none none 243N 4-Cl—C₆H₅O H H HCH H H OCCl₂CCl₂H H H none none 244N 4-F-C₆H₅O H H H CH H H OCCl₂CCl₂H HH none none 245N 3,4-Cl— H H H CH H H OCCl₂CCl₂H H H none none C₆H₅O246N H C₆H₅ H H CH H H OCCl₂CCl₂H H H none none 247N H 4-Cl—C₆H₅ H H CHH H OCCl₂CCl₂H H H none none 248N H 4-F—C₆H₅ H H CH H H OCCl₂CCl₂H H Hnone none 249N H 4-Br—C₆H₅ H H CH H H OCCl₂CCl₂H H H none none 250N4-Br—C₆H₅O H H H CH H H OCCl₂CCl₂H H H none none 251N C₆H₅O H H H CH H HOCCl₂CCl₃ H H none none 252N 4-Cl—C₆H₅O H H H CH H H OCCl₂CCl₃ H H nonenone 253N 4-F—C₆H₅O H H H CH H H OCCl₂CCl₃ H H none none 254N 3,4-Cl— HH H CH H H OCCl₂CCl₃ H H none none C₆H₅O 255N H C₆H₅ H H CH H HOCCl₂CCl₃ H H none none 256N H 4-Cl—C₆H₅ H H CH H H OCCl₂CCl₃ H H nonenone 257N H 4-F—C₆H₅ H H CH H H OCCl₂CCl₃ H H none none 258N H 4-Br—C₆H₅H H CH H H OCCl₂CCl₃ H H none none 259N 4-Br—C₆H₅O H H H CH H HOCCl₂CCl₃ H H none none 260N C₆H₅O H H H CH H H OCCl₂CF₃ H H none none261N 4-Cl—C₆H₅O H H H CH H H OCCl₂CF₃ H H none none 262N 4-F—C₆H₅O H H HCH H H OCCl₂CF₃ H H none none 263N 3,4-Cl— H H H CH H H OCCl₂CF₃ H Hnone none C₆H₅O 264N H C₆H₅ H H CH H H OCCl₂CF₃ H H none none 265N H4-Cl—C₆H₅ H H CH H H OCCl₂CF₃ H H none none 266N H 4-F—C₆H₅ H H CH H HOCCl₂CF₃ H H none none 267N H 4-Br—C₆H₅ H H CH H H OCCl₂CF₃ H H nonenone 268N 4-Br—C₆H₅O H H H CH H H OCCl₂CF₃ H H none none 269N C₆H₅O H HH CH H H OCF₂CCl₃ H H none none 270N 4-Cl—C₆H₅O H H H CH H H OCF₂CCl₃ HH none none 271N 4-F—C₆H₅O H H H CH H H OCF₂CCl₃ H H none none 272N3,4-Cl— H H H CH H H OCF₂CCl₃ H H none none C₆H₅O 273N H C₆H₅ H H CH H HOCF₂CCl₃ H H none none 274N H 4-Cl—C₆H₅ H H CH H H OCF₂CCl₃ H H nonenone 275N H 4-F—C₆H₅ H H CH H H OCF₂CCl₃ H H none none 276N H 4-Br—C₆H₅H H CH H H OCF₂CCl₃ H H none none 277N 4-Br—C₆H₅O H H H CH H H OCF₂CCl₃H H none none 278N C₆H₅O H H H CH H H OCF₂CF₂H OCF₂CF₂H H none none 279N4-Cl—C₆H₅O H H H CH H H OCF₂CF₂H OCF₂CF₂H H none none 280N 4-F—C₆H₅O H HH CH H H OCF₂CF₂H OCF₂CF₂H H none none 281N 3,4-Cl— H H H CH H HOCF₂CF₂H OCF₂CF₂H H none none C₆H₅O 282N H C₆H₅ H H CH H H OcF₂CF₂HOCF₂CF₂H H none none 283N H 4-Cl—C₆H₅ H H CH H H OCF₂CF₂H OCF₂CF₂H Hnone none 284N H 4-F—C₆H₅ H H CH H H OCF₂CF₂H OCF₂CF₂H H none none 285NH 4-Br—C₆H₅ H H CH H H OCF₂CF₂H OCF₂CF₂H H none none 286N 4-Br—C₆H₅O H HH CH H H OCF₂CF₂H OCF₂CF₂H H none none 287N C₆H₅O H H H CH H H OCF₃ OCF₃H none none 288N 4-Cl—C₆H₅O H H H CH H H OCF₃ OCF₃ H none none 289N4-F—C₆H₅O H H H CH H H OCF₃ OCF₃ H none none 290N 3,4-Cl— H H H CH H HOCF₃ OCF₃ H none none C₆H₅O 291N H C₆H₅ H H CH H H OCF₃ OCF₃ H none none292N H 4-Cl—C₆H₅ H H CH H H OCF₃ OCF₃ H none none 293N H 4-F—C₆H₅ H H CHH H OCF₃ OCF₃ H none none 294N H 4-Br—C₆H₅ H H CH H H OCF₃ OCF₃ H nonenone 295N 4-Br—C₆H₅O H H H CH H H OCF₃ OCF₃ H none none 296N C₆H₅O H H HCH H H OCF₂H OCF₂H H none none 297N 4-Cl—C₆H₅O H H H CH H H OCF₂H OCF₂HH none none 298N 4-F—C₆H₅O H H H CH H H OCF₂H OCF₂H H none none 299N3,4-Cl— H H H CH H H OCF₂H OCF₂H H none none C₆H₅O 300N H C₆H₅ H H CH HH OCF₂H OCF₂H H none none 301N H 4-Cl—C₆H₅ H H CH H H OCF₂H OCF₂H H nonenone 302N H 4-F—C₆H₅ H H CH H H OCF₂H OCF₂H H none none 303N H 4-Br—C₆H₅H H CH H H OCF₂H OCF₂H H none none 304N 4-Br—C₆H₅O H H H CH H H OCF₂HOCF₂H H none none 305N C₆H₅O H H H CH H H R₁₀ + R₁₁ = OCF₂CF₂O H nonenone 306N 4-Cl—C₆H₅O H H H CH H H R₁₀ + R₁₁ = OCF₂CF₂O H none none 307N4-F—C₆H₅O H H H CH H H R₁₀ + R₁₁ = OCF₂CF₂O H none none 308N 3,4-Cl— H HH CH H H R₁₀ + R₁₁ = OCF₂CF₂O H none none C₆H₅O 309N H C₆H₅ H H CH H HR₁₀ + R₁₁ = OCF₂CF₂O H none none 310N H 4-Cl—C₆H₅ H H CH H H R₁₀ + R₁₁ =OCF₂CF₂O H none none 311N H 4-F—C₆H₅ H H CH H H R₁₀ + R₁₁ = OCF₂CF₂O Hnone none 312N H 4-Br—C₆H₅ H H CH H H R₁₀ + R₁₁ = OCF₂CF₂O H none none313N 4-Br—C₆H₅O H H H CH H H R₁₀ + R₁₁ = OCF₂CF₂O H none none 314N C₆H₅OH H H CH H H R₁₀ + R₁₁ = OCCl₂CCl₂O H none none 315N 4-Cl—C₆H₅O H H H CHH H R₁₀ + R₁₁ = OCCl₂CCl₂O H none none 316N 4-F—C₆H₅O H H H CH H H R₁₀ +R₁₁ = OCCl₂CCl₂O H none none 317N 3-4-Cl— H H H CH H H R₁₀ + R₁₁ =OCCl₂CCl₂O H none none C₆H₅O 318N H C₆H₅ H H CH H H R₁₀ + R₁₁ =OCCl₂CCl₂O H none none 319N H 4-Cl—C₆H₅ H H CH H H R₁₀ + R₁₁ =OCCl₂CCl₂O H none none 320N H 4-F—C₆H₅ H H CH H H R₁₀ + R₁₁ = OCCl₂CCl₂OH none none 321N H 4-Br—C₆H₅ H H CH H H R₁₀ + R₁₁ = OCCl₂CCl₂O H nonenone 322N 4-Br—C₆H₅O H H H CH H H R₁₀ + R₁₁ = OCCl₂CCl₂O H none none323N H H H H CH H H OH H H none none 324N H H H H CH H H OH OH H nonenone 325N H H H H CH H H H OH H none none 326N H H H H CH H H OCH₂CF₃ HH none none 327N H H H H CH H H H OCH₂CF₃ H none none 328N H H H H CH HH OCH₂CF₂CF₃ H H none none 329N H H H H CH H H OCH₂CH₂CF₃ H H none none330N H H H H CH H H OCH(CF₃)₃ H H none none 331N H 4-F—C₆H₅O H H CH H HH H H none none 332N 4-F—C₆H₅O H H H CH H H H H H none none 333N Hcyclohexoxy H H CH H H H H H none none 334N cyclohexoxy H H H CH H H H HH none none 335N H CH(CH₃)₃ H H CH H H H H H none none 336N F H H H CH HH

bond to indicated phenyl carbon of R₁₀ substituent H none none

TABLE 7 Structure of Substituted Phenyltertiary-2-Heteroalkylamines (Y =CH; Z is covalent bond; R₁₅ absent; R₃, R₄, R₈, R₉, R₁₃, R₁₄, and R₁₆all equal H unless indicated below).

Inhibitor Number Column 1 + Column 2 Reagent Reagent R₁ R₂ X R₅ R₆ R₇R₁₄ R₁₀ R₁₁ R₁₂ 1  96N CF₃ H O OH OH H H C₆H₅O H H 1  97N CF₃ H O C₆H₅OH H H OH OH H 1  98N CF₃ H O 3-pyridyl H H H CF₃ H H 1  99N CF₃ H O SO₂NH H H OCF₃ H H (CH₃)₂ 1 100N CF₃ H O SO₂CH₃ H H H OCF₃ H H 1 101N CF₃ HO C₆H₅O H H H C₆H₅O H H 1 102N CF₃ H O CF₃O H H H C₆H₅O H H 1 103N CF₃ HO C₆H₅ H H H C₆H₅O H H 1 104N CF₃ H O H C₆H₅ H H C₆H₅O H H 1 105N CF₃ HO C₆H₅O H H H 4-Cl—C₆H₄O H H 1 106N CF₃ H O CF₃O H H H 4-Cl—C₆H₄O H H 1107N CF₃ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 1 108N CF₃ H O CF₃O H H H3,4-Cl—C₆H₃O H H 1 109N CF₃ H O CF₃O H H H 3,5-Cl—C₆H₃O H H 1 110N CF₃ HO CF₃O H H H 3-CH₃O—C₆H₄O H H 1 111N CF₃ H O CF₃O H H H H 3-CH₃O—C₆H₄O H1 112N CF₃ H O CF₃O H H H 3-CF₃—C₆H₄O H H 1 113N CF₃ H O CF₃O H H HC₆H₅—CH₂O H H 1 114N CF₃ H O CF₃O H H H C₆H₅—CH₂O CH₃O H 1 115N CF₃ H OCF₃O H H H C₆H₅—CH₂O C₆H₅—CH₂O H 1 116N CF₃ H O CF₃O H H H ethoxy H H 1117N CF₃ H O CF₃O H H H CH₃CO₂ H H 1 118N CF₃ H O CF₃O H H H HOCH₂—CH₂OH H 1 119N CF₃ H O CF₃O H H H

H H 1 120N CF₃ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 1 121N CF₃ H O CF₃O HH H R₁₀ + R₁₁ = OCH₂CH₂O H 1 122N CF₃ H O CF₃O H H H CH₃O CH₃O H 1 123NCF₃ H O CF₃O H H H ethoxy CH₃O H 1 124N CF₃ H O CF₃O H H H ethoxy ethoxyH 1 125N CF₃ H O CF₃O H H H CH₃CO₂ CH₃CO₂ H 1 126N CF₃ H O CF₃O H H HCH₃O CH₃CO₂ H 1 127N CF₃ H O CF₃O H H H n-butoxy H H 1 128N CF₃ H O CF₃OH H H CH₃O H H 1 129N CF₃ H O CF₃O H H H H CH₃O H 1 130N CF₃ H O CH₃O HH H CH₃O H H 1 131N CF₃ H O CH₃O H H H H CF₃O H 1 132N CF₃ H O CF₃O H HH H ethoxy H 1 133N CF₃ H O CF₃O H H H H n-propoxy H 1 134N CF₃ H OC₆H₅—CH₂O H H H CF₃O H H 1 135N CF₃ H O C₆H₅—CH₂O H H H C₆H₅O H H 1 136NCF₃ H O ethoxy H H H CF₃O H H 1 137N CF₃ H O R₅ + R₆ = OCH₂O H H CF₃O HH 1 138N CF₃ H O R₅ + R₆ = OCH₂O H H C₆H₅O H H 1 139N CF₃ H O R₅ + R₆ =OCH₂CH₂O H H CF₃O H H 1 140N CF₃ H O CH₃O CH₃O H H CF₃O H H 1 141N CF₃ HO R₅ + R₆ = OCH₂CH₂CH₂O H H CF₃O H H 1 142N CF₃ H O cyclo CH₃O H H CF₃OH H pentoxy 1 143N CF₃ H O H C₆H₅O H H CF₃O H H 1 144N CF₃ H O CH₃O CH₃OCH₃O H CF₃O H H 1 145N CF₃ H O H CF₃O H H CF₃O H H 1 146N CF₃ H O HC₆H₅—CH₂ H H CF₃O H H 1 147N CF₃ H O C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H1 148N CF₃ H O H CF₃O H H CF₃ H H 1 149N CF₃ H O C₆H₅O H H H CF₃ H H 1150N CF₃ H O C₆H₅ H H H CF₃ H H 1 151N CF₃ H O H C₆H₅ H H CF₃ H H 1 152NCF₃ H O CN H H H CF₃ H H 1 153N CF₃ H O H OCF₃ H H CF₃ H H 1 154N CF₃ HO OCF₃ H H H H CF₃ H 1 155N CF₃ H O C₆H₅O H H H H CF₃ H 1 156N CF₃ H OC₆H₅ H H H H CF₃ H 1 157N CF₃ H O H C₆H₅ H H H CF₃ H 1 158N CF₃ H O CN HH H H CF₃ H 1 159N CF₃ H O OCF₃ H H H H CF₃ H 1 160N CF₃ H O CF₃ H H H HC₆H₅ H 1 161N CF₃ H O CF₃ H H H 3-CF₃—C₆H₅O H H 1 162N CF₃ H O CF₃ H H HC₆H₅O H H 1 163N CF₃ H O CF₃ H H H CF₃O H H 1 164N CF₃ H O H CF₃ H H HC₆H₅ H 1 165N CF₃ H O H CF₃ H H 3-CF₃—C₆H₅O H H 1 166N CF₃ H O H CF₃ H HCF₃O H H 1 167N CF₃ H O H CF₃ H H C₆H₅O H H 1 168N CF₃ H O CF₃ H CF₃ HCF₃O H H 1 169N CF₃ H O CF₃ H CF₃ H C₆H₅O H H 1 170N CF₃ H O CF₃O H H HCF₃ H CF₃ 1 171N CF₃ H O C₆H₅O H H H CF₃ H CF₃ 1 172N CF₃ H O H C₆H₅O HH C₆H₅O H H 1 173N CF₃ H O H CF₃O H H CF₃O H H 1 174N CF₃ H O H CF₃O H HH C₆H₅O H 1 175N CF₃ H O C₆H₅O H H H H C₆H₅O H 1 176N CF₃ H O H C₆H₅O HH H OCF₃ H 1 177N CF₃ H O H C₆H₅O H H H C₆H₅O H 1 178N CF₃ H O C₆H₅O H HH H CN H 1 179N CF₃ H O C₆H₅O H H H CN H H 1 180N CF₃ H O C₆H₅O H H HNO₂ H H 1 181N CF₃ H O C₆H₅O H H H H NO₂ H 1 182N CF₃ H O C₆H₅O H H H HSO₂CH₃ H 1 183N CF₃ H O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 1 184N CF₃ H OC₆H₅O H H H 4-Cl—C₆H₄O H H 1 185N CF₃ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 1186N CF₃ H O C₆H₅O H H H 3-CF₃—C₆H₃O H H 1 187N CF₃ H O C₆H₅O H H H3,5-Cl—C₆H₃O H H 1 188N CF₃ H O C₆H₅O H H H H CH₃O H 1 189N CF₃ H OC₆H₅O H H H H CO₂CH₃ H 1 190N CF₃ H O C₆H₅O H H H 3-CH₃O H H C₆H₅O 1191N CF₃ H O C₆H₅O H H H 4-CH₃O H H C₆H₅O 1 193N CF₃ H O C₆H₅O H H HCO₂CH₃ H H 1 194N CF₃ H O CN H H H OCF₃ H H 1 195N CF₃ H O NO₂ H H HOCF₃ H H 1 196N CF₃ H O H CN H H OCF₃ H H 1 197N CF₃ H O H NO₂ H H OCF₃H H 1 198N CF₃ H O SO₂CH₃ H H H OCF₃ H H 1 199N CF₃ H O H SO₂CH₃ H HOCF₃ H H 1 200N CF₃ H O H 4-F—C₆H₅SO₂ H H OCF₃ H H 1 201N CF₃ H O SO₂N HH H OCF₃ H H (CH₃)₂ 1 202N CF₃ H O H SO₂N(CH₃)₂ H H OCF₃ H H 1 203N CF₃H O H CONH₂ H H OCF₃ H H 1 204N CF₃ H O H CONH—C₆H₅ H H OCF₃ H H 1 205NCF₃ H O H CO₂CH₃ H H OCF₃ H H 1 206N CF₃ H O H CO₂C₄H₉ H H OCF₃ H H 1207N CF₃ H O H 4-Cl—C₆H₅ H H C₆H₅O H H 1 208N CF₃ H O H 4-CF₃O—C₆H₅ H HCF₃O H H 1 209N CF₃ H O 4-F—C₆H₄O H H H CF₃O H H 1 210N CF₃ H O C₆F₅O HH H CF₃O H H 1 211N CF₃ H O H 4-F—C₆H₅ H H CF₃O H H 1 212N CF₃ H O H4-CN—C₆H₅ H H CF₃O H H 1 213N CF₃ H O H 4-C₆H₅—C₆H₅ H H CF₃O H H 1 214NCF₃ H O C₆H₅O H H CH₃ CF₃O H H 1 215N CF₃ H O C₆H₅O H H CH₃ NO₂ H H 1216N CF₃ H O C₆H₅O H H CH₃ H CN H 1 217N CF₃ H O C₆H₅O H H 3-CF₃ CF₃ H HC₆H₅ 1 218N CF₃ H O C₆H₅O H H C₆H₅ H C₆H₅ H 1 219N CF₃ H O C₆H₅O H HC₆H₅ CF₃ H H 1 220N CF₃ H O C₆H₅O H H CH₃ F H H 1 221N CF₃ H O C₆H₅O H HCF₃ H H H 1 222N CF₃ H O bond to —O— of R₆ aryl group

H H CF₃O H H 1 223N CF₃ H O to CH₂ of R₆ aryl group

H H CF₃O H H 2  96N CCl₃ H O OH OH H H C₆H₅O H H 2  97N CCl₃ H O C₆H₅O HH H OH OH H 2  98N CCl₃ H O 3-pyridyl H H H CF₃ H H 2  99N CCl₃ H O SO₂NH H H OCF₃ H H (CH₃)₂ 2 100N CCl₃ H O SO₂CH₃ H H H OCF₃ H H 2 101N CCl₃H O C₆H₅O H H H C₆H₅O H H 2 102N CCl₃ H O CF₃O H H H C₆H₅O H H 2 103NCCl₃ H O C₆H₅ H H H C₆H₅O H H 2 104N CCl₃ H O H C₆H₅ H H C₆H₅O H H 2105N CCl₃ H O C₆H₅O H H H 4-Cl—C₆H₄O H H 2 106N CCl₃ H O CF₃O H H H4-Cl—C₆H₄O H H 2 107N CCl₃ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 2 108N CCl₃H O CF₃O H H H 3,4-Cl—C₆H₃O H H 2 109N CCl₃ H O CF₃O H H H 3,5-Cl—C₆H₃OH H 2 110N CCl₃ H O CF₃O H H H 3-CH₃O—C₆H₄O H H 2 111N CCl₃ H O CF₃O H HH H 3-CH₃O—C₆H₄O H 2 112N CCl₃ H O CF₃O H H H 3-CF₃—C₆H₄O H H 2 113NCCl₃ H O CF₃O H H H C₆H₅—CH₂O H H 2 114N CCl₃ H O CF₃O H H H C₆H₅—CH₂OCH₃O H 2 115N CCl₃ H O CF₃O H H H C₆H₅—CH₂O C₆H₅—CH₂O H 2 116N CCl₃ H OCF₃O H H H ethoxy H H 2 117N CCl₃ H O CF₃O H H H CH₃CO₂ H H 2 118N CCl₃H O CF₃O H H H HOCH₂—CH₂O H H 2 119N CCl₃ H O CF₃O H H H

H H 2 120N CCl₃ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 2 121N CCl₃ H O CF₃OH H H R₁₀ + R₁₁ = OCH₂CH₂O H 2 122N CCl₃ H O CF₃O H H H CH₃O CH₃O H 2123N CCl₃ H O CF₃O H H H ethoxy CH₃O H 2 124N CCl₃ H O CF₃O H H H ethoxyethoxy H 2 125N CCl₃ H O CF₃O H H H CH₃CO₂ CH₃CO₂ H 2 126N CCl₃ H O CF₃OH H H CH₃O CH₃CO₂ H 2 127N CCl₃ H O CF₃O H H H n-butoxy H H 2 128N CCl₃H O CF₃O H H H CH₃O H H 2 129N CCl₃ H O CF₃O H H H H CH₃O H 2 130N CCl₃H O CH₃O H H H CH₃O H H 2 131N CCl₃ H O CH₃O H H H H CF₃O H 2 132N CCl₃H O CF₃O H H H H ethoxy H 2 133N CCl₃ H O CF₃O H H H H n-propoxy H 2134N CCl₃ H O C₆H₅—CH₂O H H H CF₃O H H 2 135N CCl₃ H O C₆H₅—CH₂O H H HC₆H₅O H H 2 136N CCl₃ H O ethoxy H H H CF₃O H H 2 137N CCl₃ H O R₅ + R₆= OCH₂O H H CF₃O H H 2 138N CCl₃ H O R₅ + R₆ = OCH₂O H H C₆H₅O H H 2139N CCl₃ H O R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 2 140N CCl₃ H O CH₃O CH₃OH H CF₃O H H 2 141N CCl₃ H O R₅ + R₆ = OCH₂CH₂CH₂O H H CF₃O H H 2 142NCCl₃ H O cyclo CH₃O H H CF₃O H H pentoxy 2 143N CCl₃ H O H C₆H₅O H HCF₃O H H 2 144N CCl₃ H O CH₃O CH₃O CH₃O H CF₃O H H 2 145N CCl₃ H O HCF₃O H H CF₃O H H 2 146N CCl₃ H O H C₆H₅—CH₂ H H CF₃O H H 2 147N CCl₃ HO C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 2 148N CCl₃ H O H CF₃O H H CF₃ H H2 149N CCl₃ H O C₆H₅O H H H CF₃ H H 2 150N CCl₃ H O C₆H₅ H H H CF₃ H H 2151N CCl₃ H O H C₆H₅ H H CF₃ H H 2 152N CCl₃ H O CN H H H CF₃ H H 2 153NCCl₃ H O H OCF₃ H H CF₃ H H 2 154N CCl₃ H O OCF₃ H H H H CF₃ H 2 155NCCl₃ H O C₆H₅O H H H H CF₃ H 2 156N CCl₃ H O C₆H₅ H H H H CF₃ H 2 157NCCl₃ H O H C₆H₅ H H H CF₃ H 2 158N CCl₃ H O CN H H H H CF₃ H 2 159N CCl₃H O OCF₃ H H H H CF₃ H 2 160N CCl₃ H O CF₃ H H H H C₆H₅ H 2 161N CCl₃ HO CF₃ H H H 3-CF₃—C₆H₅O H H 2 162N CCl₃ H O CF₃ H H H C₆H₅O H H 2 163NCCl₃ H O CF₃ H H H CF₃O H H 2 164N CCl₃ H O H CF₃ H H H C₆H₅ H 2 165NCCl₃ H O H CF₃ H H 3-CF₃—C₆H₅O H H 2 166N CCl₃ H O H CF₃ H H CF₃O H H 2167N CCl₃ H O H CF₃ H H C₆H₅O H H 2 168N CCl₃ H O CF₃ H CF₃ H CF₃O H H 2169N CCl₃ H O CF₃ H CF₃ H C₆H₅O H H 2 170N CCl₃ H O CF₃O H H H CF₃ H CF₃2 171N CCl₃ H O C₆H₅O H H H CF₃ H CF₃ 2 172N CCl₃ H O H C₆H₅O H H C₆H₅OH H 2 173N CCl₃ H O H CF₃O H H CF₃O H H 2 174N CCl₃ H O H CF₃O H H HC₆H₅O H 2 175N CCl₃ H O C₆H₅O H H H H C₆H₅O H 2 176N CCl₃ H O H C₆H₅O HH H OCF₃ H 2 177N CCl₃ H O H C₆H₅O H H H C₆H₅O H 2 178N CCl₃ H O C₆H₅O HH H H CN H 2 179N CCl₃ H O C₆H₅O H H H CN H H 2 180N CCl₃ H O C₆H₅O H HH NO₂ H H 2 181N CCl₃ H O C₆H₅O H H H H NO₂ H 2 182N CCl₃ H O C₆H₅O H HH H SO₂CH₃ H 2 183N CCl₃ H O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 2 184NCCl₃ H O C₆H₅O H H H 4-Cl—C₆H₄O H H 2 185N CCl₃ H O C₆H₅O H H H3,4-Cl—C₆H₃O H H 2 186N CCl₃ H O C₆H₅O H H H 3-CF₃—C₆H₃O H H 2 187N CCl₃H O C₆H₅O H H H 3,5-Cl—C₆H₃O H H 2 188N CCl₃ H O C₆H₅O H H H H CH₃O H 2189N CCl₃ H O C₆H₅O H H H H CO₂CH₃ H 2 190N CCl₃ H O C₆H₅O H H H 3-CH₃OH H C₆H₅O 2 191N CCl₃ H O C₆H₅O H H H 4-CH₃O H H C₆H₅O 2 193N CCl₃ H OC₆H₅O H H H CO₂CH₃ H H 2 194N CCl₃ H O CN H H H OCF₃ H H 2 195N CCl₃ H ONO₂ H H H OCF₃ H H 2 196N CCl₃ H O H CN H H OCF₃ H H 2 197N CCl₃ H O HNO₂ H H OCF₃ H H 2 198N CCl₃ H O SO₂CH₃ H H H OCF₃ H H 2 199N CCl₃ H O HSO₂CH₃ H H OCF₃ H H 2 200N CCl₃ H O H 4-F—C₆H₅SO₂ H H OCF₃ H H 2 201NCCl₃ H O SO₂N H H H OCF₃ H H (CH₃)₂ 2 202N CCl₃ H O H SO₂N(CH₃)₂ H HOCF₃ H H 2 203N CCl₃ H O H CONH₂ H H OCF₃ H H 2 204N CCl₃ H O HCONH—C₆H₅ H H OCF₃ H H 2 205N CCl₃ H O H CO₂CH₃ H H OCF₃ H H 2 206N CCl₃H O H CO₂C₄H₉ H H OCF₃ H H 2 207N CCl₃ H O H 4-Cl—C₆H₅ H H C₆H₅O H H 2208N CCl₃ H O H 4-CF₃O—C₆H₅ H H CF₃O H H 2 209N CCl₃ H O 4-F—C₆H₄O H H HCF₃O H H 2 210N CCl₃ H O C₆F₅O H H H CF₃O H H 2 211N CCl₃ H O H 4-F—C₆H₅H H CF₃O H H 2 212N CCl₃ H O H 4-CN—C₆H₅ H H CF₃O H H 2 213N CCl₃ H O H4-C₆H₅—C₆H₅ H H CF₃O H H 2 214N CCl₃ H O C₆H₅O H H CH₃ CF₃O H H 2 215NCCl₃ H O C₆H₅O H H CH₃ NO₂ H H 2 216N CCl₃ H O C₆H₅O H H CH₃ H CN H 2217N CCl₃ H O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 2 218N CCl₃ H O C₆H₅O H HC₆H₅ H C₆H₅ H 2 219N CCl₃ H O C₆H₅O H H C₆H₅ CF₃ H H 2 220N CCl₃ H OC₆H₅O H H CH₃ F H H 2 221N CCl₃ H O C₆H₅O H H CF₃ H H H 2 222N CCl₃ H Obond to —O— of R₆ aryl group

H H CF₃O H H 2 223N CCl₃ H O to CH₂ of R₆ aryl group

H H CF₃O H H 3  96N CF₃ CH₃ O OH OH H H C₆H₅O H H 3  97N CF₃ CH₃ O C₆H₅OH H H OH OH H 3  98N CF₃ CH₃ O 3-pyridyl H H H CF₃ H H 3  99N CF₃ CH₃ OSO₂N H H H OCF₃ H H (CH₃)₂ 3 100N CF₃ CH₃ O SO₂CH₃ H H H OCF₃ H H 3 101NCF₃ CH₃ O C₆H₅O H H H C₆H₅O H H 3 102N CF₃ CH₃ O CF₃O H H H C₆H₅O H H 3103N CF₃ CH₃ O C₆H₅ H H H C₆H₅O H H 3 104N CF₃ CH₃ O H C₆H₅ H H C₆H₅O HH 3 105N CF₃ CH₃ O C₆H₅O H H H 4-Cl—C₆H₄O H H 3 106N CF₃ CH₃ O CF₃O H HH 4-Cl—C₆H₄O H H 3 107N CF₃ CH₃ O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 3 108NCF₃ CH₃ O CF₃O H H H 3,4-Cl—C₆H₃O H H 3 109N CF₃ CH₃ O CF₃O H H H3,5-Cl—C₆H₃O H H 3 110N CF₃ CH₃ O CF₃O H H H 3-CH₃O—C₆H₄O H H 3 111N CF₃CH₃ O CF₃O H H H H 3-CH₃O—C₆H₄O H 3 112N CF₃ CH₃ O CF₃O H H H3-CF₃—C₆H₄O H H 3 113N CF₃ CH₃ O CF₃O H H H C₆H₅—CH₂O H H 3 114N CF₃ CH₃O CF₃O H H H C₆H₅—CH₂O CH₃O H 3 115N CF₃ CH₃ O CF₃O H H H C₆H₅—CH₂OC₆H₅—CH₂O H 3 116N CF₃ CH₃ O CF₃O H H H ethoxy H H 3 117N CF₃ CH₃ O CF₃OH H H CH₃CO₂ H H 3 118N CF₃ CH₃ O CF₃O H H H HOCH₂—CH₂O H H 3 119N CF₃CH₃ O CF₃O H H H

H H 3 120N CF₃ CH₃ O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 3 121N CF₃ CH₃ OCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 3 122N CF₃ CH₃ O CF₃O H H H CH₃O CH₃OH 3 123N CF₃ CH₃ O CF₃O H H H ethoxy CH₃O H 3 124N CF₃ CH₃ O CF₃O H H Hethoxy ethoxy H 3 125N CF₃ CH₃ O CF₃O H H H CH₃CO₂ CH₃CO₂ H 3 126N CF₃CH₃ O CF₃O H H H CH₃O CH₃CO₂ H 3 127N CF₃ CH₃ O CF₃O H H H n-butoxy H H3 128N CF₃ CH₃ O CF₃O H H H CH₃O H H 3 129N CF₃ CH₃ O CF₃O H H H H CH₃OH 3 130N CF₃ CH₃ O CH₃O H H H CH₃O H H 3 131N CF₃ CH₃ O CH₃O H H H HCF₃O H 3 132N CF₃ CH₃ O CF₃O H H H H ethoxy H 3 133N CF₃ CH₃ O CF₃O H HH H n-propoxy H 3 134N CF₃ CH₃ O C₆H₅—CH₂O H H H CF₃O H H 3 135N CF₃ CH₃O C₆H₅—CH₂O H H H C₆H₅O H H 3 136N CF₃ CH₃ O ethoxy H H H CF₃O H H 3137N CF₃ CH₃ O R₅ + R₆ = OCH₂O H H CF₃O H H 3 138N CF₃ CH₃ O R₅ + R₆ =OCH₂O H H C₆H₅O H H 3 139N CF₃ CH₃ O R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 3140N CF₃ CH₃ O CH₃O CH₃O H H CF₃O H H 3 141N CF₃ CH₃ O R₅ + R₆ =OCH₂CH₂CH₂O H H CF₃O H H 3 142N CF₃ CH₃ O cyclo CH₃O H H CF₃O H Hpentoxy 3 143N CF₃ CH₃ O H C₆H₅O H H CF₃O H H 3 144N CF₃ CH₃ O CH₃O CH₃OCH₃O H CF₃O H H 3 145N CF₃ CH₃ O H CF₃O H H CF₃O H H 3 146N CF₃ CH₃ O HC₆H₅—CH₂ H H CF₃O H H 3 147N CF₃ CH₃ O C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂OH 3 148N CF₃ CH₃ O H CF₃O H H CF₃ H H 3 149N CF₃ CH₃ O C₆H₅O H H H CF₃ HH 3 150N CF₃ CH₃ O C₆H₅ H H H CF₃ H H 3 151N CF₃ CH₃ O H C₆H₅ H H CF₃ HH 3 152N CF₃ CH₃ O CN H H H CF₃ H H 3 153N CF₃ CH₃ O H OCF₃ H H CF₃ H H3 154N CF₃ CH₃ O OCF₃ H H H H CF₃ H 3 155N CF₃ CH₃ O C₆H₅O H H H H CF₃ H3 156N CF₃ CH₃ O C₆H₅ H H H H CF₃ H 3 157N CF₃ CH₃ O H C₆H₅ H H H CF₃ H3 158N CF₃ CH₃ O CN H H H H CF₃ H 3 159N CF₃ CH₃ O OCF₃ H H H H CF₃ H 3160N CF₃ CH₃ O CF₃ H H H H C₆H₅ H 3 161N CF₃ CH₃ O CF₃ H H H 3-CF₃—C₆H₅OH H 3 162N CF₃ CH₃ O CF₃ H H H C₆H₅O H H 3 163N CF₃ CH₃ O CF₃ H H H CF₃OH H 3 164N CF₃ CH₃ O H CF₃ H H H C₆H₅ H 3 165N CF₃ CH₃ O H CF₃ H H3-CF₃—C₆H₅O H H 3 166N CF₃ CH₃ O H CF₃ H H CF₃O H H 3 167N CF₃ CH₃ O HCF₃ H H C₆H₅O H H 3 168N CF₃ CH₃ O CF₃ H CF₃ H CF₃O H H 3 169N CF₃ CH₃ OCF₃ H CF₃ H C₆H₅O H H 3 170N CF₃ CH₃ O CF₃O H H H CF₃ H CF₃ 3 171N CF₃CH₃ O C₆H₅O H H H CF₃ H CF₃ 3 172N CF₃ CH₃ O H C₆H₅O H H C₆H₅O H H 3173N CF₃ CH₃ O H CF₃O H H CF₃O H H 3 174N CF₃ CH₃ O H CF₃O H H H C₆H₅O H3 175N CF₃ CH₃ O C₆H₅O H H H H C₆H₅O H 3 176N CF₃ CH₃ O H C₆H₅O H H HOCF₃ H 3 177N CF₃ CH₃ O H C₆H₅O H H H C₆H₅O H 3 178N CF₃ CH₃ O C₆H₅O H HH H CN H 3 179N CF₃ CH₃ O C₆H₅O H H H CN H H 3 180N CF₃ CH₃ O C₆H₅O H HH NO₂ H H 3 181N CF₃ CH₃ O C₆H₅O H H H H NO₂ H 3 182N CF₃ CH₃ O C₆H₅O HH H H SO₂CH₃ H 3 183N CF₃ CH₃ O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 3 184NCF₃ CH₃ O C₆H₅O H H H 4-Cl—C₆H₄O H H 3 185N CF₃ CH₃ O C₆H₅O H H H3,4-Cl—C₆H₃O H H 3 186N CF₃ CH₃ O C₆H₅O H H H 3-CF₃—C₆H₃O H H 3 187N CF₃CH₃ O C₆H₅O H H H 3,5-Cl—C₆H₃O H H 3 188N CF₃ CH₃ O C₆H₅O H H H H CH₃O H3 189N CF₃ CH₃ O C₆H₅O H H H H CO₂CH₃ H 3 190N CF₃ CH₃ O C₆H₅O H H H3-CH₃O H H C₆H₅O 3 191N CF₃ CH₃ O C₆H₅O H H H 4-CH₃O H H C₆H₅O 3 193NCF₃ CH₃ O C₆H₅O H H H CO₂CH₃ H H 3 194N CF₃ CH₃ O CN H H H OCF₃ H H 3195N CF₃ CH₃ O NO₂ H H H OCF₃ H H 3 196N CF₃ CH₃ O H CN H H OCF₃ H H 3197N CF₃ CH₃ O H NO₂ H H OCF₃ H H 3 198N CF₃ CH₃ O SO₂CH₃ H H H OCF₃ H H3 199N CF₃ CH₃ O H SO₂CH₃ H H OCF₃ H H 3 200N CF₃ CH₃ O H 4-F—C₆H₅SO₂ HH OCF₃ H H 3 201N CF₃ CH₃ O SO₂N H H H OCF₃ H H (CH₃)₂ 3 202N CF₃ CH₃ OH SO₂N(CH₃)₂ H H OCF₃ H H 3 203N CF₃ CH₃ O H CONH₂ H H OCF₃ H H 3 204NCF₃ CH₃ O H CONH—C₆H₅ H H OCF₃ H H 3 205N CF₃ CH₃ O H CO₂CH₃ H H OCF₃ HH 3 206N CF₃ CH₃ O H CO₂C₄H₉ H H OCF₃ H H 3 207N CF₃ CH₃ O H 4-Cl—C₆H₅ HH C₆H₅O H H 3 208N CF₃ CH₃ O H 4-CF₃O—C₆H₅ H H CF₃O H H 3 209N CF₃ CH₃ O4-F—C₆H₄O H H H CF₃O H H 3 210N CF₃ CH₃ O C₆F₅O H H H CF₃O H H 3 211NCF₃ CH₃ O H 4-F—C₆H₅ H H CF₃O H H 3 212N CF₃ CH₃ O H 4-CN—C₆H₅ H H CF₃OH H 3 213N CF₃ CH₃ O H 4-C₆H₅—C₆H₅ H H CF₃O H H 3 214N CF₃ CH₃ O C₆H₅O HH CH₃ CF₃O H H 3 215N CF₃ CH₃ O C₆H₅O H H CH₃ NO₂ H H 3 216N CF₃ CH₃ OC₆H₅O H H CH₃ H CN H 3 217N CF₃ CH₃ O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 3218N CF₃ CH₃ O C₆H₅O H H C₆H₅ H C₆H₅ H 3 219N CF₃ CH₃ O C₆H₅O H H C₆H₅CF₃ H H 3 220N CF₃ CH₃ O C₆H₅O H H CH₃ F H H 3 221N CF₃ CH₃ O C₆H₅O H HCF₃ H H H 3 222N CF₃ CH₃ O bond to —O— of R₆ aryl group

H H CF₃O H H 3 223N CF₃ CH₃ O to CH₂ of R₆ aryl group

H H CF₃O H H 4  96N CF₃CF₂ H O OH OH H H C₆H₅O H H 4  97N CF₃CF₂ H OC₆H₅O H H H OH OH H 4  98N CF₃CF₂ H O 3-pyridyl H H H CF₃ H H 4  99NCF₃CF₂ H O SO₂N H H H OCF₃ H H (CH₃)₂ 4 100N CF₃CF₂ H O SO₂CH₃ H H HOCF₃ H H 4 101N CF₃CF₂ H O C₆H₅O H H H C₆H₅O H H 4 102N CF₃CF₂ H O CF₃OH H H C₆H₅O H H 4 103N CF₃CF₂ H O C₆H₅ H H H C₆H₅O H H 4 104N CF₃CF₂ H OH C₆H₅ H H C₆H₅O H H 4 105N CF₃CF₂ H O C₆H₅O H H H 4-Cl—C₆H₄O H H 4 106NCF₃CF₂ H O CF₃O H H H 4-Cl—C₆H₄O H H 4 107N CF₃CF₂ H O C₆H₅O H H H3,4-Cl—C₆H₃O H H 4 108N CF₃CF₂ H O CF₃O H H H 3,4-Cl—C₆H₃O H H 4 109NCF₃CF₂ H O CF₃O H H H 3,5-Cl—C₆H₃O H H 4 110N CF₃CF₂ H O CF₃O H H H3-CH₃O—C₆H₄O H H 4 111N CF₃CF₂ H O CF₃O H H H H 3-CH₃O—C₆H₄O H 4 112NCF₃CF₂ H O CF₃O H H H 3-CF₃—C₆H₄O H H 4 113N CF₃CF₂ H O CF₃O H H HC₆H₅—CH₂O H H 4 114N CF₃CF₂ H O CF₃O H H H C₆H₅—CH₂O CH₃O H 4 115NCF₃CF₂ H O CF₃O H H H C₆H₅—CH₂O C₆H₅—CH₂O H 4 116N CF₃CF₂ H O CF₃O H H Hethoxy H H 4 117N CF₃CF₂ H O CF₃O H H H CH₃CO₂ H H 4 118N CF₃CF₂ H OCF₃O H H H HOCH₂—CH₂O H H 4 119N CF₃CF₂ H O CF₃O H H H

H H 4 120N CF₃CF₂ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 4 121N CF₃CF₂ H OCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 4 122N CF₃CF₂ H O CF₃O H H H CH₃O CH₃OH 4 123N CF₃CF₂ H O CF₃O H H H ethoxy CH₃O H 4 124N CF₃CF₂ H O CF₃O H HH ethoxy ethoxy H 4 125N CF₃CF₂ H O CF₃O H H H CH₃CO₂ CH₃CO₂ H 4 126NCF₃CF₂ H O CF₃O H H H CH₃O CH₃CO₂ H 4 127N CF₃CF₂ H O CF₃O H H Hn-butoxy H H 4 128N CF₃CF₂ H O CF₃O H H H CH₃O H H 4 129N CF₃CF₂ H OCF₃O H H H H CH₃O H 4 130N CF₃CF₂ H O CH₃O H H H CH₃O H H 4 131N CF₃CF₂H O CH₃O H H H H CF₃O H 4 132N CF₃CF₂ H O CF₃O H H H H ethoxy H 4 133NCF₃CF₂ H O CF₃O H H H H n-propoxy H 4 134N CF₃CF₂ H O C₆H₅—CH₂O H H HCF₃O H H 4 135N CF₃CF₂ H O C₆H₅—CH₂O H H H C₆H₅O H H 4 136N CF₃CF₂ H Oethoxy H H H CF₃O H H 4 137N CF₃CF₂ H O R₅ + R₆ = OCH₂O H H CF₃O H H 4138N CF₃CF₂ H O R₅ + R₆ = OCH₂O H H C₆H₅O H H 4 139N CF₃CF₂ H O R₅ + R₆= OCH₂CH₂O H H CF₃O H H 4 140N CF₃CF₂ H O CH₃O CH₃O H H CF₃O H H 4 141NCF₃CF₂ H O R₅ + R₆ = OCH₂CH₂CH₂O H H CF₃O H H 4 142N CF₃CF₂ H O cycloCH₃O H H CF₃O H H pentoxy 4 143N CF₃CF₂ H O H C₆H₅O H H CF₃O H H 4 144NCF₃CF₂ H O CH₃O CH₃O CH₃O H CF₃O H H 4 145N CF₃CF₂ H O H CF₃O H H CF₃O HH 4 146N CF₃CF₂ H O H C₆H₅—CH₂ H H CF₃O H H 4 147N CF₃CF₂ H O C₆H₅O H HH R₁₀ + R₁₁ = OCH₂CH₂O H 4 148N CF₃CF₂ H O H CF₃O H H CF₃ H H 4 149NCF₃CF₂ H O C₆H₅O H H H CF₃ H H 4 150N CF₃CF₂ H O C₆H₅ H H H CF₃ H H 4151N CF₃CF₂ H O H C₆H₅ H H CF₃ H H 4 152N CF₃CF₂ H O CN H H H CF₃ H H 4153N CF₃CF₂ H O H OCF₃ H H CF₃ H H 4 154N CF₃CF₂ H O OCF₃ H H H H CF₃ H4 155N CF₃CF₂ H O C₆H₅O H H H H CF₃ H 4 156N CF₃CF₂ H O C₆H₅ H H H H CF₃H 4 157N CF₃CF₂ H O H C₆H₅ H H H CF₃ H 4 158N CF₃CF₂ H O CN H H H H CF₃H 4 159N CF₃CF₂ H O OCF₃ H H H H CF₃ H 4 160N CF₃CF₂ H O CF₃ H H H HC₆H₅ H 4 161N CF₃CF₂ H O CF₃ H H H 3-CF₃—C₆H₅O H H 4 162N CF₃CF₂ H O CF₃H H H C₆H₅O H H 4 163N CF₃CF₂ H O CF₃ H H H CF₃O H H 4 164N CF₃CF₂ H O HCF₃ H H H C₆H₅ H 4 165N CF₃CF₂ H O H CF₃ H H 3-CF₃—C₆H₅O H H 4 166NCF₃CF₂ H O H CF₃ H H CF₃O H H 4 167N CF₃CF₂ H O H CF₃ H H C₆H₅O H H 4168N CF₃CF₂ H O CF₃ H CF₃ H CF₃O H H 4 169N CF₃CF₂ H O CF₃ H CF₃ H C₆H₅OH H 4 170N CF₃CF₂ H O CF₃O H H H CF₃ H CF₃ 4 171N CF₃CF₂ H O C₆H₅O H H HCF₃ H CF₃ 4 172N CF₃CF₂ H O H C₆H₅O H H C₆H₅O H H 4 173N CF₃CF₂ H O HCF₃O H H CF₃O H H 4 174N CF₃CF₂ H O H CF₃O H H H C₆H₅O H 4 175N CF₃CF₂ HO C₆H₅O H H H H C₆H₅O H 4 176N CF₃CF₂ H O H C₆H₅O H H H OCF₃ H 4 177NCF₃CF₂ H O H C₆H₅O H H H C₆H₅O H 4 178N CF₃CF₂ H O C₆H₅O H H H H CN H 4179N CF₃CF₂ H O C₆H₅O H H H CN H H 4 180N CF₃CF₂ H O C₆H₅O H H H NO₂ H H4 181N CF₃CF₂ H O C₆H₅O H H H H NO₂ H 4 182N CF₃CF₂ H O C₆H₅O H H H HSO₂CH₃ H 4 183N CF₃CF₂ H O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 4 184NCF₃CF₂ H O C₆H₅O H H H 4-Cl—C₆H₄O H H 4 185N CF₃CF₂ H O C₆H₅O H H H3,4-Cl—C₆H₃O H H 4 186N CF₃CF₂ H O C₆H₅O H H H 3-CF₃—C₆H₃O H H 4 187NCF₃CF₂ H O C₆H₅O H H H 3,5-Cl—C₆H₃O H H 4 188N CF₃CF₂ H O C₆H₅O H H H HCH₃O H 4 189N CF₃CF₂ H O C₆H₅O H H H H CO₂CH₃ H 4 190N CF₃CF₂ H O C₆H₅OH H H 3-CH₃O H H C₆H₅O 4 191N CF₃CF₂ H O C₆H₅O H H H 4-CH₃O H H C₆H₅O 4193N CF₃CF₂ H O C₆H₅O H H H CO₂CH₃ H H 4 194N CF₃CF₂ H O CN H H H OCF₃ HH 4 195N CF₃CF₂ H O NO₂ H H H OCF₃ H H 4 196N CF₃CF₂ H O H CN H H OCF₃ HH 4 197N CF₃CF₂ H O H NO₂ H H OCF₃ H H 4 198N CF₃CF₂ H O SO₂CH₃ H H HOCF₃ H H 4 199N CF₃CF₂ H O H SO₂CH₃ H H OCF₃ H H 4 200N CF₃CF₂ H O H4-F—C₆H₅SO₂ H H OCF₃ H H 4 201N CF₃CF₂ H O SO₂N H H H OCF₃ H H (CH₃)₂ 4202N CF₃CF₂ H O H SO₂N(CH₃)₂ H H OCF₃ H H 4 203N CF₃CF₂ H O H CONH₂ H HOCF₃ H H 4 204N CF₃CF₂ H O H CONH—C₆H₅ H H OCF₃ H H 4 205N CF₃CF₂ H O HCO₂CH₃ H H OCF₃ H H 4 206N CF₃CF₂ H O H CO₂C₄H₉ H H OCF₃ H H 4 207NCF₃CF₂ H O H 4-Cl—C₆H₅ H H C₆H₅O H H 4 208N CF₃CF₂ H O H 4-CF₃O—C₆H₅ H HCF₃O H H 4 209N CF₃CF₂ H O 4-F—C₆H₄O H H H CF₃O H H 4 210N CF₃CF₂ H OC₆F₅O H H H CF₃O H H 4 211N CF₃CF₂ H O H 4-F—C₆H₅ H H CF₃O H H 4 212NCF₃CF₂ H O H 4-CN—C₆H₅ H H CF₃O H H 4 213N CF₃CF₂ H O H 4-C₆H₅—C₆H₅ H HCF₃O H H 4 214N CF₃CF₂ H O C₆H₅O H H CH₃ CF₃O H H 4 215N CF₃CF₂ H OC₆H₅O H H CH₃ NO₂ H H 4 216N CF₃CF₂ H O C₆H₅O H H CH₃ H CN H 4 217NCF₃CF₂ H O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 4 218N CF₃CF₂ H O C₆H₅O H H C₆H₅H C₆H₅ H 4 219N CF₃CF₂ H O C₆H₅O H H C₆H₅ CF₃ H H 4 220N CF₃CF₂ H OC₆H₅O H H CH₃ F H H 4 221N CF₃CF₂ H O C₆H₅O H H CF₃ H H H 4 222N CF₃CF₂H O bond to —O— of R₆ aryl group

H H CF₃O H H 4 223N CF₃CF₂ H O to CH₂ of R₆ aryl group

H H CF₃O H H 5  96N CF₃CF₂CF₂ H O OH OH H H C₆H₅O H H 5  97N CF₃CF₂CF₂ HO C₆H₅O H H H OH OH H 5  98N CF₃CF₂CF₂ H O 3-pyridyl H H H CF₃ H H 5 99N CF₃CF₂CF₂ H O SO₂N H H H OCF₃ H H (CH₃)₂ 5 100N CF₃CF₂CF₂ H OSO₂CH₃ H H H OCF₃ H H 5 101N CF₃CF₂CF₂ H O C₆H₅O H H H C₆H₅O H H 5 102NCF₃CF₂CF₂ H O CF₃O H H H C₆H₅O H H 5 103N CF₃CF₂CF₂ H O C₆H₅ H H H C₆H₅OH H 5 104N CF₃CF₂CF₂ H O H C₆H₅ H H C₆H₅O H H 5 105N CF₃CF₂CF₂ H O C₆H₅OH H H 4-Cl—C₆H₄O H H 5 106N CF₃CF₂CF₂ H O CF₃O H H H 4-Cl—C₆H₄O H H 5107N CF₃CF₂CF₂ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 5 108N CF₃CF₂CF₂ H OCF₃O H H H 3,4-Cl—C₆H₃O H H 5 109N CF₃CF₂CF₂ H O CF₃O H H H 3,5-Cl—C₆H₃OH H 5 110N CF₃CF₂CF₂ H O CF₃O H H H 3-CH₃O—C₆H₄O H H 5 111N CF₃CF₂CF₂ HO CF₃O H H H H 3-CH₃O—C₆H₄O H 5 112N CF₃CF₂CF₂ H O CF₃O H H H3-CF₃—C₆H₄O H H 5 113N CF₃CF₂CF₂ H O CF₃O H H H C₆H₅—CH₂O H H 5 114NCF₃CF₂CF₂ H O CF₃O H H H C₆H₅—CH₂O CH₃O H 5 115N CF₃CF₂CF₂ H O CF₃O H HH C₆H₅—CH₂O C₆H₅—CH₂O H 5 116N CF₃CF₂CF₂ H O CF₃O H H H ethoxy H H 5117N CF₃CF₂CF₂ H O CF₃O H H H CH₃CO₂ H H 5 118N CF₃CF₂CF₂ H O CF₃O H H HHOCH₂—CH₂O H H 5 119N CF₃CF₂CF₂ H O CF₃O H H H

H H 5 120N CF₃CF₂CF₂ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 5 121N CF₃CF₂CF₂H O CF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 5 122N CF₃CF₂CF₂ H O CF₃O H H HCH₃O CH₃O H 5 123N CF₃CF₂CF₂ H O CF₃O H H H ethoxy CH₃O H 5 124NCF₃CF₂CF₂ H O CF₃O H H H ethoxy ethoxy H 5 125N CF₃CF₂CF₂ H O CF₃O H H HCH₃CO₂ CH₃CO₂ H 5 126N CF₃CF₂CF₂ H O CF₃O H H H CH₃O CH₃CO₂ H 5 127NCF₃CF₂CF₂ H O CF₃O H H H n-butoxy H H 5 128N CF₃CF₂CF₂ H O CF₃O H H HCH₃O H H 5 129N CF₃CF₂CF₂ H O CF₃O H H H H CH₃O H 5 130N CF₃CF₂CF₂ H OCH₃O H H H CH₃O H H 5 131N CF₃CF₂CF₂ H O CH₃O H H H H CF₃O H 5 132NCF₃CF₂CF₂ H O CF₃O H H H H ethoxy H 5 133N CF₃CF₂CF₂ H O CF₃O H H H Hn-propoxy H 5 134N CF₃CF₂CF₂ H O C₆H₅—CH₂O H H H CF₃O H H 5 135NCF₃CF₂CF₂ H O C₆H₅—CH₂O H H H C₆H₅O H H 5 136N CF₃CF₂CF₂ H O ethoxy H HH CF₃O H H 5 137N CF₃CF₂CF₂ H O R₅ + R₆ = OCH₂O H H CF₃O H H 5 138NCF₃CF₂CF₂ H O R₅ + R₆ = OCH₂O H H C₆H₅O H H 5 139N CF₃CF₂CF₂ H O R₅ + R₆= OCH₂CH₂O H H CF₃O H H 5 140N CF₃CF₂CF₂ H O CH₃O CH₃O H H CF₃O H H 5141N CF₃CF₂CF₂ H O R₅ + R₆ = OCH₂CH₂CH₂O H H CF₃O H H 5 142N CF₃CF₂CF₂ HO cyclo CH₃O H H CF₃O H H pentoxy 5 143N CF₃CF₂CF₂ H O H C₆H₅O H H CF₃OH H 5 144N CF₃CF₂CF₂ H O CH₃O CH₃O CH₃O H CF₃O H H 5 145N CF₃CF₂CF₂ H OH CF₃O H H CF₃O H H 5 146N CF₃CF₂CF₂ H O H C₆H₅—CH₂ H H CF₃O H H 5 147NCF₃CF₂CF₂ H O C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 5 148N CF₃CF₂CF₂ H O HCF₃O H H CF₃ H H 5 149N CF₃CF₂CF₂ H O C₆H₅O H H H CF₃ H H 5 150NCF₃CF₂CF₂ H O C₆H₅ H H H CF₃ H H 5 151N CF₃CF₂CF₂ H O H C₆H₅ H H CF₃ H H5 152N CF₃CF₂CF₂ H O CN H H H CF₃ H H 5 153N CF₃CF₂CF₂ H O H OCF₃ H HCF₃ H H 5 154N CF₃CF₂CF₂ H O OCF₃ H H H H CF₃ H 5 155N CF₃CF₂CF₂ H OC₆H₅O H H H H CF₃ H 5 156N CF₃CF₂CF₂ H O C₆H₅ H H H H CF₃ H 5 157NCF₃CF₂CF₂ H O H C₆H₅ H H H CF₃ H 5 158N CF₃CF₂CF₂ H O CN H H H H CF₃ H 5159N CF₃CF₂CF₂ H O OCF₃ H H H H CF₃ H 5 160N CF₃CF₂CF₂ H O CF₃ H H H HC₆H₅ H 5 161N CF₃CF₂CF₂ H O CF₃ H H H 3-CF₃—C₆H₅O H H 5 162N CF₃CF₂CF₂ HO CF₃ H H H C₆H₅O H H 5 163N CF₃CF₂CF₂ H O CF₃ H H H CF₃O H H 5 164NCF₃CF₂CF₂ H O H CF₃ H H H C₆H₅ H 5 165N CF₃CF₂CF₂ H O H CF₃ H H3-CF₃—C₆H₅O H H 5 166N CF₃CF₂CF₂ H O H CF₃ H H CF₃O H H 5 167N CF₃CF₂CF₂H O H CF₃ H H C₆H₅O H H 5 168N CF₃CF₂CF₂ H O CF₃ H CF₃ H CF₃O H H 5 169NCF₃CF₂CF₂ H O CF₃ H CF₃ H C₆H₅O H H 5 170N CF₃CF₂CF₂ H O CF₃O H H H CF₃H CF₃ 5 171N CF₃CF₂CF₂ H O C₆H₅O H H H CF₃ H CF₃ 5 172N CF₃CF₂CF₂ H O HC₆H₅O H H C₆H₅O H H 5 173N CF₃CF₂CF₂ H O H CF₃O H H CF₃O H H 5 174NCF₃CF₂CF₂ H O H CF₃O H H H C₆H₅O H 5 175N CF₃CF₂CF₂ H O C₆H₅O H H H HC₆H₅O H 5 176N CF₃CF₂CF₂ H O H C₆H₅O H H H OCF₃ H 5 177N CF₃CF₂CF₂ H O HC₆H₅O H H H C₆H₅O H 5 178N CF₃CF₂CF₂ H O C₆H₅O H H H H CN H 5 179NCF₃CF₂CF₂ H O C₆H₅O H H H CN H H 5 180N CF₃CF₂CF₂ H O C₆H₅O H H H NO₂ HH 5 181N CF₃CF₂CF₂ H O C₆H₅O H H H H NO₂ H 5 182N CF₃CF₂CF₂ H O C₆H₅O HH H H SO₂CH₃ H 5 183N CF₃CF₂CF₂ H O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 5184N CF₃CF₂CF₂ H O C₆H₅O H H H 4-Cl—C₆H₄O H H 5 185N CF₃CF₂CF₂ H O C₆H₅OH H H 3,4-Cl—C₆H₃O H H 5 186N CF₃CF₂CF₂ H O C₆H₅O H H H 3-CF₃—C₆H₃O H H5 187N CF₃CF₂CF₂ H O C₆H₅O H H H 3,5-Cl—C₆H₃O H H 5 188N CF₃CF₂CF₂ H OC₆H₅O H H H H CH₃O H 5 189N CF₃CF₂CF₂ H O C₆H₅O H H H H CO₂CH₃ H 5 190NCF₃CF₂CF₂ H O C₆H₅O H H H 3-CH₃O H H C₆H₅O 5 191N CF₃CF₂CF₂ H O C₆H₅O HH H 4-CH₃O H H C₆H₅O 5 193N CF₃CF₂CF₂ H O C₆H₅O H H H CO₂CH₃ H H 5 194NCF₃CF₂CF₂ H O CN H H H OCF₃ H H 5 195N CF₃CF₂CF₂ H O NO₂ H H H OCF₃ H H5 196N CF₃CF₂CF₂ H O H CN H H OCF₃ H H 5 197N CF₃CF₂CF₂ H O H NO₂ H HOCF₃ H H 5 198N CF₃CF₂CF₂ H O SO₂CH₃ H H H OCF₃ H H 5 199N CF₃CF₂CF₂ H OH SO₂CH₃ H H OCF₃ H H 5 200N CF₃CF₂CF₂ H O H 4-F—C₆H₅SO₂ H H OCF₃ H H 5201N CF₃CF₂CF₂ H O SO₂N H H H OCF₃ H H (CH₃)₂ 5 202N CF₃CF₂CF₂ H O HSO₂N(CH₃)₂ H H OCF₃ H H 5 203N CF₃CF₂CF₂ H O H CONH₂ H H OCF₃ H H 5 204NCF₃CF₂CF₂ H O H CONH—C₆H₅ H H OCF₃ H H 5 205N CF₃CF₂CF₂ H O H CO₂CH₃ H HOCF₃ H H 5 206N CF₃CF₂CF₂ H O H CO₂C₄H₉ H H OCF₃ H H 5 207N CF₃CF₂CF₂ HO H 4-Cl—C₆H₅ H H C₆H₅O H H 5 208N CF₃CF₂CF₂ H O H 4-CF₃O—C₆H₅ H H CF₃OH H 5 209N CF₃CF₂CF₂ H O 4-F—C₆H₄O H H H CF₃O H H 5 210N CF₃CF₂CF₂ H OC₆F₅O H H H CF₃O H H 5 211N CF₃CF₂CF₂ H O H 4-F—C₆H₅ H H CF₃O H H 5 212NCF₃CF₂CF₂ H O H 4-CN—C₆H₅ H H CF₃O H H 5 213N CF₃CF₂CF₂ H O H4-C₆H₅—C₆H₅ H H CF₃O H H 5 214N CF₃CF₂CF₂ H O C₆H₅O H H CH₃ CF₃O H H 5215N CF₃CF₂CF₂ H O C₆H₅O H H CH₃ NO₂ H H 5 216N CF₃CF₂CF₂ H O C₆H₅O H HCH₃ H CN H 5 217N CF₃CF₂CF₂ H O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 5 218NCF₃CF₂CF₂ H O C₆H₅O H H C₆H₅ H C₆H₅ H 5 219N CF₃CF₂CF₂ H O C₆H₅O H HC₆H₅ CF₃ H H 5 220N CF₃CF₂CF₂ H O C₆H₅O H H CH₃ F H H 5 221N CF₃CF₂CF₂ HO C₆H₅O H H CF₃ H H H 5 222N CF₃CF₂CF₂ H O bond to —O— of R₆ aryl group

H H CF₃O H H 5 223N CF₃CF₂CF₂ H O to CH₂ of R₆ aryl group

H H CF₃O H H 6  96N CF₃OCF₂CF₂ H O OH OH H H C₆H₅O H H 6  97N CF₃OCF₂CF₂H O C₆H₅O H H H OH OH H 6  98N CF₃OCF₂CF₂ H O 3-pyridyl H H H CF₃ H H 6 99N CF₃OCF₂CF₂ H O SO₂N H H H OCF₃ H H (CH₃)₂ 6 100N CF₃OCF₂CF₂ H OSO₂CH₃ H H H OCF₃ H H 6 101N CF₃OCF₂CF₂ H O C₆H₅O H H H C₆H₅O H H 6 102NCF₃OCF₂CF₂ H O CF₃O H H H C₆H₅O H H 6 103N CF₃OCF₂CF₂ H O C₆H₅ H H HC₆H₅O H H 6 104N CF₃OCF₂CF₂ H O H C₆H₅ H H C₆H₅O H H 6 105N CF₃OCF₂CF₂ HO C₆H₅O H H H 4-Cl—C₆H₄O H H 6 106N CF₃OCF₂CF₂ H O CF₃O H H H 4-Cl—C₆H₄OH H 6 107N CF₃OCF₂CF₂ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 6 108N CF₃OCF₂CF₂H O CF₃O H H H 3,4-Cl—C₆H₃O H H 6 109N CF₃OCF₂CF₂ H O CF₃O H H H3,5-Cl—C₆H₃O H H 6 110N CF₃OCF₂CF₂ H O CF₃O H H H 3-CH₃O—C₆H₄O H H 6111N CF₃OCF₂CF₂ H O CF₃O H H H H 3-CH₃O—C₆H₄O H 6 112N CF₃OCF₂CF₂ H OCF₃O H H H 3-CF₃—C₆H₄O H H 6 113N CF₃OCF₂CF₂ H O CF₃O H H H C₆H₅—CH₂O HH 6 114N CF₃OCF₂CF₂ H O CF₃O H H H C₆H₅—CH₂O CH₃O H 6 115N CF₃OCF₂CF₂ HO CF₃O H H H C₆H₅—CH₂O C₆H₅—CH₂O H 6 116N CF₃OCF₂CF₂ H O CF₃O H H Hethoxy H H 6 117N CF₃OCF₂CF₂ H O CF₃O H H H CH₃CO₂ H H 6 118N CF₃OCF₂CF₂H O CF₃O H H H HOCH₂—CH₂O H H 6 119N CF₃OCF₂CF₂ H O CF₃O H H H

H H 6 120N CF₃OCF₂CF₂ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 6 121NCF₃OCF₂CF₂ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 6 122N CF₃OCF₂CF₂ H OCF₃O H H H CH₃O CH₃O H 6 123N CF₃OCF₂CF₂ H O CF₃O H H H ethoxy CH₃O H 6124N CF₃OCF₂CF₂ H O CF₃O H H H ethoxy ethoxy H 6 125N CF₃OCF₂CF₂ H OCF₃O H H H CH₃CO₂ CH₃CO₂ H 6 126N CF₃OCF₂CF₂ H O CF₃O H H H CH₃O CH₃CO₂H 6 127N CF₃OCF₂CF₂ H O CF₃O H H H n-butoxy H H 6 128N CF₃OCF₂CF₂ H OCF₃O H H H CH₃O H H 6 129N CF₃OCF₂CF₂ H O CF₃O H H H H CH₃O H 6 130NCF₃OCF₂CF₂ H O CH₃O H H H CH₃O H H 6 131N CF₃OCF₂CF₂ H O CH₃O H H H HCF₃O H 6 132N CF₃OCF₂CF₂ H O CF₃O H H H H ethoxy H 6 133N CF₃OCF₂CF₂ H OCF₃O H H H H n-propoxy H 6 134N CF₃OCF₂CF₂ H O C₆H₅—CH₂O H H H CF₃O H H6 135N CF₃OCF₂CF₂ H O C₆H₅—CH₂O H H H C₆H₅O H H 6 136N CF₃OCF₂CF₂ H Oethoxy H H H CF₃O H H 6 137N CF₃OCF₂CF₂ H O R₅ + R₆ = OCH₂O H H CF₃O H H6 138N CF₃OCF₂CF₂ H O R₅ + R₆ = OCH₂O H H C₆H₅O H H 6 139N CF₃OCF₂CF₂ HO R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 6 140N CF₃OCF₂CF₂ H O CH₃O CH₃O H HCF₃O H H 6 141N CF₃OCF₂CF₂ H O R₅ + R₆ = OCH₂CH₂CH₂O H H CF₃O H H 6 142NCF₃OCF₂CF₂ H O cyclo CH₃O H H CF₃O H H pentoxy 6 143N CF₃OCF₂CF₂ H O HC₆H₅O H H CF₃O H H 6 144N CF₃OCF₂CF₂ H O CH₃O CH₃O CH₃O H CF₃O H H 6145N CF₃OCF₂CF₂ H O H CF₃O H H CF₃O H H 6 146N CF₃OCF₂CF₂ H O H C₆H₅—CH₂H H CF₃O H H 6 147N CF₃OCF₂CF₂ H O C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 6148N CF₃OCF₂CF₂ H O H CF₃O H H CF₃ H H 6 149N CF₃OCF₂CF₂ H O C₆H₅O H H HCF₃ H H 6 150N CF₃OCF₂CF₂ H O C₆H₅ H H H CF₃ H H 6 151N CF₃OCF₂CF₂ H O HC₆H₅ H H CF₃ H H 6 152N CF₃OCF₂CF₂ H O CN H H H CF₃ H H 6 153NCF₃OCF₂CF₂ H O H OCF₃ H H CF₃ H H 6 154N CF₃OCF₂CF₂ H O OCF₃ H H H H CF₃H 6 155N CF₃OCF₂CF₂ H O C₆H₅O H H H H CF₃ H 6 156N CF₃OCF₂CF₂ H O C₆H₅ HH H H CF₃ H 6 157N CF₃OCF₂CF₂ H O H C₆H₅ H H H CF₃ H 6 158N CF₃OCF₂CF₂ HO CN H H H H CF₃ H 6 159N CF₃OCF₂CF₂ H O OCF₃ H H H H CF₃ H 6 160NCF₃OCF₂CF₂ H O CF₃ H H H H C₆H₅ H 6 161N CF₃OCF₂CF₂ H O CF₃ H H H3-CF₃—C₆H₅O H H 6 162N CF₃OCF₂CF₂ H O CF₃ H H H C₆H₅O H H 6 163NCF₃OCF₂CF₂ H O CF₃ H H H CF₃O H H 6 164N CF₃OCF₂CF₂ H O H CF₃ H H H C₆H₅H 6 165N CF₃OCF₂CF₂ H O H CF₃ H H 3-CF₃—C₆H₅O H H 6 166N CF₃OCF₂CF₂ H OH CF₃ H H CF₃O H H 6 167N CF₃OCF₂CF₂ H O H CF₃ H H C₆H₅O H H 6 168NCF₃OCF₂CF₂ H O CF₃ H CF₃ H CF₃O H H 6 169N CF₃OCF₂CF₂ H O CF₃ H CF₃ HC₆H₅O H H 6 170N CF₃OCF₂CF₂ H O CF₃O H H H CF₃ H CF₃ 6 171N CF₃OCF₂CF₂ HO C₆H₅O H H H CF₃ H CF₃ 6 172N CF₃OCF₂CF₂ H O H C₆H₅O H H C₆H₅O H H 6173N CF₃OCF₂CF₂ H O H CF₃O H H CF₃O H H 6 174N CF₃OCF₂CF₂ H O H CF₃O H HH C₆H₅O H 6 175N CF₃OCF₂CF₂ H O C₆H₅O H H H H C₆H₅O H 6 176N CF₃OCF₂CF₂H O H C₆H₅O H H H OCF₃ H 6 177N CF₃OCF₂CF₂ H O H C₆H₅O H H H C₆H₅O H 6178N CF₃OCF₂CF₂ H O C₆H₅O H H H H CN H 6 179N CF₃OCF₂CF₂ H O C₆H₅O H H HCN H H 6 180N CF₃OCF₂CF₂ H O C₆H₅O H H H NO₂ H H 6 181N CF₃OCF₂CF₂ H OC₆H₅O H H H H NO₂ H 6 182N CF₃OCF₂CF₂ H O C₆H₅O H H H H SO₂CH₃ H 6 183NCF₃OCF₂CF₂ H O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 6 184N CF₃OCF₂CF₂ H OC₆H₅O H H H 4-Cl—C₆H₄O H H 6 185N CF₃OCF₂CF₂ H O C₆H₅O H H H3,4-Cl—C₆H₃O H H 6 186N CF₃OCF₂CF₂ H O C₆H₅O H H H 3-CF₃—C₆H₃O H H 6187N CF₃OCF₂CF₂ H O C₆H₅O H H H 3,5-Cl—C₆H₃O H H 6 188N CF₃OCF₂CF₂ H OC₆H₅O H H H H CH₃O H 6 189N CF₃OCF₂CF₂ H O C₆H₅O H H H H CO₂CH₃ H 6 190NCF₃OCF₂CF₂ H O C₆H₅O H H H 3-CH₃O H H C₆H₅O 6 191N CF₃OCF₂CF₂ H O C₆H₅OH H H 4-CH₃O H H C₆H₅O 6 193N CF₃OCF₂CF₂ H O C₆H₅O H H H CO₂CH₃ H H 6194N CF₃OCF₂CF₂ H O CN H H H OCF₃ H H 6 195N CF₃OCF₂CF₂ H O NO₂ H H HOCF₃ H H 6 196N CF₃OCF₂CF₂ H O H CN H H OCF₃ H H 6 197N CF₃OCF₂CF₂ H O HNO₂ H H OCF₃ H H 6 198N CF₃OCF₂CF₂ H O SO₂CH₃ H H H OCF₃ H H 6 199NCF₃OCF₂CF₂ H O H SO₂CH₃ H H OCF₃ H H 6 200N CF₃OCF₂CF₂ H O H 4-F—C₆H₅SO₂H H OCF₃ H H 6 201N CF₃OCF₂CF₂ H O SO₂N H H H OCF₃ H H (CH₃)₂ 6 202NCF₃OCF₂CF₂ H O H SO₂N(CH₃)₂ H H OCF₃ H H 6 203N CF₃OCF₂CF₂ H O H CONH₂ HH OCF₃ H H 6 204N CF₃OCF₂CF₂ H O H CONH—C₆H₅ H H OCF₃ H H 6 205NCF₃OCF₂CF₂ H O H CO₂CH₃ H H OCF₃ H H 6 206N CF₃OCF₂CF₂ H O H CO₂C₄H₉ H HOCF₃ H H 6 207N CF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ H H C₆H₅O H H 6 208NCF₃OCF₂CF₂ H O H 4-CF₃O—C₆H₅ H H CF₃O H H 6 209N CF₃OCF₂CF₂ H O4-F—C₆H₄O H H H CF₃O H H 6 210N CF₃OCF₂CF₂ H O C₆F₅O H H H CF₃O H H 6211N CF₃OCF₂CF₂ H O H 4-F—C₆H₅ H H CF₃O H H 6 212N CF₃OCF₂CF₂ H O H4-CN—C₆H₅ H H CF₃O H H 6 213N CF₃OCF₂CF₂ H O H 4-C₆H₅—C₆H₅ H H CF₃O H H6 214N CF₃OCF₂CF₂ H O C₆H₅O H H CH₃ CF₃O H H 6 215N CF₃OCF₂CF₂ H O C₆H₅OH H CH₃ NO₂ H H 6 216N CF₃OCF₂CF₂ H O C₆H₅O H H CH₃ H CN H 6 217NCF₃OCF₂CF₂ H O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 6 218N CF₃OCF₂CF₂ H O C₆H₅OH H C₆H₅ H C₆H₅ H 6 219N CF₃OCF₂CF₂ H O C₆H₅O H H C₆H₅ CF₃ H H 6 220NCF₃OCF₂CF₂ H O C₆H₅O H H CH₃ F H H 6 221N CF₃OCF₂CF₂ H O C₆H₅O H H CF₃ HH H 6 222N CF₃OCF₂CF₂ H O bond to —O— of R₆ aryl group

H H CF₃O H H 6 223N CF₃OCF₂CF₂ H O to CH₂ of R₆ aryl group

H H CF₃O H H 7  96N CF₃CH₂ CH₃ O OH OH H H C₆H₅O H H 7  97N CF₃CH₂ CH₃ OC₆H₅O H H H OH OH H 7  98N CF₃CH₂ CH₃ O 3-pyridyl H H H CF₃ H H 7  99NCF₃CH₂ CH₃ O SO₂N H H H OCF₃ H H (CH₃)₂ 7 100N CF₃CH₂ CH₃ O SO₂CH₃ H H HOCF₃ H H 7 101N CF₃CH₂ CH₃ O C₆H₅O H H H C₆H₅O H H 7 102N CF₃CH₂ CH₃ OCF₃O H H H C₆H₅O H H 7 103N CF₃CH₂ CH₃ O C₆H₅ H H H C₆H₅O H H 7 104NCF₃CH₂ CH₃ O H C₆H₅ H H C₆H₅O H H 7 105N CF₃CH₂ CH₃ O C₆H₅O H H H4-Cl—C₆H₄O H H 7 106N CF₃CH₂ CH₃ O CF₃O H H H 4-Cl—C₆H₄O H H 7 107NCF₃CH₂ CH₃ O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 7 108N CF₃CH₂ CH₃ O CF₃O H H H3,4-Cl—C₆H₃O H H 7 109N CF₃CH₂ CH₃ O CF₃O H H H 3,5-Cl—C₆H₃O H H 7 110NCF₃CH₂ CH₃ O CF₃O H H H 3-CH₃O—C₆H₄O H H 7 111N CF₃CH₂ CH₃ O CF₃O H H HH 3-CH₃O—C₆H₄O H 7 112N CF₃CH₂ CH₃ O CF₃O H H H 3-CF₃—C₆H₄O H H 7 113NCF₃CH₂ CH₃ O CF₃O H H H C₆H₅—CH₂O H H 7 114N CF₃CH₂ CH₃ O CF₃O H H HC₆H₅—CH₂O CH₃O H 7 115N CF₃CH₂ CH₃ O CF₃O H H H C₆H₅—CH₂O C₆H₅—CH₂O H 7116N CF₃CH₂ CH₃ O CF₃O H H H ethoxy H H 7 117N CF₃CH₂ CH₃ O CF₃O H H HCH₃CO₂ H H 7 118N CF₃CH₂ CH₃ O CF₃O H H H HOCH₂—CH₂O H H 7 119N CF₃CH₂CH₃ O CF₃O H H H

H H 7 120N CF₃CH₂ CH₃ O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 7 121N CF₃CH₂ CH₃O CF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 7 122N CF₃CH₂ CH₃ O CF₃O H H H CH₃OCH₃O H 7 123N CF₃CH₂ CH₃ O CF₃O H H H ethoxy CH₃O H 7 124N CF₃CH₂ CH₃ OCF₃O H H H ethoxy ethoxy H 7 125N CF₃CH₂ CH₃ O CF₃O H H H CH₃CO₂ CH₃CO₂H 7 126N CF₃CH₂ CH₃ O CF₃O H H H CH₃O CH₃CO₂ H 7 127N CF₃CH₂ CH₃ O CF₃OH H H n-butoxy H H 7 128N CF₃CH₂ CH₃ O CF₃O H H H CH₃O H H 7 129N CF₃CH₂CH₃ O CF₃O H H H H CH₃O H 7 130N CF₃CH₂ CH₃ O CH₃O H H H CH₃O H H 7 131NCF₃CH₂ CH₃ O CH₃O H H H H CF₃O H 7 132N CF₃CH₂ CH₃ O CF₃O H H H H ethoxyH 7 133N CF₃CH₂ CH₃ O CF₃O H H H H n-propoxy H 7 134N CF₃CH₂ CH₃ OC₆H₅—CH₂O H H H CF₃O H H 7 135N CF₃CH₂ CH₃ O C₆H₅—CH₂O H H H C₆H₅O H H 7136N CF₃CH₂ CH₃ O ethoxy H H H CF₃O H H 7 137N CF₃CH₂ CH₃ O R₅ + R₆ =OCH₂O H H CF₃O H H 7 138N CF₃CH₂ CH₃ O R₅ + R₆ = OCH₂O H H C₆H₅O H H 7139N CF₃CH₂ CH₃ O R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 7 140N CF₃CH₂ CH₃ OCH₃O CH₃O H H CF₃O H H 7 141N CF₃CH₂ CH₃ O R₅ + R₆ = OCH₂CH₂CH₂O H HCF₃O H H 7 142N CF₃CH₂ CH₃ O cyclo CH₃O H H CF₃O H H pentoxy 7 143NCF₃CH₂ CH₃ O H C₆H₅O H H CF₃O H H 7 144N CF₃CH₂ CH₃ O CH₃O CH₃O CH₃O HCF₃O H H 7 145N CF₃CH₂ CH₃ O H CF₃O H H CF₃O H H 7 146N CF₃CH₂ CH₃ O HC₆H₅—CH₂ H H CF₃O H H 7 147N CF₃CH₂ CH₃ O C₆H₅O H H H R₁₀ + R₁₁ =OCH₂CH₂O H 7 148N CF₃CH₂ CH₃ O H CF₃O H H CF₃ H H 7 149N CF₃CH₂ CH₃ OC₆H₅O H H H CF₃ H H 7 150N CF₃CH₂ CH₃ O C₆H₅ H H H CF₃ H H 7 151N CF₃CH₂CH₃ O H C₆H₅ H H CF₃ H H 7 152N CF₃CH₂ CH₃ O CN H H H CF₃ H H 7 153NCF₃CH₂ CH₃ O H OCF₃ H H CF₃ H H 7 154N CF₃CH₂ CH₃ O OCF₃ H H H H CF₃ H 7155N CF₃CH₂ CH₃ O C₆H₅O H H H H CF₃ H 7 156N CF₃CH₂ CH₃ O C₆H₅ H H H HCF₃ H 7 157N CF₃CH₂ CH₃ O H C₆H₅ H H H CF₃ H 7 158N CF₃CH₂ CH₃ O CN H HH H CF₃ H 7 159N CF₃CH₂ CH₃ O OCF₃ H H H H CF₃ H 7 160N CF₃CH₂ CH₃ O CF₃H H H H C₆H₅ H 7 161N CF₃CH₂ CH₃ O CF₃ H H H 3-CF₃—C₆H₅O H H 7 162NCF₃CH₂ CH₃ O CF₃ H H H C₆H₅O H H 7 163N CF₃CH₂ CH₃ O CF₃ H H H CF₃O H H7 164N CF₃CH₂ CH₃ O H CF₃ H H H C₆H₅ H 7 165N CF₃CH₂ CH₃ O H CF₃ H H3-CF₃—C₆H₅O H H 7 166N CF₃CH₂ CH₃ O H CF₃ H H CF₃O H H 7 167N CF₃CH₂ CH₃O H CF₃ H H C₆H₅O H H 7 168N CF₃CH₂ CH₃ O CF₃ H CF₃ H CF₃O H H 7 169NCF₃CH₂ CH₃ O CF₃ H CF₃ H C₆H₅O H H 7 170N CF₃CH₂ CH₃ O CF₃O H H H CF₃ HCF₃ 7 171N CF₃CH₂ CH₃ O C₆H₅O H H H CF₃ H CF₃ 7 172N CF₃CH₂ CH₃ O HC₆H₅O H H C₆H₅O H H 7 173N CF₃CH₂ CH₃ O H CF₃O H H CF₃O H H 7 174NCF₃CH₂ CH₃ O H CF₃O H H H C₆H₅O H 7 175N CF₃CH₂ CH₃ O C₆H₅O H H H HC₆H₅O H 7 176N CF₃CH₂ CH₃ O H C₆H₅O H H H OCF₃ H 7 177N CF₃CH₂ CH₃ O HC₆H₅O H H H C₆H₅O H 7 178N CF₃CH₂ CH₃ O C₆H₅O H H H H CN H 7 179N CF₃CH₂CH₃ O C₆H₅O H H H CN H H 7 180N CF₃CH₂ CH₃ O C₆H₅O H H H NO₂ H H 7 181NCF₃CH₂ CH₃ O C₆H₅O H H H H NO₂ H 7 182N CF₃CH₂ CH₃ O C₆H₅O H H H HSO₂CH₃ H 7 183N CF₃CH₂ CH₃ O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 7 184NCF₃CH₂ CH₃ O C₆H₅O H H H 4-Cl—C₆H₄O H H 7 185N CF₃CH₂ CH₃ O C₆H₅O H H H3,4-Cl—C₆H₃O H H 7 186N CF₃CH₂ CH₃ O C₆H₅O H H H 3-CF₃—C₆H₃O H H 7 187NCF₃CH₂ CH₃ O C₆H₅O H H H 3,5-Cl—C₆H₃O H H 7 188N CF₃CH₂ CH₃ O C₆H₅O H HH H CH₃O H 7 189N CF₃CH₂ CH₃ O C₆H₅O H H H H CO₂CH₃ H 7 190N CF₃CH₂ CH₃O C₆H₅O H H H 3-CH₃O H H C₆H₅O 7 191N CF₃CH₂ CH₃ O C₆H₅O H H H 4-CH₃O HH C₆H₅O 7 193N CF₃CH₂ CH₃ O C₆H₅O H H H CO₂CH₃ H H 7 194N CF₃CH₂ CH₃ OCN H H H OCF₃ H H 7 195N CF₃CH₂ CH₃ O NO₂ H H H OCF₃ H H 7 196N CF₃CH₂CH₃ O H CN H H OCF₃ H H 7 197N CF₃CH₂ CH₃ O H NO₂ H H OCF₃ H H 7 198NCF₃CH₂ CH₃ O SO₂CH₃ H H H OCF₃ H H 7 199N CF₃CH₂ CH₃ O H SO₂CH₃ H H OCF₃H H 7 200N CF₃CH₂ CH₃ O H 4-F—C₆H₅SO₂ H H OCF₃ H H 7 201N CF₃CH₂ CH₃ OSO₂N H H H OCF₃ H H (CH₃)₂ 7 202N CF₃CH₂ CH₃ O H SO₂N(CH₃)₂ H H OCF₃ H H7 203N CF₃CH₂ CH₃ O H CONH₂ H H OCF₃ H H 7 204N CF₃CH₂ CH₃ O H CONH—C₆H₅H H OCF₃ H H 7 205N CF₃CH₂ CH₃ O H CO₂CH₃ H H OCF₃ H H 7 206N CF₃CH₂ CH₃O H CO₂C₄H₉ H H OCF₃ H H 7 207N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅ H H C₆H₅O H H 7208N CF₃CH₂ CH₃ O H 4-CF₃O—C₆H₅ H H CF₃O H H 7 209N CF₃CH₂ CH₃ O4-F—C₆H₄O H H H CF₃O H H 7 210N CF₃CH₂ CH₃ O C₆F₅O H H H CF₃O H H 7 211NCF₃CH₂ CH₃ O H 4-F—C₆H₅ H H CF₃O H H 7 212N CF₃CH₂ CH₃ O H 4-CN—C₆H₅ H HCF₃O H H 7 213N CF_(3CH) ₂ CH₃ O H 4-C₆H₅—C₆H₅ H H CF₃O H H 7 214NCF₃CH₂ CH₃ O C₆H₅O H H CH₃ CF₃O H H 7 215N CF₃CH₂ CH₃ O C₆H₅O H H CH₃NO₂ H H 7 216N CF₃CH₂ CH₃ O C₆H₅O H H CH₃ H CN H 7 217N CF₃CH₂ CH₃ OC₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 7 218N CF₃CH₂ CH₃ O C₆H₅O H H C₆H₅ H C₆H₅ H7 219N CF₃CH₂ CH₃ O C₆H₅O H H C₆H₅ CF₃ H H 7 220N CF₃CH₂ CH₃ O C₆H₅O H HCH₃ F H H 7 221N CF₃CH₂ CH₃ O C₆H₅O H H CF₃ H H H 7 222N CF₃CH₂ CH₃ Obond to —O— of R₆ aryl group

H H CF₃O H H 7 223N CF₃CH₂ CH₃ O to CH₂ of R₆ aryl group

H H CF₃O H H 10  96N CF₃ CF₃ O OH OH H H C₆H₅O H H 10  97N CF₃ CF₃ OC₆H₅O H H H OH OH H 10  98N CF₃ CF₃ O 3-pyridyl H H H CF₃ H H 10  99NCF₃ CF₃ O SO₂N H H H OCF₃ H H (CH₃)₂ 10 100N CF₃ CF₃ O SO₂CH₃ H H H OCF₃H H 10 101N CF₃ CF₃ O C₆H₅O H H H C₆H₅O H H 10 102N CF₃ CF₃ O CF₃O H H HC₆H₅O H H 10 103N CF₃ CF₃ O C₆H₅ H H H C₆H₅O H H 10 104N CF₃ CF₃ O HC₆H₅ H H C₆H₅O H H 10 105N CF₃ CF₃ O C₆H₅O H H H 4-Cl—C₆H₄O H H 10 106NCF₃ CF₃ O CF₃O H H H 4-Cl—C₆H₄O H H 10 107N CF₃ CF₃ O C₆H₅O H H H3,4-Cl—C₆H₃O H H 10 108N CF₃ CF₃ O CF₃O H H H 3,4-Cl—C₆H₃O H H 10 109NCF₃ CF₃ O CF₃O H H H 3,5-Cl—C₆H₃O H H 10 110N CF₃ CF₃ O CF₃O H H H3-CH₃O—C₆H₄O H H 10 111N CF₃ CF₃ O CF₃O H H H H 3-CH₃O—C₆H₄O H 10 112NCF₃ CF₃ O CF₃O H H H 3-CF₃—C₆H₄O H H 10 113N CF₃ CF₃ O CF₃O H H HC₆H₅—CH₂O H H 10 114N CF₃ CF₃ O CF₃O H H H C₆H₅—CH₂O CH₃O H 10 115N CF₃CF₃ O CF₃O H H H C₆H₅—CH₂O C₆H₅—CH₂O H 10 116N CF₃ CF₃ O CF₃O H H Hethoxy H H 10 117N CF₃ CF₃ O CF₃O H H H CH₃CO₂ H H 10 118N CF₃ CF₃ OCF₃O H H H HOCH₂—CH₂O H H 10 119N CF₃ CF₃ O CF₃O H H H

H H 10 120N CF₃ CF₃ O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 10 121N CF₃ CF₃ OCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 10 122N CF₃ CF₃ O CF₃O H H H CH₃O CH₃OH 10 123N CF₃ CF₃ O CF₃O H H H ethoxy CH₃O H 10 124N CF₃ CF₃ O CF₃O H HH ethoxy ethoxy H 10 125N CF₃ CF₃ O CF₃O H H H CH₃CO₂ CH₃CO₂ H 10 126NCF₃ CF₃ O CF₃O H H H CH₃O CH₃CO₂ H 10 127N CF₃ CF₃ O CF₃O H H H n-butoxyH H 10 128N CF₃ CF₃ O CF₃O H H H CH₃O H H 10 129N CF₃ CF₃ O CF₃O H H H HCH₃O H 10 130N CF₃ CF₃ O CH₃O H H H CH₃O H H 10 131N CF₃ CF₃ O CH₃O H HH H CF₃O H 10 132N CF₃ CF₃ O CF₃O H H H H ethoxy H 10 133N CF₃ CF₃ OCF₃O H H H H n-propoxy H 10 134N CF₃ CF₃ O C₆H₅—CH₂O H H H CF₃O H H 10135N CF₃ CF₃ O C₆H₅—CH₂O H H H C₆H₅O H H 10 136N CF₃ CF₃ O ethoxy H H HCF₃O H H 10 137N CF₃ CF₃ O R₅ + R₆ = OCH₂O H H CF₃O H H 10 138N CF₃ CF₃O R₅ + R₆ = OCH₂O H H C₆H₅O H H 10 139N CF₃ CF₃ O R₅ + R₆ = OCH₂CH₂O H HCF₃O H H 10 140N CF₃ CF₃ O CH₃O CH₃O H H CF₃O H H 10 141N CF₃ CF₃ O R₅ +R₆ = OCH₂CH₂CH₂O H H CF₃O H H 10 142N CF₃ CF₃ O cyclo CH₃O H H CF₃O H Hpentoxy 10 143N CF₃ CF₃ O H C₆H₅O H H CF₃O H H 10 144N CF₃ CF₃ O CH₃OCH₃O CH₃O H CF₃O H H 10 145N CF₃ CF₃ O H CF₃O H H CF₃O H H 10 146N CF₃CF₃ O H C₆H₅—CH₂ H H CF₃O H H 10 147N CF₃ CF₃ O C₆H₅O H H H R₁₀ + R₁₁ =OCH₂CH₂O H 10 148N CF₃ CF₃ O H CF₃O H H CF₃ H H 10 149N CF₃ CF₃ O C₆H₅OH H H CF₃ H H 10 150N CF₃ CF₃ O C₆H₅ H H H CF₃ H H 10 151N CF₃ CF₃ O HC₆H₅ H H CF₃ H H 10 152N CF₃ CF₃ O CN H H H CF₃ H H 10 153N CF₃ CF₃ O HOCF₃ H H CF₃ H H 10 154N CF₃ CF₃ O OCF₃ H H H H CF₃ H 10 155N CF₃ CF₃ OC₆H₅O H H H H CF₃ H 10 156N CF₃ CF₃ O C₆H₅ H H H H CF₃ H 10 157N CF₃ CF₃O H C₆H₅ H H H CF₃ H 10 158N CF₃ CF₃ O CN H H H H CF₃ H 10 159N CF₃ CF₃O OCF₃ H H H H CF₃ H 10 160N CF₃ CF₃ O CF₃ H H H H C₆H₅ H 10 161N CF₃CF₃ O CF₃ H H H 3-CF₃—C₆H₅O H H 10 162N CF₃ CF₃ O CF₃ H H H C₆H₅O H H 10163N CF₃ CF₃ O CF₃ H H H CF₃O H H 10 164N CF₃ CF₃ O H CF₃ H H H C₆H₅ H10 165N CF₃ CF₃ O H CF₃ H H 3-CF₃—C₆H₅O H H 10 166N CF₃ CF₃ O H CF₃ H HCF₃O H H 10 167N CF₃ CF₃ O H CF₃ H H C₆H₅O H H 10 168N CF₃ CF₃ O CF₃ HCF₃ H CF₃O H H 10 169N CF₃ CF₃ O CF₃ H CF₃ H C₆H₅O H H 10 170N CF₃ CF₃ OCF₃O H H H CF₃ H CF₃ 10 171N CF₃ CF₃ O C₆H₅O H H H CF₃ H CF₃ 10 172N CF₃CF₃ O H C₆H₅O H H C₆H₅O H H 10 173N CF₃ CF₃ O H CF₃O H H CF₃O H H 10174N CF₃ CF₃ O H CF₃O H H H C₆H₅O H 10 175N CF₃ CF₃ O C₆H₅O H H H HC₆H₅O H 10 176N CF₃ CF₃ O H C₆H₅O H H H OCF₃ H 10 177N CF₃ CF₃ O H C₆H₅OH H H C₆H₅O H 10 178N CF₃ CF₃ O C₆H₅O H H H H CN H 10 179N CF₃ CF₃ OC₆H₅O H H H CN H H 10 180N CF₃ CF₃ O C₆H₅O H H H NO₂ H H 10 181N CF₃ CF₃O C₆H₅O H H H H NO₂ H 10 182N CF₃ CF₃ O C₆H₅O H H H H SO₂CH₃ H 10 183NCF₃ CF₃ O C₆H₅O H H H H 2-NO₂-4-Cl—C₆H₃O H 10 184N CF₃ CF₃ O C₆H₅O H H H4-Cl—C₆H₄O H H 10 185N CF₃ CF₃ O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 10 186NCF₃ CF₃ O C₆H₅O H H H 3-CF₃—C₆H₃O H H 10 187N CF₃ CF₃ O C₆H₅O H H H3,5-Cl—C₆H₃O H H 10 188N CF₃ CF₃ O C₆H₅O H H H H CH₃O H 10 189N CF₃ CF₃O C₆H₅O H H H H CO₂CH₃ H 10 190N CF₃ CF₃ O C₆H₅O H H H 3-CH₃O H H C₆H₅O10 191N CF₃ CF₃ O C₆H₅O H H H 4-CH₃O H H C₆H₅O 10 193N CF₃ CF₃ O C₆H₅O HH H CO₂CH₃ H H 10 194N CF₃ CF₃ O CN H H H OCF₃ H H 10 195N CF₃ CF₃ O NO₂H H H OCF₃ H H 10 196N CF₃ CF₃ O H CN H H OCF₃ H H 10 197N CF₃ CF₃ O HNO₂ H H OCF₃ H H 10 198N CF₃ CF₃ O SO₂CH₃ H H H OCF₃ H H 10 199N CF₃ CF₃O H SO₂CH₃ H H OCF₃ H H 10 200N CF₃ CF₃ O H 4-F—C₆H₅SO₂ H H OCF₃ H H 10201N CF₃ CF₃ O SO₂N H H H OCF₃ H H (CH₃)₂ 10 202N CF₃ CF₃ O H SO₂N(CH₃)₂H H OCF₃ H H 10 203N CF₃ CF₃ O H CONH₂ H H OCF₃ H H 10 204N CF₃ CF₃ O HCONH—C₆H₅ H H OCF₃ H H 10 205N CF₃ CF₃ O H CO₂CH₃ H H OCF₃ H H 10 206NCF₃ CF₃ O H CO₂C₄H₉ H H OCF₃ H H 10 207N CF₃ CF₃ O H 4-Cl—C₆H₅ H H C₆H₅OH H 10 208N CF₃ CF₃ O H 4-CF₃O—C₆H₅ H H CF₃O H H 10 209N CF₃ CF₃ O4-F—C₆H₄O H H H CF₃O H H 10 210N CF₃ CF₃ O C₆F₅O H H H CF₃O H H 10 211NCF₃ CF₃ O H 4-F—C₆H₅ H H CF₃O H H 10 212N CF₃ CF₃ O H 4-CN—C₆H₅ H H CF₃OH H 10 213N CF₃ CF₃ O H 4-C₆H₅—C₆H₅ H H CF₃O H H 10 214N CF₃ CF₃ O C₆H₅OH H CH₃ CF₃O H H 10 215N CF₃ CF₃ O C₆H₅O H H CH₃ NO₂ H H 10 216N CF₃ CF₃O C₆H₅O H H CH₃ H CN H 10 217N CF₃ CF₃ O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 10218N CF₃ CF₃ O C₆H₅O H H C₆H₅ H C₆H₅ H 10 219N CF₃ CF₃ O C₆H₅O H H C₆H₅CF₃ H H 10 220N CF₃ CF₃ O C₆H₅O H H CH₃ F H H 10 221N CF₃ CF₃ O C₆H₅O HH CF₃ H H H 10 222N CF₃ CF₃ O bond to —O— of R₆ aryl group

H H CF₃O H H 10 223N CF₃ CF₃ O to CH₂ of R₆ aryl group

H H CF₃O H H

TABLE 8 Structure of Substituted Phenyltertiary-2-Heteroalkylamines (Y =CH; Z is covalent bond; there is no R₁₅ substituent; R₃, R₄, R₈, R₉,R₁₃, R₁₄, and R₁₆ all equal H unless indicated below).

Inhibitor Number Column 1 + Column 2 Reagent Reagent R₁ R₂ X R₅ R₆ R₇R₁₄ R₁₀ R₁₁ R₁₂ 19  96N CF₃ CF₃ NH OH OH H H C₆H₅O H H 19  97N CF₃ CF₃NH C₆H₅O H H H OH OH H 19  98N CF₃ CF₃ NH 3-pyridyl H H H CF₃ H H 19 99N CF₃ CF₃ NH SO₂N H H H OCF₃ H H (CH₃)₂ 19 100N CF₃ CF₃ NH SO₂CH₃ H HH OCF₃ H H 19 101N CF₃ CF₃ NH C₆H₅O H H H C₆H₅O H H 19 102N CF₃ CF₃ NHCF₃O H H H C₆H₅O H H 19 103N CF₃ CF₃ NH C₆H₅ H H H C₆H₅O H H 19 104N CF₃CF₃ NH H C₆H₅ H H C₆H₅O H H 19 105N CF₃ CF₃ NH C₆H₅O H H H 4-Cl—C₆H₄O HH 19 106N CF₃ CF₃ NH CF₃O H H H 4-Cl—C₆H₄O H H 19 107N CF₃ CF₃ NH C₆H₅OH H H 3,4-Cl—C₆H₃O H H 19 108N CF₃ CF₃ NH CF₃O H H H 3,4-Cl—C₆H₃O H H 19109N CF₃ CF₃ NH CF₃O H H H 3,5-Cl—C₆H₃O H H 19 110N CF₃ CF₃ NH CF₃O H HH 3-CH₃O— H H C₆H₄O 19 111N CF₃ CF₃ NH CF₃O H H H H 3-CH₃O— H C₆H₄O 19112N CF₃ CF₃ NH CF₃O H H H 3-CF₃—C₆H₄O H H 19 113N CF₃ CF₃ NH CF₃O H H HC₆H₅—CH₂O H H 19 114N CF₃ CF₃ NH CF₃O H H H C₆H₅—CH₂O CH₃O H 19 115N CF₃CF₃ NH CF₃O H H H C₆H₅—CH₂O C₆H₅— H CH₂O 19 116N CF₃ CF₃ NH CF₃O H H Hethoxy H H 19 117N CF₃ CF₃ NH CF₃O H H H CH₃CO₂ H H 19 118N CF₃ CF₃ NHCF₃O H H H HOCH₂— H H CH₂O 19 119N CF₃ CF₃ NH CF₃O H H H

H H 19 120N CF₃ CF₃ NH CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 19 121N CF₃ CF₃ NHCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 19 122N CF₃ CF₃ NH CF₃O H H H CH₃OCH₃O H 19 123N CF₃ CF₃ NH CF₃O H H H ethoxy CH₃O H 19 124N CF₃ CF₃ NHCF₃O H H H ethoxy ethoxy H 19 125N CF₃ CF₃ NH CF₃O H H H CH₃CO₂ CH₃CO₂ H19 126N CF₃ CF₃ NH CF₃O H H H CH₃O CH₃CO₂ H 19 127N CF₃ CF₃ NH CF₃O H HH n-butoxy H H 19 128N CF₃ CF₃ NH CF₃O H H H CH₃O H H 19 129N CF₃ CF₃ NHCF₃O H H H H CH₃O H 19 130N CF₃ CF₃ NH CH₃O H H H CH₃O H H 19 131N CF₃CF₃ NH CH₃O H H H H CF₃O H 19 132N CF₃ CF₃ NH CF₃O H H H H ethoxy H 19133N CF₃ CF₃ NH CF₃O H H H H n-propoxy H 19 134N CF₃ CF₃ NH C₆H₅— H H HCF₃O H H CH₂O 19 135N CF₃ CF₃ NH C₆H₅— H H H C₆H₅O H H CH₂O 19 136N CF₃CF₃ NH ethoxy H H H CF₃O H H 19 137N CF₃ CF₃ NH R₅ + R₆ = OCH₂O H H CF₃OH H 19 138N CF₃ CF₃ NH R₅ + R₆ = OCH₂O H H C₆H₅O H H 19 139N CF₃ CF₃ NHR₅ + R₆ = OCH₂CH₂O H H CF₃O H H 19 140N CF₃ CF₃ NH CH₃O CH₃O H H CF₃O HH 19 141N CF₃ CF₃ NH R₅ + R₆ = H H CF₃O H H OCH₂CH₂CH₂O 19 142N CF₃ CF₃NH cyclo CH₃O H H CF₃O H H pentoxy 19 143N CF₃ CF₃ NH H C₆H₅O H H CF₃O HH 19 144N CF₃ CF₃ NH CH₃O CH₃O CH₃O H CF₃O H H 19 145N CF₃ CF₃ NH H CF₃OH H CF₃O H H 19 146N CF₃ CF₃ NH H C₆H₅— H H CF₃O H H CH₂ 19 147N CF₃ CF₃NH C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 19 148N CF₃ CF₃ NH H CF₃O H H CF₃H H 19 149N CF₃ CF₃ NH C₆H₅O H H H CF₃ H H 19 150N CF₃ CF₃ NH C₆H₅ H H HCF₃ H H 19 151N CF₃ CF₃ NH H C₆H₅ H H CF₃ H H 19 152N CF₃ CF₃ NH CN H HH CF₃ H H 19 153N CF₃ CF₃ NH H OCF₃ H H CF₃ H H 19 154N CF₃ CF₃ NH OCF₃H H H H CF₃ H 19 155N CF₃ CF₃ NH C₆H₅O H H H H CF₃ H 19 156N CF₃ CF₃ NHC₆H₅ H H H H CF₃ H 19 157N CF₃ CF₃ NH H C₆H₅ H H H CF₃ H 19 158N CF₃ CF₃NH CN H H H H CF₃ H 19 159N CF₃ CF₃ NH OCF₃ H H H H CF₃ H 19 160N CF₃CF₃ NH CF₃ H H H H C₆H₅ H 19 161N CF₃ CF₃ NH CF₃ H H H 3-CF₃—C₆H₅O H H19 162N CF₃ CF₃ NH CF₃ H H H C₆H₅O H H 19 163N CF₃ CF₃ NH CF₃ H H H CF₃OH H 19 164N CF₃ CF₃ NH H CF₃ H H H C₆H₅ H 19 165N CF₃ CF₃ NH H CF₃ H H3-CF₃—C₆H₅O H H 19 166N CF₃ CF₃ NH H CF₃ H H CF₃O H H 19 167N CF₃ CF₃ NHH CF₃ H H C₆H₅O H H 19 168N CF₃ CF₃ NH CF₃ H CF₃ H CF₃O H H 19 169N CF₃CF₃ NH CF₃ H CF₃ H C₆H₅O H H 19 170N CF₃ CF₃ NH CF₃O H H H CF₃ H CF₃ 19171N CF₃ CF₃ NH C₆H₅O H H H CF₃ H CF₃ 19 172N CF₃ CF₃ NH H C₆H₅O H HC₆H₅O H H 19 173N CF₃ CF₃ NH H CF₃O H H CF₃O H H 19 174N CF₃ CF₃ NH HCF₃O H H H C₆H₅O H 19 175N CF₃ CF₃ NH C₆H₅O H H H H C₆H₅O H 19 176N CF₃CF₃ NH H C₆H₅O H H H OCF₃ H 19 177N CF₃ CF₃ NH H C₆H₅O H H H C₆H₅O H 19178N CF₃ CF₃ NH C₆H₅O H H H H CN H 19 179N CF₃ CF₃ NH C₆H₅O H H H CN H H19 180N CF₃ CF₃ NH C₆H₅O H H H NO₂ H H 19 181N CF₃ CF₃ NH C₆H₅O H H H HNO₂ H 19 182N CF₃ CF₃ NH C₆H₅O H H H H SO₂CH₃ H 19 183N CF₃ CF₃ NH C₆H₅OH H H H 2-NO₂-4- H Cl—C₆H₃O 19 184N CF₃ CF₃ NH C₆H₅O H H H 4-Cl—C₆H₄O HH 19 185N CF₃ CF₃ NH C₆H₅O H H H 3,4-Cl—C₆H₃O H H 19 186N CF₃ CF₃ NHC₆H₅O H H H 3-CF₃—C₆H₃O H H 19 187N CF₃ CF₃ NH C₆H₅O H H H 3,5-Cl—C₆H₃OH H 19 188N CF₃ CF₃ NH C₆H₅O H H H H CH₃O H 19 189N CF₃ CF₃ NH C₆H₅O H HH H CO₂CH₃ H 19 190N CF₃ CF₃ NH C₆H₅O H H H 3-CH₃O H H C₆H₅O 19 191N CF₃CF₃ NH C₆H₅O H H H 4-CH₃O H H C₆H₅O 19 193N CF₃ CF₃ NH C₆H₅O H H HCO₂CH₃ H H 19 194N CF₃ CF₃ NH CN H H H OCF₃ H H 19 195N CF₃ CF₃ NH NO₂ HH H OCF₃ H H 19 196N CF₃ CF₃ NH H CN H H OCF₃ H H 19 197N CF₃ CF₃ NH HNO₂ H H OCF₃ H H 19 198N CF₃ CF₃ NH SO₂CH₃ H H H OCF₃ H H 19 199N CF₃CF₃ NH H SO₂CH₃ H H OCF₃ H H 19 200N CF₃ CF₃ NH H 4-F—C₆H₅ H H OCF₃ H HSO₂ 19 201N CF₃ CF₃ NH SO₂N H H H OCF₃ H H (CH₃)₂ 19 202N CF₃ CF₃ NH HSO₂N H H OCF₃ H H (CH₃)₂ 19 203N CF₃ CF₃ NH H CONH₂ H H OCF₃ H H 19 204NCF₃ CF₃ NH H CONH— H H OCF₃ H H C₆H₅ 19 205N CF₃ CF₃ NH H CO₂CH₃ H HOCF₃ H H 19 206N CF₃ CF₃ NH H CO₂C₄H₉ H H OCF₃ H H 19 207N CF₃ CF₃ NH H4-Cl—C₆H₅ H H C₆H₅O H H 19 208N CF₃ CF₃ NH H 4-CF₃O— H H CF₃O H H C₆H₅19 209N CF₃ CF₃ NH 4-F— H H H CF₃O H H C₆H₄O 19 210N CF₃ CF₃ NH C₆F₅O HH H CF₃O H H 19 211N CF₃ CF₃ NH H 4-F—C₆H₅ H H CF₃O H H 19 212N CF₃ CF₃NH H 4-CN— H H CF₃O H H C₆H₅ 19 213N CF₃ CF₃ NH H 4-C₆H₅— H H CF₃O H HC₆H₅ 19 214N CF₃ CF₃ NH C₆H₅O H H CH₃ CF₃O H H 19 215N CF₃ CF₃ NH C₆H₅OH H CH₃ NO₂ H H 19 216N CF₃ CF₃ NH C₆H₅O H H CH₃ H CN H 19 217N CF₃ CF₃NH C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 19 218N CF₃ CF₃ NH C₆H₅O H H C₆H₅ H C₆H₅H 19 219N CF₃ CF₃ NH C₆H₅O H H C₆H₅ CF₃ H H 19 220N CF₃ CF₃ NH C₆H₅O H HCH₃ F H H 19 221N CF₃ CF₃ NH C₆H₅O H H CF₃ H H H 19 222N CF₃ CF₃ NH bondto —O— of R₆ aryl group

H H CF₃O H H 19 223N CF₃ CF₃ NH to CH₂ of R₆ aryl group

H H CF₃O H H 20  96N CF₃ H NH OH OH H H C₆H₅O H H 20  97N CF₃ H NH C₆H₅OH H H OH OH H 20  98N CF₃ H NH 3-pyridyl H H H CF₃ H H 20  99N CF₃ H NHSO₂N H H H OCF₃ H H (CH₃)₂ 20 100N CF₃ H NH SO₂CH₃ H H H OCF₃ H H 20101N CF₃ H NH C₆H₅O H H H C₆H₅O H H 20 102N CF₃ H NH CF₃O H H H C₆H₅O HH 20 103N CF₃ H NH C₆H₅ H H H C₆H₅O H H 20 104N CF₃ H NH H C₆H₅ H HC₆H₅O H H 20 105N CF₃ H NH C₆H₅O H H H 4-Cl—C₆H₄O H H 20 106N CF₃ H NHCF₃O H H H 4-Cl—C₆H₄O H H 20 107N CF₃ H NH C₆H₅O H H H 3,4-Cl—C₆H₃O H H20 108N CF₃ H NH CF₃O H H H 3,4-Cl—C₆H₃O H H 20 109N CF₃ H NH CF₃O H H H3,5-Cl—C₆H₃O H H 20 110N CF₃ H NH CF₃O H H H 3-CH₃O— H H C₆H₄O 20 111NCF₃ H NH CF₃O H H H H 3-CH₃O— H C₆H₄O 20 112N CF₃ H NH CF₃O H H H3-CF₃—C₆H₄O H H 20 113N CF₃ H NH CF₃O H H H C₆H₅—CH₂O H H 20 114N CF₃ HNH CF₃O H H H C₆H₅—CH₂O CH₃O H 20 115N CF₃ H NH CF₃O H H H C₆H₅—CH₂OC₆H₅— H CH₂O 20 116N CF₃ H NH CF₃O H H H ethoxy H H 20 117N CF₃ H NHCF₃O H H H CH₃CO₂ H H 20 118N CF₃ H NH CF₃O H H H HOCH₂— H H CH₂O 20119N CF₃ H NH CF₃O H H H

H H 20 120N CF₃ H NH CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 20 121N CF₃ H NHCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 20 122N CF₃ H NH CF₃O H H H CH₃O CH₃OH 20 123N CF₃ H NH CF₃O H H H ethoxy CH₃O H 20 124N CF₃ H NH CF₃O H H Hethoxy ethoxy H 20 125N CF₃ H NH CF₃O H H H CH₃CO₂ CH₃CO₂ H 20 126N CF₃H NH CF₃O H H H CH₃O CH₃CO₂ H 20 127N CF₃ H NH CF₃O H H H n-butoxy H H20 128N CF₃ H NH CF₃O H H H CH₃O H H 20 129N CF₃ H NH CF₃O H H H H CH₃OH 20 130N CF₃ H NH CH₃O H H H CH₃O H H 20 131N CF₃ H NH CH₃O H H H HCF₃O H 20 132N CF₃ H NH CF₃O H H H H ethoxy H 20 133N CF₃ H NH CF₃O H HH H n-propoxy H 20 134N CF₃ H NH C₆H₅— H H H CF₃O H H CH₂O 20 135N CF₃ HNH C₆H₅— H H H C₆H₅O H H CH₂O 20 136N CF₃ H NH ethoxy H H H CF₃O H H 20137N CF₃ H NH R₅ + R₆ = OCH₂O H H CF₃O H H 20 138N CF₃ H NH R₅ + R₆ =OCH₂O H H C₆H₅O H H 20 139N CF₃ H NH R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 20140N CF₃ H NH CH₃O CH₃O H H CF₃O H H 20 141N CF₃ H NH R₅ + R₆ = H H CF₃OH H OCH₂CH₂CH₂O 20 142N CF₃ H NH cyclo CH₃O H H CF₃O H H pentoxy 20 143NCF₃ H NH H C₆H₅O H H CF₃O H H 20 144N CF₃ H NH CH₃O CH₃O CH₃O H CF₃O H H20 145N CF₃ H NH H CF₃O H H CF₃O H H 20 146N CF₃ H NH H C₆H₅— H H CF₃O HH CH₂ 20 147N CF₃ H NH C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 20 148N CF₃ HNH H CF₃O H H CF₃ H H 20 149N CF₃ H NH C₆H₅O H H H CF₃ H H 20 150N CF₃ HNH C₆H₅ H H H CF₃ H H 20 151N CF₃ H NH H C₆H₅ H H CF₃ H H 20 152N CF₃ HNH CN H H H CF₃ H H 20 153N CF₃ H NH H OCF₃ H H CF₃ H H 20 154N CF₃ H NHOCF₃ H H H H CF₃ H 20 155N CF₃ H NH C₆H₅O H H H H CF₃ H 20 156N CF₃ H NHC₆H₅ H H H H CF₃ H 20 157N CF₃ H NH H C₆H₅ H H H CF₃ H 20 158N CF₃ H NHCN H H H H CF₃ H 20 159N CF₃ H NH OCF₃ H H H H CF₃ H 20 160N CF₃ H NHCF₃ H H H H C₆H₅ H 20 161N CF₃ H NH CF₃ H H H 3-CF₃—C₆H₅O H H 20 162NCF₃ H NH CF₃ H H H C₆H₅O H H 20 163N CF₃ H NH CF₃ H H H CF₃O H H 20 164NCF₃ H NH H CF₃ H H H C₆H₅ H 20 165N CF₃ H NH H CF₃ H H 3-CF₃—C₆H₅O H H20 166N CF₃ H NH H CF₃ H H CF₃O H H 20 167N CF₃ H NH H CF₃ H H C₆H₅O H H20 168N CF₃ H NH CF₃ H CF₃ H CF₃O H H 20 169N CF₃ H NH CF₃ H CF₃ H C₆H₅OH H 20 170N CF₃ H NH CF₃O H H H CF₃ H CF₃ 20 171N CF₃ H NH C₆H₅O H H HCF₃ H CF₃ 20 172N CF₃ H NH H C₆H₅O H H C₆H₅O H H 20 173N CF₃ H NH H CF₃OH H CF₃O H H 20 174N CF₃ H NH H CF₃O H H H C₆H₅O H 20 175N CF₃ H NHC₆H₅O H H H H C₆H₅O H 20 176N CF₃ H NH H C₆H₅O H H H OCF₃ H 20 177N CF₃H NH H C₆H₅O H H H C₆H₅O H 20 178N CF₃ H NH C₆H₅O H H H H CN H 20 179NCF₃ H NH C₆H₅O H H H CN H H 20 180N CF₃ H NH C₆H₅O H H H NO₂ H H 20 181NCF₃ H NH C₆H₅O H H H H NO₂ H 20 182N CF₃ H NH C₆H₅O H H H H SO₂CH₃ H 20183N CF₃ H NH C₆H₅O H H H H 2-NO₂-4- H Cl—C₆H₃O 20 184N CF₃ H NH C₆H₅O HH H 4-Cl—C₆H₄O H H 20 185N CF₃ H NH C₆H₅O H H H 3,4-Cl—C₆H₃O H H 20 186NCF₃ H NH C₆H₅O H H H 3-CF₃—C₆H₃O H H 20 187N CF₃ H NH C₆H₅O H H H3,5-Cl—C₆H₃O H H 20 188N CF₃ H NH C₆H₅O H H H H CH₃O H 20 189N CF₃ H NHC₆H₅O H H H H CO₂CH₃ H 20 190N CF₃ H NH C₆H₅O H H H 3-CH₃O H H C₆H₅O 20191N CF₃ H NH C₆H₅O H H H 4-CH₃O H H C₆H₅O 20 193N CF₃ H NH C₆H₅O H H HCO₂CH₃ H H 20 194N CF₃ H NH CN H H H OCF₃ H H 20 195N CF₃ H NH NO₂ H H HOCF₃ H H 20 196N CF₃ H NH H CN H H OCF₃ H H 20 197N CF₃ H NH H NO₂ H HOCF₃ H H 20 198N CF₃ H NH SO₂CH₃ H H H OCF₃ H H 20 199N CF₃ H NH HSO₂CH₃ H H OCF₃ H H 20 200N CF₃ H NH H 4-F—C₆H₅ H H OCF₃ H H SO₂ 20 201NCF₃ H NH SO₂N H H H OCF₃ H H (CH₃)₂ 20 202N CF₃ H NH H SO₂N H H OCF₃ H H(CH₃)₂ 20 203N CF₃ H NH H CONH₂ H H OCF₃ H H 20 204N CF₃ H NH H CONH— HH OCF₃ H H C₆H₅ 20 205N CF₃ H NH H CO₂CH₃ H H OCF₃ H H 20 206N CF₃ H NHH CO₂C₄H₉ H H OCF₃ H H 20 207N CF₃ H NH H 4-Cl—C₆H₅ H H C₆H₅O H H 20208N CF₃ H NH H 4-CF₃O— H H CF₃O H H C₆H₅ 20 209N CF₃ H NH 4-F— H H HCF₃O H H C₆H₄O 20 210N CF₃ H NH C₆F₅O H H H CF₃O H H 20 211N CF₃ H NH H4-F—C₆H₅ H H CF₃O H H 20 212N CF₃ H NH H 4-CN— H H CF₃O H H C₆H₅ 20 213NCF₃ H NH H 4-C₆H₅— H H CF₃O H H C₆H₅ 20 214N CF₃ H NH C₆H₅O H H CH₃ CF₃OH H 20 215N CF₃ H NH C₆H₅O H H CH₃ NO₂ H H 20 216N CF₃ H NH C₆H₅O H HCH₃ H CN H 20 217N CF₃ H NH C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 20 218N CF₃ HNH C₆H₅O H H C₆H₅ H C₆H₅ H 20 219N CF₃ H NH C₆H₅O H H C₆H₅ CF₃ H H 20220N CF₃ H NH C₆H₅O H H CH₃ F H H 20 221N CF₃ H NH C₆H₅O H H CF₃ H H H20 222N CF₃ H NH bond to —O— of R₆ aryl group

H H CF₃O H H 20 223N CF₃ H NH to CH₂ of R₆ aryl group

H H CF₃O H H 25  96N CF₃ H S OH OH H H C₆H₅O H H 25  97N CF₃ H S C₆H₅O HH H OH OH H 25  98N CF₃ H S 3-pyridyl H H H CF₃ H H 25  99N CF₃ H S SO₂NH H H OCF₃ H H (CH₃)₂ 25 100N CF₃ H S SO₂CH₃ H H H OCF₃ H H 25 101N CF₃H S C₆H₅O H H H C₆H₅O H H 25 102N CF₃ H S CF₃O H H H C₆H₅O H H 25 103NCF₃ H S C₆H₅ H H H C₆H₅O H H 25 104N CF₃ H S H C₆H₅ H H C₆H₅O H H 25105N CF₃ H S C₆H₅O H H H 4-Cl—C₆H₄O H H 25 106N CF₃ H S CF₃O H H H4-Cl—C₆H₄O H H 25 107N CF₃ H S C₆H₅O H H H 3,4-Cl—C₆H₃O H H 25 108N CF₃H S CF₃O H H H 3,4-Cl—C₆H₃O H H 25 109N CF₃ H S CF₃O H H H 3,5-Cl—C₆H₃OH H 25 110N CF₃ H S CF₃O H H H 3-CH₃O— H H C₆H₄O 25 111N CF₃ H S CF₃O HH H H 3-CH₃O— H C₆H₄O 25 112N CF₃ H S CF₃O H H H 3-CF₃—C₆H₄O H H 25 113NCF₃ H S CF₃O H H H C₆H₅—CH₂O H H 25 114N CF₃ H S CF₃O H H H C₆H₅—CH₂OCH₃O H 25 115N CF₃ H S CF₃O H H H C₆H₅—CH₂O C₆H₅— H CH₂O 25 116N CF₃ H SCF₃O H H H ethoxy H H 25 117N CF₃ H S CF₃O H H H CH₃CO₂ H H 25 118N CF₃H S CF₃O H H H HOCH₂— H H CH₂O 25 119N CF₃ H S CF₃O H H H

H H 25 120N CF₃ H S CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 25 121N CF₃ H S CF₃OH H H R₁₀ + R₁₁ = OCH₂CH₂O H 25 122N CF₃ H S CF₃O H H H CH₃O CH₃O H 25123N CF₃ H S CF₃O H H H ethoxy CH₃O H 25 124N CF₃ H S CF₃O H H H ethoxyethoxy H 25 125N CF₃ H S CF₃O H H H CH₃CO₂ CH₃CO₂ H 25 126N CF₃ H S CF₃OH H H CH₃O CH₃CO₂ H 25 127N CF₃ H S CF₃O H H H n-butoxy H H 25 128N CF₃H S CF₃O H H H CH₃O H H 25 129N CF₃ H S CF₃O H H H H CH₃O H 25 130N CF₃H S CH₃O H H H CH₃O H H 25 131N CF₃ H S CH₃O H H H H CF₃O H 25 132N CF₃H S CF₃O H H H H ethoxy H 25 133N CF₃ H S CF₃O H H H H n-propoxy H 25134N CF₃ H S C₆H₅— H H H CF₃O H H CH₂O 25 135N CF₃ H S C₆H₅— H H H C₆H₅OH H CH₂O 25 136N CF₃ H S ethoxy H H H CF₃O H H 25 137N CF₃ H S R₅ + R₆ =OCH₂O H H CF₃O H H 25 138N CF₃ H S R₅ + R₆ = OCH₂O H H C₆H₅O H H 25 139NCF₃ H S R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 25 140N CF₃ H S CH₃O CH₃O H HCF₃O H H 25 141N CF₃ H S R₅ + R₆ = H H CF₃O H H OCH₂CH₂CH₂O 25 142N CF₃H S cyclo CH₃O H H CF₃O H H pentoxy 25 143N CF₃ H S H C₆H₅O H H CF₃O H H25 144N CF₃ H S CH₃O CH₃O CH₃O H CF₃O H H 25 145N CF₃ H S H CF₃O H HCF₃O H H 25 146N CF₃ H S H C₆H₅— H H CF₃O H H CH₂ 25 147N CF₃ H S C₆H₅OH H H R₁₀ + R₁₁ = OCH₂CH₂O H 25 148N CF₃ H S H CF₃O H H CF₃ H H 25 149NCF₃ H S C₆H₅O H H H CF₃ H H 25 150N CF₃ H S C₆H₅ H H H CF₃ H H 25 151NCF₃ H S H C₆H₅ H H CF₃ H H 25 152N CF₃ H S CN H H H CF₃ H H 25 153N CF₃H S H OCF₃ H H CF₃ H H 25 154N CF₃ H S OCF₃ H H H H CF₃ H 25 155N CF₃ HS C₆H₅O H H H H CF₃ H 25 156N CF₃ H S C₆H₅ H H H H CF₃ H 25 157N CF₃ H SH C₆H₅ H H H CF₃ H 25 158N CF₃ H S CN H H H H CF₃ H 25 159N CF₃ H S OCF₃H H H H CF₃ H 25 160N CF₃ H S CF₃ H H H H C₆H₅ H 25 161N CF₃ H S CF₃ H HH 3-CF₃—C₆H₅O H H 25 162N CF₃ H S CF₃ H H H C₆H₅O H H 25 163N CF₃ H SCF₃ H H H CF₃O H H 25 164N CF₃ H S H CF₃ H H H C₆H₅ H 25 165N CF₃ H S HCF₃ H H 3-CF₃—C₆H₅O H H 25 166N CF₃ H S H CF₃ H H CF₃O H H 25 167N CF₃ HS H CF₃ H H C₆H₅O H H 25 168N CF₃ H S CF₃ H CF₃ H CF₃O H H 25 169N CF₃ HS CF₃ H CF₃ H C₆H₅O H H 25 170N CF₃ H S CF₃O H H H CF₃ H CF₃ 25 171N CF₃H S C₆H₅O H H H CF₃ H CF₃ 25 172N CF₃ H S H C₆H₅O H H C₆H₅O H H 25 173NCF₃ H S H CF₃O H H CF₃O H H 25 174N CF₃ H S H CF₃O H H H C₆H₅O H 25 175NCF₃ H S C₆H₅O H H H H C₆H₅O H 25 176N CF₃ H S H C₆H₅O H H H OCF₃ H 25177N CF₃ H S H C₆H₅O H H H C₆H₅O H 25 178N CF₃ H S C₆H₅O H H H H CN H 25179N CF₃ H S C₆H₅O H H H CN H H 25 180N CF₃ H S C₆H₅O H H H NO₂ H H 25181N CF₃ H S C₆H₅O H H H H NO₂ H 25 182N CF₃ H S C₆H₅O H H H H SO₂CH₃ H25 183N CF₃ H S C₆H₅O H H H H 2-NO₂-4- H Cl—C₆H₃O 25 184N CF₃ H S C₆H₅OH H H 4-Cl—C₆H₄O H H 25 185N CF₃ H S C₆H₅O H H H 3,4-Cl—C₆H₃O H H 25186N CF₃ H S C₆H₅O H H H 3-CF₃—C₆H₃O H H 25 187N CF₃ H S C₆H₅O H H H3,5-Cl—C₆H₃O H H 25 188N CF₃ H S C₆H₅O H H H H CH₃O H 25 189N CF₃ H SC₆H₅O H H H H CO₂CH₃ H 25 190N CF₃ H S C₆H₅O H H H 3-CH₃O H H C₆H₅O 25191N CF₃ H S C₆H₅O H H H 4-CH₃O H H C₆H₅O 25 193N CF₃ H S C₆H₅O H H HCO₂CH₃ H H 25 194N CF₃ H S CN H H H OCF₃ H H 25 195N CF₃ H S NO₂ H H HOCF₃ H H 25 196N CF₃ H S H CN H H OCF₃ H H 25 197N CF₃ H S H NO₂ H HOCF₃ H H 25 198N CF₃ H S SO₂CH₃ H H H OCF₃ H H 25 199N CF₃ H S H SO₂CH₃H H OCF₃ H 25 200N CF₃ H S H 4-F—C₆H₅ H H OCF₃ H H SO₂ 25 201N CF₃ H SSO₂N H H H OCF₃ H H (CH₃)₂ 25 202N CF₃ H S H SO₂N H H OCF₃ H H (CH₃)₂ 25203N CF₃ H S H CONH₂ H H OCF₃ H H 25 204N CF₃ H S H CONH— H H OCF₃ H HC₆H₅ 25 205N CF₃ H S H CO₂CH₃ H H OCF₃ H H 25 206N CF₃ H S H CO₂C₄H₉ H HOCF₃ H H 25 207N CF₃ H S H 4-Cl—C₆H₅ H H C₆H₅O H H 25 208N CF₃ H S H4-CF₃O— H H CF₃O H H C₆H₅ 25 209N CF₃ H S 4-F— H H H CF₃O H H C₆H₄O 25210N CF₃ H S C₆F₅O H H H CF₃O H H 25 211N CF₃ H S H 4-F—C₆H₅ H H CF₃O HH 25 212N CF₃ H S H 4-CN— H H CF₃O H H C₆H₅ 25 213N CF₃ H S H 4-C₆H₅— HH CF₃O H H C₆H₅ 25 214N CF₃ H S C₆H₅O H H CH₃ CF₃O H H 25 215N CF₃ H SC₆H₅O H H CH₃ NO₂ H H 25 216N CF₃ H S C₆H₅O H H CH₃ H CN H 25 217N CF₃ HS C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 25 218N CF₃ H S C₆H₅O H H C₆H₅ H C₆H₅ H25 219N CF₃ H S C₆H₅O H H C₆H₅ CF₃ H H 25 220N CF₃ H S C₆H₅O H H CH₃ F HH 25 221N CF₃ H S C₆H₅O H H CF₃ H H H 25 222N CF₃ H S bond to —O— of R₆aryl group

H H CF₃O H H 25 223N CF₃ H S to CH₂ of R₆ aryl group

H H CF₃O H H 26  96N CF₃CF₂ H S OH OH H H C₆H₅O H H 26  97N CF₃CF₂ H SC₆H₅O H H H OH OH H 26  98N CF₃CF₂ H S 3-pyridyl H H H CF₃ H H 26  99NCF₃CF₂ H S SO₂N H H H OCF₃ H H (CH₃)₂ 26 100N CF₃CF₂ H S SO₂CH₃ H H HOCF₃ H H 26 101N CF₃CF₂ H S C₆H₅O H H H C₆H₅O H H 26 102N CF₃CF₂ H SCF₃O H H H C₆H₅O H H 26 103N CF₃CF₂ H S C₆H₅ H H H C₆H₅O H H 26 104NCF₃CF₂ H S H C₆H₅ H H C₆H₅O H H 26 105N CF₃CF₂ H S C₆H₅O H H H4-Cl—C₆H₄O H H 26 106N CF₃CF₂ H S CF₃O H H H 4-Cl—C₆H₄O H H 26 107NCF₃CF₂ H S C₆H₅O H H H 3,4-Cl—C₆H₃O H H 26 108N CF₃CF₂ H S CF₃O H H H3,4-Cl—C₆H₃O H H 26 109N CF₃CF₂ H S CF₃O H H H 3,5-Cl—C₆H₃O H H 26 110NCF₃CF₂ H S CF₃O H H H 3-CH₃O— H H C₆H₄O 26 111N CF₃CF₂ H S CF₃O H H H H3-CH₃O— H C₆H₄O 26 112N CF₃CF₂ H S CF₃O H H H 3-CF₃—C₆H₄O H H 26 113NCF₃CF₂ H S CF₃O H H H C₆H₅—CH₂O H H 26 114N CF₃CF₂ H S CF₃O H H HC₆H₅—CH₂O CH₃O H 26 115N CF₃CF₂ H S CF₃O H H H C₆H₅—CH₂O C₆H₅— H CH₂O 26116N CF₃CF₂ H S CF₃O H H H ethoxy H H 26 117N CF₃CF₂ H S CF₃O H H HCH₃CO₂ H H 26 118N CF₃CF₂ H S CF₃O H H H HOCH₂— H H CH₂O 26 119N CF₃CF₂H S CF₃O H H H

H H 26 120N CF₃CF₂ H S CF₃O H H H R₁₀ +R₁₁ = OCH₂O H 26 121N CF₃CF₂ H SCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 26 122N CF₃CF₂ H S CF₃O H H H CH₃OCH₃O H 26 123N CF₃CF₂ H S CF₃O H H H ethoxy CH₃O H 26 124N CF₃CF₂ H SCF₃O H H H ethoxy ethoxy H 26 125N CF₃CF₂ H S CF₃O H H H CH₃CO₂ CH₃CO₂ H26 126N CF₃CF₂ H S CF₃O H H H CH₃O CH₃CO₂ H 26 127N CF₃CF₂ H S CF₃O H HH n-butoxy H H 26 128N CF₃CF₂ H S CF₃O H H H CH₃O H H 26 129N CF₃CF₂ H SCF₃O H H H H CH₃O H 26 130N CF₃CF₂ H S CH₃O H H H CH₃O H H 26 131NCF₃CF₂ H S CH₃O H H H H CF₃O H 26 132N CF₃CF₂ H S CF₃O H H H H ethoxy H26 133N CF₃CF₂ H S CF₃O H H H H n-propoxy H 26 134N CF₃CF₂ H S C₆H₅— H HH CF₃O H H CH₂O 26 135N CF₃CF₂ H S C₆H₅— H H H C₆H₅O H H CH₂O 26 136NCF₃CF₂ H S ethoxy H H H CF₃O H H 26 137N CF₃CF₂ H S R₅ + R₆ = OCH₂O H HCF₃O H H 26 138N CF₃CF₂ H S R₅ + R₆ = OCH₂O H H C₆H₅O H H 26 139N CF₃CF₂H S R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 26 140N CF₃CF₂ H S CH₃O CH₃O H HCF₃O H H 26 141N CF₃CF₂ H S R₅ + R₆ = H H CF₃O H H OCH₂CH₂CH₂O 26 142NCF₃CF₂ H S cyclo CH₃O H H CF₃O H H pentoxy 26 143N CF₃CF₂ H S H C₆H₅O HH CF₃O H H 26 144N CF₃CF₂ H S CH₃O CH₃O CH₃O H CF₃O H H 26 145N CF₃CF₂ HS H CF₃O H H CF₃O H H 26 146N CF₃CF₂ H S H C₆H₅— H H CF₃O H H CH₂ 26147N CF₃CF₂ H S C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 26 148N CF₃CF₂ H S HCF₃O H H CF₃ H H 26 149N CF₃CF₂ H S C₆H₅O H H H CF₃ H H 26 150N CF₃CF₂ HS C₆H₅ H H H CF₃ H H 26 151N CF₃CF₂ H S H C₆H₅ H H CF₃ H H 26 152NCF₃CF₂ H S CN H H H CF₃ H H 26 153N CF₃CF₂ H S H OCF₃ H H CF₃ H H 26154N CF₃CF₂ H S OCF₃ H H H H CF₃ H 26 155N CF₃CF₂ H S C₆H₅O H H H H CF₃H 26 156N CF₃CF₂ H S C₆H₅ H H H H CF₃ H 26 157N CF₃CF₂ H S H C₆H₅ H H HCF₃ H 26 158N CF₃CF₂ H S CN H H H H CF₃ H 26 159N CF₃CF₂ H S OCF₃ H H HH CF₃ H 26 160N CF₃CF₂ H S CF₃ H H H H C₆H₅ H 26 161N CF₃CF₂ H S CF₃ H HH 3-CF₃—C₆H₅O H H 26 162N CF₃CF₂ H S CF₃ H H H C₆H₅O H H 26 163N CF₃CF₂H S CF₃ H H H CF₃O H H 26 164N CF₃CF₂ H S H CF₃ H H H C₆H₅ H 26 165NCF₃CF₂ H S H CF₃ H H 3-CF₃—C₆H₅O H H 26 166N CF₃CF₂ H S H CF₃ H H CF₃O HH 26 167N CF₃CF₂ H S H CF₃ H H C₆H₅O H H 26 168N CF₃CF₂ H S CF₃ H CF₃ HCF₃O H H 26 169N CF₃CF₂ H S CF₃ H CF₃ H C₆H₅O H H 26 170N CF₃CF₂ H SCF₃O H H H CF₃ H CF₃ 26 171N CF₃CF₂ H S C₆H₅O H H H CF₃ H CF₃ 26 172NCF₃CF₂ H S H C₆H₅O H H C₆H₅O H H 26 173N CF₃CF₂ H S H CF₃O H H CF₃O H H26 174N CF₃CF₂ H S H CF₃O H H H C₆H₅O H 26 175N CF₃CF₂ H S C₆H₅O H H H HC₆H₅O H 26 176N CF₃CF₂ H S H C₆H₅O H H H OCF₃ H 26 177N CF₃CF₂ H S HC₆H₅O H H H C₆H₅O H 26 178N CF₃CF₂ H S C₆H₅O H H H H CN H 26 179N CF₃CF₂H S C₆H₅O H H H CN H H 26 180N CF₃CF₂ H S C₆H₅O H H H NO₂ H H 26 181NCF₃CF₂ H S C₆H₅O H H H H NO₂ H 26 182N CF₃CF₂ H S C₆H₅O H H H H SO₂CH₃ H26 183N CF₃CF₂ H S C₆H₅O H H H H 2-NO₂-4- H Cl—C₆H₃O 26 184N CF₃CF₂ H SC₆H₅O H H H 4-Cl—C₆H₄O H H 26 185N CF₃CF₂ H S C₆H₅O H H H 3,4-Cl—C₆H₃O HH 26 186N CF₃CF₂ H S C₆H₅O H H H 3-CF₃—C₆H₃O H H 26 187N CF₃CF₂ H SC₆H₅O H H H 3,5-Cl—C₆H₃O H H 26 188N CF₃CF₂ H S C₆H₅O H H H H CH₃O H 26189N CF₃CF₂ H S C₆H₅O H H H H CO₂CH₃ H 26 190N CF₃CF₂ H S C₆H₅O H H H3-CH₃O H H C₆H₅O 26 191N CF₃CF₂ H S C₆H₅O H H H 4-CH₃O H H C₆H₅O 26 193NCF₃CF₂ H S C₆H₅O H H H CO₂CH₃ H H 26 194N CF₃CF₂ H S CN H H H OCF₃ H H26 195N CF₃CF₂ H S NO₂ H H H OCF₃ H H 26 196N CF₃CF₂ H S H CN H H OCF₃ HH 26 197N CF₃CF₂ H S H NO₂ H H OCF₃ H H 26 198N CF₃CF₂ H S SO₂CH₃ H H HOCF₃ H H 26 199N CF₃CF₂ H S H SO₂CH₃ H H OCF₃ H H 26 200N CF₃CF₂ H S H4-F—C₆H₅ H H OCF₃ H H SO₂ 26 201N CF₃CF₂ H S SO₂N H H H OCF₃ H H (CH₃)₂26 202N CF₃CF₂ H S H SO₂N H H OCF₃ H H (CH₃)₂ 26 203N CF₃CF₂ H S H CONH₂H H OCF₃ H H 26 204N CF₃CF₂ H S H CONH— H H OCF₃ H H C₆H₅ 26 205N CF₃CF₂H S H CO₂CH₃ H H OCF₃ H H 26 206N CF₃CF₂ H S H CO₂C₄H₉ H H OCF₃ H H 26207N CF₃CF₂ H S H 4-Cl—C₆H₅ H H C₆H₅O H H 26 208N CF₃CF₂ H S H 4-CF₃O— HH CF₃O H H C₆H₅ 26 209N CF₃CF₂ H S 4-F— H H H CF₃O H H C₆H₄O 26 210NCF₃CF₂ H S C₆F₅O H H H CF₃O H H 26 211N CF₃CF₂ H S H 4-F—C₆H₅ H H CF₃O HH 26 212N CF₃CF₂ H S H 4-CN— H H CF₃O H H C₆H₅ 26 213N CF₃CF₂ H S H4-C₆H₅— H H CF₃O H H C₆H₅ 26 214N CF₃CF₂ H S C₆H₅O H H CH₃ CF₃O H H 26215N CF₃CF₂ H S C₆H₅O H H CH₃ NO₂ H H 26 216N CF₃CF₂ H S C₆H₅O H H CH₃ HCN H 26 217N CF₃CF₂ H S C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 26 218N CF₃CF₂ H SC₆H₅O H H C₆H₅ H C₆H₅ H 26 219N CF₃CF₂ H S C₆H₅O H H C₆H₅ CF₃ H H 26220N CF₃CF₂ H S C₆H₅O H H CH₃ F H H 26 221N CF₃CF₂ H S C₆H₅O H H CF₃ H HH 26 222N CF₃CF₂ H S bond to —O— of R₆ aryl group

H H CF₃O H H 26 223N CF₃CF₂ H S to CH₂ of R₆ aryl group

H H CF₃O H H 63  96N C₆H₅ H O OH OH H H C₆H₅O H H 63  97N C₆H₅ H O C₆H₅OH H H OH OH H 63  98N C₆H₅ H O 3-pyridyl H H H CF₃ H H 63  99N C₆H₅ H OSO₂N H H H OCF₃ H H (CH₃)₂ 63 100N C₆H₅ H O SO₂CH₃ H H H OCF₃ H H 63101N C₆H₅ H O C₆H₅O H H H C₆H₅O H H 63 102N C₆H₅ H O CF₃O H H H C₆H₅O HH 63 103N C₆H₅ H O C₆H₅ H H H C₆H₅O H H 63 104N C₆H₅ H O H C₆H₅ H HC₆H₅O H H 63 105N C₆H₅ H O C₆H₅O H H H 4-Cl—C₆H₄O H H 63 106N C₆H₅ H OCF₃O H H H 4-Cl—C₆H₄O H H 63 107N C₆H₅ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H63 108N C₆H₅ H O CF₃O H H H 3,4-Cl—C₆H₃O H H 63 109N C₆H₅ H O CF₃O H H H3,5-Cl—C₆H₃O H H 63 110N C₆H₅ H O CF₃O H H H 3-CH₃O— H H C₆H₄O 63 111NC₆H₅ H O CF₃O H H H H 3-CH₃O— H C₆H₄O 63 112N C₆H₅ H O CF₃O H H H3-CF₃—C₆H₄O H H 63 113N C₆H₅ H O CF₃O H H H C₆H₅—CH₂O H H 63 114N C₆H₅ HO CF₃O H H H C₆H₅—CH₂O CH₃O H 63 115N C₆H₅ H O CF₃O H H H C₆H₅—CH₂OC₆H₅— H CH₂O 63 116N C₆H₅ H O CF₃O H H H ethoxy H H 63 117N C₆H₅ H OCF₃O H H H CH₃CO₂ H H 63 118N C₆H₅ H O CF₃O H H H HOCH₂— H H CH₂O 63119N C₆H₅ H O CF₃O H H H

H H 63 120N C₆H₅ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 63 121N C₆H₅ H OCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 63 122N C₆H₅ H O CF₃O H H H CH₃O CH₃OH 63 123N C₆H₅ H O CF₃O H H H ethoxy CH₃O H 63 124N C₆H₅ H O CF₃O H H Hethoxy ethoxy H 63 125N C₆H₅ H O CF₃O H H H CH₃CO₂ CH₃CO₂ H 63 126N C₆H₅H O CF₃O H H H CH₃O CH₃CO₂ H 63 127N C₆H₅ H O CF₃O H H H n-butoxy H H 63128N C₆H₅ H O CF₃O H H H CH₃O H H 63 129N C₆H₅ H O CF₃O H H H H CH₃O H63 130N C₆H₅ H O CH₃O H H H CH₃O H H 63 131N C₆H₅ H O CH₃O H H H H CF₃OH 63 132N C₆H₅ H O CF₃O H H H H ethoxy H 63 133N C₆H₅ H O CF₃O H H H Hn-propoxy H 63 134N C₆H₅ H O C₆H₅— H H H CF₃O H H CH₂O 63 135N C₆H₅ H OC₆H₅— H H H C₆H₅O H H CH₂O 63 136N C₆H₅ H O ethoxy H H H CF₃O H H 63137N C₆H₅ H O R₅ + R₆ = OCH₂O H H CF₃O H H 63 138N C₆H₅ H O R₅ + R₆ =OCH₂O H H C₆H₅O H H 63 139N C₆H₅ H O R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 63140N C₆H₅ H O CH₃O CH₃O H H CF₃O H H 63 141N C₆H₅ H O R₅ + R₆ = H H CF₃OH H OCH₂CH₂CH₂O 63 142N C₆H₅ H O cyclo CH₃O H H CF₃O H H pentoxy 63 143NC₆H₅ H O H C₆H₅O H H CF₃O H H 63 144N C₆H₅ H O CH₃O CH₃O CH₃O H CF₃O H H63 145N C₆H₅ H O H CF₃O H H CF₃O H H 63 146N C₆H₅ H O H C₆H₅— H H CF₃O HH CH₂ 63 147N C₆H₅ H O C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 63 148N C₆H₅ HO H CF₃O H H CF₃ H H 63 149N C₆H₅ H O C₆H₅O H H H CF₃ H H 63 150N C₆H₅ HO C₆H₅ H H H CF₃ H H 63 151N C₆H₅ H O H C₆H₅ H H CF₃ H H 63 152N C₆H₅ HO CN H H H CF₃ H H 63 153N C₆H₅ H O H OCF₃ H H CF₃ H H 63 154N C₆H₅ H OOCF₃ H H H H CF₃ H 63 155N C₆H₅ H O C₆H₅O H H H H CF₃ H 63 156N C₆H₅ H OC₆H₅ H H H H CF₃ H 63 157N C₆H₅ H O H C₆H₅ H H H CF₃ H 63 158N C₆H₅ H OCN H H H H CF₃ H 63 159N C₆H₅ H O OCF₃ H H H H CF₃ H 63 160N C₆H₅ H OCF₃ H H H H C₆H₅ H 63 161N C₆H₅ H O CF₃ H H H 3-CF₃—C₆H₅O H H 63 162NC₆H₅ H O CF₃ H H H C₆H₅O H H 63 163N C₆H₅ H O CF₃ H H H CF₃O H H 63 164NC₆H₅ H O H CF₃ H H H C₆H₅ H 63 165N C₆H₅ H O H CF₃ H H 3-CF₃—C₆H₅O H H63 166N C₆H₅ H O H CF₃ H H CF₃O H H 63 167N C₆H₅ H O H CF₃ H H C₆H₅O H H63 168N C₆H₅ H O CF₃ H CF₃ H CF₃O H H 63 169N C₆H₅ H O CF₃ H CF₃ H C₆H₅OH H 63 170N C₆H₅ H O CF₃O H H H CF₃ H CF₃ 63 171N C₆H₅ H O C₆H₅O H H HCF₃ H CF₃ 63 172N C₆H₅ H O H C₆H₅O H H C₆H₅O H H 63 173N C₆H₅ H O H CF₃OH H CF₃O H H 63 174N C₆H₅ H O H CF₃O H H H C₆H₅O H 63 175N C₆H₅ H OC₆H₅O H H H H C₆H₅O H 63 176N C₆H₅ H O H C₆H₅O H H H OCF₃ H 63 177N C₆H₅H O H C₆H₅O H H H C₆H₅O H 63 178N C₆H₅ H O C₆H₅O H H H H CN H 63 179NC₆H₅ H O C₆H₅O H H H CN H H 63 180N C₆H₅ H O C₆H₅O H H H NO₂ H H 63 181NC₆H₅ H O C₆H₅O H H H H NO₂ H 63 182N C₆H₅ H O C₆H₅O H H H H SO₂CH₃ H 63183N C₆H₅ H O C₆H₅O H H H H 2-NO₂-4- H Cl—C₆H₃O 63 184N C₆H₅ H O C₆H₅O HH H 4-Cl—C₆H₄O H H 63 185N C₆H₅ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 63 186NC₆H₅ H O C₆H₅O H H H 3-CF₃—C₆H₃O H H 63 187N C₆H₅ H O C₆H₅O H H H3,5-Cl—C₆H₃O H H 63 188N C₆H₅ H O C₆H₅O H H H H CH₃O H 63 189N C₆H₅ H OC₆H₅O H H H H CO₂CH₃ H 63 190N C₆H₅ H O C₆H₅O H H H 3-CH₃O H H C₆H₅O 63191N C₆H₅ H O C₆H₅O H H H 4-CH₃O H H C₆H₅O 63 193N C₆H₅ H O C₆H₅O H H HCO₂CH₃ H H 63 194N C₆H₅ H O CN H H H OCF₃ H H 63 195N C₆H₅ H O NO₂ H H HOCF₃ H H 63 196N C₆H₅ H O H CN H H OCF₃ H 63 197N C₆H₅ H O H NO₂ H HOCF₃ H H 63 198N C₆H₅ H O SO₂CH₃ H H H OCF₃ H H 63 199N C₆H₅ H O HSO₂CH₃ H H OCF₃ H H 63 200N C₆H₅ H O H 4-F—C₆H₅ H H OCF₃ H H SO₂ 63 201NC₆H₅ H O SO₂N H H H OCF₃ H H (CH₃)₂ 63 202N C₆H₅ H O H SO₂N H H OCF₃ H H(CH₃)₂ 63 203N C₆H₅ H O H CONH₂ H H OCF₃ H H 63 204N C₆H₅ H O H CONH— HH OCF₃ H H C₆H₅ 63 205N C₆H₅ H O H CO₂CH₃ H H OCF₃ H H 63 206N C₆H₅ H OH CO₂C₄H₉ H H OCF₃ H H 63 207N C₆H₅ H O H 4-Cl—C₆H₅ H H C₆H₅O H H 63208N C₆H₅ H O H 4-CF₃O— H H CF₃O H H C₆H₅ 63 209N C₆H₅ H O 4-F— H H HCF₃O H H C₆H₄O 63 210N C₆H₅ H O C₆F₅O H H H CF₃O H H 63 211N C₆H₅ H O H4-F—C₆H₅ H H CF₃O H H 63 212N C₆H₅ H O H 4-CN— H H CF₃O H H C₆H₅ 63 213NC₆H₅ H O H 4-C₆H₅— H H CF₃O H H C₆H₅ 63 214N C₆H₅ H O C₆H₅O H H CH₃ CF₃OH H 63 215N C₆H₅ H O C₆H₅O H H CH₃ NO₂ H H 63 216N C₆H₅ H O C₆H₅O H HCH₃ H CN H 63 217N C₆H₅ H O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 63 218N C₆H₅ HO C₆H₅O H H C₆H₅ H C₆H₅ H 63 219N C₆H₅ H O C₆H₅O H H C₆H₅ CF₃ H H 63220N C₆H₅ H O C₆H₅O H H CH₃ F H H 63 221N C₆H₅ H O C₆H₅O H H CF₃ H H H63 222N C₆H₅ H O bond to —O— of R₆ aryl group

H H CF₃O H H 63 223N C₆H₅ H O to CH₂ of R₆ aryl group

H H CF₃O H H 65  96N C₆F₅ H O OH OH H H C₆H₅O H H 65  97N C₆F₅ H O C₆H₅OH H H OH OH H 65  98N C₆F₅ H O 3-pyridyl H H H CF₃ H H 65  99N C₆F₅ H OSO₂N H H H OCF₃ H H (CH₃)₂ 65 100N C₆F₅ H O SO₂CH₃ H H H OCF₃ H H 65101N C₆F₅ H O C₆H₅O H H H C₆H₅O H H 65 102N C₆F₅ H O CF₃O H H H C₆H₅O HH 65 103N C₆F₅ H O C₆H₅ H H H C₆H₅O H H 65 104N C₆F₅ H O H C₆H₅ H HC₆H₅O H H 65 105N C₆F₅ H O C₆H₅O H H H 4-Cl—C₆H₄O H H 65 106N C₆F₅ H OCF₃O H H H 4-Cl—C₆H₄O H H 65 107N C₆F₅ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H65 108N C₆F₅ H O CF₃O H H H 3,4-Cl—C₆H₃O H H 65 109N C₆F₅ H O CF₃O H H H3,5-Cl—C₆H₃O H H 65 110N C₆F₅ H O CF₃O H H H 3-CH₃O— H H C₆H₄O 65 111NC₆F₅ H O CF₃O H H H H 3-CH₃O— H C₆H₄O 65 112N C₆F₅ H O CF₃O H H H3-CF₃—C₆H₄O H H 65 113N C₆F₅ H O CF₃O H H H C₆H₅—CH₂O H H 65 114N C₆F₅ HO CF₃O H H H C₆H₅—CH₂O CH₃O H 65 115N C₆F₅ H O CF₃O H H H C₆H₅—CH₂OC₆H₅— H CH₂O 65 116N C₆F₅ H O CF₃O H H H ethoxy H H 65 117N C₆F₅ H OCF₃O H H H CH₃CO₂ H H 65 118N C₆F₅ H O CF₃O H H H HOCH₂— H H CH₂O 65119N C₆F₅ H O CF₃O H H H

H H 65 120N C₆F₅ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H 65 121N C₆F₅ H OCF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H 65 122N C₆F₅ H O CF₃O H H H CH₃O CH₃OH 65 123N C₆F₅ H O CF₃O H H H ethoxy CH₃O H 65 124N C₆F₅ H O CF₃O H H Hethoxy ethoxy H 65 125N C₆F₅ H O CF₃O H H H CH₃CO₂ CH₃CO₂ H 65 126N C₆F₅H O CF₃O H H H CH₃O CH₃CO₂ H 65 127N C₆F₅ H O CF₃O H H H n-butoxy H H 65128N C₆F₅ H O CF₃O H H H CH₃O H H 65 129N C₆F₅ H O CF₃O H H H H CH₃O H65 130N C₆F₅ H O CH₃O H H H CH₃O H H 65 131N C₆F₅ H O CH₃O H H H H CF₃OH 65 132N C₆F₅ H O CF₃O H H H H ethoxy H 65 133N C₆F₅ H O CF₃O H H H Hn-propoxy H 65 134N C₆F₅ H O C₆H₅— H H H CF₃O H H CH₂O 65 135N C₆F₅ H OC₆H₅— H H H C₆H₅O H H CH₂O 65 136N C₆F₅ H O ethoxy H H H CF₃O H H 65137N C₆F₅ H O R₅ + R₆ = OCH₂O H H CF₃O H H 65 138N C₆F₅ H O R₅ + R₆ =OCH₂O H H C₆H₅O H H 65 139N C₆F₅ H O R₅ + R₆ = OCH₂CH₂O H H CF₃O H H 65140N C₆F₅ H O CH₃O CH₃O H H CF₃O H H 65 141N C₆F₅ H O R₅ + R₆ = H H CF₃OH H OCH₂CH₂CH₂O 65 142N C₆F₅ H O cyclo CH₃O H H CF₃O H H pentoxy 65 143NC₆F₅ H O H C₆H₅O H H CF₃O H H 65 144N C₆F₅ H O CH₃O CH₃O CH₃O H CF₃O H H65 145N C₆F₅ H O H CF₃O H H CF₃O H H 65 146N C₆F₅ H O H C₆H₅— H H CF₃O HH CH₂ 65 147N C₆F₅ H O C₆H₅O H H H R₁₀ = R₁₁ = OCH₂CH₂O H 65 148N C₆F₅ HO H CF₃O H H CF₃ H H 65 149N C₆F₅ H O C₆H₅O H H H CF₃ H H 65 150N C₆F₅ HO C₆H₅ H H H CF₃ H H 65 151N C₆F₅ H O H C₆H₅ H H CF₃ H H 65 152N C₆F₅ HO CN H H H CF₃ H H 65 153N C₆F₅ H O H OCF₃ H H CF₃ H H 65 154N C₆F₅ H OOCF₃ H H H H CF₃ H 65 155N C₆F₅ H O C₆H₅O H H H H CF₃ H 65 156N C₆F₅ H OC₆H₅ H H H H CF₃ H 65 157N C₆F₅ H O H C₆H₅ H H H CF₃ H 65 158N C₆F₅ H OCN H H H H CF₃ H 65 159N C₆F₅ H O OCF₃ H H H H CF₃ H 65 160N C₆F₅ H OCF₃ H H H H C₆H₅ H 65 161N C₆F₅ H O CF₃ H H H 3-CF₃—C₆H₅O H H 65 162NC₆F₅ H O CF₃ H H H C₆H₅O H H 65 163N C₆F₅ H O CF₃ H H H CF₃O H H 65 164NC₆F₅ H O H CF₃ H H H C₆H₅ H 65 165N C₆F₅ H O H CF₃ H H 3-CF₃—C₆H₅O H H65 166N C₆F₅ H O H CF₃ H H CF₃O H H 65 167N C₆F₅ H O H CF₃ H H C₆H₅O H H65 168N C₆F₅ H O CF₃ H CF₃ H CF₃O H H 65 169N C₆F₅ H O CF₃ H CF₃ H C₆H₅OH H 65 170N C₆F₅ H O CF₃O H H H CF₃ H CF₃ 65 171N C₆F₅ H O C₆H₅O H H HCF₃ H CF₃ 65 172N C₆F₅ H O H C₆H₅O H H C₆H₅O H H 65 173N C₆F₅ H O H CF₃OH H CF₃O H H 65 174N C₆F₅ H O H CF₃O H H H C₆H₅O H 65 175N C₆F₅ H OC₆H₅O H H H H C₆H₅O H 65 176N C₆F₅ H O H C₆H₅O H H H OCF₃ H 65 177N C₆F₅H O H C₆H₅O H H H C₆H₅O H 65 178N C₆F₅ H O C₆H₅O H H H H CN H 65 179NC₆F₅ H O C₆H₅O H H H CN H H 65 180N C₆F₅ H O C₆H₅O H H H NO₂ H H 65 181NC₆F₅ H O C₆H₅O H H H H NO₂ H 65 182N C₆F₅ H O C₆H₅O H H H H SO₂CH₃ H 65183N C₆F₅ H O C₆H₅O H H H H 2-NO₂-4- H Cl—C₆H₃O 65 184N C₆F₅ H O C₆H₅O HH H 4-Cl—C₆H₄O H H 65 185N C₆F₅ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H 65 186NC₆F₅ H O C₆H₅O H H H 3-CF₃—C₆H₃O H H 65 187N C₆F₅ H O C₆H₅O H H H3,5-Cl—C₆H₃O H H 65 188N C₆F₅ H O C₆H₅O H H H H CH₃O H 65 189N C₆F₅ H OC₆H₅O H H H H CO₂CH₃ H 65 190N C₆F₅ H O C₆H₅O H H H 3-CH₃O H H C₆H₅O 65191N C₆F₅ H O C₆H₅O H H H 4-CH₃O H H C₆H₅O 65 193N C₆F₅ H O C₆H₅O H H HCO₂CH₃ H H 65 194N C₆F₅ H O CN H H H OCF₃ H H 65 195N C₆F₅ H O NO₂ H H HOCF₃ H H 65 196N C₆F₅ H O H CN H H OCF₃ H H 65 197N C₆F₅ H O H NO₂ H HOCF₃ H H 65 198N C₆F₅ H O SO₂CH₃ H H H OCF₃ H H 65 199N C₆F₅ H O HSO₂CH₃ H H OCF₃ H H 65 200N C₆F₅ H O H 4-F—C₆H₅ H H OCF₃ H H SO₂ 65 201NC₆F₅ H O SO₂N H H H OCF₃ H H (CH₃)₂ 65 202N C₆F₅ H O H SO₂N H H OCF₃ H H(CH₃)₂ 65 203N C₆F₅ H O H CONH₂ H H OCF₃ H H 65 204N C₆F₅ H O H CONH— HH OCF₃ H H C₆H₅ 65 205N C₆F₅ H O H CO₂CH₃ H H OCF₃ H H 65 206N C₆F₅ H OH CO₂C₄H₉ H H OCF₃ H H 65 207N C₆F₅ H O H 4-Cl—C₆H₅ H H C₆H₅O H H 65208N C₆F₅ H O H 4-CF₃O— H H CF₃O H H C₆H₅ 65 209N C₆F₅ H O 4-F— H H HCF₃O H H C₆H₄O 65 210N C₆F₅ H O C₆F₅O H H H CF₃O H H 65 211N C₆F₅ H O H4-F—C₆H₅ H H CF₃O H H 65 212N C₆F₅ H O H 4-CN— H H CF₃O H H C₆H₅ 65 213NC₆F₅ H O H 4-C₆H₅— H H CF₃O H H C₆H₅ 65 214N C₆F₅ H O C₆H₅O H H CH₃ CF₃OH H 65 215N C₆F₅ H O C₆H₅O H H CH₃ NO₂ H H 65 216N C₆F₅ H O C₆H₅O H HCH₃ H CN H 65 217N C₆F₅ H O C₆H₅O H H 3-CF₃ CF₃ H H C₆H₅ 65 218N C₆F₅ HO C₆H₅O H H C₆H₅ H C₆H₅ H 65 219N C₆F₅ H O C₆H₅O H H C₆H₅ CF₃ H H 65220N C₆F₅ H O C₆H₅O H H CH₃ F H H 65 221N C₆F₅ H O C₆H₅O H H CF₃ H H H(CH₂)₃ 46 101N CF₃ R₂ + R₃ = O C₆H₅O H H H C₆H₅O H H (CH₂)₃ 46 102N CF₃R₂ + R₃ = O CF₃O H H H C₆H₅O H H (CH₂)₃ 46 103N CF₃ R₂ + R₃ = O C₆H₅ H HH C₆H₅O H H (CH₂)₃ 46 104N CF₃ R₂ + R₃ = O H C₆H₅ H H C₆H₅O H H (CH₂)₃46 105N CF₃ R₂ + R₃ = O C₆H₅O H H H 4-Cl—C₆H₄O H H (CH₂)₃ 46 106N CF₃R₂ + R₃ = O CF₃O H H H 4-Cl—C₆H₄O H H (CH₂)₃ 46  99N CF₃ R₂ + R₃ = OSO₂N H H H OCF₃ H H (CH₂)₃ (CH₃)₂ 46 100N CF₃ R₂ + R₃ = O SO₂CH₃ H H HOCF₃ H H (CH₂)₃ 46 101N CF₃ R₂ + R₃ = O C₆H₅O H H H C₆H₅O H H (CH₂)₃ 46102N CF₃ R₂ + R₃ = O CF₃O H H H C₆H₅O H H (CH₂)₃ 46 103N CF₃ R₂ + R₃ = OC₆H₅ H H H C₆H₅O H H (CH₂)₃ 46 104N CF₃ R₂ + R₃ = O H C₆H₅ H H C₆H₅O H H(CH₂)₃ 46 105N CF₃ R₂ + R₃ = O C₆H₅O H H H 4-Cl—C₆H₄O H H (CH₂)₃ 46 106NCF₃ R₂ + R₃ = O CF₃O H H H 4-Cl—C₆H₄O H H (CH₂)₃ 46 107N CF₃ R₂ + R₃ = OC₆H₅O H H H 3,4-Cl—C₆H₃O H H (CH₂)₃ 46 108N CF₃ R₂ + R₃ = O CF₃O H H H3,4-Cl—C₆H₃O H H (CH₂)₃ 46 109N CF₃ R₂ + R₃ = O CF₃O H H H 3,5-Cl—C₆H₃OH H (CH₂)₃ 46 110N CF₃ R₂ + R₃ = O CF₃O H H H 3-CH₃O— H H (CH₂)₃ C₆H₄O46 111N CF₃ R₂ + R₃ = O CF₃O H H H H 3-CH₃O— H (CH₂)₃ C₆H₄O 46 112N CF₃R₂ + R₃ = O CF₃O H H H 3-CF₃—C₆H₄O H H (CH₂)₃ 46 113N CF₃ R₂ + R₃ = OCF₃O H H H C₆H₅—CH₂O H H (CH₂)₃ 46 114N CF₃ R₂ + R₃ = O CF₃O H H HC₆H₅—CH₂O CH₃O H (CH₂)₃ 46 115N CF₃ R₂ + R₃ = O CF₃O H H H C₆H₅—CH₂OC₆H₅— H (CH₂)₃ CH₂O 46 116N CF₃ R₂ + R₃ = O CF₃O H H H ethoxy H H (CH₂)₃46 117N CF₃ R₂ + R₃ = O CF₃O H H H CH₃CO₂ H H (CH₂)₃ 46 118N CF₃ R₂ + R₃= O CF₃O H H H HOCH₂— H H (CH₂)₃ CH₂O 46 119N CF₃ R₂ + R₃ = (CH₂)₃ OCF₃O H H H

H H 46 120N CF₃ R₂ + R₃ = O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H (CH₂)₃ 46121N CF₃ R₂ + R₃ = O CF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H (CH₂)₃ 46 122NCF₃ R₂ + R₃ = O CF₃O H H H CH₃O CH₃O H (CH₂)₃ 46 123N CF₃ R₂ + R₃ = OCF₃O H H H ethoxy CH₃O H (CH₂)₃ 46 124N CF₃ R₂ + R₃ = O CF₃O H H Hethoxy ethoxy H (CH₂)₃ 46 125N CF₃ R₂ + R₃ = O CF₃O H H H CH₃CO₂ CH₃CO₂H (CH₂)₃ 46 126N CF₃ R₂ + R₃ = O CF₃O H H H CH₃O CH₃CO₂ H (CH₂)₃ 46 127NCF₃ R₂ + R₃ = O CF₃O H H H n-butoxy H H (CH₂)₃ 46 128N CF₃ R₂ + R₃ = OCF₃O H H H CH₃O H H (CH₂)₃ 46 129N CF₃ R₂ + R₃ = O CF₃O H H H H CH₃O H(CH₂)₃ 46 130N CF₃ R₂ + R₃ = O CH₃O H H H CH₃O H H (CH₂)₃ 46 131N CF₃R₂ + R₃ = O CH₃O H H H H CF₃O H (CH₂)₃ 46 132N CF₃ R₂ + R₃ = O CF₃O H HH H ethoxy H (CH₂)₃ 46 133N CF₃ R₂ + R₃ = O CF₃O H H H H n-propoxy H(CH₂)₃ 46 134N CF₃ R₂ + R₃ = O C₆H₅— H H H CF₃O H H (CH₂)₃ CH₂O 46 135NCF₃ R₂ + R₃ = O C₆H₅— H H H C₆H₅O H H (CH₂)₃ CH₂O 46 136N CF₃ R₂ + R₃ =O ethoxy H H H CF₃O H H (CH₂)₃ 46 137N CF₃ R₂ + R₃ = O R₅ + R₆ = OCH₂O HH CF₃O H H (CH₂)₃ 46 138N CF₃ R₂ + R₃ = O R₅ + R₆ = OCH₂O H H C₆H₅O H H(CH₂)₃ 46 139N CF₃ R₂ + R₃ = O R₅ + R₆ = OCH₂CH₂O H H CF₃O H H (CH₂)₃ 46140N CF₃ R₂ + R₃ = O CH₃O CH₃O H H CF₃O H H (CH₂)₃ 46 141N CF₃ R₂ + R₃ =O R₅ + R₆ = H H CF₃O H H (CH₂)₃ OCH₂CH₂CH₂O 46 142N CF₃ R₂ + R₃ = Ocyclo CH₃O H H CF₃O H H (CH₂)₃ pentoxy 46 143N CF₃ R₂ + R₃ = O H C₆H₅O HH CF₃O H H (CH₂)₃ 46 144N CF₃ R₂ + R₃ = O CH₃O CH₃O CH₃O H CF₃O H H(CH₂)₃ 46 145N CF₃ R₂ + R₃ = O H CF₃O H H CF₃O H H (CH₂)₃ 46 146N CF₃R₂ + R₃ = O H C₆H₅— H H CF₃O H H (CH₂)₃ CH₂ 46 147N CF₃ R₂ + R₃ = OC₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O H (CH₂)₃ 46 148N CF₃ R₂ + R₃ = O H CF₃OH H CF₃ H H (CH₂)₃ 46 149N CF₃ R₂ + R₃ = O C₆H₅O H H H CF₃ H H (CH₂)₃ 46150N CF₃ R₂ + R₃ = O C₆H₅ H H H CF₃ H H (CH₂)₃ 46 151N CF₃ R₂ + R₃ = O HC₆H₅ H H CF₃ H H (CH₂)₃ 46 152N CF₃ R₂ + R₃ = O CN H H H CF₃ H H (CH₂)₃46 153N CF₃ R₂ + R₃ = O H OCF₃ H H CF₃ H H (CH₂)₃ 46 154N CF₃ R₂ + R₃ =O OCF₃ H H H H CF₃ H (CH₂)₃ 46 155N CF₃ R₂ + R₃ = O C₆H₅O H H H H CF₃ H(CH₂)₃ 46 156N CF₃ R₂ + R₃ = O C₆H₅ H H H H CF₃ H (CH₂)₃ 46 157N CF₃R₂ + R₃ = O H C₆H₅ H H H CF₃ H (CH₂)₃ 46 158N CF₃ R₂ + R₃ = O CN H H H HCF₃ H (CH₂)₃ 46 159N CF₃ R₂ + R₃ = O OCF₃ H H H H CF₃ H (CH₂)₃ 46 160NCF₃ R₂ + R₃ = O CF₃ H H H H C₆H₅ H (CH₂)₃ 46 161N CF₃ R₂ + R₃ = O CF₃ HH H 3-CF₃—C₆H₅O H H (CH₂)₃ 46 162N CF₃ R₂ + R₃ = O CF₃ H H H C₆H₅O H H(CH₂)₃ 46 163N CF₃ R₂ + R₃ = O CF₃ H H H CF₃O H H (CH₂)₃ 46 164N CF₃R₂ + R₃ = O H CF₃ H H H C₆H₅ H (CH₂)₃ 46 165N CF₃ R₂ + R₃ = O H CF₃ H H3-CF₃—C₆H₅O H H (CH₂)₃ 46 166N CF₃ R₂ + R₃ = O H CF₃ H H CF₃O H H (CH₂)₃46 167N CF₃ R₂ + R₃ = O H CF₃ H H C₆H₅O H H (CH₂)₃ 46 168N CF₃ R₂ + R₃ =O CF₃ H CF₃ H CF₃O H H (CH₂)₃ 46 169N CF₃ R₂ + R₃ = O CF₃ H CF₃ H C₆H₅OH H (CH₂)₃ 46 170N CF₃ R₂ + R₃ = O CF₃O H H H CF₃ H CF₃ (CH₂)₃ 46 171NCF₃ R₂ + R₃ = O C₆H₅O H H H CF₃ H CF₃ (CH₂)₃ 46 172N CF₃ R₂ + R₃ = O HC₆H₅O H H C₆H₅O H H (CH₂)₃ 46 173N CF₃ R₂ + R₃ = O H CF₃O H H CF₃O H H(CH₂)₃ 46 174N CF₃ R₂ + R₃ = O H CF₃O H H H C₆H₅O H (CH₂)₃ 46 175N CF₃R₂ + R₃ = O C₆H₅O H H H H C₆H₅O H (CH₂)₃ 46 176N CF₃ R₂ + R₃ = O H C₆H₅OH H H OCF₃ H (CH₂)₃ 46 177N CF₃ R₂ + R₃ = O H C₆H₅O H H H C₆H₅O H (CH₂)₃46 178N CF₃ R₂ + R₃ = O C₆H₅O H H H H CN H (CH₂)₃ 46 179N CF₃ R₂ + R₃ =O C₆H₅O H H H CN H H (CH₂)₃ 46 180N CF₃ R₂ + R₃ = O C₆H₅O H H H NO₂ H H(CH₂)₃ 46 181N CF₃ R₂ + R₃ = O C₆H₅O H H H H NO₂ H (CH₂)₃ 46 182N CF₃R₂ + R₃ = O C₆H₅O H H H H SO₂CH₃ H (CH₂)₃ 46 183N CF₃ R₂ + R₃ = O C₆H₅OH H H H 2-NO₂-4- H (CH₂)₃ Cl—C₆H₃O 46 184N CF₃ R₂ + R₃ = O C₆H₅O H H H4-Cl—C₆H₄O H H (CH₂)₃ 46 185N CF₃ R₂ + R₃ = O C₆H₅O H H H 3,4-Cl—C₆H₃O HH (CH₂)₃ 46 186N CF₃ R₂ + R₃ = O C₆H₅O H H H 3-CF₃—C₆H₃O H H (CH₂)₃ 46187N CF₃ R₂ + R₃ = O C₆H₅O H H H 3,5-Cl—C₆H₃O H H (CH₂)₃ 46 188N CF₃R₂ + R₃ = O C₆H₅O H H H H CH₃O H (CH₂)₃ 46 189N CF₃ R₂ + R₃ = O C₆H₅O HH H H CO₂CH₃ H (CH₂)₃ 46 190N CF₃ R₂ + R₃ = O C₆H₅O H H H 3-CH₃O H H(CH₂)₃ C₆H₅O 46 191N CF₃ R₂ + R₃ = O C₆H₅O H H H 4-CH₃O H H (CH₂)₃ C₆H₅O46 193N CF₃ R₂ + R₃ = O C₆H₅O H H H CO₂CH₃ H H (CH₂)₃ 46 194N CF₃ R₂ +R₃ = O CN H H H OCF₃ H H (CH₂)₃ 46 195N CF₃ R₂ + R₃ = O NO₂ H H H OCF₃ HH (CH₂)₃ 46 196N CF₃ R₂ + R₃ = O H CN H H OCF₃ H H (CH₂)₃ 46 197N CF₃R₂ + R₃ = O H NO₂ H H OCF₃ H H (CH₂)₃ 46 198N CF₃ R₂ + R₃ = O SO₂CH₃ H HH OCF₃ H H (CH₂)₃ 46 199N CF₃ R₂ + R₃ = O H SO₂CH₃ H H OCF₃ H H (CH₂)₃46 200N CF₃ R₂ + R₃ = O H 4-F—C₆H₅ H H OCF₃ H H (CH₂)₃ SO₂ 46 201N CF₃R₂ + R₃ = O SO₂N H H H OCF₃ H H (CH₂)₃ (CH₃)₂ 46 202N CF₃ R₂ + R₃ = O HSO₂N H H OCF₃ H H (CH₂)₃ (CH₃)₂ 46 203N CF₃ R₂ + R₃ = O H CONH₂ H H OCF₃H H (CH₂)₃ 46 204N CF₃ R₂ + R₃ = O H CONH— H H OCF₃ H H (CH₂)₃ C₆H₅ 46205N CF₃ R₂ + R₃ = O H CO₂CH₃ H H OCF₃ H H (CH₂)₃ 46 206N CF₃ R₂ + R₃ =O H CO₂C₄H₉ H H OCF₃ H H (CH₂)₃ 46 207N CF₃ R₂ + R₃ = O H 4-Cl—C₆H₅ H HC₆H₅O H H (CH₂)₃ 46 208N CF₃ R₂ + R₃ = O H 4-CF₃O— H H CF₃O H H (CH₂)₃C₆H₅ 46 209N CF₃ R₂ + R₃ = O 4-F— H H H CF₃O H H (CH₂)₃ C₆H₄O 46 210NCF₃ R₂ + R₃ = O C₆H₅O H H H CF₃O H H (CH₂)₃ 46 211N CF₃ R₂ + R₃ = O H4-F—C₆H₅ H H CF₃O H H (CH₂)₃ 46 212N CF₃ R₂ + R₃ = O H 4-CN— H H CF₃O HH (CH₂)₃ C₆H₅ 46 213N CF₃ R₂ + R₃ = O H 4-C₆H₅— H H CF₃O H H (CH₂)₃ 46214N CF₃ R₂ + R₃ = O C₆H₅O H H CH₃ CF₃O H H (CH₂)₃ 46 215N CF₃ R₂ + R₃ =O C₆H₅O H H CH₃ NO₂ H H (CH₂)₃ 46 216N CF₃ R₂ + R₃ = O C₆H₅O H H CH₃ HCN H (CH₂)₃ 46 217N CF₃ R₂ + R₃ = O C₆H₅O H H 3-CF₃ CF₃ H H (CH₂)₃ C₆H₅46 218N CF₃ R₂ + R₃ = O C₆H₅O H H C₆H₅ H C₆H₅ H (CH₂)₃ 46 219N CF₃ R₂ +R₃ = O C₆H₅O H H C₆H₅ CF₃ H H (CH₂)₃ 46 220N CF₃ R₂ + R₃ = O C₆H₅O H HCH₃ F H H (CH₂)₃ 46 221N CF₃ R₂ + R₃ = O C₆H₅O H H CF₃ H H H (CH₂)₃ 46222N CF₃ R₂ + R₃ = (CH₂)₃ O bond to —O— of R₆ aryl group

H H CF₃O H H 46 223N CF₃ R₂ + R₃ = (CH₂)₃ O to CH₂ of R₆ aryl group

H H CF₃O H H 57  96N HCF₂CF₂ H O OH OH H H C₆H₅O H H OCH₂ 57  97NHCF₂CF₂ H O C₆H₅O H H H OH OH H OCH₂ 57  98N HCF₂CF₂ H O 3-pyridyl H H HCF₃ H H OCH₂ 57  99N HCF₂CF₂ H O SO₂N H H H OCF₃ H H OCH₂ (CH₃)₂ 57 100NHCF₂CF₂ H O SO₂CH₃ H H H OCF₃ H H OCH₂ 57 101N HCF₂CF₂ H O C₆H₅O H H HC₆H₅O H H OCH₂ 57 102N HCF₂CF₂ H O CF₃O H H H C₆H₅O H H OCH₂ 57 103NHCF₂CF₂ H O C₆H₅ H H H C₆H₅O H H OCH₂ 57 104N HCF₂CF₂ H O H C₆H₅ H HC₆H₅O H H OCH₂ 57 105N HCF₂CF₂ H O C₆H₅O H H H 4-Cl—C₆H₄O H H OCH₂ 57106N HCF₂CF₂ H O CF₃O H H H 4-Cl—C₆H₄O H H OCH₂ 57 107N HCF₂CF₂ H OC₆H₅O H H H 3,4-Cl—C₆H₃O H H OCH₂ 57 108N HCF₂CF₂ H O CF₃O H H H3,4-Cl—C₆H₃O H H OCH₂ 57 109N HCF₂CF₂ H O CF₃O H H H 3,5-Cl—C₆H₃O H HOCH₂ 57 110N HCF₂CF₂ H O CF₃O H H H 3-CH₃O— H H OCH₂ C₆H₄O 57 111NHCF₂CF₂ H O CF₃O H H H H 3-CH₃O— H OCH₂ C₆H₄O 57 112N HCF₂CF₂ H O CF₃O HH H 3-CF₃—C₆H₄O H H OCH₂ 57 113N HCF₂CF₂ H O CF₃O H H H C₆H₅—CH₂O H HOCH₂ 57 114N HCF₂CF₂ H O CF₃O H H H C₆H₅—CH₂O CH₃O H OCH₂ 57 115NHCF₂CF₂ H O CF₃O H H H C₆H₅—CH₂O C₆H₅— H OCH₂ CH₂O 57 116N HCF₂CF₂ H OCF₃O H H H ethoxy H H OCH₂ 57 117N HCF₂CF₂ H O CF₃O H H H CH₃CO₂ H HOCH₂ 57 118N HCF₂CF₂ H O CF₃O H H H HOCH₂— H H OCH₂ CH₂O 57 119N HCF₂CF₂OCH₂ H O CF₃O H H H

H H 57 120N HCF₂CF₂ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂O H OCH₂ 57 121NHCF₂CF₂ H O CF₃O H H H R₁₀ + R₁₁ = OCH₂CH₂O H OCH₂ 57 122N HCF₂CF₂ H OCF₃O H H H CH₃O CH₃O H OCH₂ 57 123N HCF₂CF₂ H O CF₃O H H H ethoxy CH₃O HOCH₂ 57 124N HCF₂CF₂ H O CF₃O H H H ethoxy ethoxy H OCH₂ 57 125N HCF₂CF₂H O CF₃O H H H CH₃CO₂ CH₃CO₂ H OCH₂ 57 126N HCF₂CF₂ H O CF₃O H H H CH₃OCH₃CO₂ H OCH₂ 57 127N HCF₂CF₂ H O CF₃O H H H n-butoxy H H OCH₂ 57 128NHCF₂CF₂ H O CF₃O H H H CH₃O H H OCH₂ 57 129N HCF₂CF₂ H O CF₃O H H H HCH₃O H OCH₂ 57 130N HCF₂CF₂ H O CF₃O H H H CH₃O H H OCH₂ 57 131N HCF₂CF₂H O CF₃O H H H H CF₃O H OCH₂ 57 132N HCF₂CF₂ H O CF₃O H H H H ethoxy HOCH₂ 57 133N HCF₂CF₂ H O CF₃O H H H H n-propoxy H OCH₂ 57 134N HCF₂CF₂ HO C₆H₅— H H H CF₃O H H OCH₂ CH₂O 57 135N HCF₂CF₂ H O C₆H₅— H H H C₆H₅O HH OCH₂ CH₂O 57 136N HCF₂CF₂ H O ethoxy H H H CF₃O H H OCH₂ 57 137NHCF₂CF₂ H O R₅ + R₆ = OCH₂O H H CF₃O H H OCH₂ 57 138N HCF₂CF₂ H O R₅ +R₆ = OCH₂O H H C₆H₅O H H OCH₂ 57 139N HCF₂CF₂ H O R₅ + R₆ = OCH₂CH₂O H HCF₃O H H OCH₂ 57 140N HCF₂CF₂ H O CH₃O CH₃O H H CF₃O H H OCH₂ 57 141NHCF₂CF₂ H O R₅ + R₆ = H H CF₃O H H OCH₂ OCH₂CH₂CH₂O 57 142N HCF₂CF₂ H Ocyclo CH₃O H H CF₃O H H OCH₂ pentoxy 57 143N HCF₂CF₂ H O H C₆H₅O H HCF₃O H H OCH₂ 57 144N HCF₂CF₂ H O CH₃O CH₃O CH₃O H CF₃O H H OCH₂ 57 145NHCF₂CF₂ H O H CF₃O H H CF₃O H H OCH₂ 57 146N HCF₂CF₂ H O H C₆H₅— H HCF₃O H H OCH₂ CH₂ 57 147N HCF₂CF₂ H O C₆H₅O H H H R₁₀ + R₁₁ = OCH₂CH₂O HOCH₂ 57 148N HCF₂CF₂ H O H CF₃O H H CF₃ H H OCH₂ 57 149N HCF₂CF₂ H OC₆H₅O H H H CF₃ H H OCH₂ 57 150N HCF₂CF₂ H O C₆H₅ H H H CF₃ H H OCH₂ 57151N HCF₂CF₂ H O H C₆H₅ H H CF₃ H H OCH₂ 57 152N HCF₂CF₂ H O CN H H HCF₃ H H OCH₂ 57 153N HCF₂CF₂ H O H OCF₃ H H CF₃ H H OCH₂ 57 154N HCF₂CF₂H O OCF₃ H H H H CF₃ H OCH₂ 57 155N HCF₂CF₂ H O C₆H₅O H H H H CF₃ H OCH₂57 156N HCF₂CF₂ H O C₆H₅ H H H H CF₃ H OCH₂ 57 157N HCF₂CF₂ H O H C₆H₅ HH H CF₃ H OCH₂ 57 158N HCF₂CF₂ H O CN H H H H CF₃ H OCH₂ 57 159N HCF₂CF₂H O OCF₃ H H H H CF₃ H OCH₂ 57 160N HCF₂CF₂ H O CF₃ H H H H C₆H₅ H OCH₂57 161N HCF₂CF₂ H O CF₃ H H H 3-CF₃—C₆H₅O H H OCH₂ 57 162N HCF₂CF₂ H OCF₃ H H H C₆H₅O H H OCH₂ 57 163N HCF₂CF₂ H O CF₃ H H H CF₃O H H OCH₂ 57164N HCF₂CF₂ H O H CF₃ H H H C₆H₅ H OCH₂ 57 165N HCF₂CF₂ H O H CF₃ H H3-CF₃—C₆H₅O H H OCH₂ 57 166N HCF₂CF₂ H O H CF₃ H H CF₃O H H OCH₂ 57 167NHCF₂CF₂ H O H CF₃ H H C₆H₅O H H OCH₂ 57 168N HCF₂CF₂ H O CF₃ H CF₃ HCF₃O H H OCH₂ 57 169N HCF₂CF₂ H O CF₃ H CF₃ H C₆H₅O H H OCH₂ 57 170NHCF₂CF₂ H O CF₃O H H H CF₃ H CF₃ OCH₂ 57 171N HCF₂CF₂ H O C₆H₅O H H HCF₃ H CF₃ OCH₂ 57 172N HCF₂CF₂ H O H C₆H₅O H H C₆H₅O H H OCH₂ 57 173NHCF₂CF₂ H O H CF₃O H H CF₃O H H OCH₂ 57 174N HCF₂CF₂ H O H CF₃O H H HC₆H₅O H OCH₂ 57 175N HCF₂CF₂ H O C₆H₅O H H H H C₆H₅O H OCH₂ 57 176NHCF₂CF₂ H O H C₆H₅O H H H OCF₃ H OCH₂ 57 177N HCF₂CF₂ H O H C₆H₅O H H HC₆H₅O H OCH₂ 57 178N HCF₂CF₂ H O C₆H₅O H H H H CN H OCH₂ 57 179N HCF₂CF₂H O C₆H₅O H H H CN H H OCH₂ 57 180N HCF₂CF₂ H O C₆H₅O H H H NO₂ H H OCH₂57 181N HCF₂CF₂ H O C₆H₅O H H H H NO₂ H OCH₂ 57 182N HCF₂CF₂ H O C₆H₅O HH H H SO₂CH₃ H OCH₂ 57 183N HCF₂CF₂ H O C₆H₅O H H H H 2-NO₂-4- H OCH₂Cl—C₆H₃O 57 184N HCF₂CF₂ H O C₆H₅O H H H 4-Cl—C₆H₄O H H OCH₂ 57 185NHCF₂CF₂ H O C₆H₅O H H H 3,4-Cl—C₆H₃O H H OCH₂ 57 186N HCF₂CF₂ H O C₆H₅OH H H 3-CF₃—C₆H₃O H H OCH₂ 57 187N HCF₂CF₂ H O C₆H₅O H H H 3,5-Cl—C₆H₃OH H OCH₂ 57 188N HCF₂CF₂ H O C₆H₅O H H H H CH₃O H OCH₂ 57 189N HCF₂CF₂ HO C₆H₅O H H H H CO₂CH₃ H OCH₂ 57 190N HCF₂CF₂ H O C₆H₅O H H H 3-CH₃O H HOCH₂ C₆H₅O 57 191N HCF₂CF₂ H O C₆H₅O H H H 4-CH₃O H H OCH₂ C₆H₅O 57 193NHCF₂CF₂ H O C₆H₅O H H H CO₂CH₃ H H OCH₂ 57 194N HCF₂CF₂ H O CN H H HOCF₃ H H OCH₂ 57 195N HCF₂CF₂ H O NO₂ H H H OCF₃ H H OCH₂ 57 196NHCF₂CF₂ H O H CN H H OCF₃ H H OCH₂ 57 197N HCF₂CF₂ H O H NO₂ H H OCF₃ HH OCH₂ 57 198N HCF₂CF₂ H O SO₂CH₃ H H H OCF₃ H H OCH₂ 57 199N HCF₂CF₂ HO H SO₂CH₃ H H OCF₃ H H OCH₂ 57 200N HCF₂CF₂ H O H 4-F—C₆H₅ H H OCF₃ H HOCH₂ SO₂ 57 201N HCF₂CF₂ H O SO₂N H H H OCF₃ H H OCH₂ (CH₃)₂ 57 202NHCF₂CF₂ H O H SO₂N H H OCF₃ H H OCH₂ (CH₃)₂ 57 203N HCF₂CF₂ H O H CONH₂H H OCF₃ H H OCH₂ 57 204N HCF₂CF₂ H O H CONH— H H OCF₃ H H OCH₂ C₆H₅ 57205N HCF₂CF₂ H O H CO₂CH₃ H H OCF₃ H H OCH₂ 57 206N HCF₂CF₂ H O HCO₂C₄H₉ H H OCF₃ H H OCH₂ 57 207N HCF₂CF₂ H O H 4-Cl—C₆H₅ H H C₆H₅O H HOCH₂ 57 208N HCF₂CF₂ H O H 4-CF₃O— H H CF₃O H H OCH₂ C₆H₅ 57 209NHCF₂CF₂ H O 4-F— H H H CF₃O H H OCH₂ C₆H₄O 57 210N HCF₂CF₂ H O C₆F₅O H HH CF₃O H H OCH₂ 57 211N HCF₂CF₂ H O H 4-F—C₆H₅ H H CF₃O H H OCH₂ 57 212NHCF₂CF₂ H O H 4-CN— H H CF₃O H H OCH₂ C₆H₅ 57 213N HCF₂CF₂ H O H 4-C₆H₅—H H CF₃O H H OCH₂ C₆H₅ 57 214N HCF₂CF₂ H O C₆H₅O H H CH₃ CF₃O H H OCH₂57 215N HCF₂CF₂ H O C₆H₅O H H CH₃ NO₂ H H OCH₂ 57 216N HCF₂CF₂ H O C₆H₅OH H CH₃ H CN H OCH₂ 57 217N HCF₂CF₂ H O C₆H₅O H H 3-CF₃ CF₃ H H OCH₂C₆H₅ 57 218N HCF₂CF₂ H O C₆H₅O H H C₆H₅ H C₆H₅ H OCH₂ 57 219N HCF₂CF₂ HO C₆H₅O H H C₆H₅ CF₃ H H OCH₂ 57 220N HCF₂CF₂ H O C₆H₅O H H CH₃ F H HOCH₂ 57 221N HCF₂CF₂ H O C₆H₅O H H CF₃ H H H OCH₂ 57 222N HCF₂CF₂ OCH₂ HO bond to —O— of R₆ aryl group

H H CF₃O H H 57 223N HCF₂CF₂ OCH₂ H O to CH₂ of R₆ aryl group

H H CF₃O H H

TABLE 9 Structure of Substituted Polycyclictertiary-2-Heteroalkylamines(Substituents are as defined below and for Reagents 93N, 94N, and 95N).

Inhibitor Number Column 1 and Column 2 Reagent Reagent R₁ R₂ R₃ R₁₆ X93N 1 CF₃ H H nothing O 93N 2 CCl₃ H H nothing O 93N 3 CF₃ CH₃ H nothingO 93N 4 CF₃CF₂ H H nothing O 93N 5 CF₃CF₂CF₂ H H nothing O 93N 6CF₃OCF₂CF₂ H H nothing O 93N 7 CF₃CH₂ H H nothing O 93N 8 CF₃ CHF₂ Hnothing O 93N 9 CF₃ H CF₃ nothing O 93N 10 CF₃ CF₃ H nothing O 93N 11CF₃ C₆H₅ H nothing O 93N 12 CCl₃ C₆H₅ H nothing O 93N 13 CCl₃Cyclopropyl H nothing O 93N 14 CCl₃ CH₃ H nothing O 93N 15 CCl₃ (CH₃)₂CHH nothing O 93N 16 CHCl₂ H H nothing O 93N 17 CHCl₂ Cl H nothing O 93N18 CF₃ H CH₃ nothing O 93N 19 CF₃ CF₃ H H N 93N 20 CF₃ H H H N 93N 21CF₃ H H Benzyl N 93N 22 CF₃ H H CH₃O N 93N 23 CF₃ H H CH₃ N 93N 24 CF₃ HH Benzyloxy N 93N 25 CF₃ H H nothing S 93N 26 CF₃CF₂ H H nothing S 93N27 CCl₃CH₂ H H nothing O 93N 28 CBr₃CH₂ H H nothing O 93N 29 CHBr₂CH₂ HH nothing O 93N 30 CBrCl₂ H H nothing O 93N 31 CClF₂ H H nothing O 93N32 CCl₂F H H nothing O 93N 33 CCl₃CCl₂ H H nothing O 93N 34 CH₃ H Hnothing O 93N 35 CH₃ CH₃ H nothing O 93N 36 CH₃CH₂ H H nothing O 93N 37CH₃═CH H H nothing O 93N 38 CH₃CH₂CH₂ H H nothing O 93N 39 CH₂═CHCH₂CH₂H H nothing O 93N 40 CH₃(CH₂)₄CH₂ H H nothing O 93N 41 CH₂═CH(CH₂)₃CH₂ HH nothing O 93N 42 HOCH₂ H H nothing O 93N 43 FCH₂ H H nothing O 93N 44(CH₃)₃COCH₂ H H nothing O 93N 45 R₁ + R₂ = (CH₂)₅ H nothing O 93N 46 CF₃R₂ + R₃ = (CH₂)₃ nothing O 93N 47 CF₃ R₂ + R₃ = (CH₂)₄ nothing O 93N 48CHF₂ R₂ + R₃ = (CH₂)₄ nothing O 93N 49 H R₂ + R₃ = (CF₃)CH(CH₂)₃ nothingO 93N 50 H R₂ + R₃ = (CF₃)CH(CH₂)₂ nothing O 93N 51 H R₂ + R₃ =CH₂(CF₃)CHCH₂ nothing O 93N 52 R₁ + R₂ = (CH₂)₆ H nothing O 93N 53CH₃CH₂O₂C H H nothing O 93N 54 CH₃CH₂CH₂ H H nothing O 93N 55 CH₃OCH₂ HH nothing O 93N 56 CBrF₂CClFCH₂ H H nothing O 93N 57 HCF₂CF₂OCH₂ H Hnothing O 93N 58 [(CH₃CH₂O)]₂POCH₂ H H nothing O 93N 59 H R₂ + R₃ =(CH₂)₂SO₂ nothing O 93N 60 Cl^(—)(CH₃)₃N^(⊕)CH₂ H H nothing O 93N 61N-piperidinyl-CH₂ H H nothing O 93N 62 N-phthalimido-CH₂ H H nothing O93N 63 C₆H₅ H H nothing O 93N 64 C₆H₅ H CH₃ nothing O 93N 65 C₆F₅ H Hnothing O 93N 66 C₆F₅ CH₃ H nothing O 93N 67 C₆F₅ CClH₂ H nothing O 93N68 2-CH₃C₆H₄ H H nothing O 93N 69 3-CH₃C₆H₄ H H nothing O 93N 704-CH₃C₆H₄ H H nothing O 93N 71 2-BrC₆H₄ H H nothing O 93N 72 4-BrC₆H₄ HH nothing O 93N 73 2-ClC₆H₄ H H nothing O 93N 74 3-ClC₆H₄ H H nothing O93N 75 4-ClC₆H₄ H H nothing O 93N 76 2-CH₃OC₆H₄ H H nothing O 93N 773-CH₃OC₆H₄ H H nothing O 93N 78 4-CH₃OC₆H₄ H H nothing O 93N 793-CF₃C₆H₄ H H nothing O 93N 80 C₆H₅CH₂ H H nothing O 93N 81 4F-C₆H₄ H Hnothing O 93N 82 4F-C₆H₄ H 4F-C₆H₄ nothing O 93N 83 2-CH₃O-4-CH₃OC₆H₃ HH nothing O 93N 84 3,4-OCH₂O—C₆H₃ H H nothing O 93N 85 3-Cl-4-Cl—C₆H₃ HH nothing O 93N 86 3-Cl-5-Cl—C₆H₃ H H nothing O 93N 87 C₆H₅OCH₂ H Hnothing O 93N 88 4Cl—C₆H₄OCH₂ H H nothing O 93N 89 CH₃OC₆H₄OCH₂ H Hnothing O 93N 90 C₆H₅ H CO₂C₂H₅ nothing O 93N 91 2-Pyridyl H H nothing O94N 1 CF₃ H H nothing O 94N 2 CCl₃ H H nothing O 94N 3 CF₃ CH₃ H nothingO 94N 4 CF₃CF₂ H H nothing O 94N 5 CF₃CF₂CF₂ H H nothing O 94N 6CF₃OCF₂CF₂ H H nothing O 94N 7 CF₃CH₂ H H nothing O 94N 8 CF₃ CHF₂ Hnothing O 94N 9 CF₃ H CF₃ nothing O 94N 10 CF₃ CF₃ H nothing O 94N 11CF₃ C₆H₅ H nothing O 94N 12 CCl₃ C₆H₅ H nothing O 94N 13 CCl₃Cyclopropyl H nothing O 94N 14 CCl₃ CH₃ H nothing O 94N 15 CCl₃ (CH₃)₂CHH nothing O 94N 16 CHCl₂ H H nothing O 94N 17 CHCl₂ Cl H nothing O 94N18 CF₃ H CH₃ nothing O 94N 19 CF₃ CF₃ H H N 94N 20 CF₃ H H H N 94N 21CF₃ H H Benzyl N 94N 22 CF₃ H H CH₃O N 94N 23 CF₃ H H CH₃ N 94N 24 CF₃ HH Benzyloxy N 94N 25 CF₃ H H nothing S 94N 26 CF₃CF₂ H H nothing S 94N27 CCl₃CH₂ H H nothing O 94N 28 CBr₃CH₂ H H nothing O 94N 29 CHBr₂CH₂ HH nothing O 94N 30 CBrCl₂ H H nothing O 94N 31 CClF₂ H H nothing O 94N32 CCl₂F H H nothing O 94N 33 CCl₃CCl₂ H H nothing O 94N 34 CH₃ H Hnothing O 94N 35 CH₃ CH₃ H nothing O 94N 36 CH₃CH₂ H H nothing O 94N 37CH₂═CH H H nothing O 94N 38 CH₃CH₂CH₂ H H nothing O 94N 39 CH₂═CHCH₂CH₂H H nothing O 94N 40 CH₃(CH₂)₄CH₂ H H nothing O 94N 41 CH₂ ═CH(CH₂)₃CH₂H H nothing O 94N 42 HOCH₂ H H nothing O 94N 43 FCH₂ H H nothing O 94N44 (CH₃)₃COCH₂ H H nothing O 94N 45 R₁ + R₂ = (CH₂)₅ H nothing O 94N 46CF₃ R₂ + R₃ = (CH₂)₃ nothing O 94N 47 CF₃ R₂ + R₃ = (CH₂)₄ nothing O 94N48 CHF₂ R₂ + R₃ = (CH₂)₄ nothing O 94N 49 H R₂ + R₃ = (CF₃)CH(CH₂)₃nothing O 94N 50 H R₂ + R₃ = (CF₃)CH(CH₂)₂ nothing O 94N 51 H R₂ + R₃ =CH₂(CF₃)CHCH₂ nothing O 94N 52 R₁ + R₂ = (CH₂)₆ H nothing O 94N 53CH₃CH₂O₂C H H nothing O 94N 54 CH₃CH₂CH₂ H H nothing O 94N 55 CH₃OCH₂ HH nothing O 94N 56 CBrF₂CClFCH₂ H H nothing O 94N 57 HCF₂CF₂OCH₂ H Hnothing O 94N 58 [(CH₃CH₂O)]₂POCH₂ H H nothing O 94N 59 H R₂ + R₃ =(CH₂)₂SO₂ O 94N 60 Cl^(—)(CH₃)₃N^(⊕)CH₂ H H nothing O 94N 61N-piperidinyl-CH₂ H H nothing O 94N 62 N-phthalimido-CH₂ H H nothing O94N 63 C₆H₅ H H nothing O 94N 64 C₆H₅ H CH₃ nothing O 94N 65 C₆F₅ H Hnothing O 94N 66 C₆F₅ CH₃ H nothing O 94N 67 C₆F₅ CClH₂ H nothing O 94N68 2-CH₃C₆H₄ H H nothing O 94N 69 3-CH₃C₆H₄ H H nothing O 94N 704-CH₃C₆H₄ H H nothing O 94N 71 2-BrC₆H₄ H H nothing O 94N 72 4-BrC₆H₄ HH nothing O 94N 73 2-ClC₆H₄ H H nothing O 94N 74 3-ClC₆H₄ H H nothing O94N 75 4-ClC₆H₄ H H nothing O 94N 76 2-CH₃OC₆H₄ H H nothing O 94N 773-CH₃OC₆H₄ H H nothing O 94N 78 4-CH₃OC₆H₄ H H nothing O 94N 793-CF₃C₆H₄ H H nothing O 94N 80 C₆H₅CH₂ H H nothing O 94N 81 4F—C₆H₄ H Hnothing O 94N 82 4F—C₆H₄ H 4F—C₆H₄ nothing O 94N 83 2-CH₃O-4-CH₃OC₆H₃ HH nothing O 94N 84 3,4-OCH₂O-C₆H₃ H H nothing O 94N 85 3-Cl-4-Cl—C₆H₃ HH nothing O 94N 86 3-Cl-5-Cl-C₆H₃ H H nothing O 94N 87 C₆H₅OCH₂ H Hnothing O 94N 88 4Cl—C₆H₄OCH₂ H H nothing O 94N 89 CH₃OC₆H₄OCH₂ H Hnothing O 94N 90 C₆H₅ H CO₂C₂H₅ nothing O 94N 91 2-Pyridyl H H nothing O95N 1 CF₃ H H nothing O 95N 2 CCl₃ H H nothing O 95N 3 CF₃ CH₃ H nothingO 95N 4 CF₃CF₂ H H nothing O 95N 5 CF₃CF₂CF₂ H H nothing O 95N 6CF₃OCF₂CF₂ H H nothing O 95N 7 CF₃CH₂ H H nothing O 95N 8 CF₃ CHF₂ Hnothing O 95N 9 CF₃ H CF₃ nothing O 95N 10 CF₃ CF₃ H nothing O 95N 11CF₃ C₆H₅ H nothing O 95N 12 CCl₃ C₆H₅ H nothing O 95N 13 CCl₃Cyclopropyl H nothing O 95N 14 CCl₃ CH₃ H nothing O 95N 15 CCl₃ (CH₃)₂CHH nothing O 95N 16 CHCl₂ H H nothing O 95N 17 CHCl₂ Cl H nothing O 95N18 CF₃ H CH₃ nothing O 95N 19 CF₃ CF₃ H H N 95N 20 CF₃ H H H N 95N 21CF₃ H H Benzyl N 95N 22 CF₃ H H CH₃O N 95N 23 CF₃ H H CH₃ N 95N 24 CF₃ HH Benzyloxy N 95N 25 CF₃ H H nothing S 95N 26 CF₃CF₂ H H nothing S 95N27 CCl₃CH₂ H H nothing O 95N 28 CBr₃CH₂ H H nothing O 95N 29 CHBr₂CH₂ HH nothing O 95N 30 CBrCl₂ H H nothing O 95N 31 CClF₂ H H nothing O 95N32 CCl₂F H H nothing O 95N 33 CCl₃CCl₂ H H nothing O 95N 34 CH₃ H Hnothing O 95N 35 CH₃ CH₃ H nothing O 95N 36 CH₃CH₂ H H nothing O 95N 37CH₂═CH H H nothing O 95N 38 CH₃CH₂CH₂ H H nothing O 95N 39 CH₂═CHCH₂CH₂H H nothing O 95N 40 CH₃(CH₂)₄CH₂ H H nothing O 95N 41 CH₂═CH(CH₂)₃CH₂ HH nothing O 95N 42 HOCH₂ H H nothing O 95N 43 FCH₂ H H nothing O 95N 44(CH₃)₃COCH₂ H H nothing O 95N 45 R₁ + R₂ = (CH₂)₅ H nothing O 95N 46 CF₃R₂ + R_(3 = (CH) ₂)₃ nothing O 95N 47 CF₃ R₂ + R₃ = (CH₂)₄ nothing O 95N48 CHF₂ R₂ + R₃ = (CH₂)₄ nothing O 95N 49 H R₂ + R₃ = (CF₃)CH(CH₂)₃nothing O 95N 50 H R₂ + R₃ = (CF₃)CH(CH₂)₂ nothing O 95N 51 H R₂ +R_(3 = CH) ₂(CF₃)CHCH₂ nothing O 95N 52 R₁ + R₂ = (CH₂)₆ H nothing O 95N53 CH₃CH₂O₂C H H nothing O 95N 54 CH₃CH₂CH₂ H H nothing O 95N 55 CH₃OCH₂H H nothing O 95N 56 CBrF₂CClFCH₂ H H nothing O 95N 57 HCF₂CF₂OCH₂ H Hnothing O 95N 58 [(CH₃CH₂O)]₂POCH₂ H H nothing O 95N 59 H R₂ + R₃ =(CH₂)₂SO₂ O 95N 60 Cl^(—)(CH₃)₃N^(⊕)CH₂ H H nothing O 95N 61N-piperidinyl-CH₂ H H nothing O 95N 62 N-phthalimido-CH₂ H H nothing O95N 63 C₆H₅ H H nothing O 95N 64 C₆H₅ H CH₃ nothing O 95N 65 C₆F₅ H Hnothing O 95N 66 C₆F₅ CH₃ H nothing O 95N 67 C₆F₅ CClH₂ H nothing O 95N68 2-CH₃C₆H₄ H H nothing O 95N 69 3-CH₃C₆H₄ H H nothing O 95N 704-CH₃C₆H₄ H H nothing O 95N 71 2-BrC₆H₄ H H nothing O 95N 72 4-BrC₆H₄ HH nothing O 95N 73 2-ClC₆H₄ H H nothing O 95N 74 3-ClC₆H₄ H H nothing O95N 75 4-ClC₆H₄ H H nothing O 95N 76 2-CH₃OC₆H₄ H H nothing O 95N 773-CH₃OC₆H₄ H H nothing O 95N 78 4-CH₃OC₆H₄ H H nothing O 95N 793-CF₃C₆H₄ H H nothing O 95N 80 C₆H₅CH₂ H H nothing O 95N 81 4F—C₆H₄ H Hnothing O 95N 82 4F—C₆H₄ H 4F—C₆H₄ nothing O 95N 83 2-CH₃O-4-CH₃OC₆H₃ HH nothing O 95N 84 3,4-OCH₂O—C₆H₃ H H nothing O 95N 85 3-Cl-4-Cl—C₆H₃ HH nothing O 95N 86 3-Cl-5-Cl—C₆H₃ H H nothing O 95N 87 C₆H₅OCH₂ H Hnothing O 95N 88 4Cl—C₆H₄OCH₂ H H nothing O 95N 89 CH₃OC₆H₄OCH₂ H Hnothing O 95N 90 C₆H₅ H CO₂C₂H₅ nothing O 95N 91 2-Pyridyl H H nothing O

TABLE 10 IC₅₀ Values for CETP Inhibitors. Values from the CEPT activityassay and from the whole serum CETP activity assay are given. CEPT SerumActivity Assay IC₅₀ Activity Assay IC₅₀ Inhibitor Number (μM) (μM) 1-1N 0.15 6.9 1-2N  1.2 36 1-5N  0.8 45 1-6N  1.5 47  1-1BN 1.5 55 1-7N  1.560 1-3N  2.0 65 1-9N  3.0 100 1-57N 3.5 120 1-4N  4.0 110 1-8N  4.0 1201-10N 4.0 >200 1-59N 5.5 120 1-2BN 6.0 >200 1-58N 7.0 100 1-60N 7.0 200 1-2DB 7.0 NT 1-11N 7.0 NT  1-3DB 7.0 NT  1-154N 8.0 NT 1-12N 10.0 NT1-13N 10.0 NT  1-336N 10.0 NT 1-14N 10.0 NT 1-15N 10.0 NT  1-4DB 10.0 NT1-19N 12.0 NT 1-17N 12.0 NT 1-18N 12.0 NT 1-22N 12.5 NT 1-20N 14.2 NT1-21N 15.0 NT 1-61N 15.0 NT  1-5DB 15.0 NT  1-6DB 15.0 NT 1-62N 15.0 NT  1-10BN 15.0 NT  1-4BN 15.0 NT 1-63N 15.0 NT 1-92N 15.0 NT 1-64N 15.0NT 1-65N 15.0 NT 1-25N 15.0 NT 1-23N 15.0 NT   1-14BN 15.0 NT  1-337N15.0 >200 1-24N 15.0 NT 1-66N 15.0 NT 1-26N 15.7 NT 1-67N 18.0 NT  1-8DB20.0 NT 1-28N 20.0 NT 1-68N 20.0 NT 1-69N 20.0 NT 1-70N 20.0 NT 1-27N20.0 NT 1-76N 20.0 NT 20.020  1-5BN 20.0 NT 1-16N 20.7 NT 1-71N 22.5 NT1-20N 37.5 NT 1-29N 45.0 NT 1-72N 50.0 NT 1-73N 50.0 NT   1-13BN 50.0 NT1-30N 60.0 NT 1-74N 60.0 NT 1-31N 60.0 NT 1-32N 60.0 NT 1-33N 60.0 NT1-75N 65.0 NT 1-76N 70.0 NT 1-20N 70.0 NT (Acetylated) 1-34N 75.0 NT41-4N  80.0 NT 1-35N 100 NT 1-88N 100 NT 1-90N 100 NT  1-3BN 100 NT  1-12BN 100 NT 1-78N >100 NT 1-37N >100 NT 1-79N >100 NT 1-45N >100 NT1-41N >100 NT 1-46N >100 NT 1-80N >100 NT 1-81N >100 NT 1-47N >100 NT1-48N >100 NT 1-49N >100 NT 1-82N >100 NT 1-50N >100 NT 1-83N >100 NT 1-9DB >100 NT   1-10DB >100 NT   1-11DB >100 NT   1-12DB >100 NT  1-13DB >100 NT   1-14DB >100 NT   1-16DB >100 NT   1-17DB >100 NT  1-19DB >100 NT   1-21DB >100 NT   1-22DB >100 NT   1-23DB >100 NT  1-24DB >100 NT   1-25DB >100 NT 1-86N >100 NT 1-87N >100 NT 1-51N >100NT   1-26DB >100 NT 1-52N >100 NT 1-54N >100 NT 1-42N >100 NT 1-43N >100NT 1-89N >100 NT 1-55N >100 NT 1-91N >100 NT 1-38N >100 NT 1-39N >100 NT1-36N >100 NT  1-40N1 1-40N >100 NT   1-11BN >100 NT 1-44N >100 NT1-85N >100 NT 1-53N >100 NT 1-84N >100 NT  1-6BN >100 NT  1-7BN >100 NT 1-8BN >100 NT  1-1DB >100 NT

TABLE 11 Structure of “Secondary Phenyl Amine” Reagents (Y and Z eachequal CH; R₈, R₁₃, R₁₄, and R₁₅ each equal H). (XIII-A)

Reagent Number R₄ R₅ R₆ R₇ R₉ R₁₀ R₁₁ R₁₂ 1DB H OCF₃ H H H OCF₃ H H 2DBH Cl H H H H CF₃ H 3DB H Br H H H OCF₃ H H 4DB H Cl H H H OCF₃ H H 5DB HCl H H H CF₃ H H 6DB H H Cl H H CF₃ H H 7DB H F H H H OCF₃ H H 8DB H HCl H H H CF₃ H 9DB H F H H H H CF₃ H 10DB H H F H H H CF₃ H 11DB F H H HH H CF₃ H 12DB H Cl H H CF₃ H H H 13DB H H Cl H CF₃ H H H 14DB Cl H H HCF₃ H H H 15DB H F H H CH₃ H H H 16DB H H F H H H CH₃ H 17DB H F H H HCH₃ H H 18DB F H H H CH₃ H H H 19DB H H F H H CH₃ H H 20DB F H H H H HCH₃ H 21DB F H H H H CF₃ H H 22DB Cl H H H H CF₃ H H 23DB H F H H CF₃ HH H 24DB H H F H CF₃ H H H 25DB H F H H H CF₃ H H 26DB H H F H H CF₃ H H27DB H OCF₃ H H H H OCF₃ H

TABLE 12 Structure of Substituted Phenyltertiary-2-Heteroalkylamines (Zand Y are each CH; R₇, R₈, R₁₂, R₁₃, R₁₄ and R₁₅ each equal H).

Inhibitor Number Column 1 + Column 2 Reagent Reagent R₁ R₂ R₃ R₁₆ X R₄R₅ R₆ R₉ R₁₀ R₁₁ 1 1DB CF₃ H H H O H OCF₃ H H OCF₃ H 1 2DB CF₃ H H H O HCl H H H CF₃ 1 3DB CF₃ H H H O H Br H H OCF₃ H 1 4DB CF₃ H H H O H Cl HH OCF₃ H 1 5DB CF₃ H H H O H Cl H H CF₃ H 1 6DB CF₃ H H H O H H Cl H CF₃H 1 7DB CF₃ H H H O H F H H OCF₃ H 1 8DB CF₃ H H H O H H Cl H H CF₃ 19DB CF₃ H H H O H F H H H CF₃ 1 10DB CF₃ H H H O H H F H H CF₃ 1 11DBCF₃ H H H O F H H H H CF₃ 1 12DB CF₃ H H H O H Cl H CF₃ H H 1 13DB CF₃ HH H O H H Cl CF₃ H H 1 14DB CF₃ H H H O Cl H H CF₃ H H 1 15DB CF₃ H H HO H F H CH₃ H H 1 16DB CF₃ H H H O H H F H H CH₃ 1 17DB CF₃ H H H O H FH H CH₃ H 1 18DB CF₃ H H H O F H H CH₃ H H 1 19DB CF₃ H H H O H H F HCH₃ H 1 20DB CF₃ H H H O F H H H H CH₃ 1 21DB CF₃ H H H O F H H H CF₃ H1 22DB CF₃ H H H O Cl H H H CF₃ H 1 23DB CF₃ H H H O H F H CF₃ H H 124DB CF₃ H H H O H H F CF₃ H H 1 25DB CF₃ H H H O H F H H CF₃ H 1 26DBCF₃ H H H O H H F H CF₃ H 1 27DB CF₃ H H H O H OCF₃ H H H OCF₃ 2 1DBCCl₃ H H H O H OCF₃ H H OCF₃ H 2 2DB CCl₃ H H H O H Cl H H H CF₃ 2 3DBCCl₃ H H H O H Br H H OCF₃ H 2 4DB CCl₃ H H H O H Cl H H OCF₃ H 2 5DBCCl₃ H H H O H Cl H H CF₃ H 2 6DB CCl₃ H H H O H H Cl H CF₃ H 2 7DB CCl₃H H H O H F H H OCF₃ H 2 8DB CCl₃ H H H O H H Cl H H CF₃ 2 9DB CCl₃ H HH O H F H H H CF₃ 2 10DB CCl₃ H H H O H H F H H CF₃ 2 11DB CCl₃ H H H OF H H H H CF₃ 2 12DB CCl₃ H H H O H Cl H CF₃ H H 2 13DB CCl₃ H H H O H HCl CF₃ H H 2 14DB CCl₃ H H H O Cl H H CF₃ H H 2 15DB CCl₃ H H H O H F HCH₃ H H 2 16DB CCl₃ H H H O H H F H H CH₃ 2 17DB CCl₃ H H H O H F H HCH₃ H 2 18DB CCl₃ H H H O F H H CH₃ H H 2 19DB CCl₃ H H H O H H F H CH₃H 2 20DB CCl₃ H H H O F H H H H CH₃ 2 21DB CCl₃ H H H O F H H H CF₃ H 222DB CCl₃ H H H O Cl H H H CF₃ H 2 23DB CCl₃ H H H O H F H CF₃ H H 224DB CCl₃ H H H O H H F CF₃ H H 2 25DB CCl₃ H H H O H F H H CF₃ H 2 26DBCCl₃ H H H O H H F H CF₃ H 2 27DB CCl₃ H H H O H OCF₃ H H H OCF₃ 3 1DBCF₃ CH₃ H H O H OCF₃ H H OCF₃ H 3 2DB CF₃ CH₃ H H O H Cl H H H CF₃ 3 3DBCF₃ CH₃ H H O H Br H H OCF₃ H 3 4DB CF₃ CH₃ H H O H Cl H H OCF₃ H 3 5DBCF₃ CH₃ H H O H Cl H H CF₃ H 3 6DB CF₃ CH₃ H H O H H Cl H CF₃ H 3 7DBCF₃ CH₃ H H O H F H H OCF₃ H 3 8DB CF₃ CH₃ H H O H H Cl H H CF₃ 3 9DBCF₃ CH₃ H H O H F H H H CF₃ 3 10DB CF₃ CH₃ H H O H H F H H CF₃ 3 11DBCF₃ CH₃ H H O F H H H H CF₃ 3 12DB CF₃ CH₃ H H O H Cl H CF₃ H H 3 13DBCF₃ CH₃ H H O H H Cl CF₃ H H 3 14DB CF₃ CH₃ H H O Cl H H CF₃ H H 3 15DBCF₃ CH₃ H H O H F H CH₃ H H 3 16DB CF₃ CH₃ H H O H H F H H CH₃ 3 17DBCF₃ CH₃ H H O H F H H CH₃ H 3 18DB CF₃ CH₃ H H O F H H CH₃ H H 3 19DBCF₃ CH₃ H H O H H F H CH₃ H 3 20DB CF₃ CH₃ H H O F H H H H CH₃ 3 21DBCF₃ CH₃ H H O F H H H CF₃ H 3 22DB CF₃ CH₃ H H O Cl H H H CF₃ H 3 23DBCF₃ CH₃ H H O H F H CF₃ H H 3 24DB CF₃ CH₃ H H O H H F CF₃ H H 3 25DBCF₃ CH₃ H H O H F H H CF₃ H 3 26DB CF₃ CH₃ H H O H H F H CF₃ H 3 27DBCF₃ CH₃ H H O H OCF₃ H H H OCF₃ 4 1DB CF₃CF₂ H H H O H OCF₃ H H OCF₃ H 42DB CF₃CF₂ H H H O H Cl H H H CF₃ 4 3DB CF₃CF₂ H H H O H Br H H OCF₃ H 44DB CF₃CF₂ H H H O H Cl H H OCF₃ H 4 5DB CF₃CF₂ H H H O H Cl H H CF₃ H 46DB CF₃CF₂ H H H O H H Cl H CF₃ H 4 7DB CF₃CF₂ H H H O H F H H OCF₃ H 48DB CF₃CF₂ H H H O H H Cl H H CF₃ 4 9DB CF₃CF₂ H H H O H F H H H CF₃ 410DB CF₃CF₂ H H H O H H F H H CF₃ 4 11DB CF₃CF₂ H H H O F H H H H CF₃ 412DB CF₃CF₂ H H H O H Cl H CF₃ H H 4 13DB CF₃CF₂ H H H O H H Cl CF₃ H H4 14DB CF₃CF₂ H H H O Cl H H CF₃ H H 4 15DB CF₃CF₂ H H H O H F H CH₃ H H4 16DB CF₃CF₂ H H H O H H F H H CH₃ 4 17DB CF₃CF₂ H H H O H F H H CH₃ H4 18DB CF₃CF₂ H H H O F H H CH₃ H H 4 19DB CF₃CF₂ H H H O H H F H CH₃ H4 20DB CF₃CF₂ H H H O F H H H H CH₃ 4 21DB CF₃CF₂ H H H O F H H H CF₃ H4 22DB CF₃CF₂ H H H O Cl H H H CF₃ H 4 23DB CF₃CF₂ H H H O H F H CF₃ H H4 24DB CF₃CF₂ H H H O H H F CF₃ H H 4 25DB CF₃CF₂ H H H O H F H H CF₃ H4 26DB CF₃CF₂ H H H O H H F H CF₃ H 4 27DB CF₃CF₂ H H H O H OCF₃ H H HOCF₃ 5 1DB CF₃CF₂CF₂ H H H O H OCF₃ H H OCF₃ H 5 2DB CF₃CF₂CF₂ H H H O HCl H H H CF₃ 5 3DB CF₃CF₂CF₂ H H H O H Br H H OCF₃ H 5 4DB CF₃CF₂CF₂ H HH O H Cl H H OCF₃ H 5 5DB CF₃CF₂CF₂ H H H O H Cl H H CF₃ H 5 6DBCF₃CF₂CF₂ H H H O H H Cl H CF₃ H 5 7DB CF₃CF₂CF₂ H H H O H F H H OCF₃ H5 8DB CF₃CF₂CF₂ H H H O H H Cl H H CF₃ 5 9DB CF₃CF₂CF₂ H H H O H F H H HCF₃ 5 10DB CF₃CF₂CF₂ H H H O H H F H H CF₃ 5 11DB CF₃CF₂CF₂ H H H O F HH H H CF₃ 5 12DB CF₃CF₂CF₂ H H H O H Cl H CF₃ H H 5 13DB CF₃CF₂CF₂ H H HO H H Cl CF₃ H H 5 14DB CF₃CF₂CF₂ H H H O Cl H H CF₃ H H 5 15DBCF₃CF₂CF₂ H H H O H F H CH₃ H H 5 16DB CF₃CF₂CF₂ H H H O H H F H H CH₃ 517DB CF₃CF₂CF₂ H H H O H F H H CH₃ H 5 18DB CF₃CF₂CF₂ H H H O F H H CH₃H H 5 19DB CF₃CF₂CF₂ H H H O H H F H CH₃ H 5 20DB CF₃CF₂CF₂ H H H O F HH H H CH₃ 5 21DB CF₃CF₂CF₂ H H H O F H H H CF₃ H 5 22DB CF₃CF₂CF₂ H H HO Cl H H H CF₃ H 5 23DB CF₃CF₂CF₂ H H H O H F H CF₃ H H 5 24DB CF₃CF₂CF₂H H H O H H F CF₃ H H 5 25DB CF₃CF₂CF₂ H H H O H F H H CF₃ H 5 26DBCF₃CF₂CF₂ H H H O H H F H CF₃ H 5 27DB CF₃CF₂CF₂ H H H O H OCF₃ H H HOCF₃ 6 1DB CF₃OCF₂CF₂ H H H O H OCF₃ H H OCF₃ H 6 2DB CF₃OCF₂CF₂ H H H OH Cl H H H CF₃ 6 3DB CF₃OCF₂CF₂ H H H O H Br H H OCF₃ H 6 4DB CF₃OCF₂CF₂H H H O H Cl H H OCF₃ H 6 5DB CF₃OCF₂CF₂ H H H O H Cl H H CF₃ H 6 6DBCF₃OCF₂CF₂ H H H O H H Cl H CF₃ H 6 7DB CF₃OCF₂CF₂ H H H O H F H H OCF₃H 6 8DB CF₃OCF₂CF₂ H H H O H H Cl H H CF₃ 6 9DB CF₃OCF₂CF₂ H H H O H F HH H CF₃ 6 10DB CF₃OCF₂CF₂ H H H O H H F H H CF₃ 6 11DB CF₃OCF₂CF₂ H H HO F H H H H CF₃ 6 12DB CF₃OCF₂CF₂ H H H O H Cl H CF₃ H H 6 13DBCF₃OCF₂CF₂ H H H O H H Cl CF₃ H H 6 14DB CF₃OCF₂CF₂ H H H O Cl H H CF₃ HH 6 15DB CF₃OCF₂CF₂ H H H O H F H CH₃ H H 6 16DB CF₃OCF₂CF₂ H H H O H HF H H CH₃ 6 17DB CF₃OCF₂CF₂ H H H O H F H H CH₃ H 6 18DB CF₃OCF₂CF₂ H HH O F H H CH₃ H H 6 19DB CF₃OCF₂CF₂ H H H O H H F H CH₃ H 6 20DBCF₃OCF₂CF₂ H H H O F H H H H CH₃ 6 21DB CF₃OCF₂CF₂ H H H O F H H H CF₃ H6 22DB CF₃OCF₂CF₂ H H H O Cl H H H CF₃ H 6 23DB CF₃OCF₂CF₂ H H H O H F HCF₃ H H 6 24DB CF₃OCF₂CF₂ H H H O H H F CF₃ H H 6 25DB CF₃OCF₂CF₂ H H HO H F H H CF₃ H 6 26DB CF₃OCF₂CF₂ H H H O H H F H CF₃ H 6 27DBCF₃OCF₂CF₂ H H H O H OCF₃ H H H OCF₃ 7 1DB CF₃CH₂ H H H O H OCF₃ H HOCF₃ H 7 2DB CF₃CH₂ H H H O H Cl H H H CF₃ 7 3DB CF₃CH₂ H H H O H Br H HOCF₃ H 7 4DB CF₃CH₂ H H H O H Cl H H OCF₃ H 7 5DB CF₃CH₂ H H H O H Cl HH CF₃ H 7 6DB CF₃CH₂ H H H O H H Cl H CF₃ H 7 7DB CF₃CH₂ H H H O H F H HOCF₃ H 7 8DB CF₃CH₂ H H H O H H Cl H H CF₃ 7 9DB CF₃CH₂ H H H O H F H HH CF₃ 7 10DB CF₃CH₂ H H H O H H F H H CF₃ 7 11DB CF₃CH₂ H H H O F H H HH CF₃ 7 12DB CF₃CH₂ H H H O H Cl H CF₃ H H 7 13DB CF₃CH₂ H H H O H H ClCF₃ H H 7 14DB CF₃CH₂ H H H O Cl H H CF₃ H H 7 15DB CF₃CH₂ H H H O H F HCH₃ H H 7 16DB CF₃CH₂ H H H O H H F H H CH₃ 7 17DB CF₃CH₂ H H H O H F HH CH₃ H 7 18DB CF₃CH₂ H H H O F H H CH₃ H H 7 19DB CF₃CH₂ H H H O H H FH CH₃ H 7 20DB CF₃CH₂ H H H O F H H H H CH₃ 7 21DB CF₃CH₂ H H H O F H HH CF₃ H 7 22DB CF₃CH₂ H H H O Cl H H H CF₃ H 7 23DB CF₃CH₂ H H H O H F HCF₃ H H 7 24DB CF₃CH₂ H H H O H H F CF₃ H H 7 25DB CF₃CH₂ H H H O H F HH CF₃ H 7 26DB CF₃CH₂ H H H O H H F H CF₃ H 7 27DB CF₃CH₂ H H H O H OCF₃H H H OCF₃ 8 1DB CF₃ CHF₂ H H O H OCF₃ H H OCF₃ H 8 2DB CF₃ CHF₂ H H O HCl H H H CF₃ 8 3DB CF₃ CHF₂ H H O H Br H H OCF₃ H 8 4DB CF₃ CHF₂ H H O HCl H H OCF₃ H 8 5DB CF₃ CHF₂ H H O H Cl H H CF₃ H 8 6DB CF₃ CHF₂ H H O HH Cl H CF₃ H 8 7DB CF₃ CHF₂ H H O H F H H OCF₃ H 8 8DB CF₃ CHF₂ H H O HH Cl H H CF₃ 8 9DB CF₃ CHF₂ H H O H F H H H CF₃ 8 10DB CF₃ CHF₂ H H O HH F H H CF₃ 8 11DB CF₃ CHF₂ H H O F H H H H CF₃ 8 12DB CF₃ CHF₂ H H O HCl H CF₃ H H 8 13DB CF₃ CHF₂ H H O H H Cl CF₃ H H 8 14DB CF₃ CHF₂ H H OCl H H CF₃ H H 8 15DB CF₃ CHF₂ H H O H F H CH₃ H H 8 16DB CF₃ CHF₂ H H OH H F H H CH₃ 8 17DB CF₃ CHF₂ H H O H F H H CH₃ H 8 18DB CF₃ CHF₂ H H OF H H CH₃ H H 8 19DB CF₃ CHF₂ H H O H H F H CH₃ H 8 20DB CF₃ CHF₂ H H OF H H H H CH₃ 8 21DB CF₃ CHF₂ H H O F H H H CF₃ H 8 22DB CF₃ CHF₂ H H OCl H H H CF₃ H 8 23DB CF₃ CHF₂ H H O H F H CF₃ H H 8 24DB CF₃ CHF₂ H H OH H F CF₃ H H 8 25DB CF₃ CHF₂ H H O H F H H CF₃ H 8 26DB CF₃ CHF₂ H H OH H F H CF₃ H 8 27DB CF₃ CHF₂ H H O H OCF₃ H H H OCF₃ 9 1DB CF₃ H CF₃ HO H OCF₃ H H OCF₃ H 9 2DB CF₃ H CF₃ H O H Cl H H H CF₃ 9 3DB CF₃ H CF₃ HO H Br H H OCF₃ H 9 4DB CF₃ H CF₃ H O H Cl H H OCF₃ H 9 5DB CF₃ H CF₃ HO H Cl H H CF₃ H 9 6DB CF₃ H CF₃ H O H H Cl H CF₃ H 9 7DB CF₃ H CF₃ H OH F H H OCF₃ H 9 8DB CF₃ H CF₃ H O H H Cl H H CF₃ 9 9DB CF₃ H CF₃ H O HF H H H CF₃ 9 10DB CF₃ H CF₃ H O H H F H H CF₃ 9 11DB CF₃ H CF₃ H O F HH H H CF₃ 9 12DB CF₃ H CF₃ H O H Cl H CF₃ H H 9 13DB CF₃ H CF₃ H O H HCl CF₃ H H 9 14DB CF₃ H CF₃ H O Cl H H CF₃ H H 9 15DB CF₃ H CF₃ H O H FH CH₃ H H 9 16DB CF₃ H CF₃ H O H H F H H CH₃ 9 17DB CF₃ H CF₃ H O H F HH CH₃ H 9 18DB CF₃ H CF₃ H O F H H CH₃ H H 9 19DB CF₃ H CF₃ H O H H F HCH₃ H 9 20DB CF₃ H CF₃ H O F H H H H CH₃ 9 21DB CF₃ H CF₃ H O F H H HCF₃ H 9 22DB CF₃ H CF₃ H O Cl H H H CF₃ H 9 23DB CF₃ H CF₃ H O H F H CF₃H H 9 24DB CF₃ H CF₃ H O H H F CF₃ H H 9 25DB CF₃ H CF₃ H O H F H H CF₃H 9 26DB CF₃ H CF₃ H O H H F H CF₃ H 9 27DB CF₃ H CF₃ H O H OCF₃ H H HOCF₃ 10 1DB CF₃ CF₃ H H O H OCF₃ H H OCF₃ H 10 2DB CF₃ CF₃ H H O H Cl HH H CF₃ 10 3DB CF₃ CF₃ H H O H Br H H OCF₃ H 10 4DB CF₃ CF₃ H H O H Cl HH OCF₃ H 10 5DB CF₃ CF₃ H H O H Cl H H CF₃ H 10 6DB CF₃ CF₃ H H O H H ClH CF₃ H 10 7DB CF₃ CF₃ H H O H F H H OCF₃ H 10 8DB CF₃ CF₃ H H O H H ClH H CF₃ 10 9DB CF₃ CF₃ H H O H F H H H CF₃ 10 10DB CF₃ CF₃ H H O H H F HH CF₃ 10 11DB CF₃ CF₃ H H O F H H H H CF₃ 10 12DB CF₃ CF₃ H H O H Cl HCF₃ H H 10 13DB CF₃ CF₃ H H O H H Cl CF₃ H H 10 14DB CF₃ CF₃ H H O Cl HH CF₃ H H 10 15DB CF₃ CF₃ H H O H F H CH₃ H H 10 16DB CF₃ CF₃ H H O H HF H H CH₃ 10 17DB CF₃ CF₃ H H O H F H H CH₃ H 10 18DB CF₃ CF₃ H H O F HH CH₃ H H 10 19DB CF₃ CF₃ H H O H H F H CH₃ H 10 20DB CF₃ CF₃ H H O F HH H H CH₃ 10 21DB CF₃ CF₃ H H O F H H H CF₃ H 10 22DB CF₃ CF₃ H H O Cl HH H CF₃ H 10 23DB CF₃ CF₃ H H O H F H CF₃ H H 10 24DB CF₃ CF₃ H H O H HF CF₃ H H 10 25DB CF₃ CF₃ H H O H F H H CF₃ H 10 26DB CF₃ CF₃ H H O H HF H CF₃ H 10 27DB CF₃ CF₃ H H O H OCF₃ H H H OCF₃ 11 1DB CF₃ C₆H₅ H H OH OCF₃ H H OCF₃ H 11 2DB CF₃ C₆H₅ H H O H Cl H H H CF₃ 11 3DB CF₃ C₆H₅ HH O H Br H H OCF₃ H 11 4DB CF₃ C₆H₅ H H O H Cl H H OCF₃ H 11 5DB CF₃C₆H₅ H H O H Cl H H CF₃ H 11 6DB CF₃ C₆H₅ H H O H H Cl H CF₃ H 11 7DBCF₃ C₆H₅ H H O H F H H OCF₃ H 11 8DB CF₃ C₆H₅ H H O H H Cl H H CF₃ 119DB CF₃ C₆H₅ H H O H F H H H CF₃ 11 10DB CF₃ C₆H₅ H H O H H F H H CF₃ 1111DB CF₃ C₆H₅ H H O F H H H H CF₃ 11 12DB CF₃ C₆H₅ H H O H Cl H CF₃ H H11 13DB CF₃ C₆H₅ H H O H H Cl CF₃ H H 11 14DB CF₃ C₆H₅ H H O Cl H H CF₃H H 11 15DB CF₃ C₆H₅ H H O H F H CH₃ H H 11 16DB CF₃ C₆H₅ H H O H H F HH CH₃ 11 17DB CF₃ C₆H₅ H H O H F H H CH₃ H 11 18DB CF₃ C₆H₅ H H O F H HCH₃ H H 11 19DB CF₃ C₆H₅ H H O H H F H CH₃ H 11 20DB CF₃ C₆H₅ H H O F HH H H CH₃ 11 21DB CF₃ C₆H₅ H H O F H H H CF₃ H 11 22DB CF₃ C₆H₅ H H O ClH H H CF₃ H 11 23DB CF₃ C₆H₅ H H O H F H CF₃ H H 11 24DB CF₃ C₆H₅ H H OH H F CF₃ H H 11 25DB CF₃ C₆H₅ H H O H F H H CF₃ H 11 26DB CF₃ C₆H₅ H HO H H F H CF₃ H 11 27DB CF₃ C₆H₅ H H O H OCF₃ H H H OCF₃ 12 1DB CCl₃C₆H₅ H H O H OCF₃ H H OCF₃ H 12 2DB CCl₃ C₆H₅ H H O H Cl H H H CF₃ 123DB CCl₃ C₆H₅ H H O H Br H H OCF₃ H 12 4DB CCl₃ C₆H₅ H H O H Cl H H OCF₃H 12 5DB CCl₃ C₆H₅ H H O H Cl H H CF₃ H 12 6DB CCl₃ C₆H₅ H H O H H Cl HCF₃ H 12 7DB CCl₃ C₆H₅ H H O H F H H OCF₃ H 12 8DB CCl₃ C₆H₅ H H O H HCl H H CF₃ 12 9DB CCl₃ C₆H₅ H H O H F H H H CF₃ 12 10DB CCl₃ C₆H₅ H H OH H F H H CF₃ 12 11DB CCl₃ C₆H₅ H H O F H H H H CF₃ 12 12DB CCl₃ C₆H₅ HH O H Cl H CF₃ H H 12 13DB CCl₃ C₆H₅ H H O H H Cl CF₃ H H 12 14DB CCl₃C₆H₅ H H O Cl H H CF₃ H H 12 15DB CCl₃ C₆H₅ H H O H F H CH₃ H H 12 16DBCCl₃ C₆H₅ H H O H H F H H CH₃ 12 17DB CCl₃ C₆H₅ H H O H F H H CH₃ H 1218DB CCl₃ C₆H₅ H H O F H H CH₃ H H 12 19DB CCl₃ C₆H₅ H H O H H F H CH₃ H12 20DB CCl₃ C₆H₅ H H O F H H H H CH₃ 12 21DB CCl₃ C₆H₅ H H O F H H HCF₃ H 12 22DB CCl₃ C₆H₅ H H O Cl H H H CF₃ H 12 23DB CCl₃ C₆H₅ H H O H FH CF₃ H H 12 24DB CCl₃ C₆H₅ H H O H H F CF₃ H H 12 25DB CCl₃ C₆H₅ H H OH F H H CF₃ H 12 26DB CCl₃ C₆H₅ H H O H H F H CF₃ H 12 27DB CCl₃ C₆H₅ HH O H OCF₃ H H H OCF₃ 13 1DB CCl₃ cyclo-propyl H H O H OCF₃ H H OCF₃ H13 2DB CCl₃ cyclo-propyl H H O H Cl H H H CF₃ 13 3DB CCl₃ cyclo-propyl HH O H Br H H OCF₃ H 13 4DB CCl₃ cyclo-propyl H H O H Cl H H OCF₃ H 135DB CCl₃ cyclo-propyl H H O H Cl H H CF₃ H 13 6DB CCl₃ cyclo-propyl H HO H H Cl H CF₃ H 13 7DB CCl₃ cyclo-propyl H H O H F H H OCF₃ H 13 8DBCCl₃ cyclo-propyl H H O H H Cl H H CF₃ 13 9DB CCl₃ cyclo-propyl H H O HF H H H CF₃ 13 10DB CCl₃ cyclo-propyl H H O H H F H H CF₃ 13 11DB CCl₃cyclo-propyl H H O F H H H H CF₃ 13 12DB CCl₃ cyclo-propyl H H O H Cl HCF₃ H H 13 13DB CCl₃ cyclo-propyl H H O H H Cl CF₃ H H 13 14DB CCl₃cyclo-propyl H H O Cl H H CF₃ H H 13 15DB CCl₃ cyclo-propyl H H O H F HCH₃ H H 13 16DB CCl₃ cyclo-propyl H H O H H F H H CH₃ 13 17DB CCl₃cyclo-propyl H H O H F H H CH₃ H 13 18DB CCl₃ cyclo-propyl H H O F H HCH₃ H H 13 19DB CCl₃ cyclo-propyl H H O H H F H CH₃ H 13 20DB CCl₃cyclo-propyl H H O F H H H H CH₃ 13 21DB CCl₃ cyclo-propyl H H O F H H HCF₃ H 13 22DB CCl₃ cyclo-propyl H H O Cl H H H CF₃ H 13 23DB CCl₃cyclo-propyl H H O H F H CF₃ H H 13 24DB CCl₃ cyclo-propyl H H O H H FCF₃ H H 13 25DB CCl₃ cyclo-propyl H H O H F H H CF₃ H 13 26DB CCl₃cyclo-propyl H H O H H F H CF₃ H 13 27DB CCl₃ cyclo-propyl H H O H OCF₃H H H OCF₃ 14 1DB CCl₃ CH₃ H H O H OCF₃ H H OCF₃ H 14 2DB CCl₃ CH₃ H H OH Cl H H H CF₃ 14 3DB CCl₃ CH₃ H H O H Br H H OCF₃ H 14 4DB CCl₃ CH₃ H HO H Cl H H OCF₃ H 14 5DB CCl₃ CH₃ H H O H Cl H H CF₃ H 14 6DB CCl₃ CH₃ HH O H H Cl H CF₃ H 14 7DB CCl₃ CH₃ H H O H F H H OCF₃ H 14 8DB CCl₃ CH₃H H O H H Cl H H CF₃ 14 9DB CCl₃ CH₃ H H O H F H H H CF₃ 14 10DB CCl₃CH₃ H H O H H F H H CF₃ 14 11DB CCl₃ CH₃ H H O F H H H H CF₃ 14 12DBCCl₃ CH₃ H H O H Cl H CF₃ H H 14 13DB CCl₃ CH₃ H H O H H Cl CF₃ H H 1414DB CCl₃ CH₃ H H O Cl H H CF₃ H H 14 15DB CCl₃ CH₃ H H O H F H CH₃ H H14 16DB CCl₃ CH₃ H H O H H F H H CH₃ 14 17DB CCl₃ CH₃ H H O H F H H CH₃H 14 18DB CCl₃ CH₃ H H O F H H CH₃ H H 14 19DB CCl₃ CH₃ H H O H H F HCH₃ H 14 20DB CCl₃ CH₃ H H O F H H H H CH₃ 14 21DB CCl₃ CH₃ H H O F H HH CF₃ H 14 22DB CCl₃ CH₃ H H O Cl H H H CF₃ H 14 23DB CCl₃ CH₃ H H O H FH CF₃ H H 14 24DB CCl₃ CH₃ H H O H H F CF₃ H H 14 25DB CCl₃ CH₃ H H O HF H H CF₃ H 14 26DB CCl₃ CH₃ H H O H H F H CF₃ H 14 27DB CCl₃ CH₃ H H OH OCF₃ H H H OCF₃ 15 1DB CCl₃ (CH₃)₂CH H H O H OCF₃ H H OCF₃ H 15 2DBCCl₃ (CH₃)₂CH H H O H Cl H H H CF₃ 15 3DB CCl₃ (CH₃)₂CH H H O H Br H HOCF₃ H 15 4DB CCl₃ (CH₃)₂CH H H O H Cl H H OCF₃ H 15 5DB CCl₃ (CH₃)₂CH HH O H Cl H H CF₃ H 15 6DB CCl₃ (CH₃)₂CH H H O H H Cl H CF₃ H 15 7DB CCl₃(CH₃)₂CH H H O H F H H OCF₃ H 15 8DB CCl₃ (CH₃)₂CH H H O H H Cl H H CF₃15 9DB CCl₃ (CH₃)₂CH H H O H F H H H CF₃ 15 10DB CCl₃ (CH₃)₂CH H H O H HF H H CF₃ 15 11DB CCl₃ (CH₃)₂CH H H O F H H H H CF₃ 15 12DB CCl₃(CH₃)₂CH H H O H Cl H CF₃ H H 15 13DB CCl₃ (CH₃)₂CH H H O H H Cl CF₃ H H15 14DB CCl₃ (CH₃)₂CH H H O Cl H H CF₃ H H 15 15DB CCl₃ (CH₃)₂CH H H O HF H CH₃ H H 15 16DB CCl₃ (CH₃)₂CH H H O H H F H H CH₃ 15 17DB CCl₃(CH₃)₂CH H H O H F H H CH₃ H 15 18DB CCl₃ (CH₃)₂CH H H O F H H CH₃ H H15 19DB CCl₃ (CH₃)₂CH H H O H H F H CH₃ H 15 20DB CCl₃ (CH₃)₂CH H H O FH H H H CH₃ 15 21DB CCl₃ (CH₃)₂CH H H O F H H H CF₃ H 15 22DB CCl₃(CH₃)₂CH H H O Cl H H H CF₃ H 15 23DB CCl₃ (CH₃)₂CH H H O H F H CF₃ H H15 24DB CCl₃ (CH₃)₂CH H H O H H F CF₃ H H 15 25DB CCl₃ (CH₃)₂CH H H O HF H H CF₃ H 15 26DB CCl₃ (CH₃)₂CH H H O H H F H CF₃ H 15 27DB CCl₃(CH₃)₂CH H H O H OCF₃ H H H OCF₃ 16 1DB CHCl₂ H H H O H OCF₃ H H OCF₃ H16 2DB CHCl₂ H H H O H Cl H H H CF₃ 16 3DB CHCl₂ H H H O H Br H H OCF₃ H16 4DB CHCl₂ H H H O H Cl H H OCF₃ H 16 5DB CHCl₂ H H H O H Cl H H CF₃ H16 6DB CHCl₂ H H H O H H Cl H CF₃ H 16 7DB CHCl₂ H H H O H F H H OCF₃ H16 8DB CHCl₂ H H H O H H Cl H H CF₃ 16 9DB CHCl₂ H H H O H F H H H CF₃16 10DB CHCl₂ H H H O H H F H H CF₃ 16 11DB CHCl₂ H H H O F H H H H CF₃16 12DB CHCl₂ H H H O H Cl H CF₃ H H 16 13DB CHCl₂ H H H O H H Cl CF₃ HH 16 14DB CHCl₂ H H H O Cl H H CF₃ H H 16 15DB CHCl₂ H H H O H F H CH₃ HH 16 16DB CHCl₂ H H H O H H F H H CH₃ 16 17DB CHCl₂ H H H O H F H H CH₃H 16 18DB CHCl₂ H H H O F H H CH₃ H H 16 19DB CHCl₂ H H H O H H F H CH₃H 16 20DB CHCl₂ H H H O F H H H H CH₃ 16 21DB CHCl₂ H H H O F H H H CF₃H 16 22DB CHCl₂ H H H O Cl H H H CF₃ H 16 23DB CHCl₂ H H H O H F H CF₃ HH 16 24DB CHCl₂ H H H O H H F CF₃ H H 16 25DB CHCl₂ H H H O H F H H CF₃H 16 26DB CHCl₂ H H H O H H F H CF₃ H 16 27DB CHCl₂ H H H O H OCF₃ H H HOCF₃ 18 1DB CF₃ H CH₃ H O H OCF₃ H H OCF₃ H 18 2DB CF₃ H CH₃ H O H Cl HH H CF₃ 18 3DB CF₃ H CH₃ H O H Br H H OCF₃ H 18 4DB CF₃ H CH₃ H O H Cl HH OCF₃ H 18 5DB CF₃ H CH₃ H O H Cl H H CF₃ H 18 6DB CF₃ H CH₃ H O H H ClH CF₃ H 18 7DB CF₃ H CH₃ H O H F H H OCF₃ H 18 8DB CF₃ H CH₃ H O H H ClH H CF₃ 18 9DB CF₃ H CH₃ H O H F H H H CF₃ 18 10DB CF₃ H CH₃ H O H H F HH CF₃ 18 11DB CF₃ H CH₃ H O F H H H H CF₃ 18 12DB CF₃ H CH₃ H O H Cl HCF₃ H H 18 13DB CF₃ H CH₃ H O H H Cl CF₃ H H 18 14DB CF₃ H CH₃ H O Cl HH CF₃ H H 18 15DB CF₃ H CH₃ H O H F H CH₃ H H 18 16DB CF₃ H CH₃ H O H HF H H CH₃ 18 17DB CF₃ H CH₃ H O H F H H CH₃ H 18 18DB CF₃ H CH₃ H O F HH CH₃ H H 18 19DB CF₃ H CH₃ H O H H F H CH₃ H 18 20DB CF₃ H CH₃ H O F HH H H CH₃ 18 21DB CF₃ H CH₃ H O F H H H CF₃ H 18 22DB CF₃ H CH₃ H O Cl HH H CF₃ H 18 23DB CF₃ H CH₃ H O H F H CF₃ H H 18 24DB CF₃ H CH₃ H O H HF CF₃ H H 18 25DB CF₃ H CH₃ H O H F H H CF₃ H 18 26DB CF₃ H CH₃ H O H HF H CF₃ H 18 27DB CF₃ H CH₃ H O H OCF₃ H H H OCF₃ 19 1DB CF₃ CF₃ H H N HOCF₃ H H OCF₃ H 19 2DB CF₃ CF₃ H H N H Cl H H H CF₃ 19 3DB CF₃ CF₃ H H NH Br H H OCF₃ H 19 4DB CF₃ CF₃ H H N H Cl H H OCF₃ H 19 5DB CF₃ CF₃ H HN H Cl H H CF₃ H 19 6DB CF₃ CF₃ H H N H H Cl H CF₃ H 19 7DB CF₃ CF₃ H HN H F H H OCF₃ H 19 8DB CF₃ CF₃ H H N H H Cl H H CF₃ 19 9DB CF₃ CF₃ H HN H F H H H CF₃ 19 10DB CF₃ CF₃ H H N H H F H H CF₃ 19 11DB CF₃ CF₃ H HN F H H H H CF₃ 19 12DB CF₃ CF₃ H H N H Cl H CF₃ H H 19 13DB CF₃ CF₃ H HN H H Cl CF₃ H H 19 14DB CF₃ CF₃ H H N Cl H H CF₃ H H 19 15DB CF₃ CF₃ HH N H F H CH₃ H H 19 16DB CF₃ CF₃ H H N H H F H H CH₃ 19 17DB CF₃ CF₃ HH N H F H H CH₃ H 19 18DB CF₃ CF₃ H H N F H H CH₃ H H 19 19DB CF₃ CF₃ HH N H H F H CH₃ H 19 20DB CF₃ CF₃ H H N F H H H H CH₃ 19 21DB CF₃ CF₃ HH N F H H H CF₃ H 19 22DB CF₃ CF₃ H H N Cl H H H CF₃ H 19 23DB CF₃ CF₃ HH N H F H CF₃ H H 19 24DB CF₃ CF₃ H H N H H F CF₃ H H 19 25DB CF₃ CF₃ HH N H F H H CF₃ H 19 26DB CF₃ CF₃ H H N H H F H CF₃ H 19 27DB CF₃ CF₃ HH N H OCF₃ H H H OCF₃ 20 1DB CF₃ H H H N H OCF₃ H H OCF₃ H 20 2DB CF₃ HH H N H Cl H H H CF₃ 20 3DB CF₃ H H H N H Br H H OCF₃ H 20 4DB CF₃ H H HN H Cl H H OCF₃ H 20 5DB CF₃ H H H N H Cl H H CF₃ H 20 6DB CF₃ H H H N HH Cl H CF₃ H 20 7DB CF₃ H H H N H F H H OCF₃ H 20 8DB CF₃ H H H N H H ClH H CF₃ 20 9DB CF₃ H H H N H F H H H CF₃ 20 10DB CF₃ H H H N H H F H HCF₃ 20 11DB CF₃ H H H N F H H H H CF₃ 20 12DB CF₃ H H H N H Cl H CF₃ H H20 13DB CF₃ H H H N H H Cl CF₃ H H 20 14DB CF₃ H H H N Cl H H CF₃ H H 2015DB CF₃ H H H N H F H CH₃ H H 20 16DB CF₃ H H H N H H F H H CH₃ 20 17DBCF₃ H H H N H F H H CH₃ H 20 18DB CF₃ H H H N F H H CH₃ H H 20 19DB CF₃H H H N H H F H CH₃ H 20 20DB CF₃ H H H N F H H H H CH₃ 20 21DB CF₃ H HH N F H H H CF₃ H 20 22DB CF₃ H H H N Cl H H H CF₃ H 20 23DB CF₃ H H H NH F H CF₃ H H 20 24DB CF₃ H H H N H H F CF₃ H H 20 25DB CF₃ H H H N H FH H CF₃ H 20 26DB CF₃ H H H N H H F H CF₃ H 20 27DB CF₃ H H H N H OCF₃ HH H OCF₃ 23 1DB CF₃ H H CH₃ N H OCF₃ H H OCF₃ H 23 2DB CF₃ H H CH₃ N HCl H H H CF₃ 23 3DB CF₃ H H CH₃ N H Br H H OCF₃ H 23 4DB CF₃ H H CH₃ N HCl H H OCF₃ H 23 5DB CF₃ H H CH₃ N H Cl H H CF₃ H 23 6DB CF₃ H H CH₃ N HH Cl H CF₃ H 23 7DB CF₃ H H CH₃ N H F H H OCF₃ H 23 8DB CF₃ H H CH₃ N HH Cl H H CF₃ 23 9DB CF₃ H H CH₃ N H F H H H CF₃ 23 10DB CF₃ H H CH₃ N HH F H H CF₃ 24 11DB CF₃ H H CH₃ N F H H H H CF₃ 24 12DB CF₃ H H CH₃ N HCl H CF₃ H H 24 13DB CF₃ H H CH₃ N H H Cl CF₃ H H 24 14DB CF₃ H H CH₃ NCl H H CF₃ H H 24 15DB CF₃ H H CH₃ N H F H CH₃ H H 24 16DB CF₃ H H CH₃ NH H F H H CH₃ 24 17DB CF₃ H H CH₃ N H F H H CH₃ H 24 18DB CF₃ H H CH₃ NF H H CH₃ H H 23 19DB CF₃ H H CH₃ N H H F H CH₃ H 23 20DB CF₃ H H CH₃ NF H H H H CH₃ 23 21DB CF₃ H H CH₃ N F H H H CF₃ H 23 22DB CF₃ H H CH₃ NCl H H H CF₃ H 23 23DB CF₃ H H CH₃ N H F H CF₃ H H 23 24DB CF₃ H H CH₃ NH H F CF₃ H H 23 25DB CF₃ H H CH₃ N H F H H CF₃ H 23 26DB CF₃ H H CH₃ NH H F H CF₃ H 23 27DB CF₃ H H CH₃ N H OCF₃ H H H OCF₃ 25 1DB CF₃ H H H SH OCF₃ H H OCF₃ H 25 2DB CF₃ H H H S H Cl H H H CF₃ 25 3DB CF₃ H H H S HBr H H OCF₃ H 25 4DB CF₃ H H H S H Cl H H OCF₃ H 25 5DB CF₃ H H H S H ClH H CF₃ H 25 6DB CF₃ H H H S H H Cl H CF₃ H 25 7DB CF₃ H H H S H F H HOCF₃ H 25 8DB CF₃ H H H S H H Cl H H CF₃ 25 9DB CF₃ H H H S H F H H HCF₃ 25 10DB CF₃ H H H S H H F H H CF₃ 25 11DB CF₃ H H H S F H H H H CF₃25 12DB CF₃ H H H S H Cl H CF₃ H H 25 13DB CF₃ H H H S H H Cl CF₃ H H 2514DB CF₃ H H H S Cl H H CF₃ H H 25 15DB CF₃ H H H S H F H CH₃ H H 2516DB CF₃ H H H S H H F H H CH₃ 25 17DB CF₃ H H H S H F H H CH₃ H 25 18DBCF₃ H H H S F H H CH₃ H H 25 19DB CF₃ H H H S H H F H CH₃ H 25 20DB CF₃H H H S F H H H H CH₃ 25 21DB CF₃ H H H S F H H H CF₃ H 25 22DB CF₃ H HH S Cl H H H CF₃ H 25 23DB CF₃ H H H S H F H CF₃ H H 25 24DB CF₃ H H H SH H F CF₃ H H 25 25DB CF₃ H H H S H F H H CF₃ H 25 26DB CF₃ H H H S H HF H CF₃ H 25 27DB CF₃ H H H S H OCF₃ H H H OCF₃ 26 1DB CF₃CF₂ H H H S HOCF₃ H H OCF₃ H 26 2DB CF₃CF₂ H H H S H Cl H H H CF₃ 26 3DB CF₃CF₂ H H HS H Br H H OCF₃ H 26 4DB CF₃CF₂ H H H S H Cl H H OCF₃ H 26 5DB CF₃CF₂ HH H S H Cl H H CF₃ H 26 6DB CF₃CF₂ H H H S H H Cl H CF₃ H 26 7DB CF₃CF₂H H H S H F H H OCF₃ H 26 8DB CF₃CF₂ H H H S H H Cl H H CF₃ 26 9DBCF₃CF₂ H H H S H F H H H CF₃ 26 10DB CF₃CF₂ H H H S H H F H H CF₃ 2611DB CF₃CF₂ H H H S F H H H H CF₃ 26 12DB CF₃CF₂ H H H S H Cl H CF₃ H H26 13DB CF₃CF₂ H H H S H H Cl CF₃ H H 26 14DB CF₃CF₂ H H H S Cl H H CF₃H H 26 15DB CF₃CF₂ H H H S H F H CH₃ H H 26 16DB CF₃CF₂ H H H S H H F HH CH₃ 26 17DB CF₃CF₂ H H H S H F H H CH₃ H 26 18DB CF₃CF₂ H H H S F H HCH₃ H H 26 19DB CF₃CF₂ H H H S H H F H CH₃ H 26 20DB CF₃CF₂ H H H S F HH H H CH₃ 26 21DB CF₃CF₂ H H H S F H H H CF₃ H 26 22DB CF₃CF₂ H H H S ClH H H CF₃ H 26 23DB CF₃CF₂ H H H S H F H CF₃ H H 26 24DB CF₃CF₂ H H H SH H F CF₃ H H 26 25DB CF₃CF₂ H H H S H F H H CF₃ H 26 26DB CF₃CF₂ H H HS H H F H CF₃ H 26 27DB CF₃CF₂ H H H S H OCF₃ H H H OCF₃ 27 1DB CCl₃CH₂H H H O H OCF₃ H H OCF₃ H 27 2DB CCl₃CH₂ H H H O H Cl H H H CF₃ 27 3DBCCl₃CH₂ H H H O H Br H H OCF₃ H 27 4DB CCl₃CH₂ H H H O H Cl H H OCF₃ H27 5DB CCl₃CH₂ H H H O H Cl H H CF₃ H 27 6DB CCl₃CH₂ H H H O H H Cl HCF₃ H 27 7DB CCl₃CH₂ H H H O H F H H OCF₃ H 27 8DB CCl₃CH₂ H H H O H HCl H H CF₃ 27 9DB CCl₃CH₂ H H H O H F H H H CF₃ 27 10DB CCl₃CH₂ H H H OH H F H H CF₃ 27 11DB CCl₃CH₂ H H H O F H H H H CF₃ 27 12DB CCl₃CH₂ H HH O H Cl H CF₃ H H 27 13DB CCl₃CH₂ H H H O H H Cl CF₃ H H 27 14DBCCl₃CH₂ H H H O Cl H H CF₃ H H 27 15DB CCl₃CH₂ H H H O H F H CH₃ H H 2716DB CCl₃CH₂ H H H O H H F H H CH₃ 27 17DB CCl₃CH₂ H H H O H F H H CH₃ H27 18DB CCl₃CH₂ H H H O F H H CH₃ H H 27 19DB CCl₃CH₂ H H H O H H F HCH₃ H 27 20DB CCl₃CH₂ H H H O F H H H H CH₃ 27 21DB CCl₃CH₂ H H H O F HH H CF₃ H 27 22DB CCl₃CH₂ H H H O Cl H H H CF₃ H 27 23DB CCl₃CH₂ H H H OH F H CF₃ H H 27 24DB CCl₃CH₂ H H H O H H F CF₃ H H 27 25DB CCl₃CH₂ H HH O H F H H CF₃ H 27 26DB CCl₃CH₂ H H H O H H F H CF₃ H 27 27DB CCl₃CH₂H H H O H OCF₃ H H H OCF₃ 28 1DB CBr₃CH₂ H H H O H OCF₃ H H OCF₃ H 282DB CBr₃CH₂ H H H O H Cl H H H CF₃ 28 3DB CBr₃CH₂ H H H O H Br H H OCF₃H 28 4DB CBr₃CH₂ H H H O H Cl H H OCF₃ H 28 5DB CBr₃CH₂ H H H O H Cl H HCF₃ H 28 6DB CBr₃CH₂ H H H O H H Cl H CF₃ H 28 7DB CBr₃CH₂ H H H O H F HH OCF₃ H 28 8DB CBr₃CH₂ H H H O H H Cl H H CF₃ 28 9DB CBr₃CH₂ H H H O HF H H H CF₃ 28 10DB CBr₃CH₂ H H H O H H F H H CF₃ 28 11DB CBr₃CH₂ H H HO F H H H H CF₃ 28 12DB CBr₃CH₂ H H H O H Cl H CF₃ H H 28 13DB CBr₃CH₂ HH H O H H Cl CF₃ H H 28 14DB CBr₃CH₂ H H H O Cl H H CF₃ H H 28 15DBCBr₃CH₂ H H H O H F H CH₃ H H 28 16DB CBr₃CH₂ H H H O H H F H H CH₃ 2817DB CBr₃CH₂ H H H O H F H H CH₃ H 28 18DB CBr₃CH₂ H H H O F H H CH₃ H H28 19DB CBr₃CH₂ H H H O H H F H CH₃ H 28 20DB CBr₃CH₂ H H H O F H H H HCH₃ 28 21DB CBr₃CH₂ H H H O F H H H CF₃ H 28 22DB CBr₃CH₂ H H H O Cl H HH CF₃ H 28 23DB CBr₃CH₂ H H H O H F H CF₃ H H 28 24DB CBr₃CH₂ H H H O HH F CF₃ H H 28 25DB CBr₃CH₂ H H H O H F H H CF₃ H 28 26DB CBr₃CH₂ H H HO H H F H CF₃ H 28 27DB CBr₃CH₂ H H H O H OCF₃ H H H OCF₃

TABLE 13 Structure of “Generic Secondary Amine” Reagents (R₁₃ is H; R₁₄is H or not present when Y = covalent bond (XIII)

Reagent Number R₁₈ R₉ R₁₀ R₁₁ R₁₂ Y 1BN

H OCF₃ H H CH 2BN

H OCF₃ H H CH 3BN

H OCF₃ H H CH 4BN

H CF₃ H H CH 5BN

H OCF₃ H H CH 6BN isopropyl H OCF₃ H H CH 7BN propyl H OCF₃ H H CH 8BNcyclopentyl H OCF₃ H H CH 9BN

H OCF₃ H H CH 10BN

H OCF₂CF₂H H H CH 11BN

H H OCF₃ H CH 12BN

H F H H covalent bond 13BN

H F H H covalent bond 14BN

H F H H covalent bond

TABLE 14 Structure of Substituted tertiary-2-Heteroalkylamines (R₉, R₁₂,and R₁₃ are each H; R₁₄ is H or not present when Y = covalent bond).

Inhibitor Number Column1 + Column2 Reagent Reagent R₁ R₂ R₃ R₁₆ X R₁₈R₁₀ R₁₁ Y 1 1BN CF₃ H H H O

OCF₃ H CH 1 2BN CF₃ H H H O

OCF₃ H CH 1 3BN CF₃ H H H O

OCF₃ H CH 1 4BN CF₃ H H H O

CF₃ H CH 1 5BN CF₃ H H H O

OCF₃ H CH 1 6BN CF₃ H H H O isopropyl OCF₃ H CH 1 7BN CF₃ H H H O propylOCF₃ H CH 1 8BN CF₃ H H H O cyclopentyl OCF₃ H CH 1 9BN CF₃ H H H O

OCF₃ H CH 1 10BN  CF₃ H H Acetyl O

OCF₂CF₂H H CH 1 11BN  CF₃ H H H O

H OCF₃ CH 1 12BN  CF₃ H H H O

F H covalent bond 1 13BN  CF₃ H H m-CF₃Benzoyl O

F H covalent bond 1 14BN  CF₃ H H H O

F H covalent bond 2 1BN CCl₃ H H H O

OCF₃ H CH 2 2BN CCl₃ H H H O

OCF₃ H CH 2 3BN CCl₃ H H H O

OCF₃ H CH 2 4BN CCl₃ H H H O

CF₃ H CH 2 5BN CCl₃ H H H O

OCF₃ H CH 2 6BN CCl₃ H H H O isopropyl OCF₃ H CH 2 7BN CCl₃ H H H Opropyl OCF₃ H CH 2 8BN CCl₃ H H H O cyclopentyl OCF₃ H CH 2 9BN CCl₃ H HH O

OCF₃ H CH 2 10BN  CCl₃ H H Acetyl O

OCF₂CF₂H H CH 2 11BN  CCl₃ H H H O

H OCF₃ CH 2 12BN  CCl₃ H H H O

F H covalent bond 2 13BN  CCl₃ H H m-CF₃Benzoyl O

F H covalent bond 2 14BN  CCl₃ H H H O

F H covalent bond 3 1BN CH₃ H H H O

OCF₃ H CH 3 2BN CH₃ H H H O

OCF₃ H CH 3 3BN CH₃ H H H O

OCF₃ H CH 3 4BN CH₃ H H H O

CF₃ H CH 3 5BN CH₃ H H H O

OCF₃ H CH 3 6BN CH₃ H H H O isopropyl OCF₃ H CH 3 7BN CH₃ H H H O propylOCF₃ H CH 3 8BN CH₃ H H H O cyclopentyl OCF₃ H CH 3 9BN CH₃ H H H O

OCF₃ H CH 3 10BN  CH₃ H H Acetyl O

OCF₂CF₂H H CH 3 11BN  CH₃ H H H O

H OCF₃ CH 3 12BN  CH₃ H H H O

F H covalent bond 3 13BN  CH₃ H H m-CF₃Benzoyl O

F H covalent bond 3 14BN  CH₃ H H H O

F H covalent bond 4 1BN CF₃CF₂ H H H O

OCF₃ H CH 4 2BN CF₃CF₂ H H H O

OCF₃ H CH 4 3BN CF₃CF₂ H H H O

OCF₃ H CH 4 4BN CF₃CF₂ H H H O

CF₃ H CH 4 5BN CF₃CF₂ H H H O

OCF₃ H CH 4 6BN CF₃CF₂ H H H O isopropyl OCF₃ H CH 4 7BN CF₃CF₂ H H H Opropyl OCF₃ H CH 4 8BN CF₃CF₂ H H H O cyclopentyl OCF₃ H CH 4 9BN CF₃CF₂H H H O

OCF₃ H CH 4 10BN  CF₃CF₂ H H Acetyl O

OCF₂CF₂H H CH 4 11BN  CF₃CF₂ H H H O

H OCF₃ CH 4 12BN  CF₃CF₂ H H H O

F H covalent bond 4 13BN  CF₃CF₂ H H m-CF₃Benzoyl O

F H covalent bond 4 14BN  CF₃CF₂ H H H O

F H covalent bond 5 1BN CF₃CF₂CF₂ H H H O

OCF₃ H CH 5 2BN CF₃CF₂CF₂ H H H O

OCF₃ H CH 5 3BN CF₃CF₂CF₂ H H H O

OCF₃ H CH 5 4BN CF₃CF₂CF₂ H H H O

CF₃ H CH 5 5BN CF₃CF₂CF₂ H H H O

OCF₃ H CH 5 6BN CF₃CF₂CF₂ H H H O isopropyl OCF₃ H CH 5 7BN CF₃CF₂CF₂ HH H O propyl OCF₃ H CH 5 8BN CF₃CF₂CF₂ H H H O cyclopentyl OCF₃ H CH 59BN CF₃CF₂CF₂ H H H O

OCF₃ H CH 5 10BN  CF₃CF₂CF₂ H H Acetyl O

OCF₂CF₂H H CH 5 11BN  CF₃CF₂CF₂ H H H O

H OCF₃ CH 5 12BN  CF₃CF₂CF₂ H H H O

F H covalent bond 5 13BN  CF₃CF₂CF₂ H H m-CF₃Benzoyl O

F H covalent bond 5 14BN  CF₃CF₂CF₂ H H H O

F H covalent bond 6 1BN CF₃OCF₂CF₂ H H H O

OCF₃ H CH 6 2BN CF₃OCF₂CF₂ H H H O

OCF₃ H CH 6 3BN CF₃OCF₂CF₂ H H H O

OCF₃ H CH 6 4BN CF₃OCF₂CF₂ H H H O

CF₃ H CH 6 5BN CF₃OCF₂CF₂ H H H O

OCF₃ H CH 6 6BN CF₃OCF₂CF₂ H H H O isopropyl OCF₃ H CH 6 7BN CF₃OCF₂CF₂H H H O propyl OCF₃ H CH 6 8BN CF₃OCF₂CF₂ H H H O cyclopentyl OCF₃ H CH6 9BN CF₃OCF₂CF₂ H H H O

OCF₃ H CH 6 10BN  CF₃OCF₂CF₂ H H Acetyl O

OCF₂CF₂H H CH 6 11BN  CF₃OCF₂CF₂ H H H O

H OCF₃ CH 6 12BN  CF₃OCF₂CF₂ H H H O

F H covalent bond 6 13BN  CF₃OCF₂CF₂ H H m-CF₃Benzoyl O

F H covalent bond 6 14BN  CF₃OCF₂CF₂ H H H O

F H covalent bond 7 1BN CF₃CH₂ H H H O

OCF₃ H CH 7 2BN CF₃CH₂ H H H O

OCF₃ H CH 7 3BN CF₃CH₂ H H H O

OCF₃ H CH 7 4BN CF₃CH₂ H H H O

CF₃ H CH 7 5BN CF₃CH₂ H H H O

OCF₃ H CH 7 6BN CF₃CH₂ H H H O isopropyl OCF₃ H CH 7 7BN CF₃CH₂ H H H Opropyl OCF₃ H CH 7 8BN CF₃CH₂ H H H O cyclopentyl OCF₃ H CH 7 9BN CF₃CH₂H H H O

OCF₃ H CH 7 10BN  CF₃CH₂ H H Acetyl O

OCF₂CF₂H H CH 7 11BN  CF₃CH₂ H H H O

H OCF₃ CH 7 12BN  CF₃CH₂ H H H O

F H covalent bond 7 13BN  CF₃CH₂ H H m-CF₃Benzoyl O

F H covalent bond 7 14BN  CF₃CH₂ H H H O

F H covalent bond

TABLE 15 Structure of Substituted Phenyltertiary-omega-Heteroalkylamines (Y is CH; R₈, R₉, R₁₂, R₁₃, and R₁₄ areeach H; Z is covalent bond and R₁₅ is absent).

Inhibitor Number Column1 + Column2 Reagent Reagent R₁ n m R₂ R₃ XR₁₆ R₄R₅ R₆ R₇ R₁₀ R₁₁ 1A  1N CF₃ 1 1 H H CH₂OH H C₆H₅O H H OCF₂CF₂H H 1A  2NCF₃ 1 1 H H CH₂OH H OCF₃ H H OCF₂CF₂H H 1A  3N CF₃ 1 1 H H CH₂OH F H H FOCF₂CF₂H H 1A  4N CF₃ 1 1 H H CH₂OH H F H H OCF₂CF₂H H 1A  5N CF₃ 1 1 HH CH₂OH H C₆H₅O H H OCF₃ H 1A  6N CF₃ 1 1 H H CH₂OH H OCF₃ H H OCF₃ H 1A 7N CF₃ 1 1 H H CH₂OH H H phenyl H OCF₃ H 1A  8N CF₃ 1 1 H H CH₂OH Hphenyl H H OCF₃ H 1A  9N CF₃ 1 1 H H CH₂OH H H H H OCF₃ H 1A 10N CF₃ 1 1H H CH₂OH H Br H H OCF₃ H 1A 11N CF₃ 1 1 H H CH₂OH H CF₃ F H CF₃ H 1A12N CF₃ 1 1 H H CH₂OH H CH₃ H H CF₃ H 1A 13N CF₃ 1 1 H H CH₂OH H CF₃ H HCF₃ H 1A 14N CF₃ 1 1 H H CH₂OH H CH₃ H H OCF₃ H 1A 15N CF₃ 1 1 H H CH₂OHH F F H OCF₃ H 1A 16N CF₃ 1 1 H H CH₂OH H Br H H CF₃ H 1A 17N CF₃ 1 1 HH CH₂OH H CF₃ F H OCF₃ H 1A 18N CF₃ 1 1 H H CH₂OH H F H H OCF₃ H 1A 19NCF₃ 1 1 H H CH₂OH H Cl H H OCF₃ H 1A 20N CF₃ 1 1 H H CH₂OH H F H H CF₃ H1A 21N CF₃ 1 1 H H CH₂OH H F F H CF₃ H 1A 22N CF₃ 1 1 H H CH₂OH H Cl H HCF₃ H 1A 23N CF₃ 1 1 H H CH₂OH H F H H phenoxy H 1A 24N CF₃ 1 1 H HCH₂OH H CF₃ Cl H CH₃ H 1A 25N CF₃ 1 1 H H CH₂OH H CF₃ F H CH₃ H 1A 26NCF₃ 1 1 H H CH₂OH H H H H CF₃ H 1A 27N CF₃ 1 1 H H CH₂OH F F H H CF₃ H1A 28N CF₃ 1 1 H H CH₂OH H H OCH₃ H CF₃ H 1A 29N CF₃ 1 1 H H CH₂OH H F FH CH₃ H 1A 30N CF₃ 1 1 H H CH₂OH H OCH₃ H H CH₃ H 1A 31N CF₃ 1 1 H HCH₂OH H H CH₃ H H H 1A 32N CF₃ 1 1 H H CH₂OH H Cl H H H H 1A 33N CF₃ 1 1H H CH₂OH H F H H F H 1A 34N CF₃ 1 1 H H CH₂OH H H OCH₃ H CH₃ H 1A 35NCF₃ 1 1 H H CH₂OH H H H H H H 1A 36N CF₃ 1 1 H H CH₂OH H H CH₃ H CH₃ H1A 37N CF₃ 1 1 H H CH₂OH H H Cl H H H 1A 38N CF₃ 1 1 H H CH₂OH H F H H3-CF₃-phenoxy H 1A 39N CF₃ 1 1 H H CH₂OH H F H H 4-CH₃O-phenoxy H 1A 40NCF₃ 1 1 H H CH₂OH H F H H 4-Cl-phenoxy H 1A 41N CF₃ 1 1 H H CH₂OH H F HH H H 1A 42N CF₃ 1 1 H H CH₂OH H F H H CH₃ H 1A 43N CF₃ 1 1 H H CH₂OH HF H F CH₃ H 1A 44N CF₃ 1 1 H H CH₂OH F F H H CH₃ H 1A 45N CF₃ 1 1 H HCH₂OH H Cl H H CH₃ H 1A 46N CF₃ 1 1 H H CH₂OH H CH₃ H H CH₃ H 1A 47N CF₃1 1 H H CH₂OH CH₃ H H H H H 1A 48N CF₃ 1 1 H H CH₂OH H H CH₃ H CF₃ H 1A49N CF₃ 1 1 H H CH₂OH CH₃ H H H CF₃ H 1A 50N CF₃ 1 1 H H CH₂OH CH₃ H H HCH₃ H 1A 51N CF₃ 1 1 H H CH₂OH H H CH₃ H F H 1A 52N CF₃ 1 1 H H CH₂OH HCF₃ H H F H 1A 53N CF₃ 1 1 H H CH₂OH H CF₃ H H CH₃ H 1A 54N CF₃ 1 1 H HCH₂OH H OCH₃ H H CF₃ H 1A 55N CF₃ 1 1 H H CH₂OH OCH₃ H H H CH₃ H 1A 56NCF₃ 1 1 H H CH₂OH H H CH₃ H CF₃ H 1A 57N CF₃ 1 1 H H CH₂OH H C₆H₅O H H HOCF₃ 1A 58N CF₃ 1 1 H H CH₂OH H H H H H OCF₃ 1A 59N CF₃ 1 1 H H CH₂OH HOCF₃ H H H OCF₃ 1A 60N CF₃ 1 1 H H CH₂OH H CF₃ F H H CF₃ 1A 61N CF₃ 1 1H H CH₂OH H H OCH₃ H H CF₃ 1A 62N CF₃ 1 1 H H CH₂OH H CH₃ H H H CF₃ 1A63N CF₃ 1 1 H H CH₂OH H Cl H H H CF₃ 1A 64N CF₃ 1 1 H H CH₂OH H CF₃ H HH OCF₃ 1A 65N CF₃ 1 1 H H CH₂OH H F H H H OCF₃ 1A 66N CF₃ 1 1 H H CH₂OHH F H F H OCF₃ 1A 67N CF₃ 1 1 H H CH₂OH H Br H H H OCF₃ 1A 68N CF₃ 1 1 HH CH₂OH H Cl H H H OCF₃ 1A 69N CF₃ 1 1 H H CH₂OH H F F H H OCF₃ 1A 70NCF₃ 1 1 H H CH₂OH H F H H H phenyl 1A 71N CF₃ 1 1 H H CH₂OH H CH₃ H H HOCF₃ 1A 72N CF₃ 1 1 H H CH₂OH H F F H H CF₃ 1A 73N CF₃ 1 1 H H CH₂OH HCl H H H CH₃ 1A 74N CF₃ 1 1 H H CH₂OH H OCH₃ H H H CH₃ 1A 75N CF₃ 1 1 HH CH₂OH H F H H H CH₃ 1A 76N CF₃ 1 1 H H CH₂OH F F H H H OCF₃ 1A 77N CF₃1 1 H H CH₂OH OCH₃ H H H H CF₃ 1A 78N CF₃ 1 1 H H CH₂OH H H OCH₃ H H CH₃1A 79N CF₃ 1 1 H H CH₂OH H H CH₃ H H CH₃ 1A 80N CF₃ 1 1 H H CH₂OH H CH₃H H H CH₃ 1A 81N CF₃ 1 1 H H CH₂OH CH₃ H H H H CH₃ 1A 82N CF₃ 1 1 H HCH₂OH H F F H H CH₃ 1A 83N CF₃ 1 1 H H CH₂OH H F H F H CH₃ 1A 84N CF₃ 11 H H CH₂OH F F H H H CH₃ 1A 85N CF₃ 1 1 H H CH₂OH F CF₃ H H H CH₃ 1A86N CF₃ 1 1 H H CH₂OH H H CH₃ H H CF₃ 1A 87N CF₃ 1 1 H H CH₂OH CH₃ H H HH CF₃ 1A 88N CF₃ 1 1 H H CH₂OH H CF₃ H H H CH₃ 1A 89N CF₃ 1 1 H H CH₂OHOCH₃ H H H H CH₃ 1A 90N CF₃ 1 1 H H CH₂OH H H CF₃ H H CH₃ 1A 91N CF₃ 1 1H H CH₂OH CF₃ H H H H CH₃ 1A 92N CF₃ 1 1 H H CH₂OH H CF₃ F H H CH₃ 2A 1N CF₃ 1 2 H H OH H C₆H₅O H H OCF₂CF₂H H 2A  2N CF₃ 1 2 H H OH H OCF₃ HH OCF₂CF₂H H 2A  3N CF₃ 1 2 H H OH F H H F OCF₂CF₂H H 2A  4N CF₃ 1 2 H HOH H F H H OCF₂CF₂H H 2A  5N CF₃ 1 2 H H OH H C₆H₅O H H OCF₃ H 2A  6NCF₃ 1 2 H H OH H OCF₃ H H OCF₃ H 2A  7N CF₃ 1 2 H H OH H H phenyl H OCF₃H 2A  8N CF₃ 1 2 H H OH H phenyl H H OCF₃ H 2A  9N CF₃ 1 2 H H OH H H HH OCF₃ H 2A 10N CF₃ 1 2 H H OH H Br H H OCF₃ H 2A 11N CF₃ 1 2 H H OH HCF₃ F H CF₃ H 2A 12N CF₃ 1 2 H H OH H CH₃ H H CF₃ H 2A 13N CF₃ 1 2 H HOH H CF₃ H H CF₃ H 2A 14N CF₃ 1 2 H H OH H CH₃ H H OCF₃ H 2A 15N CF₃ 1 2H H OH H F F H OCF₃ H 2A 16N CF₃ 1 2 H H OH H Br H H CF₃ H 2A 17N CF₃ 12 H H OH H CF₃ F H OCF₃ H 2A 18N CF₃ 1 2 H H OH H F H H OCF₃ H 2A 19NCF₃ 1 2 H H OH H Cl H H OCF₃ H 2A 20N CF₃ 1 2 H H OH H F H H CF₃ H 2A21N CF₃ 1 2 H H OH H F F H CF₃ H 2A 22N CF₃ 1 2 H H OH H Cl H H CF₃ H 2A23N CF₃ 1 2 H H OH H F H H phenoxy H 2A 24N CF₃ 1 2 H H OH H CF₃ Cl HCH₃ H 2A 25N CF₃ 1 2 H H OH H CF₃ F H CH₃ H 2A 26N CF₃ 1 2 H H OH H H HH CF₃ H 2A 27N CF₃ 1 2 H H OH F F H H CF₃ H 2A 28N CF₃ 1 2 H H OH H HOCH₃ H CF₃ H 2A 29N CF₃ 1 2 H H OH H F F H CH₃ H 2A 30N CF₃ 1 2 H H OH HOCH₃ H H CH₃ H 2A 31N CF₃ 1 2 H H OH H H CH₃ H H H 2A 32N CF₃ 1 2 H H OHH Cl H H H H 2A 33N CF₃ 1 2 H H OH H F H H F H 2A 34N CF₃ 1 2 H H OH H HOCH₃ H CH₃ H 2A 35N CF₃ 1 2 H H OH H H H H H H 2A 36N CF₃ 1 2 H H OH H HCH₃ H CH₃ H 2A 37N CF₃ 1 2 H H OH H H Cl H H H 2A 38N CF₃ 1 2 H H OH H FH H 3-CF₃-phenoxy H 2A 39N CF₃ 1 2 H H OH H F H H 4-CH₃O-phenoxy H 2A40N CF₃ 1 2 H H OH H F H H 4-Cl-phenoxy H 2A 41N CF₃ 1 2 H H OH H F H HH H 2A 42N CF₃ 1 2 H H OH H F H H CH₃ H 2A 43N CF₃ 1 2 H H OH H F H FCH₃ H 2A 44N CF₃ 1 2 H H OH F F H H CH₃ H 2A 45N CF₃ 1 2 H H OH H Cl H HCH₃ H 2A 46N CF₃ 1 2 H H OH H CH₃ H H CH₃ H 2A 47N CF₃ 1 2 H H OH CH₃ HH H H H 2A 48N CF₃ 1 2 H H OH H H CH₃ H CF₃ H 2A 49N CF₃ 1 2 H H OH CH₃H H H CF₃ H 2A 50N CF₃ 1 2 H H OH CH₃ H H H CH₃ H 2A 51N CF₃ 1 2 H H OHH H CH₃ H F H 2A 52N CF₃ 1 2 H H OH H CF₃ H H F H 2A 53N CF₃ 1 2 H H OHH CF₃ H H CH₃ H 2A 54N CF₃ 1 2 H H OH H OCH₃ H H CF₃ H 2A 55N CF₃ 1 2 HH OH OCH₃ H H H CH₃ H 2A 56N CF₃ 1 2 H H OH H H CH₃ H CF₃ H 2A 57N CF₃ 12 H H OH H C₆H₅O H H H OCF₃ 2A 58N CF₃ 1 2 H H OH H H H H H OCF₃ 2A 59NCF₃ 1 2 H H OH H OCF₃ H H H OCF₃ 2A 60N CF₃ 1 2 H H OH H CF₃ F H H CF₃2A 61N CF₃ 1 2 H H OH H H OCH₃ H H CF₃ 2A 62N CF₃ 1 2 H H OH H CH₃ H H HCF₃ 2A 63N CF₃ 1 2 H H OH H Cl H H H CF₃ 2A 64N CF₃ 1 2 H H OH H CF₃ H HH OCF₃ 2A 65N CF₃ 1 2 H H OH H F H H H OCF₃ 2A 66N CF₃ 1 2 H H OH H F HF H OCF₃ 2A 67N CF₃ 1 2 H H OH H Br H H H OCF₃ 2A 68N CF₃ 1 2 H H OH HCl H H H OCF₃ 2A 69N CF₃ 1 2 H H OH H F F H H OCF₃ 2A 70N CF₃ 1 2 H H OHH F H H H phenyl 2A 71N CF₃ 1 2 H H OH H CH₃ H H H OCF₃ 2A 72N CF₃ 1 2 HH OH H F F H H CF₃ 2A 73N CF₃ 1 2 H H OH H Cl H H H CH₃ 2A 74N CF₃ 1 2 HH OH H OCH₃ H H H CH₃ 2A 75N CF₃ 1 2 H H OH H F H H H CH₃ 2A 76N CF₃ 1 2H H OH F F H H H OCF₃ 2A 77N CF₃ 1 2 H H OH OCH₃ H H H H CF₃ 2A 78N CF₃1 2 H H OH H H OCH₃ H H CH₃ 2A 79N CF₃ 1 2 H H OH H H CH₃ H H CH₃ 2A 80NCF₃ 1 2 H H OH H CH₃ H H H CH₃ 2A 81N CF₃ 1 2 H H OH CH₃ H H H H CH₃ 2A82N CF₃ 1 2 H H OH H F F H H CH₃ 2A 83N CF₃ 1 2 H H OH H F H F H CH₃ 2A84N CF₃ 1 2 H H OH F F H H H CH₃ 2A 85N CF₃ 1 2 H H OH F CF₃ H H H CH₃2A 86N CF₃ 1 2 H H OH H H CH₃ H H CF₃ 2A 87N CF₃ 1 2 H H OH CH₃ H H H HCF₃ 2A 88N CF₃ 1 2 H H OH H CF₃ H H H CH₃ 2A 89N CF₃ 1 2 H H OH OCH₃ H HH H CH₃ 2A 90N CF₃ 1 2 H H OH H H CF₃ H H CH₃ 2A 91N CF₃ 1 2 H H OH CF₃H H H H CH₃ 2A 92N CF₃ 1 2 H H OH H CF₃ F H H CH₃ 3A  1N CF₃CH₂CH₂ 1 1 HH OH H C₆H₅O H H OCF₂CF₂H H 3A  2N CF₃CH₂CH₂ 1 1 H H OH H OCF₃ H HOCF₂CF₂H H 3A  3N CF₃CH₂CH₂ 1 1 H H OH F H H F OCF₂CF₂H H 3A  4NCF₃CH₂CH₂ 1 1 H H OH H F H H OCF₂CF₂H H 3A  5N CF₃CH₂CH₂ 1 1 H H OH HC₆H₅O H H OCF₃ H 3A  6N CF₃CH₂CH₂ 1 1 H H OH H OCF₃ H H OCF₃ H 3A  7NCF₃CH₂CH₂ 1 1 H H OH H H phenyl H OCF₃ H 3A  8N CF₃CH₂CH₂ 1 1 H H OH Hphenyl H H OCF₃ H 3A  9N CF₃CH₂CH₂ 1 1 H H OH H H H H OCF₃ H 3A 10NCF₃CH₂CH₂ 1 1 H H OH H Br H H OCF₃ H 3A 11N CF₃CH₂CH₂ 1 1 H H OH H CF₃ FH CF₃ H 3A 12N CF₃CH₂CH₂ 1 1 H H OH H CH₃ H H CF₃ H 3A 13N CF₃CH₂CH₂ 1 1H H OH H CF₃ H H CF₃ H 3A 14N CF₃CH₂CH₂ 1 1 H H OH H CH₃ H H OCF₃ H 3A15N CF₃CH₂CH₂ 1 1 H H OH H F F H OCF₃ H 3A 16N CF₃CH₂CH₂ 1 1 H H OH H BrH H CF₃ H 3A 17N CF₃CH₂CH₂ 1 1 H H OH H CF₃ F H OCF₃ H 3A 18N CF₃CH₂CH₂1 1 H H OH H F H H OCF₃ H 3A 19N CF₃CH₂CH₂ 1 1 H H OH H Cl H H OCF₃ H 3A20N CF₃CH₂CH₂ 1 1 H H OH H F H H CF₃ H 3A 21N CF₃CH₂CH₂ 1 1 H H OH H F FH CF₃ H 3A 22N CF₃CH₂CH₂ 1 1 H H OH H Cl H H CF₃ H 3A 23N CF₃CH₂CH₂ 1 1H H OH H F H H phenoxy H 3A 24N CF₃CH₂CH₂ 1 1 H H OH H CF₃ Cl H CH₃ H 3A25N CF₃CH₂CH₂ 1 1 H H OH H CF₃ F H CH₃ H 3A 26N CF₃CH₂CH₂ 1 1 H H OH H HH H CF₃ H 3A 27N CF₃CH₂CH₂ 1 1 H H OH F F H H CF₃ H 3A 28N CF₃CH₂CH₂ 1 1H H OH H H OCH₃ H CF₃ H 3A 29N CF₃CH₂CH₂ 1 1 H H OH H F F H CH₃ H 3A 30NCF₃CH₂CH₂ 1 1 H H OH H OCH₃ H H CH₃ H 3A 31N CF₃CH₂CH₂ 1 1 H H OH H HCH₃ H H H 3A 32N CF₃CH₂CH₂ 1 1 H H OH H Cl H H H H 3A 33N CF₃CH₂CH₂ 1 1H H OH H F H H F H 3A 34N CF₃CH₂CH₂ 1 1 H H OH H H OCH₃ H CH₃ H 3A 35NCF₃CH₂CH₂ 1 1 H H OH H H H H H H 3A 36N CF₃CH₂CH₂ 1 1 H H OH H H CH₃ HCH₃ H 3A 37N CF₃CH₂CH₂ 1 1 H H OH H H Cl H H H 3A 38N CF₃CH₂CH₂ 1 1 H HOH H F H H 3-CF₃-phenoxy H 3A 39N CF₃CH₂CH₂ 1 1 H H OH H F H H4-CH₃O-phenoxy H 3A 40N CF₃CH₂CH₂ 1 1 H H OH H F H H 4-Cl-phenoxy H 3A41N CF₃CH₂CH₂ 1 1 H H OH H F H H H H 3A 42N CF₃CH₂CH₂ 1 1 H H OH H F H HCH₃ H 3A 43N CF₃CH₂CH₂ 1 1 H H OH H F H F CH₃ H 3A 44N CF₃CH₂CH₂ 1 1 H HOH F F H H CH₃ H 3A 45N CF₃CH₂CH₂ 1 1 H H OH H Cl H H CH₃ H 3A 46NCF₃CH₂CH₂ 1 1 H H OH H CH₃ H H CH₃ H 3A 47N CF₃CH₂CH₂ 1 1 H H OH CH₃ H HH H H 3A 48N CF₃CH₂CH₂ 1 1 H H OH H H CH₃ H CF₃ H 3A 49N CF₃CH₂CH₂ 1 1 HH OH CH₃ H H H CF₃ H 3A 50N CF₃CH₂CH₂ 1 1 H H OH CH₃ H H H CH₃ H 3A 51NCF₃CH₂CH₂ 1 1 H H OH H H CH₃ H F H 3A 52N CF₃CH₂CH₂ 1 1 H H OH H CF₃ H HF H 3A 53N CF₃CH₂CH₂ 1 1 H H OH H CF₃ H H CH₃ H 3A 54N CF₃CH₂CH₂ 1 1 H HOH H OCH₃ H H CF₃ H 3A 55N CF₃CH₂CH₂ 1 1 H H OH OCH₃ H H H CH₃ H 3A 56NCF₃CH₂CH₂ 1 1 H H OH H H CH₃ H CF₃ H 3A 57N CF₃CH₂CH₂ 1 1 H H OH H C₆H₅OH H H OCF₃ 3A 58N CF₃CH₂CH₂ 1 1 H H OH H H H H H OCF₃ 3A 59N CF₃CH₂CH₂ 11 H H OH H OCF₃ H H H OCF₃ 3A 60N CF₃CH₂CH₂ 1 1 H H OH H CF₃ F H H CF₃3A 61N CF₃CH₂CH₂ 1 1 H H OH H H OCH₃ H H CF₃ 3A 62N CF₃CH₂CH₂ 1 1 H H OHH CH₃ H H H CF₃ 3A 63N CF₃CH₂CH₂ 1 1 H H OH H Cl H H H CF₃ 3A 64NCF₃CH₂CH₂ 1 1 H H OH H CF₃ H H H OCF₃ 3A 65N CF₃CH₂CH₂ 1 1 H H OH H F HH H OCF₃ 3A 66N CF₃CH₂CH₂ 1 1 H H OH H F H F H OCF₃ 3A 67N CF₃CH₂CH₂ 1 1H H OH H Br H H H OCF₃ 3A 68N CF₃CH₂CH₂ 1 1 H H OH H Cl H H H OCF₃ 3A69N CF₃CH₂CH₂ 1 1 H H OH H F F H H OCF₃ 3A 70N CF₃CH₂CH₂ 1 1 H H OH H FH H H phenyl 3A 71N CF₃CH₂CH₂ 1 1 H H OH H CH₃ H H H OCF₃ 3A 72NCF₃CH₂CH₂ 1 1 H H OH H F F H H CF₃ 3A 73N CF₃CH₂CH₂ 1 1 H H OH H Cl H HH CH₃ 3A 74N CF₃CH₂CH₂ 1 1 H H OH H OCH₃ H H H CH₃ 3A 75N CF₃CH₂CH₂ 1 1H H OH H F H H H CH₃ 3A 76N CF₃CH₂CH₂ 1 1 H H OH F F H H H OCF₃ 3A 77NCF₃CH₂CH₂ 1 1 H H OH OCH₃ H H H H CF₃ 3A 78N CF₃CH₂CH₂ 1 1 H H OH H HOCH₃ H H CH₃ 3A 79N CF₃CH₂CH₂ 1 1 H H OH H H CH₃ H H CH₃ 3A 80NCF₃CH₂CH₂ 1 1 H H OH H CH₃ H H H CH₃ 3A 81N CF₃CH₂CH₂ 1 1 H H OH CH₃ H HH H CH₃ 3A 82N CF₃CH₂CH₂ 1 1 H H OH H F F H H CH₃ 3A 83N CF₃CH₂CH₂ 1 1 HH OH H F H F H CH₃ 3A 84N CF₃CH₂CH₂ 1 1 H H OH F F H H H CH₃ 3A 85NCF₃CH₂CH₂ 1 1 H H OH F CF₃ H H H CH₃ 3A 86N CF₃CH₂CH₂ 1 1 H H OH H H CH₃H H CF₃ 3A 87N CF₃CH₂CH₂ 1 1 H H OH CH₃ H H H H CF₃ 3A 88N CF₃CH₂CH₂ 1 1H H OH H CF₃ H H H CH₃ 3A 89N CF₃CH₂CH₂ 1 1 H H OH OCH₃ H H H H CH₃ 3A90N CF₃CH₂CH₂ 1 1 H H OH H H CF₃ H H CH₃ 3A 91N CF₃CH₂CH₂ 1 1 H H OH CF₃H H H H CH₃ 3A 92N CF₃CH₂CH₂ 1 1 H H OH H CF₃ F H H CH₃ 4A  1N CF₃ 1 1 HH OH H C₆H₅O H H OCF₂CF₂H H 4A  2N CF₃ 1 1 H H OH H OCF₃ H H OCF₂CF₂H H4A  3N CF₃ 1 1 H H OH F H H F OCF₂CF₂H H 4A  4N CF₃ 1 1 H H OH H F H HOCF₂CF₂H H 4A  5N CF₃ 1 1 H H OH H C₆H₅O H H OCF₃ H 4A  6N CF₃ 1 1 H HOH H OCF₃ H H OCF₃ H 4A  7N CF₃ 1 1 H H OH H H phenyl H OCF₃ H 4A  8NCF₃ 1 1 H H OH H phenyl H H OCF₃ H 4A  9N CF₃ 1 1 H H OH H H H H OCF₃ H4A 10N CF₃ 1 1 H H OH H Br H H OCF₃ H 4A 11N CF₃ 1 1 H H OH H CF₃ F HCF₃ H 4A 12N CF₃ 1 1 H H OH H CH₃ H H CF₃ H 4A 13N CF₃ 1 1 H H OH H CF₃H H CF₃ H 4A 14N CF₃ 1 1 H H OH H CH₃ H H OCF₃ H 4A 15N CF₃ 1 1 H H OH HF F H OCF₃ H 4A 16N CF₃ 1 1 H H OH H Br H H CF₃ H 4A 17N CF₃ 1 1 H H OHH CF₃ F H OCF₃ H 4A 18N CF₃ 1 1 H H OH H F H H OCF₃ H 4A 19N CF₃ 1 1 H HOH H Cl H H OCF₃ H 4A 20N CF₃ 1 1 H H OH H F H H CF₃ H 4A 21N CF₃ 1 1 HH OH H F F H CF₃ H 4A 22N CF₃ 1 1 H H OH H Cl H H CF₃ H 4A 23N CF₃ 1 1 HH OH H F H H phenoxy H 4A 24N CF₃ 1 1 H H OH H CF₃ Cl H CH₃ H 4A 25N CF₃1 1 H H OH H CF₃ F H CH₃ H 4A 26N CF₃ 1 1 H H OH H H H H CF₃ H 4A 27NCF₃ 1 1 H H OH F F H H CF₃ H 4A 28N CF₃ 1 1 H H OH H H OCH₃ H CF₃ H 4A29N CF₃ 1 1 H H OH H F F H CH₃ H 4A 30N CF₃ 1 1 H H OH H OCH₃ H H CH₃ H4A 31N CF₃ 1 1 H H OH H H CH₃ H H H 4A 32N CF₃ 1 1 H H OH H Cl H H H H4A 33N CF₃ 1 1 H H OH H F H H F H 4A 34N CF₃ 1 1 H H OH H H OCH₃ H CH₃ H4A 35N CF₃ 1 1 H H OH H H H H H H 4A 36N CF₃ 1 1 H H OH H H CH₃ H CH₃ H4A 37N CF₃ 1 1 H H OH H H Cl H H H 4A 38N CF₃ 1 1 H H OH H F H H3-CF₃-phenoxy H 4A 39N CF₃ 1 1 H H OH H F H H 4-CH₃O-phenoxy H 4A 40NCF₃ 1 1 H H OH H F H H 4-Cl-phenoxy H 4A 41N CF₃ 1 1 H H OH H F H H H H4A 42N CF₃ 1 1 H H OH H F H H CH₃ H 4A 43N CF₃ 1 1 H H OH H F H F CH₃ H4A 44N CF₃ 1 1 H H OH F F H H CH₃ H 4A 45N CF₃ 1 1 H H OH H Cl H H CH₃ H4A 46N CF₃ 1 1 H H OH H CH₃ H H CH₃ H 4A 47N CF₃ 1 1 H H OH CH₃ H H H HH 4A 48N CF₃ 1 1 H H OH H H CH₃ H CF₃ H 4A 49N CF₃ 1 1 H H OH CH₃ H H HCF₃ H 4A 50N CF₃ 1 1 H H OH CH₃ H H H CH₃ H 4A 51N CF₃ 1 1 H H OH H HCH₃ H F H 4A 52N CF₃ 1 1 H H OH H CF₃ H H F H 4A 53N CF₃ 1 1 H H OH HCF₃ H H CH₃ H 4A 54N CF₃ 1 1 H H OH H OCH₃ H H CF₃ H 4A 55N CF₃ 1 1 H HOH OCH₃ H H H CH₃ H 4A 56N CF₃ 1 1 H H OH H H CH₃ H CF₃ H 4A 57N CF₃ 1 1H H OH H C₆H₅O H H H OCF₃ 4A 58N CF₃ 1 1 H H OH H H H H H OCF₃ 4A 59NCF₃ 1 1 H H OH H OCF₃ H H H OCF₃ 4A 60N CF₃ 1 1 H H OH H CF₃ F H H CF₃4A 61N CF₃ 1 1 H H OH H H OCH₃ H H CF₃ 4A 62N CF₃ 1 1 H H OH H CH₃ H H HCF₃ 4A 63N CF₃ 1 1 H H OH H Cl H H H CF₃ 4A 64N CF₃ 1 1 H H OH H CF₃ H HH OCF₃ 4A 65N CF₃ 1 1 H H OH H F H H H OCF₃ 4A 66N CF₃ 1 1 H H OH H F HF H OCF₃ 4A 67N CF₃ 1 1 H H OH H Br H H H OCF₃ 4A 68N CF₃ 1 1 H H OH HCl H H H OCF₃ 4A 69N CF₃ 1 1 H H OH H F F H H OCF₃ 4A 70N CF₃ 1 1 H H OHH F H H H phenyl 4A 71N CF₃ 1 1 H H OH H CH₃ H H H OCF₃ 4A 72N CF₃ 1 1 HH OH H F F H H CF₃ 4A 73N CF₃ 1 1 H H OH H Cl H H H CH₃ 4A 74N CF₃ 1 1 HH OH H OCH₃ H H H CH₃ 4A 75N CF₃ 1 1 H H OH H F H H H CH₃ 4A 76N CF₃ 1 1H H OH F F H H H OCF₃ 4A 77N CF₃ 1 1 H H OH OCH₃ H H H H CF₃ 4A 78N CF₃1 1 H H OH H H OCH₃ H H CH₃ 4A 79N CF₃ 1 1 H H OH H H CH₃ H H CH₃ 4A 80NCF₃ 1 1 H H OH H CH₃ H H H CH₃ 4A 81N CF₃ 1 1 H H OH CH₃ H H H H CH₃ 4A82N CF₃ 1 1 H H OH H F F H H CH₃ 4A 83N CF₃ 1 1 H H OH H F H F H CH₃ 4A84N CF₃ 1 1 H H OH F F H H H CH₃ 4A 85N CF₃ 1 1 H H OH F CF₃ H H H CH₃4A 86N CF₃ 1 1 H H OH H H CH₃ H H CF₃ 4A 87N CF₃ 1 1 H H OH CH₃ H H H HCF₃ 4A 88N CF₃ 1 1 H H OH H CF₃ H H H CH₃ 4A 89N CF₃ 1 1 H H OH OCH₃ H HH H CH₃ 4A 90N CF₃ 1 1 H H OH H H CF₃ H H CH₃ 4A 91N CF₃ 1 1 H H OH CF₃H H H H CH₃ 4A 92N CF₃ 1 1 H H OH H CF₃ F H H CH₃

TABLE 16 Structure of Substituted Phenyltertiary-omega-Heteroalkylamines(Z and Y are each CH; R₇, R₈, R₁₂, R₁₃, R₁₄ and R₁₅ are each H).

Inhibitor Number Column 1 + Column 2 Reagent Reagent R₁ n m R₂ R₃ XR₁₆R₄ R₅ R₆ R₉ R₁₀ R₁₁ 1A  1DB CF₃ 1 1 H H CH₂OH H OCF₃ H H OCF₃ H 1A  2DBCF₃ 1 1 H H CH₂OH H Cl H H H CF₃ 1A  3DB CF₃ 1 1 H H CH₂OH H Br H H OCF₃H 1A  4DB CF₃ 1 1 H H CH₂OH H Cl H H OCF₃ H 1A  5DB CF₃ 1 1 H H CH₂OH HCl H H CF₃ H 1A  6DB CF₃ 1 1 H H CH₂OH H H Cl H CF₃ H 1A  7DB CF₃ 1 1 HH CH₂OH H F H H OCF₃ H 1A  8DB CF₃ 1 1 H H CH₂OH H H Cl H H CF₃ 1A  9DBCF₃ 1 1 H H CH₂OH H F H H H CF₃ 1A 10DB CF₃ 1 1 H H CH₂OH H H F H H CF₃1A 11DB CF₃ 1 1 H H CH₂OH F H H H H CF₃ 1A 12DB CF₃ 1 1 H H CH₂OH H Cl HCF₃ H H 1A 13DB CF₃ 1 1 H H CH₂OH H H Cl CF₃ H H 1A 14DB CF₃ 1 1 H HCH₂OH Cl H H CF₃ H H 1A 15DB CF₃ 1 1 H H CH₂OH H F H CH₃ H H 1A 16DB CF₃1 1 H H CH₂OH H H F H H CH₃ 1A 17DB CF₃ 1 1 H H CH₂OH H F H H CH₃ H 1A18DB CF₃ 1 1 H H CH₂OH F H H CH₃ H H 1A 19DB CF₃ 1 1 H H CH₂OH H H F HCH₃ H 1A 20DB CF₃ 1 1 H H CH₂OH F H H H H CH₃ 1A 21DB CF₃ 1 1 H H CH₂OHF H H H CF₃ H 1A 22DB CF₃ 1 1 H H CH₂OH Cl H H H CF₃ H 1A 23DB CF₃ 1 1 HH CH₂OH H F H CF₃ H H 1A 24DB CF₃ 1 1 H H CH₂OH H H F CF₃ H H 1A 25DBCF₃ 1 1 H H CH₂OH H F H H CF₃ H 1A 26DB CF₃ 1 1 H H CH₂OH H H F H CF₃ H1A 27DB CF₃ 1 1 H H CH₂OH H OCF₃ H H H OCF₃ 2A  1DB CF₃ 1 2 H H OH HOCF₃ H H OCF₃ H 2A  2DB CF₃ 1 2 H H OH H Cl H H H CF₃ 2A  3DB CF₃ 1 2 HH OH H Br H H OCF₃ H 2A  4DB CF₃ 1 2 H H OH H Cl H H OCF₃ H 2A  5DB CF₃1 2 H H OH H Cl H H CF₃ H 2A  6DB CF₃ 1 2 H H OH H H Cl H CF₃ H 2A  7DBCF₃ 1 2 H H OH H F H H OCF₃ H 2A  8DB CF₃ 1 2 H H OH H H Cl H H CF₃ 2A 9DB CF₃ 1 2 H H OH H F H H H CF₃ 2A 10DB CF₃ 1 2 H H OH H H F H H CF₃2A 11DB CF₃ 1 2 H H OH F H H H H CF₃ 2A 12DB CF₃ 1 2 H H OH H Cl H CF₃ HH 2A 13DB CF₃ 1 2 H H OH H H Cl CF₃ H H 2A 14DB CF₃ 1 2 H H OH Cl H HCF₃ H H 2A 15DB CF₃ 1 2 H H OH H F H CH₃ H H 2A 16DB CF₃ 1 2 H H OH H HF H H CH₃ 2A 17DB CF₃ 1 2 H H OH H F H H CH₃ H 2A 18DB CF₃ 1 2 H H OH FH H CH₃ H H 2A 19DB CF₃ 1 2 H H OH H H F H CH₃ H 2A 20DB CF₃ 1 2 H H OHF H H H H CH₃ 2A 21DB CF₃ 1 2 H H OH F H H H CF₃ H 2A 22DB CF₃ 1 2 H HOH Cl H H H CF₃ H 2A 23DB CF₃ 1 2 H H OH H F H CF₃ H H 2A 24DB CF₃ 1 2 HH OH H H F CF₃ H H 2A 25DB CF₃ 1 2 H H OH H F H H CF₃ H 2A 26DB CF₃ 1 2H H OH H H F H CF₃ H 2A 27DB CF₃ 1 2 H H OH H OCF₃ H H H OCF₃ 3A  1DBCF₃CH₂CH₂ 1 1 H H OH H OCF₃ H H OCF₃ H 3A  2DB CF₃CH₂CH₂ 1 1 H H OH H ClH H H CF₃ 3A  3DB CF₃CH₂CH₂ 1 1 H H OH H Br H H OCF₃ H 3A  4DB CF₃CH₂CH₂1 1 H H OH H Cl H H OCF₃ H 3A  5DB CF₃CH₂CH₂ 1 1 H H OH H Cl H H CF₃ H3A  6DB CF₃CH₂CH₂ 1 1 H H OH H H Cl H CF₃ H 3A  7DB CF₃CH₂CH₂ 1 1 H H OHH F H H OCF₃ H 3A  8DB CF₃CH₂CH₂ 1 1 H H OH H H Cl H H CF₃ 3A  9DBCF₃CH₂CH₂ 1 1 H H OH H F H H H CF₃ 3A 10DB CF₃CH₂CH₂ 1 1 H H OH H H F HH CF₃ 3A 11DB CF₃CH₂CH₂ 1 1 H H OH F H H H H CF₃ 3A 12DB CF₃CH₂CH₂ 1 1 HH OH H Cl H CF₃ H H 3A 13DB CF₃CH₂CH₂ 1 1 H H OH H H Cl CF₃ H H 3A 14DBCF₃CH₂CH₂ 1 1 H H OH Cl H H CF₃ H H 3A 15DB CF₃CH₂CH₂ 1 1 H H OH H F HCH₃ H H 3A 16DB CF₃CH₂CH₂ 1 1 H H OH H H F H H CH₃ 3A 17DB CF₃CH₂CH₂ 1 1H H OH H F H H CH₃ H 3A 18DB CF₃CH₂CH₂ 1 1 H H OH F H H CH₃ H H 3A 19DBCF₃CH₂CH₂ 1 1 H H OH H H F H CH₃ H 3A 20DB CF₃CH₂CH₂ 1 1 H H OH F H H HH CH₃ 3A 21DB CF₃CH₂CH₂ 1 1 H H OH F H H H CF₃ H 3A 22DB CF₃CH₂CH₂ 1 1 HH OH Cl H H H CF₃ H 3A 23DB CF₃CH₂CH₂ 1 1 H H OH H F H CF₃ H H 3A 24DBCF₃CH₂CH₂ 1 1 H H OH H H F CF₃ H H 3A 25DB CF₃CH₂CH₂ 1 1 H H OH H F H HCF₃ H 3A 26DB CF₃CH₂CH₂ 1 1 H H OH H H F H CF₃ H 3A 27DB CF₃CH₂CH₂ 1 1 HH OH H OCF₃ H H H OCF₃ 4A  1DB CF₃ 1 1 H H OH H OCF₃ H H OCF₃ H 4A  2DBCF₃ 1 1 H H OH H Cl H H H CF₃ 4A  3DB CF₃ 1 1 H H OH H Br H H OCF₃ H 4A 4DB CF₃ 1 1 H H OH H Cl H H OCF₃ H 4A  5DB CF₃ 1 1 H H OH H Cl H H CF₃H 4A  6DB CF₃ 1 1 H H OH H H Cl H CF₃ H 4A  7DB CF₃ 1 1 H H OH H F H HOCF₃ H 4A  8DB CF₃ 1 1 H H OH H H Cl H H CF₃ 4A  9DB CF₃ 1 1 H H OH H FH H H CF₃ 4A 10DB CF₃ 1 1 H H OH H H F H H CF₃ 4A 11DB CF₃ 1 1 H H OH FH H H H CF₃ 4A 12DB CF₃ 1 1 H H OH H Cl H CF₃ H H 4A 13DB CF₃ 1 1 H H OHH H Cl CF₃ H H 4A 14DB CF₃ 1 1 H H OH Cl H H CF₃ H H 4A 15DB CF₃ 1 1 H HOH H F H CH₃ H H 4A 16DB CF₃ 1 1 H H OH H H F H H CH₃ 4A 17DB CF₃ 1 1 HH OH H F H H CH₃ H 4A 18DB CF₃ 1 1 H H OH F H H CH₃ H H 4A 19DB CF₃ 1 1H H OH H H F H CH₃ H 4A 20DB CF₃ 1 1 H H OH F H H H H CH₃ 4A 21DB CF₃ 11 H H OH F H H H CF₃ H 4A 22DB CF₃ 1 1 H H OH Cl H H H CF₃ H 4A 23DB CF₃1 1 H H OH H F H CF₃ H H 4A 24DB CF₃ 1 1 H H OH H H F CF₃ H H 4A 25DBCF₃ 1 1 H H OH H F H H CF₃ H 4A 26DB CF₃ 1 1 H H OH H H F H CF₃ H 4A27DB CF₃ 1 1 H H OH H OCF₃ H H H OCF₃

TABLE 17 Structure of Substituted Phenyltertiary-2-Heteroalkylamines(Y═CH; Z is covalent bond; there is no R₁₅ substituent; R₃, R₄, R₇, R₈,R₈, R₉, R₁₂, R₁₃, R₁₄, and R₁₆ all equal H unless indicated below).

Inhibitor Number Column 1 + Column 2 Reagent Reagent R₁ R₂ X R₅ R₆ R₁₀R₁₁ 1 224N CF₃ H O C₆H₅O H OCF₂CF₂H H 1 225N CF₃ H O 4-Cl—C₆H₅O HOCF₂CF₂H H 1 226N CF₃ H O 4-F—C₆H₅O H OCF₂CF₂H H 1 227N CF₃ H O3,4-Cl—C₆H₅O H OCF₂CF₂H H 1 228N CF₃ H O H C₆H₅ OCF₂CF₂H H 1 229N CF₃ HO H 4-Cl—C₆H₅ OCF₂CF₂H H 1 230N CF₃ H O H 4-F—C₆H₅ OCF₂CF₂H H 1 231N CF₃H O H 4-Br—C₆H₅ OCF₂CF₂H H 1 232N CF₃ H O 4-Br—C₆H₅O H OCF₂CF₂H H 1 233NCF₃ H O C₆H₅O H OCF₂CF₃ H 1 234N CF₃ H O 4-Cl—C₆H₅O H OCF₂CF₃ H 1 235NCF₃ H O 4-F—C₆H₅O H OCF₂CF₃ H 1 236N CF₃ H O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 1237N CF₃ H O H C₆H₅ OCF₂CF₃ H 1 238N CF₃ H O H 4-Cl—C₆H₅ OCF₂CF₃ H 1239N CF₃ H O H 4-F—C₆H₅ CCF₂CF₃ H 1 240N CF₃ H O H 4-Br—C₆H₅ OCF₂CF₃ H 1241N CF₃ H O 4-Br—C₆H₅O H OCF₂CF₃ H 1 242N CF₃ H O C₆H₅O H OCCl₂CCl₂H H1 243N CF₃ H O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 1 244N CF₃ H O 4-F—C₆H₅O HOCCl₂CCl₂H H 1 245N CF₃ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 1 246N CF₃ H O HC₆H₅ OCCl₂CCl₂H H 1 247N CF₃ H O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 1 248N CF₃ H OH 4-F—C₆H₅ OCCl₂CCl₂H H 1 249N CF₃ H O H 4-Br—C₆H₅ OCCl₂CCl₂H H 1 250NCF₃ H O 4-Br—C₆H₅O H OCCl₂CCl₂H H 1 251N CF₃ H O C₆H₅O H OCCl₂CCl₃ H 1252N CF₃ H O 4-Cl—C₆H₅O H OCCl₂CCl₃ H 1 253N CF₃ H O 4-F—C₆H₅O HOCCl₂CCl₃ H 1 254N CF₃ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 1 255N CF₃ H O HC₆H₅ OCCl₂CCl₃ H 1 256N CF₃ H O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 1 257N CF₃ H O H4-F—C₆H₅ OCCl₂CCl₃ H 1 258N CF₃ H O H 4-Br—C₆H₅ OCCl₂CCl₃ H 1 259N CF₃ HO 4-Br—C₆H₅O H OCCl₂CCl₃ H 1 260N CF₃ H O C₆H₅O H OCCl₂CF₃ H 1 261N CF₃H O 4-Cl—C₆H₅O H OCCl₂CF₃ H 1 262N CF₃ H O 4-F—C₆H₅O H OCCl₂CF₃ H 1 263NCF₃ H O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 1 264N CF₃ H O H C₆H₅ OCCl₂CF₃ H 1265N CF₃ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 1 266N CF₃ H O H 4-F—C₆H₅ OCCl₂CF₃ H1 267N CF₃ H O H 4-Br—C₆H₅ OCCl₂CF₃ H 1 268N CF₃ H O 4-Br—C₆H₅O HOCCl₂CF₃ H 1 269N CF₃ H O C₆H₅O H OCF₂CCl₃ H 1 270N CF₃ H O 4-Cl—C₆H₅O HOCF₂CCl₃ H 1 271N CF₃ H O 4-F—C₆H₅O H OCF₂CCl₃ H 1 272N CF₃ H O3,4-Cl—C₆H₅O H OCF₂CCl₃ H 1 273N CF₃ H O H C₆H₅ OCF₂CCl₃ H 1 274N CF₃ HO H 4-Cl—C₆H₅ OCF₂CCl₃ H 1 275N CF₃ H O H 4-F—C₆H₅ OCF₂CCl₃ H 1 276N CF₃H O H 4-Br—C₆H₅ OCF₂CCl₃ H 1 277N CF₃ H O 4-Br—C₆H₅O H OCF₂CCl₃ H 1 278NCF₃ H O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 1 279N CF₃ H O 4-Cl—C₆H₅O H OCF₂CF₂HOCF₂CF₂H 1 280N CF₃ H O 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 1 281N CF₃ H O3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 1 282N CF₃ H O H C₆H₅ OCF₂CF₂H OCF₂CF₂H1 283N CF₃ H O H 4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H 1 284N CF₃ H O H 4-F—C₆H₅OCF₂CF₂H OCF₂CF₂H 1 285N CF₃ H O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 1 286NCF₃ H O 4-Br—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 1 287N CF₃ H O C₆H₅O H OCF₃ OCF₃1 288N CF₃ H O 4-Cl—C₆H₅O H OCF₃ OCF₃ 1 289N CF₃ H O 4-F—C₆H₅O H OCF₃OCF₃ 1 290N CF₃ H O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 1 291N CF₃ H O H C₆H₅ OCF₃OCF₃ 1 292N CF₃ H O H 4-Cl—C₆H₅ OCF₃ OCF₃ 1 293N CF₃ H O H 4-F—C₆H₅ OCF₃OCF₃ 1 294N CF₃ H O H 4-Br—C₆H₅ OCF₃ OCF₃ 1 295N CF₃ H O 4-Br—C₆H₅O HOCF₃ OCF₃ 1 296N CF₃ H O C₆H₅O H OCF₂H OCF₂H 1 297N CF₃ H O 4-Cl—C₆H₅O HOCF₂H OCF₂H 1 298N CF₃ H O 4-F—C₆H₅O H OCF₂H OCF₂H 1 299N CF₃ H O3,4-Cl—C₆H₅O H OCF₂H OCF₂H 1 300N CF₃ H O H C₆H₅ OCF₂H OCF₂H 1 301N CF₃H O H 4-Cl—C₆H₅ OCF₂H OCF₂H 1 302N CF₃ H O H 4-F—C₆H₅ OCF₂H OCF₂H 1 303NCF₃ H O H 4-Br—C₆H₅ OCF₂H OCF₂H 1 304N CF₃ H O 4-Br—C₆H₅O H OCF₂H OCF₂H1 305N CF₃ H O C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 1 306N CF₃ H O 4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 1 307N CF₃ H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 1308N CF₃ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 1 309N CF₃ H O H C₆H₅R₁₀ + R₁₁ = OCF₂CF₂O 1 310N CF₃ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 1311N CF₃ H O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 1 312N CF₃ H O H 4-Br—C₆H₅R₁₀ + R₁₁ = OCF₂CF₂O 1 313N CF₃ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 1314N CF₃ H O C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 1 315N CF₃ H O 4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 1 316N CF₃ H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O1 317N CF₃ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 1 318N CF₃ H O HC₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 1 319N CF₃ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 1 320N CF₃ H O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 1 321N CF₃ HO H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 1 322N CF₃ H O 4-Br—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 1 323N CF₃ H O H H OH H 1 324N CF₃ H O H H OH OH 1 325NCF₃ H O H H H OH 1 326N CF₃ H O H H OCH₂CF₃ H 1 327N CF₃ H O H H HOCH₂CF₃ 1 328N CF₃ H O H H OCH₂CF₂CF₃ H 1 329N CF₃ H O H H OCH₂CH₂CF₃ H1 330N CF₃ H O H H OCH(CF₃)₃ H 1 331N CF₃ H O H 4-F—C₆H₅O H H 1 332N CF₃H O 4-F—C₆H₅O H H H 1 333N CF₃ H O H cyclohexoxy H H 1 334N CF₃ H Ocyclohexoxy H H H 1 335N CF₃ H O H CH(CH₃)₃ H H 1 336N CF₃ H O F H

bond to indicated phenyl carbon of R₁₀ substituent 2 224N CCl₃ H O C₆H₅OH OCF₂CF₂H H 2 225N CCl₃ H O 4-Cl—C₆H₅O H OCF₂CF₂H H 2 226N CCl₃ H O4-F—C₆H₅O H OCF₂CF₂H H 2 227N CCl₃ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H H 2 228NCCl₃ H O H C₆H₅ OCF₂CF₂H H 2 229N CCl₃ H O H 4-Cl—C₆H₅ OCF₂CF₂H H 2 230NCCl₃ H O H 4-F—C₆H₅ OCF₂CF₂H H 2 231N CCl₃ H O H 4-Br—C₆H₅ OCF₂CF₂H H 2232N CCl₃ H O 4-Br—C₆H₅O H OCF₂CF₂H H 2 233N CCl₃ H O C₆H₅O H OCF₂CF₃ H2 234N CCl₃ H O 4-Cl—C₆H₅O H OCF₂CF₃ H 2 235N CCl₃ H O 4-F—C₆H₅O HOCF₂CF₃ H 2 236N CCl₃ H O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 2 237N CCl₃ H O HC₆H₅ OCF₂CF₃ H 2 238N CCl₃ H O H 4-Cl—C₆H₅ OCF₂CF₃ H 2 239N CCl₃ H O H4-F—C₆H₅ OCF₂CF₃ H 2 240N CCl₃ H O H 4-Br—C₆H₅ OCF₂CF₃ H 2 241N CCl₃ H O4-Br—C₆H₅O H OCF₂CF₃ H 2 242N CCl₃ H O C₆H₅O H OCCl₂CCl₂H H 2 243N CCl₃H O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 2 244N CCl₃ H O 4-F—C₆H₅O H OCCl₂CCl₂H H 2245N CCl₃ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 2 246N CCl₃ H O H C₆H₅OCCl₂CCl₂H H 2 247N CCl₃ H O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 2 248N CCl₃ H O H4-F—C₆H₅ OCCl₂CCl₂H H 2 249N CCl₃ H O H 4-Br—C₆H₅ OCCl₂CCl₂H H 2 250NCCl₃ H O 4-Br—C₆H₅O H OCCl₂CCl₂H H 2 251N CCl₃ H O C₆H₅O H OCCl₂CCl₃ H 2252N CCl₃ H O 4-Cl—C₆H₅O H OCCl₂CCl₃ H 2 253N CCl₃ H O 4-F—C₆H₅O HOCCl₂CCl₃ H 2 254N CCl₃ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 2 255N CCl₃ H O HC₆H₅ OCCl₂CCl₃ H 2 256N CCl₃ H O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 2 257N CCl₃ H OH 4-F—C₆H₅ OCCl₂CCl₃ H 2 258N CCl₃ H O H 4-Br—C₆H₅ OCCl₂CCl₃ H 2 259NCCl₃ H O 4-Br—C₆H₅O H OCCl₂CCl₃ H 2 260N CCl₃ H O C₆H₅O H OCCl₂CF₃ H 2261N CCl₃ H O 4-Cl—C₆H₅O H OCCl₂CF₃ H 2 262N CCl₃ H O 4-F—C₆H₅O HOCCl₂CF₃ H 2 263N CCl₃ H O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 2 264N CCl₃ H O HC₆H₅ OCCl₂CF₃ H 2 265N CCl₃ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 2 266N CCl₃ H O H4-F—C₆H₅ OCCl₂CF₃ H 2 267N CCl₃ H O H 4-Br—C₆H₅ OCCl₂CF₃ H 2 268N CCl₃ HO 4-Br—C₆H₅O H OCCl₂CF₃ H 2 269N CCl₃ H O C₆H₅O H OCF₂CCl₃ H 2 270N CCl₃H O 4-Cl—C₆H₅O H OCF₂CCl₃ H 2 271N CCl₃ H O 4-F—C₆H₅O H OCF₂CCl₃ H 2272N CCl₃ H O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 2 273N CCl₃ H O H C₆H₅ OCF₂CCl₃H 2 274N CCl₃ H O H 4-Cl—C₆H₅ OCF₂CCl₃ H 2 275N CCl₃ H O H 4-F—C₆H₅OCF₂CCl₃ H 2 276N CCl₃ H O H 4-Br—C₆H₅ OCF₂CCl₃ H 2 277N CCl₃ H O4-Br—C₆H₅O H OCF₂CCl₃ H 2 278N CCl₃ H O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 2 279NCCl₃ H O 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 2 280N CCl₃ H O 4-F—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 2 281N CCl₃ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 2282N CCl₃ H O H C₆H₅ OCF₂CF₂H OCF₂CF₂H 2 283N CCl₃ H O H 4-Cl—C₆H₅OCF₂CF₂H OCF₂CF₂H 2 284N CCl₃ H O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 2 285NCCl₃ H O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 2 286N CCl₃ H O 4-Br—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 2 287N CCl₃ H O C₆H₅O H OCF₃ OCF₃ 2 288N CCl₃ H O4-Cl—C₆H₅O H OCF₃ OCF₃ 2 289N CCl₃ H O 4-F—C₆H₅O H OCF₃ OCF₃ 2 290N CCl₃H O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 2 291N CCl₃ H O H C₆H₅ OCF₃ OCF₃ 2 292NCCl₃ H O H 4-Cl—C₆H₅ OCF₃ OCF₃ 2 293N CCl₃ H O H 4-F—C₆H₅ OCF₃ OCF₃ 2294N CCl₃ H O H 4-Br—C₆H₅ OCF₃ OCF₃ 2 295N CCl₃ H O 4-Br—C₆H₅O H OCF₃OCF₃ 2 296N CCl₃ H O C₆H₅O H OCF₂H OCF₂H 2 297N CCl₃ H O 4-Cl—C₆H₅O HOCF₂H OCF₂H 2 298N CCl₃ H O 4-F—C₆H₅O H OCF₂H OCF₂H 2 299N CCl₃ H O3,4-Cl—C₆H₅O H OCF₂H OCF₂H 2 300N CCl₃ H O H C₆H₅ OCF₂H OCF₂H 2 301NCCl₃ H O H 4-Cl—C₆H₅ OCF₂H OCF₂H 2 302N CCl₃ H O H 4-F—C₆H₅ OCF₂H OCF₂H2 303N CCl₃ H O H 4-Br—C₆H₅ OCF₂H OCF₂H 2 304N CCl₃ H O 4-Br—C₆H₅O HOCF₂H OCF₂H 2 305N CCl₃ H O C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 2 306N CCl₃ H O4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 2 307N CCl₃ H O 4-F—C₆H₅O H R₁₀ + R₁₁= OCF₂CF₂O 2 308N CCl₃ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 2 309NCCl₃ H O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 2 310N CCl₃ H O H 4-Cl—C₆H₅ R₁₀ +R₁₁ = OCF₂CF₂O 2 311N CCl₃ H O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 2 312NCCl₃ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 2 313N CCl₃ H O 4-Br—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 2 314N CCl₃ H O C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 2315N CCl₃ H O 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 2 316N CCl₃ H O4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 2 317N CCl₃ H O 3,4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 2 318N CCl₃ H O H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 2 319NCCl₃ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 2 320N CCl₃ H O H 4-F—C₆H₅R₁₀ + R₁₁ = OCCl₂CCl₂O 2 321N CCl₃ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 2 322N CCl₃ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 2 323NCCl₃ H O H H OH H 2 324N CCl₃ H O H H OH OH 2 325N CCl₃ H O H H H OH 2326N CCl₃ H O H H OCH₂CF₃ H 2 327N CCl₃ H O H H H OCH₂CF₃ 2 328N CCl₃ HO H H OCH₂CF₂CF₃ H 2 329N CCl₃ H O H H OCH₂CH₂CF₃ H 2 330N CCl₃ H O H HOCH(CF₃)₃ H 2 331N CCl₃ H O H 4-F—C₆H₅O H H 2 332N CCl₃ H O 4-F—C₆H₅O HH H 2 333N CCl₃ H O H cyclohexoxy H H 2 334N CCl₃ H O cyclohexoxy H H H2 335N CCl₃ H O H CH(CH₃)₃ H H 2 336N CCl₃ H O F H

bond to indicated phenyl carbon of R₁₀ substituent 3 224N CF₃ CH₃ OC₆H₅O H OCF₂CF₂H H 3 225N CF₃ CH₃ O 4-Cl—C₆H₅O H OCF₂CF₂H H 3 226N CF₃CH₃ O 4-F—C₆H₅O H OCF₂CF₂H H 3 227N CF₃ CH₃ O 3,4-Cl—C₆H₅O H OCF₂CF₂H H3 228N CF₃ CH₃ O H C₆H₅ OCF₂CF₂H H 3 229N CF₃ CH₃ O H 4-Cl—C₆H₅ OCF₂CF₂HH 3 230N CF₃ CH₃ O H 4-F—C₆H₅ OCF₂CF₂H H 3 231N CF₃ CH₃ O H 4-Br—C₆H₅OCF₂CF₂H H 3 232N CF₃ CH₃ O 4-Br—C₆H₅O H OCF₂CF₂H H 3 233N CF₃ CH₃ OC₆H₅O H OCF₂CF₃ H 3 234N CF₃ CH₃ O 4-Cl—C₆H₅O H OCF₂CF₃ H 3 235N CF₃ CH₃O 4-F—C₆H₅O H OCF₂CF₃ H 3 236N CF₃ CH₃ O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 3 237NCF₃ CH₃ O H C₆H₅ OCF₂CF₃ H 3 238N CF₃ CH₃ O H 4-Cl—C₆H₅ OCF₂CF₃ H 3 239NCF₃ CH₃ O H 4-F—C₆H₅ OCF₂CF₃ H 3 240N CF₃ CH₃ O H 4-Br—C₆H₅ OCF₂CF₃ H 3241N CF₃ CH₃ O 4-Br—C₆H₅O H OCF₂CF₃ H 3 242N CF₃ CH₃ O C₆H₅O HOCCl₂CCl₂H H 3 243N CF₃ CH₃ O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 3 244N CF₃ CH₃ O4-F—C₆H₅O H OCCl₂CCl₂H H 3 245N CF₃ CH₃ O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 3246N CF₃ CH₃ O H C₆H₅ OCCl₂CCl₂H H 3 247N CF₃ CH₃ O H 4-Cl—C₆H₅OCCl₂CCl₂H H 3 248N CF₃ CH₃ O H 4-F—C₆H₅ OCCl₂CCl₂H H 3 249N CF₃ CH₃ O H4-Br—C₆H₅ OCCl₂CCl₂H H 3 250N CF₃ CH₃ O 4-Br—C₆H₅O H OCCl₂CCl₂H H 3 251NCF₃ CH₃ O C₆H₅O H OCCl₂CCl₃ H 3 252N CF₃ CH₃ O 4-Cl—C₆H₅O H OCCl₂CCl₃ H3 253N CF₃ CH₃ O 4-F—C₆H₅O H OCCl₂CCl₃ H 3 254N CF₃ CH₃ O 3,4-Cl—C₆H₅O HOCCl₂CCl₃ R 3 255N CF₃ CH₃ O H C₆H₅ OCCl₂CCl₃ H 3 256N CF₃ CH₃ O H4-Cl—C₆H₅ OCCl₂CCl₃ H 3 257N CF₃ CH₃ O H 4-F—C₆H₅ OCCl₂CCl₃ H 3 258N CF₃CH₃ O H 4-Br—C₆H₅ OCCl₂CCl₃ H 3 259N CF₃ CH₃ O 4-Br—C₆H₅O H OCCl₂CCl₃ H3 260N CF₃ CH₃ O C₆H₅O H OCCl₂CF₃ H 3 261N CF₃ CH₃ O 4-Cl—C₆H₅O HOCCl₂CF₃ H 3 262N CF₃ CH₃ O 4-F—C₆H₅O H OCCl₂CF₃ H 3 263N CF₃ CH₃ O3,4-Cl—C₆H₅O H OCCl₂CF₃ H 3 264N CF₃ CH₃ O H C₆H₅ OCCl₂CF₃ H 3 265N CF₃CH₃ O H 4-Cl—C₆H₅ OCCl₂CF₃ H 3 266N CF₃ CH₃ O H 4-F—C₆H₅ OCCl₂CF₃ H 3267N CF₃ CH₃ O H 4-Br—C₆H₅ OCCl₂CF₃ H 3 268N CF₃ CH₃ O 4-Br—C₆H₅O HOCCl₂CF₃ H 3 269N CF₃ CH₃ O C₆H₅O H OCF₂CCl₃ H 3 270N CF₃ CH₃ O4-Cl—C₆H₅O H OCF₂CCl₃ H 3 271N CF₃ CH₃ O 4-F—C₆H₅O H OCF₂CCl₃ H 3 272NCF₃ CH₃ O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 3 273N CF₃ CH₃ O H C₆H₅ OCF₂CCl₃ H 3274N CF₃ CH₃ O H 4-Cl—C₆H₅ OCF₂CCl₃ H 3 275N CF₃ CH₃ O H 4-F—C₆H₅OCF₂CCl₃ H 3 276N CF₃ CH₃ O H 4-Br—C₆H₅ OCF₂CCl₃ H 3 277N CF₃ CH₃ O4-Br—C₆H₅O H OCF₂CCl₃ H 3 278N CF₃ CH₃ O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 3279N CF₃ CH₃ O 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 3 280N CF₃ CH₃ O 4-F—C₆H₅OH OCF₂CF₂H OCF₂CF₂H 3 281N CF₃ CH₃ O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 3282N CF₃ CH₃ O H C₆H₅ OCF₂CF₂H OCF₂CF₂H 3 283N CF₃ CH₃ O H 4-Cl—C₆H₅OCF₂CF₂H OCF₂CF₂H 3 284N CF₃ CH₃ O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 3 285NCF₃ CH₃ O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 3 286N CF₃ CH₃ O 4-Br—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 3 287N CF₃ CH₃ O C₆H₅O H OCF₃ OCF₃ 3 288N CF₃ CH₃ O4-Cl—C₆H₅O H OCF₃ OCF₃ 3 289N CF₃ CH₃ O 4-F—C₆H₅O H OCF₃ OCF₃ 3 290N CF₃CH₃ O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 3 291N CF₃ CH₃ O H C₆H₅ OCF₃ OCF₃ 3 292NCF₃ CH₃ O H 4-Cl—C₆H₅ OCF₃ OCF₃ 3 293N CF₃ CH₃ O H 4-F—C₆H₅ OCF₃ OCF₃ 3294N CF₃ CH₃ O H 4-Br—C₆H₅ OCF₃ OCF₃ 3 295N CF₃ CH₃ O 4-Br—C₆H₅O H OCF₃OCF₃ 3 296N CF₃ CH₃ O C₆H₅O H OCF₂H OCF₂H 3 297N CF₃ CH₃ O 4-Cl—C₆H₅O HOCF₂H OCF₂H 3 298N CF₃ CH₃ O 4-F—C₆H₅O H OCF₂H OCF₂H 3 299N CF₃ CH₃ O3,4-Cl—C₆H₅O H OCF₂H OCF₂H 3 300N CF₃ CH₃ O H C₆H₅ OCF₂H OCF₂H 3 301NCF₃ CH₃ O H 4-Cl—C₆H₅ OCF₂H OCF₂H 3 302N CF₃ CH₃ O H 4-F—C₆H₅ OCF₂HOCF₂H 3 303N CF₃ CH₃ O H 4-Br—C₆H₅ OCF₂H OCF₂H 3 304N CF₃ CH₃ O4-Br—C₆H₅O H OCF₂H OCF₂H 3 305N CF₃ CH₃ O C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 3306N CF₃ CH₃ O 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 3 307N CF₃ CH₃ O4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 3 308N CF₃ CH₃ O 3,4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCF₂CF₂O 3 309N CF₃ CH₃ O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 3 310N CF₃CH₃ O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 3 311N CF₃ CH₃ O H 4-F—C₆H₅ R₁₀ +R₁₁ = OCF₂CF₂O 3 312N CF₃ CH₃ O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 3 313NCF₃ CH₃ O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 3 314N CF₃ CH₃ O C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 3 315N CF₃ CH₃ O 4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 3 316N CF₃ CH₃ O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 3 317NCF₃ CH₃ O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 3 318N CF₃ CH₃ O H C₆H₅R₁₀ + R₁₁ = OCCl₂CCl₂O 3 319N CF₃ CH₃ O H 4-Cl—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 3 320N CF₃ CH₃ O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 3 321N CF₃CH₃ O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 3 322N CF₃ CH₃ O 4-Br—C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 3 323N CF₃ CH₃ O H H OH H 3 324N CF₃ CH₃ O H H OHOH 3 325N CF₃ CH₃ O H H H OH 3 326N CF₃ CH₃ O H H OCH₂CF₃ H 3 327N CF₃CH₃ O H H H OCH₂CF₃ 3 328N CF₃ CH₃ O H H OCH₂CF₂CF₃ H 3 329N CF₃ CH₃ O HH OCH₂CH₂CF₃ H 3 330N CF₃ CH₃ O H H OCH(CF₃)₃ H 3 331N CF₃ CH₃ O H4-F—C₆H₅O H H 3 332N CF₃ CH₃ O 4-F—C₆H₅O H H H 3 333N CF₃ CH₃ O Hcyclohexoxy H H 3 334N CF₃ CH₃ O cyclohexoxy H H H 3 335N CF₃ CH₃ O HCH(CH₃)₃ H H 3 336N CF₃ CH₃ O F H

bond to indicated phenyl carbon of R₁₀ substituent 4 224N CF₃CF₂ H OC₆H₅O H OCF₂CF₂H H 4 225N CF₃CF₂ H O 4-Cl—C₆H₅O H OCF₂CF₂H H 4 226NCF₃CF₂ H O 4-F—C₆H₅O H OCF₂CF₂H H 4 227N CF₃CF₂ H O 3,4-Cl—C₆H₅O HOCF₂CF₂H H 4 228N CF₃CF₂ H O H C₆H₅ OCF₂CF₂H H 4 229N CF₃CF₂ H O H4-Cl—C₆H₅ OCF₂CF₂H H 4 230N CF₃CF₂ H O H 4-F—C₆H₅ OCF₂CF₂H H 4 231NCF₃CF₂ H O H 4-Br—C₆H₅ OCF₂CF₂H H 4 232N CF₃CF₂ H O 4-Br—C₆H₅O HOCF₂CF₂H H 4 233N CF₃CF₂ H O C₆H₅O H OCF₂CF₃ H 4 234N CF₃CF₂ H O4-Cl—C₆H₅O H OCF₂CF₃ H 4 235N CF₃CF₂ H O 4-F—C₆H₅O H OCF₂CF₃ H 4 236NCF₃CF₂ H O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 4 237N CF₃CF₂ H O H C₆H₅ OCF₂CF₃ H 4238N CF₃CF₂ H O H 4-Cl—C₆H₅ OCF₂CF₃ H 4 239N CF₃CF₂ H O H 4-F—C₆H₅OCF₂CF₃ H 4 240N CF₃CF₂ H O H 4-Br—C₆H₅ OCF₂CF₃ H 4 241N CF₃CF₂ H O4-Br—C₆H₅O H OCF₂CF₃ H 4 242N CF₃CF₂ H O C₆H₅O H OCCl₂CCl₂H H 4 243NCF₃CF₂ H O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 4 244N CF₃CF₂ H O 4-F—C₆H₅O HOCCl₂CCl₂H H 4 245N CF₃CF₂ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 4 246N CF₃CF₂H O H C₆H₅ OCCl₂CCl₂H H 4 247N CF₃CF₂ H O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 4248N CF₃CF₂ H O H 4-F—C₆H₅ OCCl₂CCl₂H H 4 249N CF₃CF₂ H O H 4-Br—C₆H₅OCCl₂CCl₂H H 4 250N CF₃CF₂ H O 4-Br—C₆H₅O H OCCl₂CCl₂H H 4 251N CF₃CF₂ HO C₆H₅O H OCCl₂CCl₃ H 4 252N CF₃CF₂ H O 4-Cl—C₆H₅O H OCCl₂CCl₃ H 4 253NCF₃CF₂ H O 4-F—C₆H₅O H OCCl₂CCl₃ H 4 254N CF₃CF₂ H O 3,4-Cl—C₆H₅O HOCCl₂CCl₃ H 4 255N CF₃CF₂ H O H C₆H₅ OCCl₂CCl₃ H 4 256N CF₃CF₂ H O H4-Cl—C₆H₅ OCCl₂CCl₃ H 4 257N CF₃CF₂ H O H 4-F—C₆H₅ OCCl₂CCl₃ H 4 258NCF₃CF₂ H O H 4-Br—C₆H₅ OCCl₂CCl₃ H 4 259N CF₃CF₂ H O 4-Br—C₆H₅O HOCCl₂CCl₃ H 4 260N CF₃CF₂ H O C₆H₅O H OCCl₂CF₃ H 4 261N CF₃CF₂ H O4-Cl—C₆H₅O H OCCl₂CF₃ H 4 262N CF₃CF₂ H O 4-F—C₆H₅O H OCCl₂CF₃ H 4 263NCF₃CF₂ H O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 4 264N CF₃CF₂ H O H C₆H₅ OCCl₂CF₃ H4 265N CF₃CF₂ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 4 266N CF₃CF₂ H O H 4-F—C₆H₅OCCl₂CF₃ H 4 267N CF₃CF₂ H O H 4-Br—C₆H₅ OCCl₂CF₃ H 4 268N CF₃CF₂ H O4-Br—C₆H₅O H OCCl₂CF₃ H 4 269N CF₃CF₂ H O C₆H₅O H OCF₂CCl₃ H 4 270NCF₃CF₂ H O 4-Cl—C₆H₅O H OCF₂CCl₃ H 4 271N CF₃CF₂ H O 4-F—C₆H₅O HOCF₂CCl₃ H 4 272N CF₃CF₂ H O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 4 273N CF₃CF₂ H OH C₆H₅ OCF₂CCl₃ H 4 274N CF₃CF₂ H O H 4-Cl—C₆H₅ OCF₂CCl₃ H 4 275N CF₃CF₂H O H 4-F—C₆H₅ OCF₂CCl₃ H 4 276N CF₃CF₂ H O H 4-Br—C₆H₅ OCF₂CCl₃ H 4277N CF₃CF₂ H O 4-Br—C₆H₅O H OCF₂CCl₃ H 4 278N CF₃CF₂ H O C₆H₅O HOCF₂CF₂H OCF₂CF₂H 4 279N CF₃CF₂ H O 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 4280N CF₃CF₂ H O 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 4 281N CF₃CF₂ H O3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 4 282N CF₃CF₂ H O H C₆H₅ OCF₂CF₂HOCF₂CF₂H 4 283N CF₃CF₂ H O H 4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H 4 284N CF₃CF₂ HO H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 4 285N CF₃CF₂ H O H 4-Br—C₆H₅ OCF₂CF₂HOCF₂CF₂H 4 286N CF₃CF₂ H O 4-Br—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 4 287N CF₃CF₂H O C₆H₅O H OCF₃ OCF₃ 4 288N CF₃CF₂ H O 4-Cl—C₆H₅O H OCF₃ OCF₃ 4 289NCF₃CF₂ H O 4-F—C₆H₅O H OCF₃ OCF₃ 4 290N CF₃CF₂ H O 3,4-Cl—C₆H₅O H OCF₃OCF₃ 4 291N CF₃CF₂ H O H C₆H₅ OCF₃ OCF₃ 4 292N CF₃CF₂ H O H 4-Cl—C₆H₅OCF₃ OCF₃ 4 293N CF₃CF₂ H O H 4-F—C₆H₅ OCF₃ OCF₃ 4 294N CF₃CF₂ H O H4-Br—C₆H₅ OCF₃ OCF₃ 4 295N CF₃CF₂ H O H OCF₃ OCF₃ 4 296N CF₃CF₂ H OC₆H₅O H OCF₂H OCF₂H 4 297N CF₃CF₂ H O 4-Cl—C₆H₅O H OCF₂H OCF₂H 4 298NCF₃CF₂ H O 4-F—C₆H₅O H OCF₂H OCF₂H 4 299N CF₃CF₂ H O 3,4-Cl—C₆H₅O HOCF₂H OCF₂H 4 300N CF₃CF₂ H O H C₆H₅ OCF₂H OCF₂H 4 301N CF₃CF₂ H O H4-Cl—C₆H₅ OCF₂H OCF₂H 4 302N CF₃CF₂ H O H 4-F—C₆H₅ OCF₂H OCF₂H 4 303NCF₃CF₂ H O H 4-Br—C₆H₅ OCF₂H OCF₂H 4 304N CF₃CF₂ H O 4-Br—C₆H₅O H OCF₂HOCF₂H 4 305N CF₃CF₂ H O C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 4 306N CF₃CF₂ H O4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 4 307N CF₃CF₂ H O 4-F—C₆H₅O H R₁₀ +R₁₁ = OCF₂CF₂O 4 308N CF₃CF₂ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 4309N CF₃CF₂ H O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 4 310N CF₃CF₂ H O H4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 4 311N CF₃CF₂ H O H 4-F—C₆H₅ R₁₀ + R₁₁ =OCF₂CF₂O 4 312N CF₃CF₂ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 4 313NCF₃CF₂ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 4 314N CF₃CF₂ H O C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 4 315N CF₃CF₂ H O 4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 4 316N CF₃CF₂ H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 4 317NCF₃CF₂ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 4 318N CF₃CF₂ H O HC₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 4 319N CF₃CF₂ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 4 320N CF₃CF₂ H O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 4 321NCF₃CF₂ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 4 322N CF₃CF₂ H O4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 4 323N CF₃CF₂ H O H H OH H 4 324NCF₃CF₂ H O H H OH OH 4 325N CF₃CF₂ H O H H H OH 4 326N CF₃CF₂ H O H HOCH₂CF₃ H 4 327N CF₃CF₂ H O H H H OCH₂CF₃ 4 328N CF₃CF₂ H O H HOCH₂CF₂CF₃ H 4 329N CF₃CF₂ H O H H OCH₂CH₂CF₃ H 4 330N CF₃CF₂ H O H HOCH(CF₃)₃ H 4 331N CF₃CF₂ H O H 4-F—C₆H₅O H H 4 332N CF₃CF₂ H O4-F—C₆H₅O H H H 4 333N CF₃CF₂ H O H cyclohexoxy H H 4 334N CF₃CF₂ H Ocyclohexoxy H H H 4 335N CF₃CF₂ H O H CH(CH₃)₃ H H 4 336N CF₃CF₂ H O F H

bond to indicated phenyl carbon of R₁₀ substituent 5 224N CF₃CF₂CF₂ H OC₆H₅O H OCF₂CF₂H H 5 225N CF₃CF₂CF₂ H O 4-Cl—C₆H₅O H OCF₂CF₂H H 5 226NCF₃CF₂CF₂ H O 4-F—C₆H₅O H OCF₂CF₂H H 5 227N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O HOCF₂CF₂H H 5 228N CF₃CF₂CF₂ H O H C₆H₅ OCF₂CF₂H H 5 229N CF₃CF₂CF₂ H O H4-Cl—C₆H₅ OCF₂CF₂H H 5 230N CF₃CF₂CF₂ H O H 4-F—C₆H₅ OCF₂CF₂H H 5 231NCF₃CF₂CF₂ H O H 4-Br—C₆H₅ OCF₂CF₂H H 5 232N CF₃CF₂CF₂ H O 4-Br—C₆H₅O HOCF₂CF₂H H 5 233N CF₃CF₂CF₂ H O C₆H₅ H OCF₂CF₃ H 5 234N CF₃CF₂CF₂ H O4-Cl—C₆H₅O H OCF₂CF₃ H 5 235N CF₃CF₂CF₂ H O 4-F—C₆H₅O H OCF₂CF₃ H 5 236NCF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 5 237N CF₃CF₂CF₂ H O H C₆H₅OCF₂CF₃ H 5 238N CF₃CF₂CF₂ H O H 4-Cl-C₆H₅ OCF₂CF₃ H 5 239N CF₃CF₂CF₂ HO H 4-F—C₆H₅ OCF₂CF₃ H 5 240N CF₃CF₂CF₂ H O H 4-Br—C₆H₅ OCF₂CF₃ H 5 241NCF₃CF₂CF₂ H O 4-Br—C₆H₅O H OCF₂CF₃ H 5 242N CF₃CF₂CF₂ H O C₆H₅O HOCCl₂CCl₂H H 5 243N CF₃CF₂CF₂ H O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 5 244NCF₃CF₂CF₂ H O 4-F—C₆H₅O H OCCl₂CCl₂H H 5 245N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅OH OCCl₂CCl₂H H 5 246N CF₃CF₂CF₂ H O H C₆H₅ OCCl₂CCl₂H H 5 247N CF₃CF₂CF₂H O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 5 248N CF₃CF₂CF₂ H O H 4-F—C₆H₅ OCCl₂CCl₂HH 5 249N CF₃CF₂CF₂ H O H 4-Br—C₆H₅ OCCl₂CCl₂H H 5 250N CF₃CF₂CF₂ H O4-Br—C₆H₅O H OCCl₂CCl₂H H 5 251N CF₃CF₂CF₂ H O C₆H₅O H OCCl₂CCl₃ H 5252N CF₃CF₂CF₂ H O 4-Cl—C₆H₅O H OCCl₂CCl₃ H 5 253N CF₃CF₂CF₂ H O4-F—C₆H₅O H OCCl₂CCl₃ H 5 254N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H5 255N CF₃CF₂CF₂ H O H C₆H₅ OCCl₂CCl₃ H 5 256N CF₃CF₂CF₂ H O H 4-Cl—C₆H₅OCCl₂CCl₃ H 5 257N CF₃CF₂CF₂ H O H 4-F—C₆H₅ OCCl₂CCl₃ H 5 258N CF₃CF₂CF₂H O H 4-Br—C₆H₅ OCCl₂CCl₃ H 5 259N CF₃CF₂CF₂ H O 4-Br—C₆H₅O H OCCl₂CCl₃H 5 260N CF₃CF₂CF₂ H O C₆H₅O H OCCl₂CF₃ H 5 261N CF₃CF₂CF₂ H O4-Cl—C₆H₅O H OCCl₂CF₃ H 5 262N CF₃CF₂CF₂ H O 4-F—C₆H₅O H OCCl₂CF₃ H 5263N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 5 264N CF₃CF₂CF₂ H O H C₆H₅OCCl₂CF₃ H 5 265N CF₃CF₂CF₂ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 5 266N CF₃CF₂CF₂H O H 4-F—C₆H₅ OCCl₂CF₃ H 5 267N CF₃CF₂CF₂ H O H 4-Br—C₆H₅ OCCl₂CF₃ H 5268N CF₃CF₂CF₂ H O 4-Br—C₆H₅O H OCCl₂CF₃ H 5 269N CF₃CF₂CF₂ H O C₆H₅O HOCF₂CCl₃ H 5 270N CF₃CF₂CF₂ H O 4-Cl—C₆H₅O H OCF₂CCl₃ H 5 271N CF₃CF₂CF₂H O 4-F—C₆H₅O H OCF₂CCl₃ H 5 272N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O H OCF₂CCl₃H 5 273N CF₃CF₂CF₂ H O H C₆H₅ OCF₂CCl₃ H 5 274N CF₃CF₂CF₂ H O H4-Cl—C₆H₅ OCF₂CCl₃ H 5 275N CF₃CF₂CF₂ H O H 4-F—C₆H₅ OCF₂CCl₃ H 5 276NCF₃CF₂CF₂ H O H 4-Br—C₆H₅ OCF₂CCl₃ H 5 277N CF₃CF₂CF₂ H O 4-Br—C₆H₅O HOCF₂CCl₃ H 5 278N CF₃CF₂CF₂ H O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 5 279NCF₃CF₂CF₂ H O 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 5 280N CF₃CF₂CF₂ H O4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 5 281N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 5 282N CF₃CF₂CF₂ H O H C₆H₅ OCF₂CF₂H OCF₂CF₂H 5 283NCF₃CF₂CF₂ H O H 4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H 5 284N CF₃CF₂CF₂ H O H4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 5 285N CF₃CF₂CF₂ H O H 4-Br—C₆H₅ OCF₂CF₂HOCF₂CF₂H 5 286N CF₃CF₂CF₂ H O 4-Br—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 5 287NCF₃CF₂CF₂ H O C₆H₅O H OCF₃ OCF₃ 5 288N CF₃CF₂CF₂ H O 4-Cl—C₆H₅O H OCF₃OCF₃ 5 289N CF₃CF₂CF₂ H O 4-F—C₆H₅O H OCF₃ OCF₃ 5 290N CF₃CF₂CF₂ H O3,4-Cl—C₆H₅O H OCF₃ OCF₃ 5 291N CF₃CF₂CF₂ H O H C₆H₅ OCF₃ OCF₃ 5 292NCF₃CF₂CF₂ H O H 4-Cl—C₆H₅ OCF₃ OCF₃ 5 293N CF₃CF₂CF₂ H O H 4-F—C₆H₅ OCF₃OCF₃ 5 294N CF₃CF₂CF₂ H O H 4-Br—C₆H₅ OCF₃ OCF₃ 5 295N CF₃CF₂CF₂ H O4-Br—C₆H₅O H OCF₃ OCF₃ 5 296N CF₃CF₂CF₂ H O C₆H₅O H OCF₂H OCF₂H 5 297NCF₃CF₂CF₂ H O 4-Cl—C₆H₅O H OCF₂H OCF₂H 5 298N CF₃CF₂CF₂ H O 4-F—C₆H₅O HOCF₂H OCF₂H 5 299N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 5 300NCF₃CF₂CF₂ H O H C₆H₅ OCF₂H OCF₂H 5 301N CF₃CF₂CF₂ H O H 4-Cl—C₆H₅ OCF₂HOCF₂H 5 302N CF₃CF₂CF₂ H O H 4-F—C₆H₅ OCF₂H OCF₂H 5 303N CF₃CF₂CF₂ H O H4-Br—C₆H₅ OCF₂H OCF₂H 5 304N CF₃CF₂CF₂ H O 4-Br—C₆H₅O H OCF₂H OCF₂H 5305N CF₃CF₂CF₂ H O C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 5 306N CF₃CF₂CF₂ H O4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 5 307N CF₃CF₂CF₂ H O 4-F—C₆H₅O H R₁₀ +R₁₁ = OCF₂CF₂O 5 308N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O5 309N CF₃CF₂CF₂ H O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 5 310N CF₃CF₂CF₂ H O H4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 5 311N CF₃CF₂CF₂ H O H 4-F—C₆H₅ R₁₀ + R₁₁= OCF₂CF₂O 5 312N CF₃CF₂CF₂ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 5 313NCF₃CF₂CF₂ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 5 314N CF₃CF₂CF₂ H OC₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 5 315N CF₃CF₂CF₂ H O 4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 5 316N CF₃CF₂CF₂ H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O5 317N CF₃CF₂CF₂ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 5 318NCF₃CF₂CF₂ H O H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 5 319N CF₃CF₂CF₂ H O H4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 5 320N CF₃CF₂CF₂ H O H 4-F—C₆H₅ R₁₀ +R₁₁ = OCCl₂CCl₂O 5 321N CF₃CF₂CF₂ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O5 322N CF₃CF₂CF₂ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 5 323NCF₃CF₂CF₂ H O H H OH H 5 324N CF₃CF₂CF₂ H O H H OH OH 5 325N CF₃CF₂CF₂ HO H H H OH 5 326N CF₃CF₂CF₂ H O H H OCH₂CF₃ H 5 327N CF₃CF₂CF₂ H O H H HOCH₂CF₃ 5 328N CF₃CF₂CF₂ H O H H OCH₂CF₂CF₃ H 5 329N CF₃CF₂CF₂ H O H HOCH₂CH₂CF₃ H 5 330N CF₃CF₂CF₂ H O H H OCH(CF₃)₃ H 5 331N CF₃CF₂CF₂ H O H4-F—C₆H₅O H H 5 332N CF₃CF₂CF₂ H O 4-F—C₆H₅O H H H 5 333N CF₃CF₂CF₂ H OH cyclohexoxy H H 5 334N CF₃CF₂CF₂ H O cyclohexoxy H H H 5 335NCF₃CF₂CF₂ H O H CH(CH₃)₃ H H 5 336N CF₃CF₂CF₂ H O F H

bond to indicated phenyl carbon of R₁₀ substituent 6 224N CF₃OCF₂CF₂ H OC₆H₅O H OCF₂CF₂H H 6 225N CF₃OCF₂CF₂ H O 4-Cl—C₆H₅O H OCF₂CF₂H H 6 226NCF₃OCF₂CF₂ H O 4-F—C₆H₅O H OCF₂CF₂H H 6 227N CF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅OH OCF₂CF₂H H 6 228N CF₃OCF₂CF₂ H O H C₆H₅ OCF₂CF₂H H 6 229N CF₃OCF₂CF₂ HO H 4-Cl—C₆H₅ OCF₂CF₂H H 6 230N CF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCF₂CF₂H H 6231N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅ OCF₂CF₂H H 6 232N CF₃OCF₂CF₂ H O4-Br—C₆H₅O H OCF₂CF₂H H 6 233N CF₃OCF₂CF₂ H O C₆H₅O H OCF₂CF₃ H 6 234NCF₃OCF₂CF₂ H O 4-Cl—C₆H₅O H OCF₂CF₃ H 6 235N CF₃OCF₂CF₂ H O 4-F—C₆H₅O HOCF₂CF₃ H 6 236N CF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 6 237NCF₃OCF₂CF₂ H O H C₆H₅ OCF₂CF₃ H 6 238N CF₃OCF₂CF₂ H O H 4-Cl—C₆H₅OCF₂CF₃ H 6 239N CF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCF₂CF₃ H 6 240N CF₃OCF₂CF₂ HO H 4-Br—C₆H₅ OCF₂CF₃ H 6 241N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H OCF₂CF₃ H 6242N CF₃OCF₂CF₂ H O C₆H₅O H OCCl₂CCl₂H H 6 243N CF₃OCF₂CF₂ H O4-Cl—C₆H₅O H OCCl₂CCl₂H H 6 244N CF₃OCF₂CF₂ H O 4-F—C₆H₅O H OCCl₂CCl₂H H6 245N CF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 6 246N CF₃OCF₂CF₂ H OH C₆H₅ OCCl₂CCl₂H H 6 247N CF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 6248N CF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCCl₂CCl₂H H 6 249N CF₃OCF₂CF₂ H O H4-Br—C₆H₅ OCCl₂CCl₂H H 6 250N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H OCCl₂CCl₂H H 6251N CF₃OCF₂CF₂ H O C₆H₅O H OCCl₂CCl₃ H 6 252N CF₃OCF₂CF₂ H O 4-Cl—C₆H₅OH OCCl₂CCl₃ H 6 253N CF₃OCF₂CF₂ H O 4-F—C₆H₅O H OCCl₂CCl₃ H 6 254NCF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 6 255N CF₃OCF₂CF₂ H O H C₆H₅OCCl₂CCl₃ H 6 256N CF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 6 257NCF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCCl₂CCl₃ H 6 258N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅OCCl₂CCl₃ H 6 259N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H OCCl₂CCl₃ H 6 260NCF₃OCF₂CF₂ H O C₆H₅O H OCCl₂CF₃ H 6 261N CF₃OCF₂CF₂ H O 4-Cl—C₆H₅O HOCCl₂CF₃ H 6 262N CF₃OCF₂CF₂ H O 4-F—C₆H₅O H OCCl₂CF₃ H 6 263NCF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 6 264N CF₃OCF₂CF₂ H O H C₆H₅OCCl₂CF₃ H 6 265N CF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 6 266NCF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCCl₂CF₃ H 6 267N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅OCCl₂CF₃ H 6 268N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H OCCl₂CF₃ H 6 269NCF₃OCF₂CF₂ H O C₆H₅O H OCF₂CCl₃ H 6 270N CF₃OCF₂CF₂ H O 4-Cl—C₆H₅O HOCF₂CCl₃ H 6 271N CF₃OCF₂CF₂ H O 4-F—C₆H₅O H OCF₂CCl₃ H 6 272NCF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 6 273N CF₃OCF₂CF₂ H O H C₆H₅OCF₂CCl₃ H 6 274N CF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ OCF₂CCl₃ H 6 275NCF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCF₂CCl₃ H 6 276N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅OCF₂CCl₃ H 6 277N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H OCF₂CCl₃ H 6 278NCF₃OCF₂CF₂ H O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 6 279N CF₃OCF₂CF₂ H O4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 6 280N CF₃OCF₂CF₂ H O 4-F—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 6 281N CF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H6 282N CF₃OCF₂CF₂ H O H C₆H₅ OCF₂CF₂H OCF₂CF₂H 6 283N CF₃OCF₂CF₂ H O H4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H 6 284N CF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCF₂CF₂HOCF₂CF₂H 6 285N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 6 286NCF₃OCF₂CF₂ H O 4-Br—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 6 287N CF₃OCF₂CF₂ H OC₆H₅O H OCF₃ OCF₃ 6 288N CF₃OCF₂CF₂ H O 4-Cl—C₆H₅O H OCF₃ OCF₃ 6 289NCF₃OCF₂CF₂ H O 4-F—C₆H₅O H OCF₃ OCF₃ 6 290N CF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅OH OCF₃ OCF₃ 6 291N CF₃OCF₂CF₂ H O H C₆H₅ OCF₃ OCF₃ 6 292N CF₃OCF₂CF₂ H OH 4-Cl—C₆H₅ OCF₃ OCF₃ 6 293N CF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCF₃ OCF₃ 6 294NCF₃OCF₂CF₂ H O H 4-Br—C₆H₅ OCF₃ OCF₃ 6 295N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O HOCF₃ OCF₃ 6 296N CF₃OCF₂CF₂ H O C₆H₅O H OCF₂H OCF₂H 6 297N CF₃OCF₂CF₂ HO 4-Cl—C₆H₅O H OCF₂H OCF₂H 6 298N CF₃OCF₂CF₂ H O 4-F—C₆H₅O H OCF₂H OCF₂H6 299N CF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 6 300N CF₃OCF₂CF₂ H O HC₆H₅ OCF₂H OCF₂H 6 301N CF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ OCF₂H OCF₂H 6 302NCF₃OCF₂CF₂ H O H 4-F—C₆H₅ OCF₂H OCF₂H 6 303N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅OCF₂H OCF₂H 6 304N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H OCF₂H OCF₂H 6 305NCF₃OCF₂CF₂ H O C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 6 306N CF₃OCF₂CF₂ H O4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 6 307N CF₃OCF₂CF₂ H O 4-F—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 6 308N CF₃OCF₂CF₂ H o 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 6 309N CF₃OCF₂CF₂ H O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 6 310NCF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 6 311N CF₃OCF₂CF₂ H O H4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 6 312N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅ R₁₀ +R₁₁ = OCF₂CF₂O 6 313N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 6314N CF₃OCF₂CF₂ H O C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 6 315N CF₃OCF₂CF₂ H O4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 6 316N CF₃OCF₂CF₂ H O 4-F—C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 6 317N CF₃OCF₂CF₂ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 6 318N CF₃OCF₂CF₂ H O H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 6 319NCF₃OCF₂CF₂ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 6 320N CF₃OCF₂CF₂ H OH 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 6 321N CF₃OCF₂CF₂ H O H 4-Br—C₆H₅R₁₀ + R₁₁ = OCCl₂CCl₂O 6 322N CF₃OCF₂CF₂ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 6 323N CF₃OCF₂CF₂ H O H H OH H 6 324N CF₃OCF₂CF₂ H O H H OHOH 6 325N CF₃OCF₂CF₂ H O H H H OH 6 326N CF₃OCF₂CF₂ H O H H OCH₂CF₃ H 6327N CF₃OCF₂CF₂ H O H H H OCH₂CF₃ 6 328N CF₃OCF₂CF₂ H O H H OCH₂CF₂CF₃ H6 329N CF₃OCF₂CF₂ H O H H OCH₂CH₂CF₃ H 6 330N CF₃OCF₂CF₂ H O H HOCH(CF₃)₃ H 6 331N CF₃OCF₂CF₂ H O H 4-F—C₆H₅O H H 6 332N CF₃OCF₂CF₂ H O4-F—C₆H₅O H H H 6 333N CF₃OCF₂CF₂ H O H cyclohexoxy H H 6 334NCF₃OCF₂CF₂ H O cyclohexoxy H H H 6 335N CF₃OCF₂CF₂ H O H CH(CH₃)₃ H H 6336N CF₃OCF₂CF₂ H O F H

bond to indicated phenyl carbon of R₁₀ substituent 7 224N CF₃CH₂ CH₃ OC₆H₅O H OCF₂CF₂H H 7 225N CF₃CH₂ CH₃ O 4-Cl—C₆H₅O H OCF₂CF₂H H 7 226NCF₃CH₂ CH₃ O 4-F—C₆H₅O H OCF₂CF₂H H 7 227N CF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O HOCF₂CF₂H H 7 228N CF₃CH₂ CH₃ O H C₆H₅ OCF₂CF₂H H 7 229N CF₃CH₂ CH₃ O H4-Cl—C₆H₅ OCF₂CF₂H H 7 230N CF₃CH₂ CH₃ O H 4-F—C₆H₅ OCF₂CF₂H H 7 231NCF₃CH₂ CH₃ O H 4-Br—C₆H₅ OCF₂CF₂H H 7 232N CF₃CH₂ CH₃ O 4-Br—C₆H₅O HOCF₂CF₂H H 7 233N CF₃CH₂ CH₃ O C₆H₅O H OCF₂CF₃ H 7 234N CF₃CH₂ CH₃ O4-Cl—C₆H₅O H OCF₂CF₃ H 7 235N CF₃CH₂ CH₃ O 4-F—C₆H₅O H OCF₂CF₃ H 7 236NCF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 7 237N CF₃CH₂ CH₃ O H C₆H₅ OCF₂CF₃H 7 238N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅ OCF₂CF₃ H 7 239N CF₃CH₂ CH₃ O H4-F—C₆H₅ OCF₂CF₃ H 7 240N CF₃CH₂ CH₃ O H 4-Br—C₆H₅ OCF₂CF₃ H 7 241NCF₃CH₂ CH₃ O 4-Br—C₆H₅O H OCF₂CF₃ H 7 242N CF₃CH₂ CH₃ O C₆H₅O HOCCl₂CCl₂H H 7 243N CF₃CH₂ CH₃ O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 7 244N CF₃CH₂CH₃ O 4-F—C₆H₅O H OCCl₂CCl₂H H 7 245N CF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O HOCCl₂CCl₂H H 7 246N CF₃CH₂ CH₃ O H C₆H₅ OCCl₂CCl₂H H 7 247N CF₃CH₂ CH₃ OH 4-Cl—C₆H₅ OCCl₂CCl₂H H 7 248N CF₃CH₂ CH₃ O H 4-F—C₆H₅ OCCl₂CCl₂H H 7249N CF₃CH₂ CH₃ O H 4-Br—C₆H₅ OCCl₂CCl₂H H 7 250N CF₃CH₂ CH₃ O4-Br—C₆H₅O H OCCl₂CCl₂H H 7 251N CF₃CH₂ CH₃ O C₆H₅O H OCCl₂CCl₃ H 7 252NCF₃CH₂ CH₃ O 4-Cl—C₆H₅O H OCCl₂CCl₃ H 7 253N CF₃CH₂ CH₃ O 4-F—C₆H₅O HOCCl₂CCl₃ H 7 254N CF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 7 255N CF₃CH₂CH₃ O H C₆H₅ OCCl₂CCl₃ H 7 256N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 7257N CF₃CH₂ CH₃ O H 4-F—C₆H₅ OCCl₂CCl₃ H 7 258N CF₃CH₂ CH₃ O H 4-Br—C₆H₅OCCl₂CCl₃ H 7 259N CF₃CH₂ CH₃ O 4-Br—C₆H₅O H OCCl₂CCl₃ H 7 260N CF₃CH₂CH₃ O C₆H₅O H OCCl₂CF₃ H 7 261N CF₃CH₂ CH₃ O 4-Cl—C₆H₅O H OCCl₂CF₃ H 7262N CF₃CH₂ CH₃ O 4-F—C₆H₅O H OCCl₂CF₃ H 7 263N CF₃CH₂ CH₃ O3,4-Cl—C₆H₅O H OCCl₂CF₃ H 7 264N CF₃CH₂ CH₃ O H C₆H₅ OCCl₂CF₃ H 7 265NCF₃CH₂ CH₃ O H 4-Cl—C₆H₅ OCCl₂CF₃ H 7 266N CF₃CH₂ CH₃ O H 4-F—C₆H₅OCCl₂CF₃ H 7 267N CF₃CH₂ CH₃ O H 4-Br—C₆H₅ OCCl₂CF₃ H 7 268N CF₃CH₂ CH₃O 4-Br—C₆H₅O H OCCl₂CF₃ H 7 269N CF₃CH₂ CH₃ O C₆H₅O H OCF₂CCl₃ H 7 270NCF₃CH₂ CH₃ O 4-Cl—C₆H₅O H OCF₂CCl₃ H 7 271N CF₃CH₂ CH₃ O 4-F—C₆H₅O HOCF₂CCl₃ H 7 272N CF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 7 273N CF₃CH₂CH₃ O H C₆H₅ OCF₂CCl₃ H 7 274N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅ OCF₂CCl₃ H 7275N CF₃CH₂ CH₃ O H 4-F—C₆H₅ OCF₂CCl₃ H 7 276N CF₃CH₂ CH₃ O H 4-Br—C₆H₅OCF₂CCl₃ H 7 277N CF₃CH₂ CH₃ O 4-Br—C₆H₅O H OCF₂CCl₃ H 7 278N CF₃CH₂ CH₃O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 7 279N CF₃CH₂ CH₃ O 4-Cl—C₆H₅O H OCF₂CF₂HOCF₂CF₂H 7 280N CF₃CH₂ CH₃ O 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 7 281N CF₃CH₂CH₃ O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 7 282N CF₃CH₂ CH₃ O H C₆H₅OCF₂CF₂H OCF₂CF₂H 7 283N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H 7284N CF₃CH₂ CH₃ O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 7 285N CF₃CH₂ CH₃ O H4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 7 286N CF₃CH₂ CH₃ O 4-Br—C₆H₅O H OCF₂CF₂HOCF₂CF₂H 7 287N CF₃CH₂ CH₃ O C₆H₅O H OCF₃ OCF₃ 7 288N CF₃CH₂ CH₃ O4-Cl—C₆H₅O H OCF₃ OCF₃ 7 289N CF₃CH₂ CH₃ O 4-F—C₆H₅O H OCF₃ OCF₃ 7 290NCF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 7 291N CF₃CH₂ CH₃ O H C₆H₅ OCF₃OCF₃ 7 292N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅ OCF₃ OCF₃ 7 293N CF₃CH₂ CH₃ O H4-F—C₆H₅ OCF₃ OCF₃ 7 294N CF₃CH₂ CH₃ O H 4-Br—C₆H₅ OCF₃ OCF₃ 7 295NCF₃CH₂ CH₃ O 4-Br—C₆H₅O H OCF₃ OCF₃ 7 296N CF₃CH₂ CH₃ O C₆H₅O H OCF₂HOCF₂H 7 297N CF₃CH₂ CH₃ O 4-Cl—C₆H₅O H OCF₂H OCF₂H 7 298N CF₃CH₂ CH₃ O4-F—C₆H₅O H OCF₂H OCF₂H 7 299N CF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 7300N CF₃CH₂ CH₃ O H C₆H₅ OCF₂H OCF₂H 7 301N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅OCF₂H OCF₂H 7 302N CF₃CH₂ CH₃ O H 4-F—C₆H₅ OCF₂H OCF₂H 7 303N CF₃CH₂ CH₃O H 4-Br—C₆H₅ OCF₂H OCF₂H 7 304N CF₃CH₂ CH₃ O 4-Br—C₆H₅O H OCF₂H OCF₂H 7305N CF₃CH₂ CH₃ O C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 7 306N CF₃CH₂ CH₃ O4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 7 307N CF₃CH₂ CH₃ O 4-F—C₆H₅O H R₁₀ +R₁₁ = OCF₂CF₂O 7 308N CF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 7309N CF₃CH₂ CH₃ O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 7 310N CF₃CH₂ CH₃ O H4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 7 311N CF₃CH₂ CH₃ O H 4-F—C₆H₅ R₁₀ + R₁₁= OCF₂CF₂O 7 312N CF₃CH₂ CH₃ O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 7 313NCF₃CH₂ CH₃ O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 7 314N CF₃CH₂ CH₃ O C₆H₅OH R₁₀ + R₁₁ = OCCl₂CCl₂O 7 315N CF₃CH₂ CH₃ O 4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 7 316N CF₃CH₂ CH₃ O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 7 317NCF₃CH₂ CH₃ O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 7 318N CF₃CH₂ CH₃ O HC₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 7 319N CF₃CH₂ CH₃ O H 4-Cl—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl2O 7 320N CF₃CH₂ CH₃ O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 7 321NCF₃CH₂ CH₃ O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 7 322N CF₃CH₂ CH₃ O4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 7 323N CF₃CH₂ CH₃ O H H OH H 7 324NCF₃CH₂ CH₃ O H H OH OH 7 325N CF₃CH₂ CH₃ O H H H OH 7 326N CF₃CH₂ CH₃ OH H OCH₂CF₃ H 7 327N CF₃CH₂ CH₃ O H H H OCH₂CF₃ 7 328N CF₃CH₂ CH₃ O H HOCH₂CF₂CF₃ H 7 329N CF₃CH₂ CH₃ O H H OCH₂CH₂CF₃ H 7 330N CF₃CH₂ CH₃ O HH OCH(CF₃)₃ H 7 331N CF₃CH₂ CH₃ O H 4-F—C₆H₅O H H 7 332N CF₃CH₂ CH₃ O4-F—C₆H₅O H H H 7 333N CF₃CH₂ CH₃ O H cyclohexoxy H H 7 334N CF₃CH₂ CH₃O cyclohexoxy H H H 7 335N CF₃CH₂ CH₃ O H CH(CH₃)₃ H H 7 336N CF₃CH₂ CH₃O F H

bond to indicated phenyl carbon of R₁₀ substituent 10 224N CF₃ CF₃ OC₆H₅O H OCF₂CF₂H H 10 225N CF₃ CF₃ O 4-Cl—C₆H₅O H OCF₂CF₂H H 10 226N CF₃CF₃ O 4-F—C₆H₅O H OCF₂CF₂H H 10 227N CF₃ CF₃ O 3,4-Cl—C₆H₅O H OCF₂CF₂H H10 228N CF₃ CF₃ O H C₆H₅ OCF₂CF₂H H 10 229N CF₃ CF₃ O H 4-Cl—C₆H₅OCF₂CF₂H H 10 230N CF₃ CF₃ O H 4-F—C₆H₅ OCF₂CF₂H H 10 231N CF₃ CF₃ O H4-Br—C₆H₅ OCF₂CF₂H H 10 232N CF₃ CF₃ O 4-Br—C₆H₅O H OCF₂CF₂H H 10 233NCF₃ CF₃ O C₆H₅O H OCF₂CF₃ H 10 234N CF₃ CF₃ O 4-Cl—C₆H₅O H OCF₂CF₃ H 10235N CF₃ CF₃ O 4-F—C₆H₅O H OCF₂CF₃ H 10 236N CF₃ CF₃ O 3,4-Cl—C₆H₅O HOCF₂CF₃ H 10 237N CF₃ CF₃ O H C₆H₅ OCF₂CF₃ H 10 238N CF₃ CF₃ O H4-Cl—C₆H₅ OCF₂CF₃ H 10 239N CF₃ CF₃ O H 4-F—C₆H₅ OCF₂CF₃ H 10 240N CF₃CF₃ O H 4-Br—C₆H₅ OCF₂CF₃ H 10 241N CF₃ CF₃ O 4-Br—C₆H₅O H OCF₂CF₃ H 10242N CF₃ CF₃ O C₆H₅O H OCCl₂CCl₂H H 10 243N CF₃ CF₃ O 4-Cl—C₆H₅O HOCCl₂CCl₂H H 10 244N CF₃ CF₃ O 4-F—C₆H₅O H OCCl₂CCl₂H H 10 245N CF₃ CF₃O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 10 246N CF₃ CF₃ O H C₆H₅ OCCl₂CCl₂H H 10247N CF₃ CF₃ O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 10 248N CF₃ CF₃ O H 4-F—C₆H₅OCCl₂CCl₂H H 10 249N CF₃ CF₃ O H 4-Br—C₆H₅ OCCl₂CCl₂H H 10 250N CF₃ CF₃O 4-Br—C₆H₅O H OCCl₂CCl₂H H 10 251N CF₃ CF₃ O C₆H₅O H OCCl₂CCl₃ H 10252N CF₃ CF₃ O 4-Cl—C₆H₅O H OCCl₂CCl₃ H 10 253N CF₃ CF₃ O 4-F—C₆H₅O HOCCl₂CCl₃ H 10 254N CF₃ CF₃ O 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 10 255N CF₃ CF₃O H C₆H₅ OCCl₂CCl₃ H 10 256N CF₃ CF₃ O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 10 257NCF₃ CF₃ O H 4-F—C₆H₅ OCCl₂CCl₃ H 10 258N CF₃ CF₃ O H 4-Br—C₆H₅ OCCl₂CCl₃H 10 259N CF₃ CF₃ O 4-Br—C₆H₅O H OCCl₂CCl₃ H 10 260N CF₃ CF₃ O C₆H₅O HOCCl₂CF₃ H 10 261N CF₃ CF₃ O 4-Cl—C₆H₅O H OCCl₂CF₃ H 10 262N CF₃ CF₃ O4-F—C₆H₅O H OCCl₂CF₃ H 10 263N CF₃ CF₃ O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 10264N CF₃ CF₃ O H C₆H₅ OCCl₂CF₃ H 10 265N CF₃ CF₃ O H 4-Cl—C₆H₅ OCCl₂CF₃H 10 266N CF₃ CF₃ O H 4-F—C₆H₅ OCCl₂CF₃ H 10 267N CF₃ CF₃ O H 4-Br—C₆H₅OCCl₂CF₃ H 10 268N CF₃ CF₃ O 4-Br—C₆H₅O H OCCl₂CF₃ H 10 269N CF₃ CF₃ OC₆H₅O H OCF₂CCl₃ H 10 270N CF₃ CF₃ O 4-Cl—C₆H₅O H OCF₂CCl₃ H 10 271N CF₃CF₃ O 4-F—C₆H₅O H OCF₂CCl₃ H 10 272N CF₃ CF₃ O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H10 273N CF₃ CF₃ O H C₆H₅ OCF₂CCl₃ H 10 274N CF₃ CF₃ O H 4-Cl—C₆H₅OCF₂CCl₃ H 10 275N CF₃ CF₃ O H 4-F—C₆H₅ OCF₂CCl₃ H 10 276N CF₃ CF₃ O H4-Br—C₆H₅ OCF₂CCl₃ H 10 277N CF₃ CF₃ O 4-Br—C₆H₅O H OCF₂CCl₃ H 10 278NCF₃ CF₃ O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 10 279N CF₃ CF₃ O 4-Cl—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 10 280N CF₃ CF₃ O 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 10281N CF₃ CF₃ O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 10 282N CF₃ CF₃ O H C₆H₅OCF₂CF₂H OCF₂CF₂H 10 283N CF₃ CF₃ O H 4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H 10284N CF₃ CF₃ O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 10 285N CF₃ CF₃ O H4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 10 286N CF₃ CF₃ O 4-Br—C₆H₅O H OCF₂CF₂HOCF₂CF₂H 10 287N CF₃ CF₃ O C₆H₅O H OCF₃ OCF₃ 10 288N CF₃ CF₃ O4-Cl—C₆H₅O H OCF₃ OCF₃ 10 289N CF₃ CF₃ O 4-F—C₆H₅O H OCF₃ OCF₃ 10 290NCF₃ CF₃ O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 10 291N CF₃ CF₃ O H C₆H₅ OCF₃ OCF₃ 10292N CF₃ CF₃ O H 4-Cl—C₆H₅ OCF₃ OCF₃ 10 293N CF₃ CF₃ O H 4-F—C₆H₅ OCF₃OCF₃ 10 294N CF₃ CF₃ O H 4-Br—C₆H₅ OCF₃ OCF₃ 10 295N CF₃ CF₃ O4-Br—C₆H₅O H OCF₃ OCF₃ 10 296N CF₃ CF₃ O C₆H₅O H OCF₂H OCF₂H 10 297N CF₃CF₃ O 4-Cl—C₆H₅O H OCF₂H OCF₂H 10 298N CF₃ CF₃ O 4-F—C₆H₅O H OCF₂H OCF₂H10 299N CF₃ CF₃ O 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 10 300N CF₃ CF₃ O H C₆H₅OCF₂H OCF₂H 10 301N CF₃ CF₃ O H 4-Cl—C₆H₅ OCF₂H OCF₂H 10 302N CF₃ CF₃ OH 4-F—C₆H₅ OCF₂H OCF₂H 10 303N CF₃ CF₃ O H 4-Br—C₆H₅ OCF₂H OCF₂H 10 304NCF₃ CF₃ O 4-Br—C₆H₅O H OCF₂H OCF₂H 10 305N CF₃ CF₃ O C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 10 306N CF₃ CF₃ O 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 10 307N CF₃CF₃ O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 10 308N CF₃ CF₃ O 3,4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 10 309N CF₃ CF₃ O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 10310N CF₃ CF₃ O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 10 311N CF₃ CF₃ O H4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 10 312N CF₃ CF₃ O H 4-Br—C₆H₅ R₁₀ + R₁₁ =OCF₂CF₂O 10 313N CF₃ CF₃ O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 10 314N CF₃CF₃ O C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 10 315N CF₃ CF₃ O 4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 10 316N CF₃ CF₃ O 4-F—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 10 317N CF₃ CF₃ O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 10318N CF₃ CF₃ O H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 10 319N CF₃ CF₃ O H4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 10 320N CF₃ CF₃ O H 4-F—C₆H₅ R₁₀ + R₁₁= OCCl₂CCl₂O 10 321N CF₃ CF₃ O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 10322N CF₃ CF₃ O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 10 323N CF₃ CF₃ O H HOH H 10 324N CF₃ CF₃ O H H OH OH 10 325N CF₃ CF₃ O H H H OH 10 326N CF₃CF₃ O H H OCH₂CF₃ H 10 327N CF₃ CF₃ O H H H OCH₂CF₃ 10 328N CF₃ CF₃ O HH OCH₂CF₂CF₃ H 10 329N CF₃ CF₃ O H H OCH₂CH₂CF₃ H 10 330N CF₃ CF₃ O H HOCH(CF₃)₃ H 10 331N CF₃ CF₃ O H 4-F—C₆H₅O H H 10 332N CF₃ CF₃ O4-F—C₆H₅O H H H 10 333N CF₃ CF₃ O H cyclohexoxy H H 10 334N CF₃ CF₃ Ocyclohexoxy H H H 10 335N CF₃ CF₃ O H CH(CH₃)₃ H H 10 336N CF₃ CF₃ O F H

bond to indicated phenyl carbon of R₁₀ substituent 19 224N CF₃ CF₃ NHC₆H₅O H OCF₂CF₂H H 19 225N CF₃ CF₃ NH 4-Cl—C₆H₅O H OCF₂CF₂H H 19 226NCF₃ CF₃ NH 4-F—C₆H₅O H OCF₂CF₂H H 19 227N CF₃ CF₃ NH 3,4-Cl—C₆H₅O HOCF₂CF₂H H 19 228N CF₃ CF₃ NH H C₆H₅ OCF₂CF₂H H 19 229N CF₃ CF₃ NH H4-Cl—C₆H₅ OCF₂CF₂H H 19 230N CF₃ CF₃ NH H 4-F—C₆H₅ OCF₂CF₂H H 19 231NCF₃ CF₃ NH H 4-Br—C₆H₅ OCF₂CF₂H H 19 232N CF₃ CF₃ NH 4-Br—C₆H₅O HOCF₂CF₂H H 19 233N CF₃ CF₃ NH C₆H₅O H OCF₂CF₃ H 19 234N CF₃ CF₃ NH4-Cl—C₆H₅O H OCF₂CF₃ H 19 235N CF₃ CF₃ NH 4-F—C₆H₅O H OCF₂CF₃ H 19 236NCF₃ CF₃ NH 3,4-Cl—C₆H₅O H OCF₂CF₃ H 19 237N CF₃ CF₃ NH H C₆H₅ OCF₂CF₃ H19 238N CF₃ CF₃ NH H 4-Cl—C₆H₅ OCF₂CF₃ H 19 239N CF₃ CF₃ NH H 4-F—C₆H₅OCF₂CF₃ H 19 240N CF₃ CF₃ NH H 4-Br—C₆H₅ OCF₂CF₃ H 19 241N CF₃ CF₃ NH4-Br—C₆H₅O H OCF₂CF₃ H 19 242N CF₃ CF₃ NH C₆H₅O H OCCl₂CCl₂H H 19 243NCF₃ CF₃ NH 4-Cl—C₆H₅O H OCCl₂CCl₂H H 19 244N CF₃ CF₃ NH 4-F—C₆H₅O HOCCl₂CCl₂H H 19 245N CF₃ CF₃ NH 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 19 246N CF₃CF₃ NH H C₆H₅ OCCl₂CCl₂H H 19 247N CF₃ CF₃ NH H 4-Cl—C₆H₅ OCCl₂CCl₂H H19 248N CF₃ CF₃ NH H 4-F—C₆H₅ OCCl₂CCl₂H H 19 249N CF₃ CF₃ NH H4-Br—C₆H₅ OCCl₂CCl₂H H 19 250N CF₃ CF₃ NH 4-Br—C₆H₅O H OCCl₂CCl₂H H 19251N CF₃ CF₃ NH C₆H₅O H OCCl₂CCl₃ H 19 252N CF₃ CF₃ NH 4-Cl—C₆H₅O HOCCl₂CCl₃ H 19 253N CF₃ CF₃ NH 4-F—C₆H₅O H OCCl₂CCl₃ H 19 254N CF₃ CF₃NH 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 19 255N CF₃ CF₃ NH H C₆H₅ OCCl₂CCl₃ H 19256N CF₃ CF₃ NH H 4-Cl—C₆H₅ OCCl₂CCl₃ H 19 257N CF₃ CF₃ NH H 4-F—C₆H₅OCCl₂CCl₃ H 19 258N CF₃ CF₃ NH H 4-Br—C₆H₅ OCCl₂CCl₃ H 19 259N CF₃ CF₃NH 4-Br—C₆H₅O H OCCl₂CCl₃ H 19 260N CF₃ CF₃ NH C₆H₅O H OCCl₂CF₃ H 19261N CF₃ CF₃ NH 4-Cl—C₆H₅O H OCCl₂CF₃ H 19 262N CF₃ CF₃ NH 4-F—C₆H₅O HOCCl₂CF₃ H 19 263N CF₃ CF₃ NH 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 19 264N CF₃ CF₃NH H C₆H₅ OCCl₂CF₃ H 19 265N CF₃ CF₃ NH H 4-Cl—C₆H₅ OCCl₂CF₃ H 19 266NCF₃ CF₃ NH H 4-F—C₆H₅ OCCl₂CF₃ H 19 267N CF₃ CF₃ NH H 4-Br—C₆H₅ OCCl₂CF₃H 19 268N CF₃ CF₃ NH 4-Br—C₆H₅O H OCCl₂CF₃ H 19 269N CF₃ CF₃ NH C₆H₅O HOCF₂CCl₃ H 19 270N CF₃ CF₃ NH 4-Cl—C₆H₅O H OCF₂CCl₃ H 19 271N CF₃ CF₃ NH4-F—C₆H₅O H OCF₂CCl₃ H 19 272N CF₃ CF₃ NH 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 19273N CF₃ CF₃ NH H C₆H₅ OCF₂CCl₃ H 19 274N CF₃ CF₃ NH H 4-Cl—C₆H₅OCF₂CCl₃ H 19 275N CF₃ CF₃ NH H 4-F—C₆H₅ OCF₂CCl₃ H 19 276N CF₃ CF₃ NH H4-Br—C₆H₅ OCF₂CCl₃ H 19 277N CF₃ CF₃ NH 4-Br—C₆H₅O H OCF₂CCl₃ H 19 278NCF₃ CF₃ NH C₆H₅O H OCF₂CF₂H OCF₂CF₂H 19 279N CF₃ CF₃ NH 4-Cl—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 19 280N CF₃ CF₃ NH 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 19281N CF₃ CF₃ NH 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 19 282N CF₃ CF₃ NH HC₆H₅ OCF₂CF₂H OCF₂CF₂H 19 283N CF₃ CF₃ NH H 4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H19 284N CF₃ CF₃ NH H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 19 285N CF₃ CF₃ NH H4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 19 286N CF₃ CF₃ NH 4-Br—C₆H₅O H OCF₂CF₂HOCF₂CF₂H 19 287N CF₃ CF₃ NH C₆H₅O H OCF₃ OCF₃ 19 288N CF₃ CF₃ NH4-Cl—C₆H₅O H OCF₃ OCF₃ 19 289N CF₃ CF₃ NH 4-F—C₆H₅O H OCF₃ OCF₃ 19 290NCF₃ CF₃ NH 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 19 291N CF₃ CF₃ NH H C₆H₅ OCF₃ OCF₃19 292N CF₃ CF₃ NH H 4-Cl—C₆H₅ OCF₃ OCF₃ 19 293N CF₃ CF₃ NH H 4-F—C₆H₅OCF₃ OCF₃ 19 294N CF₃ CF₃ NH H 4-Br—C₆H₅ OCF₃ OCF₃ 19 295N CF₃ CF₃ NH4-Br—C₆H₅O H OCF₃ OCF₃ 19 296N CF₃ CF₃ NH C₆H₅O H OCF₂H OCF₂H 19 297NCF₃ CF₃ NH 4-Cl—C₆H₅O H OCF₂H OCF₂H 19 298N CF₃ CF₃ NH 4-F—C₆H₅O H OCF₂HOCF₂H 19 299N CF₃ CF₃ NH 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 19 300N CF₃ CF₃ NH HC₆H₅ OCF₂H OCF₂H 19 301N CF₃ CF₃ NH H 4-Cl—C₆H₅ OCF₂H OCF₂H 19 302N CF₃CF₃ NH H 4-F—C₆H₅ OCF₂H OCF₂H 19 303N CF₃ CF₃ NH H 4-Br—C₆H₅ OCF₂H OCF₂H19 304N CF₃ CF₃ NH 4-Br—C₆H₅O H OCF₂H OCF₂H 19 305N CF₃ CF₃ NH C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 19 306N CF₃ CF₃ NH 4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 19 307N CF₃ CF₃ NH 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 19 308N CF₃CF₃ NH 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 19 309N CF₃ CF₃ NH H C₆H₅R₁₀ + R₁₁ = OCF₂CF₂O 19 310N CF₃ CF₃ NH H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O19 311N CF₃ CF₃ NH H 4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 19 312N CF₃ CF₃ NH H4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 19 313N CF₃ CF₃ NH 4-Br—C₆H₅O H R₁₀ + R₁₁= OCF₂CF₂O 19 314N CF₃ CF₃ NH C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 19 315N CF₃CF₃ NH 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 19 316N CF₃ CF₃ NH 4-F—C₆H₅OH R₁₀ + R₁₁ = OCCl₂CCl₂O 19 317N CF₃ CF₃ NH 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 19 318N CF₃ CF₃ NH H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 19 319N CF₃CF₃ NH H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 19 320N CF₃ CF₃ NH H 4-F—C₆H₅R₁₀ + R₁₁ = OCCl₂CCl₂O 19 321N CF₃ CF₃ NH H 4-Br—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 19 322N CF₃ CF₃ NH 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 19323N CF₃ CF₃ NH H H OH H 19 324N CF₃ CF₃ NH H H OH OH 19 325N CF₃ CF₃ NHH H H OH 19 326N CF₃ CF₃ NH H H OCH₂CF₃ H 19 327N CF₃ CF₃ NH H H HOCH₂CF₃ 19 328N CF₃ CF₃ NH H H OCH₂CF₂CF₃ H 19 329N CF₃ CF₃ NH H HOCH₂CH₂CF₃ H 19 330N CF₃ CF₃ NH H H OCH(CF₃)₃ H 19 331N CF₃ CF₃ NH H4-F—C₆H₅O H H 19 332N CF₃ CF₃ NH 4-F—C₆H₅O H H H 19 333N CF₃ CF₃ NH Hcyclohexoxy H H 19 334N CF₃ CF₃ NH cyclohexoxy H H H 19 335N CF₃ CF₃ NHH CH(CH₃)₃ H H 19 336N CF₃ CF₃ NH F H

bond to indicated phenyl carbon of R₁₀ substituent 20 224N CF₃ H NHC₆H₅O H OCF₂CF₂H H 20 225N CF₃ H NH 4-Cl—C₆H₅O H OCF₂CF₂H H 20 226N CF₃H NH 4-F—C₆H₅O H OCF₂CF₂H H 20 227N CF₃ H NH 3,4-Cl—C₆H₅O H OCF₂CF₂H H20 228N CF₃ H NH H C₆H₅ OCF₂CF₂H H 20 229N CF₃ H NH H 4-Cl—C₆H₅ OCF₂CF₂HH 20 230N CF₃ H NH H 4-F—C₆H₅ OCF₂CF₂H H 20 231N CF₃ H NH H 4-Br—C₆H₅OCF₂CF₂H H 20 232N CF₃ H NH 4-Br—C₆H₅O H OCF₂CF₂H H 20 233N CF₃ H NHC₆H₅O H OCF₂CF₃ H 20 234N CF₃ H NH 4-Cl—C₆H₅O H OCF₂CF₃ H 20 235N CF₃ HNH 4-F—C₆H₅O H OCF₂CF₃ H 20 236N CF₃ H NH 3,4-Cl—C₆H₅O H OCF₂CF₃ H 20237N CF₃ H NH H C₆H₅ OCF₂CF₃ H 20 238N CF₃ H NH H 4-Cl—C₆H₅ OCF₂CF₃ H 20239N CF₃ H NH H 4-F—C₆H₅ OCF₂CF₃ H 20 240N CF₃ H NH H 4-Br—C₆H₅ OCF₂CF₃H 20 241N CF₃ H NH 4-Br—C₆H₅O H OCF₂CF₃ H 20 242N CF₃ H NH C₆H₅O HOCCl₂CCl₂H H 20 243N CF₃ H NH 4-Cl—C₆H₅O H OCCl₂CCl₂H H 20 244N CF₃ H NH4-F—C₆H₅O H OCCl₂CCl₂H H 20 245N CF₃ H NH 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 20246N CF₃ H NH H C₆H₅ OCCl₂CCl₂H H 20 247N CF₃ H NH H 4-Cl—C₆H₅OCCl₂CCl₂H H 20 248N CF₃ H NH H 4-F—C₆H₅ OCCl₂CCl₂H H 20 249N CF₃ H NH H4-Br—C₆H₅ OCCl₂CCl₂H H 20 250N CF₃ H NH 4-Br—C₆H₅O H OCCl₂CCl₂H H 20251N CF₃ H NH C₆H₅O H OCCl₂CCl₃ H 20 252N CF₃ H NH 4-Cl—C₆H₅O HOCCl₂CCl₃ H 20 253N CF₃ H NH 4-F—C₆H₅O H OCCl₂CCl₃ H 20 254N CF₃ H NH3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 20 255N CF₃ H NH H C₆H₅ OCCl₂CCl₃ H 20 256NCF₃ H NH H 4-Cl—C₆H₅ OCCl₂CCl₃ H 20 257N CF₃ H NH H 4-F—C₆H₅ OCCl₂CCl₃ H20 258N CF₃ H NH H 4-Br—C₆H₅ OCCl₂CCl₃ H 20 259N CF₃ H NH 4-Br—C₆H₅O HOCCl₂CCl₃ H 20 260N CF₃ H NH C₆H₅O H OCCl₂CF₃ H 20 261N CF₃ H NH4-Cl—C₆H₅O H OCCl₂CF₃ H 20 262N CF₃ H NH 4-F—C₆H₅O H OCCl₂CF₃ H 20 263NCF₃ H NH 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 20 264N CF₃ H NH H C₆H₅ OCCl₂CF₃ H 20265N CF₃ H NH H 4-Cl—C₆H₅ OCCl₂CF₃ H 20 266N CF₃ H NH H 4-F—C₆H₅OCCl₂CF₃ H 20 267N CF₃ H NH H 4-Br—C₆H₅ OCCl₂CF₃ H 20 268N CF₃ H NH4-Br—C₆H₅O H OCCl₂CF₃ H 20 269N CF₃ H NH C₆H₅O H OCF₂CCl₃ H 20 270N CF₃H NH 4-Cl—C₆H₅O H OCF₂CCl₃ H 20 271N CF₃ H NH 4-F—C₆H₅O H OCF₂CCl₃ H 20272N CF₃ H NH 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 20 273N CF₃ H NH H C₆H₅ OCF₂CCl₃H 20 274N CF₃ H NH H 4-Cl—C₆H₅ OCF₂CCl₃ H 20 275N CF₃ H NH H 4-F—C₆H₅OCF₂CCl₃ H 20 276N CF₃ H NH H 4-Br—C₆H₅ OCF₂CCl₃ H 20 277N CF₃ H NH4-Br—C₆H₅O H OCF₂CCl₃ H 20 278N CF₃ H NH C₆H₅O H OCF₂CF₂H OCF₂CF₂H 20279N CF₃ H NH 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 20 280N CF₃ H NH 4-F—C₆H₅OH OCF₂CF₂H OCF₂CF₂H 20 281N CF₃ H NH 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 20282N CF₃ H NH H C₆H₅ OCF₂CF₂H OCF₂CF₂H 20 283N CF₃ H NH H 4-Cl—C₆H₅OCF₂CF₂H OCF₂CF₂H 20 284N CF₃ H NH H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 20 285NCF₃ H NH H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 20 286N CF₃ H NH 4-Br—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 20 287N CF₃ H NH C₆H₅O H OCF₃ OCF₃ 20 288N CF₃ H NH4-Cl—C₆H₅O H OCF₃ OCF₃ 20 289N CF₃ H NH 4-F—C₆H₅O H OCF₃ OCF₃ 20 290NCF₃ H NH 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 20 291N CF₃ H NH H C₆H₅ OCF₃ OCF₃ 20292N CF₃ H NH H 4-Cl—C₆H₅ OCF₃ OCF₃ 20 293N CF₃ H NH H 4-F—C₆H₅ OCF₃OCF₃ 20 294N CF₃ H NH H 4-Br—C₆H₅ OCF₃ OCF₃ 20 295N CF₃ H NH 4-Br—C₆H₅OH OCF₃ OCF₃ 20 296N CF₃ H NH C₆H₅O H OCF₂H OCF₂H 20 297N CF₃ H NH4-Cl—C₆H₅O H OCF₂H OCF₂H 20 298N CF₃ H NH 4-F—C₆H₅O H OCF₂H OCF₂H 20299N CF₃ H NH 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 20 300N CF₃ H NH H C₆H₅ OCF₂HOCF₂H 20 301N CF₃ H NH H 4-Cl—C₆H₅ OCF₂H OCF₂H 20 302N CF₃ H NH H4-F—C₆H₅ OCF₂H OCF₂H 20 303N CF₃ H NH H 4-Br—C₆H₅ OCF₂H OCF₂H 20 304NCF₃ H NH 4-Br—C₆H₅O H OCF₂H OCF₂H 20 305N CF₃ H NH C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 20 306N CF₃ H NH 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 20 307N CF₃H NH 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 20 308N CF₃ H NH 3,4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 20 309N CF₃ H NH H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 20310N CF₃ H NH H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 20 311N CF₃ H NH H4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 20 312N CF₃ H NH H 4-Br—C₆H₅ R₁₀ + R₁₁ =OCF₂CF₂O 20 313N CF₃ H NH 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 20 314N CF₃H NH C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 20 315N CF₃ H NH 4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 20 316N CF₃ H NH 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 20317N CF₃ H NH 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 20 318N CF₃ H NH HC₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 20 319N CF₃ H NH H 4-Cl—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 20 320N CF₃ H NH H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 20 321NCF₃ H NH H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 20 322N CF₃ H NH 4-Br—C₆H₅OH R₁₀ + R₁₁ = OCCl₂CCl₂O 20 323N CF₃ H NH H H OH H 20 324N CF₃ H NH H HOH OH 20 325N CF₃ H NH H H H OH 20 326N CF₃ H NH H H OCH₂CF₃ H 20 327NCF₃ H NH H H H OCH₂CF₃ 20 328N CF₃ H NH H H OCH₂CF₂CF₃ H 20 329N CF₃ HNH H H OCH₂CH₂CF₃ H 20 330N CF₃ H NH H H OCH(CF₃)₃ H 20 331N CF₃ H NH H4-F—C₆H₅O H H 20 332N CF₃ H NH 4-F—C₆H₅O H H H 20 333N CF₃ H NH Hcyclo-hexoxy H H 20 334N CF₃ H NH cyclo-hexoxy H H H 20 335N CF₃ H NH HCH(CH₃)₃ H H 20 336N CF₃ H NH F H

bond to indicated phenyl carbon of R₁₀ substituent 25 224N CF₃ H S C₆H₅OH OCF₂CF₂H H 25 225N CF₃ H S 4-Cl—C₆H₅O H OCF₂CF₂H H 25 226N CF₃ H S4-F—C₆H₅O H OCF₂CF₂H H 25 227N CF₃ H S 3,4-Cl—C₆H₅O H OCF₂CF₂H H 25 228NCF₃ H S H C₆H₅ OCF₂CF₂H H 25 229N CF₃ H S H 4-Cl—C₆H₅ OCF₂CF₂H H 25 230NCF₃ H S H 4-F—C₆H₅ OCF₂CF₂H H 25 231N CF₃ H S H 4-Br—C₆H₅ OCF₂CF₂H H 25232N CF₃ H S 4-Br—C₆H₅O H OCF₂CF₂H H 25 233N CF₃ H S C₆H₅O H OCF₂CF₃ H25 234N CF₃ H S 4-Cl—C₆H₅O H OCF₂CF₃ H 25 235N CF₃ H S 4-F—C₆H₅O HOCF₂CF₃ H 25 236N CF₃ H S 3,4-Cl—C₆H₅O H OCF₂CF₃ H 25 237N CF₃ H S HC₆H₅ OCF₂CF₃ H 25 238N CF₃ H S H 4-Cl—C₆H₅ OCF₂CF₃ H 25 239N CF₃ H S H4-F—C₆H₅ OCF₂CF₃ H 25 240N CF₃ H S H 4-Br—C₆H₅ OCF₂CF₃ H 25 241N CF₃ H S4-Br—C₆H₅O H OCF₂CF₃ H 25 242N CF₃ H S C₆H₅O H OCCl₂CCl₂H H 25 243N CF₃H S 4-Cl—C₆H₅O H OCCl₂CCl₂H H 25 244N CF₃ H S 4-F—C₆H₅O H OCCl₂CCl₂H H25 245N CF₃ H S 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 25 246N CF₃ H S H C₆H₅OCCl₂CCl₂H H 25 247N CF₃ H s H 4-Cl—C₆H₅ OCCl₂CCl₂H H 25 248N CF₃ H S H4-F—C₆H₅ OCCl₂CCl₂H H 25 249N CF₃ H S H 4-Br—C₆H₅ OCCl₂CCl₂H H 25 250NCF₃ H S 4-Br—C₆H₅O H OCCl₂CCl₂H H 25 251N CF₃ H S C₆H₅O H OCCl₂CCl₃ H 25252N CF₃ H S 4-Cl—C₆H₅O H OCCl₂CCl₃ H 25 253N CF₃ H S 4-F—C₆H₅O HOCCl₂CCl₃ H 25 254N CF₃ H S 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 25 255N CF₃ H S HC₆H₅ OCCl₂CCl₃ H 25 256N CF₃ H S H 4-Cl—C₆H₅ OCCl₂CCl₃ H 25 257N CF₃ H SH 4-F—C₆H₅ OCCl₂CCl₃ H 25 258N CF₃ H S H 4-Br—C₆H₅ OCCl₂CCl₃ H 25 259NCF₃ H S 4-Br—C₆H₅O H OCCl₂CCl₃ H 25 260N CF₃ H S C₆H₅O H OCCl₂CF₃ H 25261N CF₃ H S 4-Cl—C₆H₅O H OCCl₂CF₃ H 25 262N CF₃ H S 4-F—C₆H₅O HOCCl₂CF₃ H 25 263N CF₃ H S 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 25 264N CF₃ H S HC₆H₅ OCCl₂CF₃ H 25 265N CF₃ H S H 4-Cl—C₆H₅ OCCl₂CF₃ H 25 266N CF₃ H S H4-F—C₆H₅ OCCl₂CF₃ H 25 267N CF₃ H S H 4-Br—C₆H₅ OCCl₂CF₃ H 25 268N CF₃ HS 4-Br—C₆H₅O H OCCl₂CF₃ H 25 269N CF₃ H S C₆H₅O H OCF₂CCl₃ H 25 270N CF₃H S 4-Cl—C₆H₅O H OCF₂CCl₃ H 25 271N CF₃ H S 4-F—C₆H₅O H OCF₂CCl₃ H 25272N CF₃ H S 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 25 273N CF₃ H S H C₆H₅ OCF₂CCl₃ H25 274N CF₃ H S H 4-Cl—C₆H₅ OCF₂CCl₃ H 25 275N CF₃ H S H 4-F—C₆H₅OCF₂CCl₃ H 25 276N CF₃ H S H 4-Br—C₆H₅ OCF₂CCl₃ H 25 277N CF₃ H S4-Br—C₆H₅O H OCF₂CCl₃ H 25 278N CF₃ H S C₆H₅O H OCF₂CF₂H OCF₂CF₂H 25279N CF₃ H S 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 25 280N CF₃ H S 4-F—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 25 281N CF₃ H S 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 25282N CF₃ H S H C₆H₅ OCF₂CF₂H OCF₂CF₂H 25 283N CF₃ H S H 4-Cl—C₆H₅OCF₂CF₂H OCF₂CF₂H 25 284N CF₃ H S H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 25 285NCF₃ H S H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 25 286N CF₃ H S 4-Br—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 25 287N CF₃ H S C₆H₅O H OCF₃ OCF₃ 25 288N CF₃ H S4-Cl—C₆H₅O H OCF₃ OCF₃ 25 289N CF₃ H S 4-F—C₆H₅O H OCF₃ OCF₃ 25 290N CF₃H S 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 25 291N CF₃ H S H C₆H₅ OCF₃ OCF₃ 25 292NCF₃ H S H 4-Cl—C₆H₅ OCF₃ OCF₃ 25 293N CF₃ H S H 4-F—C₆H₅ OCF₃ OCF₃ 25294N CF₃ H S H 4-Br—C₆H₅ OCF₃ OCF₃ 25 295N CF₃ H S 4-Br—C₆H₅O H OCF₃OCF₃ 25 296N CF₃ H S C₆H₅O H OCF₂H OCF₂H 25 297N CF₃ H S 4-Cl—C₆H₅O HOCF₂H OCF₂H 25 298N CF₃ H S 4-F—C₆H₅O H OCF₂H OCF₂H 25 299N CF₃ H S3,4-Cl—C₆H₅O H OCF₂H OCF₂H 25 300N CF₃ H S H C₆H₅ OCF₂H OCF₂H 25 301NCF₃ H S H 4-Cl—C₆H₅ OCF₂H OCF₂H 25 302N CF₃ H S H 4-F—C₆H₅ OCF₂H OCF₂H25 303N CF₃ H S H 4-Br—C₆H₅ OCF₂H OCF₂H 25 304N CF₃ H S 4-Br—C₆H₅O HOCF₂H OCF₂H 25 305N CF₃ H S C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 25 306N CF₃ H S4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 25 307N CF₃ H S 4-F—C₆H₅O H R₁₀ + R₁₁= OCF₂CF₂O 25 308N CF₃ H S 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 25 309NCF₃ H S H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 25 310N CF₃ H S H 4-Cl—C₆H₅ R₁₀ +R₁₁ = OCF₂CF₂O 25 311N CF₃ H S H 4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 25 312NCF₃ H S H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 25 313N CF₃ H S 4-Br—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 25 314N CF₃ H S C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 25315N CF₃ H S 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 25 316N CF₃ H S4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 25 317N CF₃ H S 3,4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 25 318N CF₃ H S H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 25 319NCF₃ H S H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 25 320N CF₃ H S H 4-F—C₆H₅R₁₀ + R₁₁ = OCCl₂CCl₂O 25 321N CF₃ H S H 4-Br—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 25 322N CF₃ H S 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 25 323NCF₃ H S H H OH H 25 324N CF₃ H S H H OH OH 25 325N CF₃ H S H H H OH 25326N CF₃ H S H H OCH₂CF₃ H 25 327N CF₃ H S H H H OCH₂CF₃ 25 328N CF₃ H SH H OCH₂CF₂CF₃ H 25 329N CF₃ H S H H OCH₂CH₂CF₃ H 25 330N CF₃ H S H HOCH(CF₃)₃ H 25 331N CF₃ H S H 4-F—C₆H₅O H H 25 332N CF₃ H S 4-F—C₆H₅O HH H 25 333N CF₃ H S H cyclo-hexoxy H H 25 334N CF₃ H S cyclo-hexoxy H HH 25 335N CF₃ H S H CH(CH₃)₃ H H 25 336N CF₃ H S F H

bond to indicated phenyl carbon of R₁₀ substituent 26 224N CF₃CF₂ H SC₆H₅O H OCF₂CF₂H H 26 225N CF₃CF₂ H S 4-Cl—C₆H₅O H OCF₂CF₂H H 26 226NCF₃CF₂ H S 4-F—C₆H₅O H OCF₂CF₂H H 26 227N CF₃CF₂ H S 3,4-Cl—C₆H₅O HOCF₂CF₂H H 26 228N CF₃CF₂ H S H C₆H₅ OCF₂CF₂H H 26 229N CF₃CF₂ H S H4-Cl—C₆H₅ OCF₂CF₂H H 26 230N CF₃CF₂ H S H 4-F—C₆H₅ OCF₂CF₂H H 26 231NCF₃CF₂ H S H 4-Br—C₆H₅ OCF₂CF₂H H 26 232N CF₃CF₂ H S 4-Br—C₆H₅O HOCF₂CF₂H H 26 233N CF₃CF₂ H S C₆H₅O H OCF₂CF₃ H 26 234N CF₃CF₂ H S4-Cl—C₆H₅O H OCF₂CF₃ H 26 235N CF₃CF₂ H S 4-F—C₆H₅O H OCF₂CF₃ H 26 236NCF₃CF₂ H S 3,4-Cl—C₆H₅O H OCF₂CF₃ H 26 237N CF₃CF₂ H S H C₆H₅ OCF₂CF₃ H26 238N CF₃CF₂ H S H 4-Cl—C₆H₅ OCF₂CF₃ H 26 239N CF₃CF₂ H S H 4-F—C₆H₅OCF₂CF₃ H 26 240N CF₃CF₂ H S H 4-Br—C₆H₅ OCF₂CF₃ H 26 241N CF₃CF₂ H S4-Br—C₆H₅O H OCF₂CF₃ H 26 242N CF₃CF₂ H S C₆H₅O H OCCl₂CCl₂H H 26 243NCF₃CF₂ H S 4-Cl—C₆H₅O H OCCl₂CCl₂H H 26 244N CF₃CF₂ H S 4-F—C₆H₅O HOCCl₂CCl₂H H 26 245N CF₃CF₂ H S 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 26 246NCF₃CF₂ H S H C₆H₅ OCCl₂CCl₂H H 26 247N CF₃CF₂ H S H 4-Cl—C₆H₅ OCCl₂CCl₂HH 26 248N CF₃CF₂ H S H 4-F—C₆H₅ OCCl₂CCl₂H H 26 249N CF₃CF₂ H S H4-Br—C₆H₅ OCCl₂CCl₂H H 26 250N CF₃CF₂ H S 4-Br—C₆H₅O H OCCl₂CCl₂H H 26251N CF₃CF₂ H S C₆H₅O H OCCl₂CCl₃ H 26 252N CF₃CF₂ H S 4-Cl—C₆H₅O HOCCl₂CCl₃ H 26 253N CF₃CF₂ H S 4-F—C₆H₅O H OCCl₂CCl₃ H 26 254N CF₃CF₂ HS 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 26 255N CF₃CF₂ H S H C₆H₅ OCCl₂CCl₃ H 26256N CF₃CF₂ H S H 4-Cl—C₆H₅ OCCl₂CCl₃ H 26 257N CF₃CF₂ H S H 4-F—C₆H₅OCCl₂CCl₃ H 26 258N CF₃CF₂ H S H 4-Br—C₆H₅ OCCl₂CCl₃ H 26 259N CF₃CF₂ HS 4-Br—C₆H₅O H OCCl₂CCl₃ H 26 260N CF₃CF₂ H S C₆H₅O H OCCl₂CF₃ H 26 261NCF₃CF₂ H S 4-Cl—C₆H₅O H OCCl₂CF₃ H 26 262N CF₃CF₂ H S 4-F—C₆H₅O HOCCl₂CF₃ H 26 263N CF₃CF₂ H S 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 26 264N CF₃CF₂ HS H C₆H₅ OCCl₂CF₃ H 26 265N CF₃CF₂ H S H 4-Cl—C₆H₅ OCCl₂CF₃ H 26 266NCF₃CF₂ H S H 4-F—C₆H₅ OCCl₂CF₃ H 26 267N CF₃CF₂ H S H 4-Br—C₆H₅ OCCl₂CF₃H 26 268N CF₃CF₂ H S 4-Br—C₆H₅O H OCCl₂CF₃ H 26 269N CF₃CF₂ H S C₆H₅O HOCF₂CCl₃ H 26 270N CF₃CF₂ H S 4-Cl—C₆H₅O H OCF₂CCl₃ H 26 271N CF₃CF₂ H S4-F—C₆H₅O H OCF₂CCl₃ H 26 272N CF₃CF₂ H S 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 26273N CF₃CF₂ H S H C₆H₅ OCF₂CCl₃ H 26 274N CF₃CF₂ H S H 4-Cl—C₆H₅OCF₂CCl₃ H 26 275N CF₃CF₂ H S H 4-F—C₆H₅ OCF₂CCl₃ H 26 276N CF₃CF₂ H S H4-Br—C₆H₅ OCF₂CCl₃ H 26 277N CF₃CF₂ H S 4-Br—C₆H₅O H OCF₂CCl₃ H 26 278NCF₃CF₂ H S C₆H₅O H OCF₂CF₂H OCF₂CF₂H 26 279N CF₃CF₂ H S 4-Cl—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 26 280N CF₃CF₂ H S 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 26281N CF₃CF₂ H S 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 26 282N CF₃CF₂ H S HC₆H₅ OCF₂CF₂H OCF₂CF₂H 26 283N CF₃CF₂ H S H 4-Cl—C₆H₅ OCF₂CF₂H OCF₂CF₂H26 284N CF₃CF₂ H S H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 26 285N CF₃CF₂ H S H4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 26 286N CF₃CF₂ H S 4-Br—C₆H₅O H OCF₂CF₂HOCF₂CF₂H 26 287N CF₃CF₂ H S C₆H₅O H OCF₃ OCF₃ 26 288N CF₃CF₂ H S4-Cl—C₆H₅O H OCF₃ OCF₃ 26 289N CF₃CF₂ H S 4-F—C₆H₅O H OCF₃ OCF₃ 26 290NCF₃CF₂ H S 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 26 291N CF₃CF₂ H S H C₆H₅ OCF₃ OCF₃26 292N CF₃CF₂ H S H 4-Cl—C₆H₅ OCF₃ OCF₃ 26 293N CF₃CF₂ H S H 4-F—C₆H₅OCF₃ OCF₃ 26 294N CF₃CF₂ H S H 4-Br—C₆H₅ OCF₃ OCF₃ 26 295N CF₃CF₂ H S4-Br—C₆H₅O H OCF₃ OCF₃ 26 296N CF₃CF₂ H S C₆H₅O H OCF₂H OCF₂H 26 297NCF₃CF₂ H S 4-Cl—C₆H₅O H OCF₂H OCF₂H 26 298N CF₃CF₂ H S 4-F—C₆H₅O H OCF₂HOCF₂H 26 299N CF₃CF₂ H S 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 26 300N CF₃CF₂ H S HC₆H₅ OCF₂H OCF₂H 26 301N CF₃CF₂ H S H 4-Cl—C₆H₅ OCF₂H OCF₂H 26 302NCF₃CF₂ H S H 4-F—C₆H₅ OCF₂H OCF₂H 26 303N CF₃CF₂ H S H 4-Br—C₆H₅ OCF₂HOCF₂H 26 304N CF₃CF₂ H S 4-Br—C₆H₅O H OCF₂H OCF₂H 26 305N CF₃CF₂ H SC₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 26 306N CF₃CF₂ H S 4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 26 307N CF₃CF₂ H S 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 26 308NCF₃CF₂ H S 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 26 309N CF₃CF₂ H S H C₆H₅R₁₀ + R₁₁ = OCF₂CF₂O 26 310N CF₃CF₂ H S H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O26 311N CF₃CF₂ H S H 4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 26 312N CF₃CF₂ H S H4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 26 313N CF₃CF₂ H S 4-Br—C₆H₅O H R₁₀ + R₁₁= OCF₂CF₂O 26 314N CF₃CF₂ H S C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 26 315NCF₃CF₂ H S 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 26 316N CF₃CF₂ H S4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 26 317N CF₃CF₂ H S 3,4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 26 318N CF₃CF₂ H S H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O26 319N CF₃CF₂ H S H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 26 320N CF₃CF₂ H SH 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 26 321N CF₃CF₂ H S H 4-Br—C₆H₅ R₁₀ +R₁₁ = OCCl₂CCl₂O 26 322N CF₃CF₂ H S 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O26 323N CF₃CF₂ H S H H OH H 26 324N CF₃CF₂ H S H H OH OH 26 325N CF₃CF₂H S H H H OH 26 326N CF₃CF₂ H S H H OCH₂CF₃ H 26 327N CF₃CF₂ H S H H HOCH₂CF₃ 26 328N CF₃CF₂ H S H H OCH₂CF₂CF₃ H 26 329N CF₃CF₂ H S H HOCH₂CH₂CF₃ H 26 330N CF₃CF₂ H S H H OCH(CF₃)₃ H 26 331N CF₃CF₂ H S H4-F—C₆H₅O H H 26 332N CF₃CF₂ H S 4-F—C₆H₅O H H H 26 333N CF₃CF₂ H S Hcyclo-hexoxy H H 26 334N CF₃CF₂ H S cyclo-hexoxy H H H 26 335N CF₃CF₂ HS H CH(CH₃)₃ H H 26 336N CF₃CF₂ H S F H

bond to indicated phenyl carbon of R₁₀ substituent 63 224N C₆H₅ H OC₆H₅O H OCF₂CF₂H H 63 225N C₆H₅ H O 4-Cl—C₆H₅O H OCF₂CF₂H H 63 226N C₆H₅H O 4-F—C₆H₅O H OCF₂CF₂H H 63 227N C₆H₅ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H H 63228N C₆H₅ H O H C₆H₅ OCF₂CF₂H H 63 229N C₆H₅ H O H 4-Cl—C₆H₅ OCF₂CF₂H H63 230N C₆H₅ H O H 4-F—C₆H₅ OCF₂CF₂H H 63 231N C₆H₅ H O H 4-Br—C₆H₅OCF₂CF₂H H 63 232N C₆H₅ H O 4-Br—C₆H₅O H OCF₂CF₂H H 63 233N C₆H₅ H OC₆H₅O H OCF₂CF₃ H 63 234N C₆H₅ H O 4-Cl—C₆H₅O H OCF₂CF₃ H 63 235N C₆H₅ HO 4-F—C₆H₅O H OCF₂CF₃ H 63 236N C₆H₅ H O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 63237N C₆H₅ H O H C₆H₅ OCF₂CF₃ H 63 238N C₆H₅ H O H 4-Cl—C₆H₅ OCF₂CF₃ H 63239N C₆H₅ H O H 4-F—C₆H₅ OCF₂CF₃ H 63 240N C₆H₅ H O H 4-Br—C₆H₅ OCF₂CF₃H 63 241N C₆H₅ H O 4-Br—C₆H₅O H OCF₂CF₃ H 63 242N C₆H₅ H O C₆H₅O HOCCl₂CCl₂H H 63 243N C₆H₅ H O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 63 244N C₆H₅ H O4-F—C₆H₅O H OCCl₂CCl₂H H 63 245N C₆H₅ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 63246N C₆H₅ H O H C₆H₅ OCCl₂CCl₂H H 63 247N C₆H₅ H O H 4-Cl—C₆H₅OCCl₂CCl₂H H 63 248N C₆H₅ H O H 4-F—C₆H₅ OCCl₂CCl₂H H 63 249N C₆H₅ H O H4-Br—C₆H₅ OCCl₂CCl₂H H 63 250N C₆H₅ H O 4-Br—C₆H₅O H OCCl₂CCl₂H H 63251N C₆H₅ H O C₆H₅O H OCCl₂CCl₃ H 63 252N C₆H₅ H O 4-Cl—C₆H₅O HOCCl₂CCl₃ H 63 253N C₆H₅ H O 4-F—C₆H₅O H OCCl₂CCl₃ H 63 254N C₆H₅ H O3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 63 255N C₆H₅ H O H C₆H₅ OCCl₂CCl₃ H 63 256NC₆H₅ H O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 63 257N C₆H₅ H O H 4-F—C₆H₅ OCCl₂CCl₃ H63 258N C₆H₅ H O H 4-Br—C₆H₅ OCCl₂CCl₃ H 63 259N C₆H₅ H O 4-Br—C₆H₅O HOCCl₂CCl₃ H 63 260N C₆H₅ H O C₆H₅O H OCCl₂CF₃ H 63 261N C₆H₅ H O4-Cl—C₆H₅O H OCCl₂CF₃ H 63 262N C₆H₅ H O 4-F—C₆H₅O H OCCl₂CF₃ H 63 263NC₆H₅ H O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 63 264N C₆H₅ H O H C₆H₅ OCCl₂CF₃ H 63265N C₆H₅ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 63 266N C₆H₅ H O H 4-F—C₆H₅OCCl₂CF₃ H 63 267N C₆H₅ H O H 4-Br—C₆H₅ OCCl₂CF₃ H 63 268N C₆H₅ H O4-Br—C₆H₅O H OCCl₂CF₃ H 63 269N C₆H₅ H O C₆H₅O H OCF₂CCl₃ H 63 270N C₆H₅H O 4-Cl—C₆H₅O H OCF₂CCl₃ H 63 271N C₆H₅ H O 4-F—C₆H₅O H OCF₂CCl₃ H 63272N C₆H₅ H O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 63 273N C₆H₅ H O H C₆H₅ OCF₂CCl₃H 63 274N C₆H₅ H O H 4-Cl—C₆H₅ OCF₂CCl₃ H 63 275N C₆H₅ H O H 4-F—C₆H₅OCF₂CCl₃ H 63 276N C₆H₅ H O H 4-Br—C₆H₅ OCF₂CCl₃ H 63 277N C₆H₅ H O4-Br—C₆H₅O H OCF₂CCl₃ H 63 278N C₆H₅ H O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 63279N C₆H₅ H O 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 63 280N C₆H₅ H O 4-F—C₆H₅OH OCF₂CF₂H OCF₂CF₂H 63 281N C₆H₅ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 63282N C₆H₅ H O H C₆H₅ OCF₂CF₂H OCF₂CF₂H 63 283N C₆H₅ H O H 4-Cl—C₆H₅OCF₂CF₂H OCF₂CF₂H 63 284N C₆H₅ H O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 63 285NC₆H₅ H O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 63 286N C₆H₅ H O 4-Br—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 63 287N C₆H₅ H O C₆H₅O H OCF₃ OCF₃ 63 288N C₆H₅ H O4-Cl—C₆H₅O H OCF₃ OCF₃ 63 289N C₆H₅ H O 4-F—C₆H₅O H OCF₃ OCF₃ 63 290NC₆H₅ H O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 63 291N C₆H₅ H O H C₆H₅ OCF₃ OCF₃ 63292N C₆H₅ H O H 4-Cl—C₆H₅ OCF₃ OCF₃ 63 293N C₆H₅ H O H 4-F—C₆H₅ OCF₃OCF₃ 63 294N C₆H₅ H O H 4-Br—C₆H₅ OCF₃ OCF₃ 63 295N C₆H₅ H O 4-Br—C₆H₅OH OCF₃ OCF₃ 63 296N C₆H₅ H O C₆H₅O H OCF₂H OCF₂H 63 297N C₆H₅ H O4-Cl—C₆H₅O H OCF₂H OCF₂H 63 298N C₆H₅ H O 4-F—C₆H₅O H OCF₂H OCF₂H 63299N C₆H₅ H O 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 63 300N C₆H₅ H O H C₆H₅ OCF₂HOCF₂H 63 301N C₆H₅ H O H 4-Cl—C₆H₅ OCF₂H OCF₂H 63 302N C₆H₅ H O H4-F—C₆H₅ OCF₂H OCF₂H 63 303N C₆H₅ H O H 4-Br—C₆H₅ OCF₂H OCF₂H 63 304NC₆H₅ H O 4-Br—C₆H₅O H OCF₂H OCF₂H 63 305N C₆H₅ H O C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 63 306N C₆H₅ H O 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 63 307N C₆H₅H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 63 308N C₆H₅ H O 3,4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 63 309N C₆H₅ H O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 63310N C₆H₅ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 63 311N C₆H₅ H O H4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 63 312N C₆H₅ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ =OCF₂CF₂O 63 313N C₆H₅ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 63 314N C₆H₅H O C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 63 315N C₆H₅ H O 4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 63 316N C₆H₅ H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 63317N C₆H₅ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 63 318N C₆H₅ H O HC₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 63 319N C₆H₅ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 63 320N C₆H₅ H O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 63 321NC₆H₅ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 63 322N C₆H₅ H O 4-Br—C₆H₅OH R₁₀ + R₁₁ = OCCl₂CCl₂O 63 323N C₆H₅ H O H H OH H 63 324N C₆H₅ H O H HOH OH 63 325N C₆H₅ H O H H H OH 63 326N C₆H₅ H O H H OCH₂CF₃ H 63 327NC₆H₅ H O H H H OCH₂CF₃ 63 328N C₆H₅ H O H H OCH₂CF₂CF₃ H 63 329N C₆H₅ HO H H OCH₂CH₂CF₃ H 63 330N C₆H₅ H O H H OCH(CF₃)₃ H 63 331N C₆H₅ H O H4-F—C₆H₅O H H 63 332N C₆H₅ H O 4-F—C₆H₅O H H H 63 333N C₆H₅ H O Hcyclo-hexoxy H H 63 334N C₆H₅ H O cyclo-hexoxy H H H 63 335N C₆H₅ H O HCH(CH₃)₃ H H 63 336N C₆H₅ H O F H

bond to indicated phenyl carbon of R₁₀ substituent 65 224N C₆F₅ H OC₆H₅O H OCF₂CF₂H H 65 225N C₆F₅ H O 4-Cl—C₆H₅O H OCF₂CF₂H H 65 226N C₆F₅H O 4-F—C₆H₅O H OCF₂CF₂H H 65 227N C₆F₅ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H H 65228N C₆F₅ H O H C₆H₅ OCF₂CF₂H H 65 229N C₆F₅ H O H 4-Cl—C₆H₅ OCF₂CF₂H H65 230N C₆F₅ H O H 4-F—C₆H₅ OCF₂CF₂H H 65 231N C₆F₅ H O H 4-Br—C₆H₅OCF₂CF₂H H 65 232N C₆F₅ H O 4-Br—C₆H₅O H OCF₂CF₂H H 65 233N C₆F₅ H OC₆H₅O H OCF₂CF₃ H 65 234N C₆F₅ H O 4-Cl—C₆H₅O H OCF₂CF₃ H 65 235N C₆F₅ HO 4-F—C₆H₅O H OCF₂CF₃ H 65 236N C₆F₅ H O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 65237N C₆F₅ H O H C₆H₅ OCF₂CF₃ H 65 238N C₆F₅ H O H 4-Cl—C₆H₅ OCF₂CF₃ H 65239N C₆F₅ H O H 4-F—C₆H₅ OCF₂CF₃ H 65 240N C₆F₅ H O H 4-Br—C₆H₅ OCF₂CF₃H 65 241N C₆F₅ H O 4-Br—C₆H₅O H OCF₂CF₃ H 65 242N C₆F₅ H O C₆H₅O HOCCl₂CCl₂H H 65 243N C₆F₅ H O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 65 244N C₆F₅ H O4-F—C₆H₅O H OCCl₂CCl₂H H 65 245N C₆F₅ H O 3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 65246N C₆F₅ H O H C₆H₅ OCCl₂CCl₂H H 65 247N C₆F₅ H O H 4-Cl—C₆H₅OCCl₂CCl₂H H 65 248N C₆F₅ H O H 4-F—C₆H₅ OCCl₂CCl₂H H 65 249N C₆F₅ H O H4-Br—C₆H₅ OCCl₂CCl₂H H 65 250N C₆F₅ H O 4-Br—C₆H₅O H OCCl₂CCl₂H H 65251N C₆F₅ H O C₆H₅O H OCCl₂CCl₃ H 65 252N C₆F₅ H O 4-Cl—C₆H₅O HOCCl₂CCl₃ H 65 253N C₆F₅ H O 4-F—C₆H₅O H OCCl₂CCl₃ H 65 254N C₆F₅ H O3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 65 255N C₆F₅ H O H C₆H₅ OCCl₂CCl₃ H 65 256NC₆F₅ H O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 65 257N C₆F₅ H O H 4-F—C₆H₅ OCCl₂CCl₃ H65 258N C₆F₅ H O H 4-Br—C₆H₅ OCCl₂CCl₃ H 65 259N C₆F₅ H O 4-Br—C₆H₅O HOCCl₂CCl₃ H 65 260N C₆F₅ H O C₆H₅O H OCCl₂CF₃ H 65 261N C₆F₅ H O4-Cl—C₆H₅O H OCCl₂CF₃ H 65 262N C₆F₅ H O 4-F—C₆H₅O H OCCl₂CF₃ H 65 263NC₆F₅ H O 3,4-Cl—C₆H₅O H OCCl₂CF₃ H 65 264N C₆F₅ H O H C₆H₅ OCCl₂CF₃ H 65265N C₆F₅ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 65 266N C₆F₅ H O H 4-F—C₆H₅OCCl₂CF₃ H 65 267N C₆F₅ H O H 4-Br—C₆H₅ OCCl₂CF₃ H 65 268N C₆F₅ H O4-Br—C₆H₅O H OCCl₂CF₃ H 65 269N C₆F₅ H O C₆H₅O H OCF₂CCl₃ H 65 270N C₆F₅H O 4-Cl—C₆H₅O H OCF₂CCl₃ H 65 271N C₆F₅ H O 4-F—C₆H₅O H OCF₂CCl₃ H 65272N C₆F₅ H O 3,4-Cl—C₆H₅O H OCF₂CCl₃ H 65 273N C₆F₅ H O H C₆H₅ OCF₂CCl₃H 65 274N C₆F₅ H O H 4-Cl—C₆H₅ OCF₂CCl₃ H 65 275N C₆F₅ H O H 4-F—C₆H₅OCF₂CCl₃ H 65 276N C₆F₅ H O H 4-Br—C₆H₅ OCF₂CCl₃ H 65 277N C₆F₅ H O4-Br—C₆H₅O H OCF₂CCl₃ H 65 278N C₆F₅ H O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 65279N C₆F₅ H O 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 65 280N C₆F₅ H O 4-F—C₆H₅OH OCF₂CF₂H OCF₂CF₂H 65 281N C₆F₅ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 65282N C₆F₅ H O H C₆H₅ OCF₂CF₂H OCF₂CF₂H 65 283N C₆F₅ H O H 4-Cl—C₆H₅OCF₂CF₂H OCF₂CF₂H 65 284N C₆F₅ H O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 65 285NC₆F₅ H O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 65 286N C₆F₅ H O 4-Br—C₆H₅O HOCF₂CF₂H OCF₂CF₂H 65 287N C₆F₅ H O C₆H₅O H OCF₃ OCF₃ 65 288N C₆F₅ H O4-Cl—C₆H₅O H OCF₃ OCF₃ 65 289N C₆F₅ H O 4-F—C₆H₅O H OCF₃ OCF₃ 65 290NC₆F₅ H O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 65 291N C₆F₅ H O H C₆H₅ OCF₃ OCF₃ 65292N C₆F₅ H O H 4-Cl—C₆H₅ OCF₃ OCF₃ 65 293N C₆F₅ H O H 4-F—C₆H₅ OCF₃OCF₃ 65 294N C₆F₅ H O H 4-Br—C₆H₅ OCF₃ OCF₃ 65 295N C₆F₅ H O 4-Br—C₆H₅OH OCF₃ OCF₃ 65 296N C₆F₅ H O C₆H₅O H OCF₂H OCF₂H 65 297N C₆F₅ H O4-Cl—C₆H₅O H OCF₂H OCF₂H 65 298N C₆F₅ H O 4-F—C₆H₅O H OCF₂H OCF₂H 65299N C₆F₅ H O 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 65 300N C₆F₅ H O H C₆H₅ OCF₂HOCF₂H 65 301N C₆F₅ H O H 4-Cl—C₆H₅ OCF₂H OCF₂H 65 302N C₆F₅ H O H4-F—C₆H₅ OCF₂H OCF₂H 65 303N C₆F₅ H O H 4-Br—C₆H₅ OCF₂H OCF₂H 65 304NC₆F₅ H O 4-Br—C₆H₅O H OCF₂H OCF₂H 65 305N C₆F₅ H O C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 65 306N C₆F₅ H O 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 65 307N C₆F₅H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 65 308N C₆F₅ H O 3,4-Cl—C₆H₅O HR₁₀ + R₁₁ = OCF₂CF₂O 65 309N C₆F₅ H O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 65310N C₆F₅ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 65 311N C₆F₅ H O H4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 65 312N C₆F₅ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ =OCF₂CF₂O 65 313N C₆F₅ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 65 314N C₆F₅H O C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 65 315N C₆F₅ H O 4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 65 316N C₆F₅ H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 65317N C₆F₅ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 65 318N C₆F₅ H O HC₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 65 319N C₆F₅ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ =OCCl₂CCl₂O 65 320N C₆F₅ H O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 65 321NC₆F₅ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 65 322N C₆F₅ H O 4-Br—C₆H₅OH R₁₀ + R₁₁ = OCCl₂CCl₂O 65 323N C₆F₅ H O H H OH H 65 324N C₆F₅ H O H HOH OH 65 325N C₆F₅ H O H H H OH 65 326N C₆F₅ H O H H OCH₂CF₃ H 65 327NC₆F₅ H O H H H OCH₂CF₃ 65 328N C₆F₅ H O H H OCH₂CF₂CF₃ H 65 329N C₆F₅ HO H H OCH₂CH₂CF₃ H 65 330N C₆F₅ H O H H OCH(CF₃)₃ H 65 331N C₆F₅ H O H4-F—C₆H₅O H H 65 332N C₆F₅ H O 4-F—C₆H₅O H H H 65 333N C₆F₅ H O Hcyclo-hexoxy H H 65 334N C₆F₅ H O cyclo-hexoxy H H H 65 335N C₆F₅ H O HCH(CH₃)₃ H H 65 336N C₆F₅ H O F H

bond to indicated phenyl carbon of R₁₀ substituent 46 224N CF₃ R₂ + R₃ =(CH₂)₃ O C₆H₅O H OCF₂CF₂H H 46 225N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O HOCF₂CF₂H H 46 226N CF₃ R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H OCF₂CF₂H H 46 227NCF₃ R₂ + R₃ = (CH₂)₃ O 3,4-Cl—C₆H₅O H OCF₂CF₂H H 46 228N CF₃ R₂ + R₃ =(CH₂)₃ O H C₆H₅ OCF₂CF₂H H 46 229N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅OCF₂CF₂H H 46 230N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCF₂CF₂H H 46 231NCF₃ R₂ + R₃ = (CH₂)₃ O H 4-Br—C₆H₅ OCF₂CF₂H H 46 232N CF₃ R₂ + R₃ =(CH₂)₃ O 4-Br—C₆H₅O H OCF₂CF₂H H 46 233N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O HOCF₂CF₃ H 46 234N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H OCF₂CF₃ H 46 235NCF₃ R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H OCF₂CF₃ H 46 236N CF₃ R₂ + R₃ =(CH₂)₃ O 3,4-Cl—C₆H₅O H OCF₂CF₃ H 46 237N CF₃ R₂ + R₃ = (CH₂)₃ O H C₆H₅OCF₂CF₃ H 46 238N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ OCF₂CF₃ H 46 239NCF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCF₂CF₃ H 46 240N CF₃ R₂ + R₃ = (CH₂)₃O H 4-Br—C₆H₅ OCF₂CF₃ H 46 241N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Br—C₆H₅O HOCF₂CF₃ H 46 242N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O H OCCl₂CCl₂H H 46 243NCF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 46 244N CF₃ R₂ + R₃ =(CH₂)₃ O 4-F—C₆H₅O H OCCl₂CCl₂H H 46 245N CF₃ R₂ + R₃ = (CH₂)₃ O3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 46 246N CF₃ R₂ + R₃ = (CH₂)₃ O H C₆H₅OCCl₂CCl₂H H 46 247N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 46248N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCCl₂CCl₂H H 46 249N CF₃ R₂ + R₃= (CH₂)₃ O H 4-Br—C₆H₅ OCCl₂CCl₂H H 46 250N CF₃ R₂ + R₃ = (CH₂)₃ O4-Br—C₆H₅O H OCCl₂CCl₂H H 46 251N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O HOCCl₂CCl₃ H 46 252N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H OCCl₂CCl₃ H 46253N CF₃ R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H OCCl₂CCl₃ H 46 254N CF₃ R₂ + R₃= (CH₂)₃ O 3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 46 255N CF₃ R₂ + R₃ = (CH₂)₃ O HC₆H₅ OCCl₂CCl₃ H 46 256N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ OCCl₂CCl₃ H46 257N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCCl₂CCl₃ H 46 258N CF₃ R₂ +R₃ = (CH₂)₃ O H 4-Br—C₆H₅ OCCl₂CCl₃ H 46 259N CF₃ R₂ + R₃ = (CH₂)₃ O4-Br—C₆H₅O H OCCl₂CCl₃ H 46 260N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O H OCCl₂CF₃H 46 261N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H OCCl₂CF₃ H 46 262N CF₃R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H OCCl₂CF₃ H 46 263N CF₃ R₂ + R₃ = (CH₂)₃ O3,4-Cl—C₆H₅O H OCCl₂CF₃ H 46 264N CF₃ R₂ + R₃ = (CH₂)₃ O H C₆H₅ OCCl₂CF₃H 46 265N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ OCCl₂CF₃ H 46 266N CF₃ R₂ +R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCCl₂CF₃ H 46 267N CF₃ R₂ + R₃ = (CH₂)₃ O H4-Br—C₆H₅ OCCl₂CF₃ H 46 268N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Br—C₆H₅O HOCCl₂CF₃ H 46 269N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O H OCF₂CCl₃ H 46 270N CF₃R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H OCF₂CCl₃ H 46 271N CF₃ R₂ + R₃ = (CH₂)₃O 4-F—C₆H₅O H OCF₂CCl₃ H 46 272N CF₃ R₂ + R₃ = (CH₂)₃ O 3,4-Cl—C₆H₅O HOCF₂CCl₃ H 46 273N CF₃ R₂ + R₃ = (CH₂)₃ O H C₆H₅ OCF₂CCl₃ H 46 274N CF₃R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ OCF₂CCl₃ H 46 275N CF₃ R₂ + R₃ = (CH₂)₃ OH 4-F—C₆H₅ OCF₂CCl₃ H 46 276N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Br—C₆H₅OCF₂CCl₃ H 46 277N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Br—C₆H₅O H OCF₂CCl₃ H 46278N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O H OCF₂CF₂H OCF₂CF₂H 46 279N CF₃ R₂ +R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 46 280N CF₃ R₂ + R₃ =(CH₂)₃ O 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 46 281N CF₃ R₂ + R₃ = (CH₂)₃ O3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 46 282N CF₃ R₂ + R₃ = (CH₂)₃ O H C₆H₅OCF₂CF₂H OCF₂CF₂H 46 283N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ OCF₂CF₂HOCF₂CF₂H 46 284N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 46285N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 46 286N CF₃R₂ + R₃ = (CH₂)₃ O 4-Br—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 46 287N CF₃ R₂ + R₃ =(CH₂)₃ O C₆H₅O H OCF₃ OCF₃ 46 288N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O HOCF₃ OCF₃ 46 289N CF₃ R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H OCF₃ OCF₃ 46 290NCF₃ R₂ + R₃ = (CH₂)₃ O 3,4-Cl—C₆H₅O H OCF₃ OCF₃ 46 291N CF₃ R₂ + R₃ =(CH₂)₃ O H C₆H₅ OCF₃ OCF₃ 46 292N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅OCF₃ OCF₃ 46 293N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCF₃ OCF₃ 46 294NCF₃ R₂ + R₃ = (CH₂)₃ O H 4-Br—C₆H₅ OCF₃ OCF₃ 46 295N CF₃ R₂ + R₃ =(CH₂)₃ O 4-Br—C₆H₅O H OCF₃ OCF₃ 46 296N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O HOCF₂H OCF₂H 46 297N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H OCF₂H OCF₂H 46298N CF₃ R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H OCF₂H OCF₂H 46 299N CF₃ R₂ + R₃= (CH₂)₃ O 3,4-Cl—C₆H₅O H OCF₂H OCF₂H 46 300N CF₃ R₂ + R₃ = (CH₂)₃ O HC₆H₅ OCF₂H OCF₂H 46 301N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ OCF₂H OCF₂H46 302N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ OCF₂H OCF₂H 46 303N CF₃ R₂ +R₃ = (CH₂)₃ O H 4-Br—C₆H₅ OCF₂H OCF₂H 46 304N CF₃ R₂ + R₃ = (CH₂)₃ O4-Br—C₆H₅O H OCF₂H OCF₂H 46 305N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O H R₁₀ +R₁₁ = OCF₂CF₂O 46 306N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 46 307N CF₃ R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O46 308N CF₃ R₂ + R₃ = (CH₂)₃ O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 46309N CF₃ R₂ + R₃ = (CH₂)₃ O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 46 310N CF₃ R₂ +R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 46 311N CF₃ R₂ + R₃ =(CH₂)₃ O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 46 312N CF₃ R₂ + R₃ = (CH₂)₃ OH 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 46 313N CF₃ R₂ + R₃ = (CH₂)₃ O4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 46 314N CF₃ R₂ + R₃ = (CH₂)₃ O C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 46 315N CF₃ R₂ + R₃ = (CH₂)₃ O 4-Cl—C₆H₅O H R₁₀ +R₁₁ = OCCl₂CCl₂O 46 316N CF₃ R₂ + R₃ = (CH₂)₃ O 4-F—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 46 317N CF₃ R₂ + R₃ = (CH₂)₃ O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ =OCCl₂CCl₂O 46 318N CF₃ R₂ + R₃ = (CH₂)₃ O H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O46 319N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 46320N CF₃ R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 46 321NCF₃ R₂ + R₃ = (CH₂)₃ O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 46 322N CF₃R₂ + R₃ = (CH₂)₃ O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 46 323N CF₃ R₂ +R₃ = (CH₂)₃ O H H OH H 46 324N CF₃ R₂ + R₃ = (CH₂)₃ O H H OH OH 46 325NCF₃ R₂ + R₃ = (CH₂)₃ O H H H OH 46 326N CF₃ R₂ + R₃ = (CH₂)₃ O H HOCH₂CF₃ H 46 327N CF₃ R₂ + R₃ = (CH₂)₃ O H H H OCH₂CF₃ 46 328N CF₃ R₂ +R₃ = (CH₂)₃ O H H OCH₂CF₂CF₃ H 46 329N CF₃ R₂ + R₃ = (CH₂)₃ O H HOCH₂CH₂CF₃ H 46 330N CF₃ R₂ + R₃ = (CH₂)₃ O H H OCH(CF₃)₃ H 46 331N CF₃R₂ + R₃ = (CH₂)₃ O H 4-F—C₆H₅O H H 46 332N CF₃ R₂ + R₃ = (CH₂)₃ O4-F—C₆H₅O H H H 46 333N CF₃ R₂ + R₃ = (CH₂)₃ O H cyclo-hexoxy H H 46334N CF₃ R₂ + R₃ = (CH₂)₃ O cyclo-hexoxy H H H 46 335N CF₃ R₂ + R₃ =(CH₂)₃ O H CH(CH₃)₃ H H 46 336N CF₃ R₂ + R₃ = (CH₂)₃ O F H

bond to indicated phenyl carbon of R₁₀ substituent 57 224N HCF₂CF₂OCH₂ HO C₆H₅O H OCF₂CF₂H H 57 225N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCF₂CF₂H H 57226N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O H OCF₂CF₂H H 57 227N HCF₂CF₂OCH₂ H O3,4-Cl—C₆H₅O H OCF₂CF₂H H 57 228N HCF₂CF₂OCH₂ H O H C₆H₅ OCF₂CF₂H H 57229N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ OCF₂CF₂H H 57 230N HCF₂CF₂OCH₂ H O H4-F—C₆H₅ OCF₂CF₂H H 57 231N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCF₂CF₂H H 57232N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅O H OCF₂CF₂H H 57 233N HCF₂CF₂OCH₂ H OC₆H₅O H OCF₂CF₃ H 57 234N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCF₂CF₃ H 57 235NHCF₂CF₂OCH₂ H O 4-F—C₆H₅O H OCF₂CF₃ H 57 236N HCF₂CF₂OCH₂ H O3,4-Cl—C₆H₅O H OCF₂CF₃ H 57 237N HCF₂CF₂OCH₂ H O H C₆H₅ OCF₂CF₃ H 57238N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ OCF₂CF₃ H 57 239N HCF₂CF₂OCH₂ H O H4-F—C₆H₅ OCF₂CF₃ H 57 240N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCF₂CF₃ H 57 241NHCF₂CF₂OCH₂ H O 4-Br—C₆H₅O H OCF₂CF₃ H 57 242N HCF₂CF₂OCH₂ H O C₆H₅O HOCCl₂CCl₂H H 57 243N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCCl₂CCl₂H H 57 244NHCF₂CF₂OCH₂ H O 4-F—C₆H₅O H OCCl₂CCl₂H H 57 245N HCF₂CF₂OCH₂ H O3,4-Cl—C₆H₅O H OCCl₂CCl₂H H 57 246N HCF₂CF₂OCH₂ H O H C₆H₅ OCCl₂CCl₂H H57 247N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ OCCl₂CCl₂H H 57 248N HCF₂CF₂OCH₂ H OH 4-F—C₆H₅ OCCl₂CCl₂H H 57 249N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCCl₂CCl₂H H57 250N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅O H OCCl₂CCl₂H H 57 251N HCF₂CF₂OCH₂ HO C₆H₅O H OCCl₂CCl₃ H 57 252N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCCl₂CCl₃ H57 253N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O H OCCl₂CCl₃ H 57 254N HCF₂CF₂OCH₂ H O3,4-Cl—C₆H₅O H OCCl₂CCl₃ H 57 255N HCF₂CF₂OCH₂ H O H C₆H₅ OCCl₂CCl₃ H 57256N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ OCCl₂CCl₃ H 57 257N HCF₂CF₂OCH₂ H O H4-F—C₆H₅ OCCl₂CCl₃ H 57 258N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCCl₂CCl₃ H 57259N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅O H OCCl₂CCl₃ H 57 260N HCF₂CF₂OCH₂ H OC₆H₅O H OCCl₂CF₃ H 57 261N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCCl₂CF₃ H 57262N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O H OCCl₂CF₃ H 57 263N HCF₂CF₂OCH₂ H O3,4-Cl—C₆H₅O H OCCl₂CF₃ H 57 264N HCF₂CF₂OCH₂ H O H C₆H₅ OCCl₂CF₃ H 57265N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ OCCl₂CF₃ H 57 266N HCF₂CF₂OCH₂ H O H4-F—C₆H₅ OCCl₂CF₃ H 57 267N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCCl₂CF₃ H 57268N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅O H OCCl₂CF₃ H 57 269N HCF₂CF₂OCH₂ H OC₆H₅O H OCF₂CCl₃ H 57 270N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCF₂CCl₃ H 57271N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O H OCF₂CCl₃ H 57 272N HCF₂CF₂OCH₂ H O3,4-Cl—C₆H₅O H OCF₂CCl₃ H 57 273N HCF₂CF₂OCH₂ H O H C₆H₅ OCF₂CCl₃ H 57274N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ OCF₂CCl₃ H 57 275N HCF₂CF₂OCH₂ H O H4-F—C₆H₅ OCF₂CCl₃ H 57 276N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCF₂CCl₃ H 57277N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅O H OCF₂CCl₃ H 57 278N HCF₂CF₂OCH₂ H OC₆H₅O H OCF₂CF₂H OCF₂CF₂H 57 279N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCF₂CF₂HOCF₂CF₂H 57 280N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 57 281NHCF₂CF₂OCH₂ H O 3,4-Cl—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 57 282N HCF₂CF₂OCH₂ H OH C₆H₅ OCF₂CF₂H OCF₂CF₂H 57 283N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ OCF₂CF₂HOCF₂CF₂H 57 284N HCF₂CF₂OCH₂ H O H 4-F—C₆H₅ OCF₂CF₂H OCF₂CF₂H 57 285NHCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCF₂CF₂H OCF₂CF₂H 57 286N HCF₂CF₂OCH₂ H O4-Br—C₆H₅O H OCF₂CF₂H OCF₂CF₂H 57 287N HCF₂CF₂OCH₂ H O C₆H₅O H OCF₃ OCF₃57 288N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCF₃ OCF₃ 57 289N HCF₂CF₂OCH₂ H O4-F—C₆H₅O H OCF₃ OCF₃ 57 290N HCF₂CF₂OCH₂ H O 3,4-Cl—C₆H₅O H OCF₃ OCF₃57 291N HCF₂CF₂OCH₂ H O H C₆H₅ OCF₃ OCF₃ 57 292N HCF₂CF₂OCH₂ H O H4-Cl—C₆H₅ OCF₃ OCF₃ 57 293N HCF₂CF₂OCH₂ H O H 4-F—C₆H₅ OCF₃ OCF₃ 57 294NHCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCF₃ OCF₃ 57 295N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅OH OCF₃ OCF₃ 57 296N HCF₂CF₂OCH₂ H O C₆H₅O H OCF₂H OCF₂H 57 297NHCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H OCF₂H OCF₂H 57 298N HCF₂CF₂OCH₂ H O4-F—C₆H₅O H OCF₂H OCF₂H 57 299N HCF₂CF₂OCH₂ H O 3,4-Cl—C₆H₅O H OCF₂HOCF₂H 57 300N HCF₂CF₂OCH₂ H O H C₆H₅ OCF₂H OCF₂H 57 301N HCF₂CF₂OCH₂ H OH 4-Cl—C₆H₅ OCF₂H OCF₂H 57 302N HCF₂CF₂OCH₂ H O H 4-F—C₆H₅ OCF₂H OCF₂H57 303N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ OCF₂H OCF₂H 57 304N HCF₂CF₂OCH₂ H O4-Br—C₆H₅O H OCF₂H OCF₂H 57 305N HCF₂CF₂OCH₂ H O C₆H₅O H R₁₀ + R₁₁ =OCF₂CF₂O 57 306N HCF₂CF₂OCH₂ H O 4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 57307N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 57 308NHCF₂CF₂OCH₂ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 57 309N HCF₂CF₂OCH₂H O H C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 57 310N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅R₁₀ + R₁₁ = OCF₂CF₂O 57 311N HCF₂CF₂OCH₂ H O H 4-F—C₆H₅ R₁₀ + R₁₁ =OCF₂CF₂O 57 312N HCF₂CF₂OCH₂ H O H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCF₂CF₂O 57313N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅O H R₁₀ + R₁₁ = OCF₂CF₂O 57 314NHCF₂CF₂OCH₂ H O C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 57 315N HCF₂CF₂OCH₂ H O4-Cl—C₆H₅O H R₁₀ + R₁₁ = OCCl₂CCl₂O 57 316N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O HR₁₀ + R₁₁ = OCCl₂CCl₂O 57 317N HCF₂CF₂OCH₂ H O 3,4-Cl—C₆H₅O H R₁₀ + R₁₁= OCCl₂CCl₂O 57 318N HCF₂CF₂OCH₂ H O H C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 57319N HCF₂CF₂OCH₂ H O H 4-Cl—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 57 320NHCF₂CF₂OCH₂ H O H 4-F—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 57 321N HCF₂CF₂OCH₂ HO H 4-Br—C₆H₅ R₁₀ + R₁₁ = OCCl₂CCl₂O 57 322N HCF₂CF₂OCH₂ H O 4-Br—C₆H₅OH R₁₀ + R₁₁ = OCCl₂CCl₂O 57 323N HCF₂CF₂OCH₂ H O H H OH H 57 324NHCF₂CF₂OCH₂ H O H H OH OH 57 325N HCF₂CF₂OCH₂ H O H H H OH 57 326NHCF₂CF₂OCH₂ H O H H OCH₂CF₃ H 57 327N HCF₂CF₂OCH₂ H O H H H OCH₂CF₃ 57328N HCF₂CF₂OCH₂ H O H H OCH₂CF₂CF₃ H 57 329N HCF₂CF₂OCH₂ H O H HOCH₂CH₂CF₃ H 57 330N HCF₂CF₂OCH₂ H O H H OCH(CF₃)₃ H 57 331N HCF₂CF₂OCH₂H O H 4-F—C₆H₅O H H 57 332N HCF₂CF₂OCH₂ H O 4-F—C₆H₅O H H H 57 333NHCF₂CF₂OCH₂ H O H cyclo-hexoxy H H 57 334N HCF₂CF₂OCH₂ H O cyclo-hexoxyH H H 57 335N HCF₂CF₂OCH₂ H O H CH(CH₃)₃ H H 57 336N HCF₂CF₂OCH₂ H O F H

bond to indicated phenyl carbon of R₁₀ substituent

TABLE 18 Structure of Substituted Tricyclic Phenyltertiary-2-Heteroalkylamines (Z is covalent bond; Y is CH and R₁₄ is H).(Cyclo-VII)

Cyclized Cyclized Compound of Compound Inhibitor Number Number R₁ R₂ R₃X R₅ R₆ R₇ R₁₀ R₁₁ 1 3N 1-337N CF₃ H H O H H F OCF₂CF₂H H 1 27N CF₃ H HO F H H CF₃ H 1 44N CF₃ H H O F H H CH₃ H 1 76N CF₃ H H O F H H H OCF₃ 184N CF₃ H H O F H H H CH₃ 1 85N CF₃ H H O CF₃ H H H CH₃ 2 3N CCl₃ H H OH H F OCF₂CF₂H H 2 27N CCl₃ H H O F H H CF₃ H 2 44N CCl₃ H H O F H H CH₃H 2 76N CCl₃ H H O F H H H OCF₃ 2 84N CCl₃ H H O F H H H CH₃ 2 85N CCl₃H H O CF₃ H H H CH₃ 3 3N CF₃ CH₃ H O H H F OCF₂CF₂H H 3 27N CF₃ CH₃ H OF H H CF₃ H 3 44N CF₃ CH₃ H O F H H CH₃ H 3 76N CF₃ CH₃ H O F H H H OCF₃3 84N CF₃ CH₃ H O F H H H CH₃ 3 85N CF₃ CH₃ H O CF₃ H H H CH₃ 4 3NCF₃CF₂ H H O H H F OCF₂CF₂H H 4 27N CF₃CF₂ H H O F H H CF₃ H 4 44NCF₃CF₂ H H O F H H CH₃ H 4 76N CF₃CF₂ H H O F H H H OCF₃ 4 84N CF₃CF₂ HH O F H H H CH₃ 4 85N CF₃CF₂ H H O CF₃ H H H CH₃ 5 3N CF₃CF₂CF₂ H H O HH F OCF₂CF₂H H 5 27N CF₃CF₂CF₂ H H O F H H CF₃ H 5 44N CF₃CF₂CF₂ H H O FH H CH₃ H 5 76N CF₃CF₂CF₂ H H O F H H H OCF₃ 5 84N CF₃CF₂CF₂ H H O F H HH CH₃ 5 85N CF₃CF₂CF₂ H H O CF₃ H H H CH₃ 6 3N CF₃OCF₂CF₂ H H O H H FOCF₂CF₂H H 6 27N CF₃OCF₂CF₂ H H O F H H CF₃ H 6 44N CF₃OCF₂CF₂ H H O F HH CH₃ H 6 76N CF₃OCF₂CF₂ H H O F H H H OCF₃ 6 84N CF₃OCF₂CF₂ H H O F H HH CH₃ 6 85N CF₃OCF₂CF₂ H H O CF₃ H H H CH₃ 7 3N CF₃CH₂ H H O H H FOCF₂CF₂H H 7 27N CF₃CH₂ H H O F H H CF₃ H 7 44N CF₃CH₂ H H O F H H CH₃ H7 76N CF₃CH₂ H H O F H H H OCF₃ 7 84N CF₃CH₂ H H O F H H H CH₃ 7 85NCF₃CH₂ H H O CF₃H H H CH₃ 8 3N CF₃ CHF₂ H O H H F OCF₂CF₂H H 8 27N CF₃CHF₂ H O F H H CF₃ H 8 44N CF₃ CHF₂ H O F H H CH₃ H 8 76N CF₃ CHF₂ H O FH H H OCF₃ 8 84N CF₃ CHF₂ H O F H H H CH₃ 8 85N CF₃ CHF₂ H O CF₃ H H HCH₃ 9 3N CF₃ H CF₃ O H H F OCF₂CF₂H H 9 27N CF₃ H CF₃ O F H H CF₃ H 944N CF₃ H CF₃ O F H H CH₃ H 9 76N CF₃ H CF₃ O F H H H OCF₃ 9 84N CF₃ HCF₃ O F H H H CH₃ 9 85N CF₃ H CF₃ O CF₃ H H H CH₃ 10 3N CF₃ CF₃ H O H HF OCF₂CF₂H H 10 27N CF₃ CF₃ H O F H H CF₃ H 10 44N CF₃ CF₃ H O F H H CH₃H 10 76N CF₃ CF₃ H O F H H H OCF₃ 10 84N CF₃ CF₃ H O F H H H CH₃ 10 85NCF₃ CF₃ H O CF₃ H H H CH₃ 11 3N CF₃ C₆H₅ H O H H F OCF₂CF₂H H 11 27N CF₃C₆H₅ H O F H H CF₃ H 11 44N CF₃ C₆H₅ H O F H H CH₃ H 11 76N CF₃ C₆H₅ H OF H H H OCF₃ 11 84N CF₃ C₆H₅ H O F H H H CH₃ 11 85N CF₃ C₆H₅ H O CF₃ H HH CH₃ 12 3N CCl₃ C₆H₅ H O H H F OCF₂CF₂H H 12 27N CCl₃ C₆H₅ H O F H HCF₃ H 12 44N CCl₃ C₆H₅ H O F H H CH₃ H 12 76N CCl₃ C₆H₅ H O F H H H OCF₃12 84N CCl₃ C₆H₅ H O F H H H CH₃ 12 85N CCl₃ C₆H₅ H O CF₃ H H H CH₃ 193N CF₃ CF₃ H NH H H F OCF₂CF₂H H 19 27N CF₃ CF₃ H NH F H H CF₃ H 19 44NCF₃ CF₃ H NH F H H CH₃ H 19 76N CF₃ CF₃ H NH F H H H OCF₃ 19 84N CF₃ CF₃H NH F H H H CH₃ 19 85N CF₃ CF₃ H NH CF₃ H H H CH₃ 20 3N CF₃ H H NH H HF OCF₂CF₂H H 20 27N CF₃ H H NH F H H CF₃ H 20 44N CF₃ H H NH F H H CH₃ H20 76N CF₃ H H NH F H H H OCF₃ 20 84N CF₃ H H NH F H H H CH₃ 20 85N CF₃H H NH CF₃ H H H CH₃ 25 3N CF₃ H H S H H F OCF₂CF₂H H 25 27N CF₃ H H S FH H CF₃ H 25 44N CF₃ H H S F H H CH₃ H 25 76N CF₃ H H S F H H H OCF₃ 2584N CF₃ H H S F H H H CH₃ 25 85N CF₃ H H S CF₃ H H H CH₃

1. A method for treating coronary artery disease in a mammal comprisingadministering to a mammal in need of treatment thereof a therapeuticallyeffective amount of a substituted tertiary-heteroalkylamine Compound ora pharmaceutically acceptable salt thereof.
 2. A method for inhibitingCETP in a mammal comprising administering to a mammal in need oftreatment thereof a therapeutically effective amount of a substitutedtertiary-heteroalkylamine compound or a pharmaceutically acceptable saltthereof.
 3. The method of claim 1 or 2, wherein the substitutedtertiary-heteroalkylamine compound is a tertiary-omegaheteroalkylaminecompound.
 4. The method of claim 1 or 2, wherein the substitutedtertiary-heteroalkylamine compound is an aromatictertiary-omegaheteroalkylamine compound.
 5. The method of claim 1 or 2,wherein the substituted tertiary-heteroalkylamine compound is atertiary-2-heteroalkylamine compound.
 6. The method of claim 1 or 2,wherein the substituted tertiary-heteroalkylamine compound is anaromatic tertiary-2-omegaheteroalkylamine compound.
 7. The method ofclaim 1 or 2, wherein the substituted tertiary-heteroalkylamine compoundis a heteroaryl tertiary-omegaheteroalkylamine compound.
 8. The methodof claim 1 or 2, wherein the substituted tertiary-heteroalkylaminecompound is a phenyl tertiary-omegaheteroalkylamine compound.